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  1. Article ; Online: Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a.

    Zheng, Yong / Wu, Shangrong / Ke, Haiqiang / Peng, Shanshan / Hu, Chengjun

    Experimental gerontology

    2022  Volume 172, Page(s) 112062

    Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms ...

    Abstract Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critical for the development of BMSC-based tissue engineering and regenerative medicine. In this study, senescent BMSCs were characterized with >80 % of BMSCs stained positive for SA-β-gal, increased expressions of senescence-related genes (p16
    MeSH term(s) Autophagy/physiology ; Bone Marrow Cells/metabolism ; Cellular Senescence/physiology ; Interleukin-6/metabolism ; Interleukin-8 ; Mesenchymal Stem Cells/physiology ; Forkhead Transcription Factors
    Chemical Substances Interleukin-6 ; Interleukin-8 ; Forkhead Transcription Factors
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2022.112062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1.

    Xiang, Ying / Yan, Kai / Zheng, Qian / Ke, Haiqiang / Cheng, Jie / Xiong, Wenjun / Shi, Xin / Wei, Lei / Zhao, Min / Yang, Fei / Wang, Ping / Lu, Xing / Fu, Li / Lu, Xuemei / Li, Feng

    Cancer research

    2018  Volume 79, Issue 1, Page(s) 86–98

    Abstract: The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene ... ...

    Abstract The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene expression and genome instability. A genome-wide analysis to evaluate the effect of KDM4B on the global or local H3K9me3 level has not been performed. In this study, we assess whole-genome H3K9me3 distribution in cancer cells and find that H3K9me3 is largely enriched in long interspersed nuclear element-1 (LINE-1). A significant proportion of KDM4B-dependent H3K9me3 was located in evolutionarily young LINE-1 elements, which likely retain retrotransposition activity. Ectopic expression of KDM4B promoted LINE-1 expression, while depletion of KDM4B reduced it. Furthermore, KDM4B overexpression enhanced LINE-1 retrotransposition efficacy, copy number, and associated DNA damage, presumably via the histone demethylase activity of KDM4B. Breast cancer cell lines expressing high levels of KDM4B also exhibited increased LINE-1 expression and copy number compared with other cell lines. Pharmacologic inhibition of KDM4B significantly reduced LINE-1 expression and DNA damage in breast cancer cells with excessive KDM4B. Our study not only identifies KDM4B as a novel regulator of LINE-1, but it also suggests an unexpected oncogenic role for KDM4B overexpression in tumorigenesis, providing clues for the development of new cancer prevention strategies and therapies. SIGNIFICANCE: The histone demethylase KDM4B promotes tumorigenesis by inducing retrotransposition and DNA damage.
    MeSH term(s) Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; DNA Damage ; Female ; Gene Expression Regulation, Neoplastic ; Genome, Human ; Histones/chemistry ; Histones/genetics ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Long Interspersed Nucleotide Elements ; Prognosis ; Tumor Cells, Cultured
    Chemical Substances Histones ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; KDM4B protein, human (EC 1.14.11.-)
    Language English
    Publishing date 2018-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-18-1310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  3. Article ; Online: E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the

    Chen, Xiaohua / Loo, Jun Xian / Shi, Xin / Xiong, Wenjun / Guo, Yong / Ke, Haiqiang / Yang, Mingkun / Jiang, Yanping / Xia, Siyu / Zhao, Min / Zhong, Shan / He, Chunjiang / Fu, Li / Li, Feng

    Cancer research

    2018  Volume 78, Issue 6, Page(s) 1418–1430

    Abstract: The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and ... ...

    Abstract The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and telomerase activation. It is also capable of stimulating expression of several oncogenes, but the molecular mechanism underlying these events is poorly understood. Here, we provide evidence that HPV16 E6 physically interacts with histone H3K4 demethylase KDM5C, resulting in its degradation in an E3 ligase E6AP- and proteasome-dependent manner. Moreover, we found that HPV16-positive cancer cell lines exhibited lower KDM5C protein levels than HPV-negative cancer cell lines. Restoration of KDM5C significantly suppressed the tumorigenicity of CaSki cells, an HPV16-positive cervical cancer cell line. Whole genome ChIP-seq and RNA-seq results revealed that CaSki cells contained super-enhancers in the proto-oncogenes
    MeSH term(s) Animals ; Cell Line, Tumor ; Enhancer Elements, Genetic ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Host-Pathogen Interactions/genetics ; Human papillomavirus 16/pathogenicity ; Humans ; Mice, Nude ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/metabolism ; Papillomavirus Infections/genetics ; Papillomavirus Infections/metabolism ; Protein Stability ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Ubiquitination ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/virology
    Chemical Substances E6 protein, Human papillomavirus type 16 ; E6 protein, Human papillomavirus type 6 ; Oncogene Proteins, Viral ; Repressor Proteins ; Histone Demethylases (EC 1.14.11.-) ; KDM5C protein, human (EC 1.14.11.-) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Language English
    Publishing date 2018-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-17-2118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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