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Article ; Online: Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.

Xu, Jinxin / Cai, Yingjie / Hong, Zhinuan / Duan, Hongbing / Ke, Sunkui

International journal of surgery (London, England)

2024 Volume 110, Issue 1, Page(s) 490–506

Abstract: Background: The application of neoadjuvant immune checkpoint inhibitors combined with chemotherapy (NICT) in treating locally advanced oesophageal squamous cell carcinoma (ESCC) is a subject of considerable research interest. In light of this, we ... ...

Abstract	Background: The application of neoadjuvant immune checkpoint inhibitors combined with chemotherapy (NICT) in treating locally advanced oesophageal squamous cell carcinoma (ESCC) is a subject of considerable research interest. In light of this, we undertook a comprehensive meta-analysis aiming to compare the efficacy and safety of this novel approach with conventional neoadjuvant chemotherapy (NCT) in the management of ESCC. Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science to gather relevant literature on the efficacy and safety of NICT compared to conventional NCT in locally advanced ESCC published before June 2023. Effect indicators, including odds ratios (ORs) with associated 95% CIs, were employed to evaluate the safety and efficacy outcomes. The risk of bias was assessed using the Cochrane bias risk assessment tool, and s ubgroup analysis and sensitivity analysis were conducted to investigate the findings further. Results: A total of nine studies qualified for the meta-analysis, all of which investigated the efficacy and safety of NICT compared to conventional NCT. The pooled rates of pathologic complete response and major pathologic response in the NICT group were significantly higher compared to the NCT group, with values of 26.9% versus 8.3% ( P <0.00001) and 48.1% versus 24.6% ( P <0.00001), respectively. The ORs for achieving pathologic complete response and major pathologic response were 4.24 (95% CI, 2.84-6.32, I 2 =14%) and 3.30 (95% CI, 2.31-4.71, I 2 =0%), respectively, indicating a significant advantage for the NICT group. Regarding safety outcomes, the pooled incidences of treatment-related adverse events and serious adverse events in the NICT group were 64.4% and 11.5%, respectively, compared to 73.8% and 9.3% in the NCT group. However, there were no significant differences observed between the two groups in terms of treatment-related adverse events (OR=0.67, 95% CI, 0.29-1.54, P =0.35, I 2 =58%) or serious adverse events (OR=1.28, 95% CI, 0.69-2.36, P =0.43, I 2 =0%). Furthermore, no significant differences were found between the NICT and NCT groups regarding R0 resection rates, anastomotic leakage, pulmonary infection, and postoperative hoarseness. Conclusions: Neoadjuvant immune checkpoint inhibitors combined with chemotherapy demonstrate efficacy and safety in treating resectable oesophageal squamous cell carcinoma. Nevertheless, additional randomized trials are required to confirm the optimal treatment regimen.
MeSH term(s)	Humans ; Neoadjuvant Therapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/surgery ; Immune Checkpoint Inhibitors/adverse effects ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/surgery ; Anastomotic Leak ; Pathologic Complete Response
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000816
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Article ; Online: Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin.

Wang, Yan / Zhang, Jingwen / Zhang, Jiaxian / Hou, Miao / Kong, Lingkun / Lin, Xiong / Xu, Jinxin / Yan, Chun / Lin, Fan / Ke, Sunkui

The Science of the total environment

2024 Volume 925, Page(s) 171742

Abstract: Background: No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure and chronic obstructive pulmonary disease (COPD) risk. This study aims to explore this relationship.: Methods: This study enrolled 4541 ... ...

Abstract	Background: No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure and chronic obstructive pulmonary disease (COPD) risk. This study aims to explore this relationship. Methods: This study enrolled 4541 individuals who had available data on PFAS, COPD, and covariates from NHANES 2007-2018. Serum PFAS including perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) were analyzed, because of high detective rates. Considering the skew distribution of PFAS levels, the natural logarithm-transformed PFAS (Ln-PFAS) was used. Logistic regression analysis, restricted cubic spline (RCS), and weighted quantile sum (WQS) regression were performed to explore the single, nonlinear, and mixed effects. A mediating analysis was used to evaluate the mediated effects of albumin. Results: Individuals with COPD had higher levels of PFHxS, PFNA, PFOA, and PFOS compared to those without COPD. Ln-PFNA (OR Conclusion: This study concludes PFOA and PFNA are linked to a higher COPD risk in males, and serum albumin plays a mediating role in the relationship between PFOA and COPD. Thess findings are beneficial for the prevention of COPD. Further studies are required to explore potential mechanisms.
MeSH term(s)	Male ; Female ; Humans ; Nutrition Surveys ; Environmental Pollutants ; Serum Albumin ; Prevalence ; Alkanesulfonic Acids ; Fluorocarbons ; Alkanesulfonates ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Caprylates ; Fatty Acids
Chemical Substances	Environmental Pollutants ; Serum Albumin ; perfluorooctane sulfonic acid (9H2MAI21CL) ; Alkanesulfonic Acids ; perfluoro-n-nonanoic acid (375-95-1) ; perfluorooctanoic acid (947VD76D3L) ; Fluorocarbons ; Alkanesulfonates ; perflexane (FX3WJ41CMX) ; Caprylates ; Fatty Acids
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171742
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Zs.A 949: Show issues

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Article: Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China.

Xu, Jinxin / Hong, Zhinuan / Cai, Yingjie / Chen, Zhen / Lin, Jingping / Yuan, Xi / Chen, Shuchen / Xie, Jinbiao / Kang, Mingqiang / Ke, Sunkui

Frontiers in oncology

2024 Volume 14, Page(s) 1279733

Abstract: Objective: This study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy.: Methods: A total of 190 LA- ... ...

Abstract	Objective: This study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy. Methods: A total of 190 LA-ESCC patients were recruited from three medical centers across China. Pre-treatment laboratory tests were utilized to calculate inflammatory nutritional scores. LASSO regression and multivariate logistic regression analyses were conducted to pinpoint predictors of pathological response. Kaplan-Meier and Cox regression analyses were employed to assess disease-free survival (DFS) prognostic factors. Results: The cohort comprised 154 males (81.05%) and 36 females (18.95%), with a median age of 61.4 years. Pathological complete response (pCR) was achieved in 17.38% of patients, while 44.78% attained major pathological response (MPR). LASSO and multivariate logistic regression analyses identified that hemoglobin, albumin, lymphocyte, and platelet (HALP) (P=0.02) as an independent predictors of MPR in LA-ESCC patients receiving neoadjuvant chemoimmunotherapy. Kaplan-Meier and log-rank tests indicated that patients with low HALP, MPR, ypT1-2, ypN0 and, ypTNM I stages had prolonged DFS (P < 0.05). Furthermore, univariate and multivariate Cox regression analyses underscored HALP (P = 0.019) and ypT (P = 0.029) as independent predictive factors for DFS in ESCC. Conclusion: Our study suggests that LA-ESCC patients with lower pre-treatment HALP scores exhibit improved pathological response and reduced recurrence rate. As a comprehensive index of inflammatory nutritional status, pre-treatment HALP may be a reliable prognostic marker in ESCC patients undergoing neoadjuvant chemoimmunotherapy.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1279733
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Article ; Online: Glutathione/pH-responsive copper-based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual glutathione depletion

Jia, Sihan / Ke, Sunkui / Du, Li / Chen, Shengqiang / Luo, Bingkun / Xiong, Yeqi / Li, Yang / Wang, Peiyuan / Ye, Shefang

Journal of Colloid And Interface Science. 2023 Aug. 07,

2023

Abstract: The rapid scavenging of reactive oxygen species (ROS) by glutathione (GSH) and insufficient endogenous hydrogen peroxide (H₂O₂) in tumor cells are the major factors greatly restricting the efficacy of chemodynamic therapy (CDT). Herein, we developed a ... ...

Abstract	The rapid scavenging of reactive oxygen species (ROS) by glutathione (GSH) and insufficient endogenous hydrogen peroxide (H₂O₂) in tumor cells are the major factors greatly restricting the efficacy of chemodynamic therapy (CDT). Herein, we developed a tumor microenvironment (TME)-responsive Cu-based metal-mesoporous organosilica nanoplatform integrating vitamin k3 (VK3), which could deplete GSH and specifically regenerate H₂O₂ for amplified CDT cancer therapy. Once the CuO@MON-PEG/VK3 nanoparticles entered into the tumor cells through enhanced permeability and retention (EPR) effect, the organosilicon shell and CuO core would be successively degraded upon the triggering of GSH and endo/lysosomal acidity. Subsequently, the enriched tetrasulfide bridges and released Cu²⁺ could consume GSH substantially, thus triggering Fenton-like reaction for CDT. Furthermore, the released VK3 could be catalyzed by the highly expressed quinone oxidoreductase-1 (NQO1) inside tumor cells to generate sufficient H₂O₂ through a “reversible” redox cycle, which in turn promoted Cu⁺-mediated Fenton-like reaction. Both in vitro and in vivo studies demonstrated that this nanoplatform could achieve synergistic CDT therapy against tumor through synergistic cycling regeneration of ROS and dual GSH exhaustion with excellent biosafety. Our finding highlight the promising potential of CuO@MON-PEG/VK3 nanoplatform with multiple oxidative stress amplification for highly efficient tumor therapy.
Keywords	acidity ; biosafety ; cancer therapy ; copper ; glutathione ; hydrogen peroxide ; menadione ; nanoparticles ; neoplasms ; organosilicon compounds ; oxidative stress ; permeability ; Tumor microenvironment ; Chemodynamic therapy ; Reactive oxygen species
Language	English
Dates of publication	2023-0807
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.043
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficacy and Safety of Neoadjuvant Chemoimmunotherapy in Resectable Esophageal Squamous Cell Carcinoma: A Meta-analysis.

Xu, Jinxin / Yan, Chun / Li, Zhe / Cao, Yunpeng / Duan, Hongbing / Ke, Sunkui

Annals of surgical oncology

2022 Volume 30, Issue 3, Page(s) 1597–1613

Abstract: Purpose: This study aimed to summarize the efficacy and safety of neoadjuvant chemoimmunotherapy in resectable esophageal squamous cell carcinoma (ESCC).: Methods: Literature focusing on the efficacy and safety of neoadjuvant immunotherapy or ... ...

Abstract	Purpose: This study aimed to summarize the efficacy and safety of neoadjuvant chemoimmunotherapy in resectable esophageal squamous cell carcinoma (ESCC). Methods: Literature focusing on the efficacy and safety of neoadjuvant immunotherapy or chemoimmunotherapy in resectable ESCC published before June 2022 was retrieved from PubMed, Embase, Cochrane Library, and Web of Science. The risk of bias was assessed using the Cochrane risk-of-bias assessment tool. Subgroup and sensitivity analyses were further performed. Results: A total of 452 patients from 15 studies were included in this meta-analysis. All of the studies explored the efficacy and safety of neoadjuvant chemoimmunotherapy. The pooled major pathological response (MPR) rate and pathological complete response (PCR) rate were 58.3% and 32.9%, respectively. The pooled incidence of treatment-related adverse events (TRAEs) and serious adverse events (SAEs) were 91.6% and 19.4%, respectively. The pooled R0 resection rate was 92.8%, and the resection rate was 81.1%. Incidence of anastomotic leakage, pulmonary infection, and postoperative hoarseness were 10.7%, 21.3%, and 13.0%, respectively. Compared with 2 cycles of neoadjuvant therapy, patients who received > 2 cycles of neoadjuvant therapy showed higher MPR rate (57.3% vs. 61.1%) and PCR rate (30.6% vs. 37.9%), and the incidence of TRAEs (89.2% vs. 98.9%) tended to be higher. However, no significant difference was found (P > 0.05). Two cycles of neoadjuvant therapy showed higher R0 resection rate and resection rate (R0 resection rate: 96.0% vs. 87.8%, P = 0.02; resection rate: 85.6% vs. 74.7%, P = 0.01). Pembrolizumab- and tislelizumab-based neoadjuvant therapy showed higher MPR rate (72.4% and 72.2%) and PCR rate (41.5 % and 50.0%). Compared with other ICIs, tislelizumab-based neoadjuvant therapy showed lower R0 resection rate (80.5%). The pooled incidence of SAEs for pembrolizumab-based neoadjuvant therapy (2.0%) was lower. Camrelizumab-based neoadjuvant therapy showed lower incidence of pulmonary infection (11.5%). Conclusions: Neoadjuvant chemoimmunotherapy is effective and safe for resectable ESCC.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/therapy ; Esophageal Squamous Cell Carcinoma/pathology ; Neoadjuvant Therapy ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Chemotherapy, Adjuvant ; Immunotherapy
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-12752-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of nomograms predictive of anastomotic leakage in patients before minimally invasive McKeown esophagectomy.

Chen, Jianqing / Xu, Jinxin / He, Jianbing / Hu, Chao / Yan, Chun / Wu, Zhaohui / Li, Zhe / Duan, Hongbing / Ke, Sunkui

Frontiers in surgery

2023 Volume 9, Page(s) 1079821

Abstract: Purpose: The present study aims to identify factors related to anastomotic leakage before esophagectomy and to construct a prediction model.: Methods: A retrospective analysis of 285 patients who underwent minimally invasive esophagectomy (MIE). An ... ...

Abstract	Purpose: The present study aims to identify factors related to anastomotic leakage before esophagectomy and to construct a prediction model. Methods: A retrospective analysis of 285 patients who underwent minimally invasive esophagectomy (MIE). An absolute shrinkage and selection operator was applied to screen the variables, and predictive models were developed using binary logistic regression. Results: A total of 28 variables were collected in this study. LASSO regression analysis, combined with previous literature and clinical experience, finally screened out four variables, including aortic calcification, heart disease, BMI, and FEV1. A binary logistic regression was conducted on the four predictors, and a prediction model was established. The prediction model showed good discrimination and calibration, with a C-statistic of 0.67 (95% CI, 0.593-0.743), a calibration curve fitting a 45° slope, and a Brier score of 0.179. The DCA demonstrated that the prediction nomogram was clinically useful. In the internal validation, the C-statistic still reaches 0.66, and the calibration curve has a good effect. Conclusions: When patients have aortic calcification, heart disease, obesity, and a low FEV1, the risk of anastomotic leakage is higher, and relevant surgical techniques can be used to prevent it. Therefore, the clinical prediction model is a practical tool to guide surgeons in the primary prevention of anastomotic leakage.
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1079821
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Article ; Online: Glutathione/pH-responsive copper-based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual glutathione depletion.

Jia, Sihan / Ke, Sunkui / Tu, Li / Chen, Shengqiang / Luo, Bingkun / Xiong, Yeqi / Li, Yang / Wang, Peiyuan / Ye, Shefang

Journal of colloid and interface science

2023 Volume 652, Issue Pt A, Page(s) 329–340

Abstract: The rapid scavenging of reactive oxygen species (ROS) by glutathione (GSH) and insufficient endogenous hydrogen peroxide ( ... ...

Abstract	The rapid scavenging of reactive oxygen species (ROS) by glutathione (GSH) and insufficient endogenous hydrogen peroxide (H
MeSH term(s)	Humans ; Copper/pharmacology ; Reactive Oxygen Species ; Hydrogen Peroxide/pharmacology ; Nanoparticles ; Glutathione ; Hydrogen-Ion Concentration ; Cell Line, Tumor ; Neoplasms ; Tumor Microenvironment
Chemical Substances	cupric oxide (V1XJQ704R4) ; Copper (789U1901C5) ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.043
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Article: Nomogram-based prediction model for survival of COVID-19 patients: A clinical study.

Xu, Jinxin / Zhang, Wenshan / Cai, Yingjie / Lin, Jingping / Yan, Chun / Bai, Meirong / Cao, Yunpeng / Ke, Sunkui / Liu, Yali

Heliyon

2023 Volume 9, Issue 9, Page(s) e20137

Abstract: The study aim to construct an effective model for predicting the survival period of COVID-19 patients.: Methods: Clinical data of 386 COVID-19 patients were collected from December 2022 to January 2023. The patients were randomly divided into training ...

Abstract	The study aim to construct an effective model for predicting the survival period of COVID-19 patients. Methods: Clinical data of 386 COVID-19 patients were collected from December 2022 to January 2023. The patients were randomly divided into training and validation cohorts in a 7:3 ratio. LASSO regression and multivariate Cox regression analyses were used to identify prognostic factors, and a nomogram was constructed. Nomogram was evaluated using decision curve analysis, receiver operating characteristic curve, consistency index (c-index), and calibration curve. Results: 86 patients (22.3%) died. A new nomogram for predicting the survival was established based on age, resting oxygen saturation, Blood urea nitrogen (BUN), c-reactive protein-to-albumin ratio (CAR), and pneumonia visual score. The decision curve indicated high clinical applicability. The nomogram c-indexes in the training and validation cohorts were 0.846 and 0.81, respectively. The area under the curves (AUCs) for the 15-day and 30-day survival probabilities were 0.906 and 0.869 in the training cohort, and 0.851 and 0.843 in the validation cohort. The calibration curves demonstrated consistency between predicted and actual survival probabilities. Conclusions: Our nomogram has the capacity to assist clinical practitioners in estimating the survival rate of COVID-19 patients, thereby facilitating more optimal management strategies and therapeutic interventions with substantial clinical applicability.
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20137
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Article ; Online: Bioengineered nanogenerator with sustainable reactive oxygen species storm for self-reinforcing sono-chemodynamic oncotherapy.

Shi, Dao / Wu, Feng / Huang, Lingling / Li, Ying / Ke, Sunkui / Li, Jinyao / Hou, Zhenqing / Fan, Zhongxiong

Journal of colloid and interface science

2023 Volume 646, Page(s) 649–662

Abstract: Oxidative stress-based antitumor modalities derived from reactive oxygen species (ROS) storms have attracted increasing attention. Nevertheless, low delivery efficiency, poor selectivity, hypoxia and overexpressed glutathione (GSH) have severely ... ...

Abstract	Oxidative stress-based antitumor modalities derived from reactive oxygen species (ROS) storms have attracted increasing attention. Nevertheless, low delivery efficiency, poor selectivity, hypoxia and overexpressed glutathione (GSH) have severely restricted the sustainable generation of the ROS storm in tumor cells. Herein, we design a bioengineered nanogenerator by coordination-driven co-assembly of sonosensitizer indocyanine green (ICG), Fenton-like agent copper ion (Cu
MeSH term(s)	Humans ; Reactive Oxygen Species ; Oxidative Stress ; Biomedical Engineering ; Copper/pharmacology ; Drug Liberation ; Glutathione ; Indocyanine Green ; Metformin/pharmacology ; Cell Line, Tumor ; Neoplasms/drug therapy ; Hydrogen Peroxide
Chemical Substances	Reactive Oxygen Species ; Copper (789U1901C5) ; Glutathione (GAN16C9B8O) ; Indocyanine Green (IX6J1063HV) ; Metformin (9100L32L2N) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.081
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Article ; Online: Amino acid-based metallo-supramolecular nanoassemblies capable of regulating cellular redox homeostasis for tumoricidal chemo-/photo-/catalytic combination therapy.

Tu, Li / Chen, Shengqiang / Yuan, Zhikang / Xiong, Yeqi / Luo, Bingkun / Chen, Ying / Hou, Zhenqing / Ke, Sunkui / Lin, Naibo / Li, Chao / Ye, Shefang

Journal of colloid and interface science

2024 Volume 663, Page(s) 810–824

Abstract: Nanozymes, as nanomaterials with natural enzyme activities, have been widely applied to deliver various therapeutic agents to synergistically combat the progression of malignant tumors. However, currently common inorganic nanozyme-based drug delivery ... ...

Abstract	Nanozymes, as nanomaterials with natural enzyme activities, have been widely applied to deliver various therapeutic agents to synergistically combat the progression of malignant tumors. However, currently common inorganic nanozyme-based drug delivery systems still face challenges such as suboptimal biosafety, inadequate stability, and inferior tumor selectivity. Herein, a super-stable amino acid-based metallo-supramolecular nanoassembly (FPIC NPs) with peroxidase (POD)- and glutathione oxidase (GSHOx)-like activities was fabricated via Pt
MeSH term(s)	Humans ; Photochemotherapy ; Amino Acids ; Combined Modality Therapy ; Indocyanine Green/pharmacology ; Neoplasms/drug therapy ; Coloring Agents ; Curcumin ; Oxidation-Reduction ; Cell Line, Tumor ; Nanoparticles
Chemical Substances	Amino Acids ; Indocyanine Green (IX6J1063HV) ; Coloring Agents ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.197
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