Article ; Online: Xanthones with multiple roles against diabetes: their synthesis, structure-activity relationship, and mechanism studies.
2024 Volume 85, Issue 2, Page(s) e22170
Abstract: A four-step synthetic process has been developed to prepare 1,3,5,8-tetrahydroxyxanthone (2a) and its isomer 1,3,7,8-tetrahydroxyxanthone (2b). 25 more xanthones were also synthesized by a modified scheme. Xanthone 2a was identified as the most active ... ...
| Abstract | A four-step synthetic process has been developed to prepare 1,3,5,8-tetrahydroxyxanthone (2a) and its isomer 1,3,7,8-tetrahydroxyxanthone (2b). 25 more xanthones were also synthesized by a modified scheme. Xanthone 2a was identified as the most active inhibitor against both α-glucosidase and aldose reductase (ALR2), with IC |
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| MeSH term(s) | Humans ; Structure-Activity Relationship ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; alpha-Glucosidases/chemistry ; alpha-Glucosidases/metabolism ; Diabetes Complications/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Xanthones/pharmacology ; Xanthones/therapeutic use ; Molecular Docking Simulation ; Diabetes Mellitus/drug therapy | |||||
| Chemical Substances | Hypoglycemic Agents ; alpha-Glucosidases (EC 3.2.1.20) ; Antioxidants ; Xanthones | |||||
| Language | English | |||||
| Publishing date | 2024-03-13 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 604587-x | |||||
| ISSN | 1098-2299 ; 0272-4391 | |||||
| ISSN (online) | 1098-2299 | |||||
| ISSN | 0272-4391 | |||||
| DOI | 10.1002/ddr.22170 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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