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  1. Book: Glenn's urologic surgery

    Keane, Thomas E. / Graham, Sam D. / Glenn, James F.

    2016  

    Title variant Urologic surgery
    Author's details ed. Thomas E. Keane ; Sam D. Graham
    Keywords Urogenital Surgical Procedures ; Female Urogenital Diseases / surgery ; Male Urogenital Diseases / surgery
    Language English
    Size XXVII, 959 S. : zahlr. Ill., graph. Darst.
    Edition 8. ed.
    Publisher Wolters Kluwer
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT018805876
    ISBN 978-1-4511-9146-2 ; 1-4511-9146-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 3830 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book ; Online: Glenn's urologic surgery

    Graham, Sam D. / Keane, Thomas E. / Glenn, James F., 1928-

    2010  

    Title variant Urologic surgery
    Author's details editors, Sam D. Graham Jr., Thomas E. Keane ; consultant editor, James F. Glenn ; associate editors, Charles B. Brendler
    Keywords Urogenital surgical procedures ; Female urogenital diseases - surgery ; Male urogenital diseases - surgery
    Language English
    Size 1 Online-Ressource
    Edition 7th ed.
    Publisher Wolters Kluwer/Lippincott Williams & Wilkins Health
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-9141-0 ; 0-7817-9141-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Approach to Androgen Deprivation in the Prostate Cancer Patient with Pre-existing Cardiovascular Disease.

    Greiman, Alyssa K / Keane, Thomas E

    Current urology reports

    2017  Volume 18, Issue 6, Page(s) 41

    Abstract: Purpose of review: Androgen deprivation therapy (ADT) is a mainstay of treatment for advanced prostate cancer. Several studies have reported an association between ADT and an increase in cardiovascular events, especially in those receiving gonadotropin- ... ...

    Abstract Purpose of review: Androgen deprivation therapy (ADT) is a mainstay of treatment for advanced prostate cancer. Several studies have reported an association between ADT and an increase in cardiovascular events, especially in those receiving gonadotropin-releasing hormone (GnRH) agonists compared to GnRH antagonists. We review the body of literature reporting the association of ADT and cardiovascular morbidity, and discuss the proposed mechanism of cardiovascular disease due to ADT including metabolic changes that may promote atherosclerosis and local hormonal effects that may increase plaque rupture and thrombosis.
    Recent findings: GnRH agonists appear to increase the risk of cardiovascular morbidity by 20-25% in men on these agents compared those who do not receive ADT. GnRH antagonists may appear to have halve this risk while improving PSA progression-free survival. GnRH antagonists may be superior to GnRH agonists for patients with significant cardiovascular disease, significant metastatic disease burden, or severe lower urinary tract symptoms.
    MeSH term(s) Androgen Antagonists/adverse effects ; Androgen Antagonists/therapeutic use ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/metabolism ; Gonadotropin-Releasing Hormone/agonists ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Lower Urinary Tract Symptoms/drug therapy ; Male ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/drug therapy ; Risk Factors ; Survival Rate
    Chemical Substances Androgen Antagonists ; Antineoplastic Agents, Hormonal ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057354-6
    ISSN 1534-6285 ; 1527-2737
    ISSN (online) 1534-6285
    ISSN 1527-2737
    DOI 10.1007/s11934-017-0688-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 5528: Show issues Location:
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  4. Book: Glenn's urologic surgery

    Keane, Thomas E / Graham, Sam D / Goldstein, Marc

    2016  

    Title variant Urologic surgery
    Author's details editors, Thomas E. Keane, Sam D. Graham, Jr. ; associate editors, Marc Goldstein [and 7 others]
    MeSH term(s) Urogenital Surgical Procedures ; Female Urogenital Diseases/surgery ; Male Urogenital Diseases/surgery
    Language English
    Size xxvii, 959 pages :, illustrations, portrait
    Edition Eighth edition.
    Document type Book
    ISBN 9781451191462 ; 1451191464
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Editorial comment.

    Prasad, Sandip M / Keane, Thomas E / Bennett, Charles L

    Urology

    2012  Volume 80, Issue 1, Page(s) 168

    MeSH term(s) Humans ; Male ; Prostate/pathology ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology ; Testosterone/blood
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2012.01.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  6. Article: Salvage options for biochemical recurrence after primary therapy for prostate cancer.

    Bong, Gary W / Keane, Thomas E

    The Canadian journal of urology

    2007  Volume 14 Suppl 1, Page(s) 2–9

    Abstract: Despite excellent success rates with radical prostatectomy and radiotherapy for the treatment of prostate cancer, a significant number of patients will experience a rise in their serum prostate specific antigen (PSA) level. A variety of salvage options ... ...

    Abstract Despite excellent success rates with radical prostatectomy and radiotherapy for the treatment of prostate cancer, a significant number of patients will experience a rise in their serum prostate specific antigen (PSA) level. A variety of salvage options in this scenario have been investigated and the choice to pursue surveillance, single therapy or combination therapy depends on clinical assessment of risk and location of tumor recurrence. After radical prostatectomy, for example, patients with low risk local disease may not require secondary therapy or may benefit from salvage radiotherapy. Those with higher risk disease, based on PSA kinetics and tumor pathology may require systemic androgen deprivation therapy (ADT) with or without radiotherapy. Local recurrence after radiotherapy has the options of cryotherapy, brachytherapy or salvage surgery. ADT can also be applied in these patients at high risk of disease progression and cancer-specific mortality. Risk assessment in these settings is paramount as all secondary therapy options for prostate cancer have potential side effects that may significantly affect quality of life. We review the literature and discuss the current methods of risk assessment and the treatment options in prostate cancer once primary therapy fails.
    MeSH term(s) Biomarkers, Tumor/blood ; Humans ; Male ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/therapy ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Salvage Therapy/methods ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2007-12
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2064475-9
    ISSN 1195-9479
    ISSN 1195-9479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Bladder cancer--resection/ablation.

    Corica, Federico A / Keane, Thomas E

    Surgical oncology clinics of North America

    2005  Volume 14, Issue 2, Page(s) 321–352

    MeSH term(s) BCG Vaccine/therapeutic use ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Chemotherapy, Adjuvant ; Clinical Protocols ; Cystectomy ; Humans ; Immunotherapy ; Lymph Node Excision ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
    Chemical Substances BCG Vaccine
    Language English
    Publishing date 2005-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2004.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1339: Show issues Location:
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  8. Book: Glenn's urologic surgery

    Graham, Sam D / Keane, Thomas E / Glenn, James F

    2010  

    Title variant Urologic surgery
    Author's details editors, Sam D. Graham Jr., Thomas E. Keane ; consultant editor, James F. Glenn ; associate editors, Charles B. Brendler ... [et al.]
    MeSH term(s) Urogenital Surgical Procedures ; Female Urogenital Diseases/surgery ; Male Urogenital Diseases/surgery
    Language English
    Size xxix, 959 p. :, ill.
    Edition 7th ed.
    Publisher Wolters Kluwer Health/Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book
    ISBN 9780781791410 ; 0781791413
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Phase I trial of weekly docetaxel, total androgen blockade, and image-guided intensity-modulated radiotherapy for localized high-risk prostate adenocarcinoma.

    Marshall, David T / Ramey, Stephen / Golshayan, Ali-Reza / Keane, Thomas E / Kraft, Andrew S / Chaudhary, Uzair

    Clinical genitourinary cancer

    2014  Volume 12, Issue 2, Page(s) 80–86

    Abstract: Background: This was a phase I study to find the maximum tolerable dose (MTD) of weekly docetaxel combined with high-dose intensity-modulated radiotherapy (IMRT) and androgen deprivation therapy (ADT).: Patients and methods: Men with localized high- ... ...

    Abstract Background: This was a phase I study to find the maximum tolerable dose (MTD) of weekly docetaxel combined with high-dose intensity-modulated radiotherapy (IMRT) and androgen deprivation therapy (ADT).
    Patients and methods: Men with localized high-risk prostate cancer (HRPC) were treated with weekly docetaxel at 10 to 30 mg/m(2) concurrent with IMRT of 77.4 Gy to the prostate and 45 Gy to the seminal vesicles. ADT consisted of a gonadotropin-releasing hormone agonist (GnRHa) and bicalutamide beginning 2 months before and during chemoradiation. GnRHa was continued for 24 months.
    Results: Nineteen patients were enrolled. No dose-limiting toxicity (DLT) was seen with docetaxel doses up to 25 mg/m(2). At the 30 mg/m(2) level, 2 of 4 patients experienced DLTs of both grade 3 fatigue and dyspepsia. At 41 months' median follow-up, 2 patients had died--1 from metastatic prostate cancer and the other from heart failure. Two other patients experienced biochemical failure. One patient with bladder invasion at diagnosis experienced late grade 2 urinary hesitancy 9 months after completion of radiotherapy, requiring short-term intermittent catheterization. All patients had erectile dysfunction, but no late toxicities worse than grade 2 were identified.
    Conclusion: Weekly docetaxel may be combined with high-dose IMRT and long-term ADT up to a MTD of 25 mg/m(2). Acute toxicities and long-term side effects of this regimen were acceptable. Future studies evaluating the efficacy of docetaxel, ADT, and IMRT for localized HRPC should use a weekly dose of 25 mg/m(2) when limiting the irradiated volume to the prostate and seminal vesicles.
    MeSH term(s) Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Aged ; Aged, 80 and over ; Androgen Antagonists/administration & dosage ; Anilides/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Nitriles/administration & dosage ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/therapy ; Radiotherapy, Image-Guided ; Radiotherapy, Intensity-Modulated ; Taxoids/administration & dosage ; Tosyl Compounds/administration & dosage ; Treatment Outcome
    Chemical Substances Androgen Antagonists ; Anilides ; Nitriles ; Taxoids ; Tosyl Compounds ; docetaxel (15H5577CQD) ; bicalutamide (A0Z3NAU9DP)
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2013.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6168: Show issues Location:
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  10. Article ; Online: Impact of Late Dosing on Testosterone Suppression with 2 Different Leuprolide Acetate Formulations: In Situ Gel and Microsphere. An Analysis of United States Clinical Data.

    Crawford, E David / Hafron, Jason M / Tagawa, Scott T / Twardowski, Przemyslaw W / Harris, Richard G / Moul, Judd W / Keane, Thomas E / Concepcion, Raoul S / Higano, Celestia S / Gordan, Lucio N / Petrylak, Daniel P / Cross, Chaundre K / Kader, A Karim / Shore, Neal D

    The Journal of urology

    2020  Volume 205, Issue 2, Page(s) 554–560

    Abstract: Purpose: Nonadherence to dosing schedules for androgen deprivation therapy increases the risk of testosterone escape for patients with prostate cancer. Two approved formulations of leuprolide acetate, the most commonly prescribed androgen deprivation ... ...

    Abstract Purpose: Nonadherence to dosing schedules for androgen deprivation therapy increases the risk of testosterone escape for patients with prostate cancer. Two approved formulations of leuprolide acetate, the most commonly prescribed androgen deprivation therapy in the United States, use different extended release delivery technologies: an in situ gel and microspheres. We evaluated the prevalence and impact of late dosing on testosterone suppression for gel and microsphere formulations of leuprolide acetate.
    Materials and methods: We retrospectively analyzed records of patients with prostate cancer treated with gel or microsphere delivery of leuprolide acetate. Analyses used 2 definitions of "month," "28-day" (late dosing after day 28, 84, 112 or 168) and "extended" (late dosing after day 32, 97, 128 and 194). Frequencies of late dosing and associated testosterone values were calculated.
    Results: A total of 2,038 patients received gel and 8,360 received microsphere formulations of leuprolide acetate. More than 80% and 27% of injections were late for 28-day and extended month, respectively. For 28-day month late injections 10% (gel delivery) and 14% (microsphere delivery) of testosterone values were above 50 ng/dl, and 25% (gel) vs 33% (microsphere) were above 20 ng/dl. For extended month 18% (gel) vs 25% (microsphere) were above 50 ng/dl, and 34% (gel) vs 44% (microsphere) were above 20 ng/dl. Microsphere leuprolide acetate was 1.5 times more likely to have testosterone above 50/20 ng/dl vs gel. Least square mean testosterone was 34 ng/dl (gel) vs 46 ng/dl (microsphere) for 28-day month, and 48 ng/dl (gel) vs 76 ng/dl (microsphere) for extended month.
    Conclusions: Leuprolide acetate therapies were frequently administered late. Gel formulation demonstrated higher rates of testosterone 50 ng/dl or less and 20 ng/dl or less than microsphere formulation. Optimal testosterone suppression can impact prostate cancer progression and patient survival, and differences in extended release technology for androgen deprivation therapy appear relevant.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Androgen Antagonists/administration & dosage ; Gels ; Humans ; Leuprolide/administration & dosage ; Male ; Microspheres ; Middle Aged ; Prostatic Neoplasms/drug therapy ; Retrospective Studies ; Testosterone/antagonists & inhibitors ; Time Factors ; United States ; Young Adult
    Chemical Substances Androgen Antagonists ; Gels ; Testosterone (3XMK78S47O) ; Leuprolide (EFY6W0M8TG)
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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