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  1. Article: Ancestral desiccation tolerance tools repurposed throughout plant evolution.

    Kearly, Alyssa

    Trends in genetics : TIG

    2024  

    Abstract: The ability to tolerate and recover from desiccation is an adaptation that permitted primitive plants to colonize land, and it persists in select species today. Zhang et al. dissected desiccation tolerance in moss species, and traced a key regulator ... ...

    Abstract The ability to tolerate and recover from desiccation is an adaptation that permitted primitive plants to colonize land, and it persists in select species today. Zhang et al. dissected desiccation tolerance in moss species, and traced a key regulator through evolution to identify a conserved mechanism of water sensing in angiosperms.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2024.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Composition and function of stress granules and P-bodies in plants.

    Kearly, Alyssa / Nelson, Andrew D L / Skirycz, Aleksandra / Chodasiewicz, Monika

    Seminars in cell & developmental biology

    2022  Volume 156, Page(s) 167–175

    Abstract: Stress Granules (SGs) and Processing-bodies (P-bodies) are biomolecular condensates formed in the cell with the highly conserved purpose of maintaining balance between storage, translation, and degradation of mRNA. This balance is particularly important ... ...

    Abstract Stress Granules (SGs) and Processing-bodies (P-bodies) are biomolecular condensates formed in the cell with the highly conserved purpose of maintaining balance between storage, translation, and degradation of mRNA. This balance is particularly important when cells are exposed to different environmental conditions and adjustments have to be made in order for plants to respond to and tolerate stressful conditions. While P-bodies are constitutively present in the cell, SG formation is a stress-induced event. Typically thought of as protein-RNA aggregates, SGs and P-bodies are formed by a process called liquid-liquid phase separation (LLPS), and both their function and composition are very dynamic. Both foci are known to contain proteins involved in translation, protein folding, and ATPase activity, alluding to their roles in regulating mRNA and protein expression levels. From an RNA perspective, SGs and P-bodies primarily consist of mRNAs, though long non-coding RNAs (lncRNAs) have also been observed, and more focus is now being placed on the specific RNAs associated with these aggregates. Recently, metabolites such as nucleotides and amino acids have been reported in purified plant SGs with implications for the energetic dynamics of these condensates. Thus, even though the field of plant SGs and P-bodies is relatively nascent, significant progress has been made in understanding their composition and biological role in stress responses. In this review, we discuss the most recent discoveries centered around SG and P-body function and composition in plants.
    MeSH term(s) Processing Bodies ; Stress Granules ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Cytoplasmic Granules ; Stress, Physiological
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2022.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.

    Kearly, Alyssa / Ottens, Kristina / Battaglia, Michael C / Satterthwaite, Anne B / Garrett-Sinha, Lee Ann

    ImmunoHorizons

    2022  Volume 6, Issue 11, Page(s) 779–789

    Abstract: Ets1 is a key transcription factor in B cells that is required to prevent premature differentiation into Ab-secreting cells. Previously, we showed that BCR and TLR signaling downregulate Ets1 levels and that the kinases PI3K, Btk, IKK, and JNK are ... ...

    Abstract Ets1 is a key transcription factor in B cells that is required to prevent premature differentiation into Ab-secreting cells. Previously, we showed that BCR and TLR signaling downregulate Ets1 levels and that the kinases PI3K, Btk, IKK, and JNK are required for this process. PI3K is important in activating Btk by generating the membrane lipid phosphatidylinositol (3,4,5)-trisphosphate, to which Btk binds via its PH domain. Btk in turn is important in activating the IKK kinase pathway, which it does by activating phospholipase Cγ2→protein kinase Cβ signaling. In this study, we have further investigated the pathways regulating Ets1 in mouse B cells. Although IKK is well known for its role in activating the canonical NF-κB pathway, IKK-mediated downregulation of Ets1 does not require either RelA or c-Rel. We also examined the potential roles of two other IKK targets that are not part of the NF-κB signaling pathway, Foxo3a and mTORC2, in regulating Ets1. We find that loss of Foxo3a or inhibition of mTORC2 does not block BCR-induced Ets1 downregulation. Therefore, these two pathways are not key IKK targets, implicating other as yet undefined IKK targets to play a role in this process.
    MeSH term(s) Animals ; Mice ; B-Lymphocytes/metabolism ; Lymphocyte Activation ; Mechanistic Target of Rapamycin Complex 2 ; NF-kappa B ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Protein c-ets-1/genetics ; I-kappa B Kinase/metabolism
    Chemical Substances Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; NF-kappa B ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Ets1 protein, mouse ; Proto-Oncogene Protein c-ets-1 ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2100065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mapping the

    van Wijk, Klaas J / Leppert, Tami / Sun, Zhi / Kearly, Alyssa / Li, Margaret / Mendoza, Luis / Guzchenko, Isabell / Debley, Erica / Sauermann, Georgia / Routray, Pratyush / Malhotra, Sagunya / Nelson, Andrew / Sun, Qi / Deutsch, Eric W

    bioRxiv : the preprint server for biology

    2023  

    Abstract: This study describes a new release of ... ...

    Abstract This study describes a new release of the
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.01.543322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detection of the

    van Wijk, Klaas J / Leppert, Tami / Sun, Zhi / Kearly, Alyssa / Li, Margaret / Mendoza, Luis / Guzchenko, Isabell / Debley, Erica / Sauermann, Georgia / Routray, Pratyush / Malhotra, Sagunya / Nelson, Andrew / Sun, Qi / Deutsch, Eric W

    Journal of proteome research

    2023  Volume 23, Issue 1, Page(s) 185–214

    Abstract: This study describes a new release of ... ...

    Abstract This study describes a new release of the
    MeSH term(s) Humans ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Proteome/analysis ; Tandem Mass Spectrometry/methods ; Protein Processing, Post-Translational ; Peptides/analysis ; Databases, Protein
    Chemical Substances Proteome ; Peptides
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6189: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.

    Garrett-Sinha, Lee Ann / Kearly, Alyssa / Satterthwaite, Anne B

    Critical reviews in immunology

    2016  Volume 36, Issue 6, Page(s) 485–510

    Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which triggers an inflammatory response and tissue damage. The genetic and environmental factors that contribute to the development of SLE have been studied extensively in both humans and mouse models of the disease. One of the important genetic contributions to SLE development is an alteration in the expression of the transcription factor Ets1, which regulates the functional differentiation of lymphocytes. Here, we review the genetic, biochemical, and immunological studies that have linked low levels of Ets1 to aberrant lymphocyte differentiation and to the pathogenesis of SLE.
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2017020284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor

    Saelee, Prontip / Kearly, Alyssa / Nutt, Stephen L / Garrett-Sinha, Lee Ann

    Frontiers in immunology

    2017  Volume 8, Page(s) 383

    Abstract: Background: The transcription factor Ets1 is highly expressed in B lymphocytes. Loss of Ets1 leads to premature B cell differentiation into antibody-secreting cells (ASCs), secretion of autoantibodies, and development of autoimmune disease. Despite the ... ...

    Abstract Background: The transcription factor Ets1 is highly expressed in B lymphocytes. Loss of Ets1 leads to premature B cell differentiation into antibody-secreting cells (ASCs), secretion of autoantibodies, and development of autoimmune disease. Despite the importance of Ets1 in B cell biology, few Ets1 target genes are known in these cells.
    Results: To obtain a more complete picture of the function of Ets1 in regulating B cell differentiation, we performed Ets1 ChIP-seq in primary mouse B cells to identify >10,000-binding sites, many of which were localized near genes that play important roles in B cell activation and differentiation. Although Ets1 bound to many sites in the genome, it was required for regulation of less than 5% of them as evidenced by gene expression changes in B cells lacking Ets1. The cohort of genes whose expression was altered included numerous genes that have been associated with autoimmune disease susceptibility. We focused our attention on four such Ets1 target genes Ptpn22, Stat4, Egr1, and Prdm1 to assess how they might contribute to Ets1 function in limiting ASC formation. We found that dysregulation of these particular targets cannot explain altered ASC differentiation in the absence of Ets1.
    Conclusion: We have identified genome-wide binding targets for Ets1 in B cells and determined that a relatively small number of these putative target genes require Ets1 for their normal expression. Interestingly, a cohort of genes associated with autoimmune disease susceptibility is among those that are regulated by Ets1. Identification of the target genes of Ets1 in B cells will help provide a clearer picture of how Ets1 regulates B cell responses and how its loss promotes autoantibody secretion.
    Language English
    Publishing date 2017-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.00383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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