Article ; Online: A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
CPT: pharmacometrics & systems pharmacology
2023 Volume 12, Issue 10, Page(s) 1553–1564
Abstract: Pomotrelvir is a new chemical entity and potent direct-acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)-mediated drug-drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, ... ...
| Abstract | Pomotrelvir is a new chemical entity and potent direct-acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)-mediated drug-drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, starting with in vitro assays followed by the basic static model assessment. The identified CYP3A4-mediated potential DDIs were evaluated clinically at a supratherapeutic dose of 1050 mg twice daily (b.i.d.) of pomotrelvir, including pomotrelvir coadministration with ritonavir (strong inhibitor of CYP3A4) or midazolam (sensitive substrate of CYP3A4). Furthermore, a physiologically-based pharmacokinetic (PBPK) model was developed within the Simcyp Population-based Simulator using in vitro and in vivo information and validated with available human pharmacokinetic (PK) data. The PBPK model was simulated to assess the DDI potential for CYP isoforms that pomotrelvir has shown a weak to moderate DDI in vitro and for CYP3A4 at the therapeutic dose of 700 mg b.i.d. To support the use of pomotrelvir in women of childbearing potential, the impact of pomotrelvir on the exposure of the representative oral hormonal contraceptive drugs ethinyl estradiol and levonorgestrel was assessed using the PBPK model. The overall assessment suggested weak inhibition of pomotrelvir on CYP3A4 and minimal impact of a strong CYP3A4 inducer or inhibitor on pomotrelvir PK. Therefore, pomotrelvir is not anticipated to have clinically meaningful DDIs at the clinical dose. These comprehensive in vitro, in clinic, and in silico efforts indicate that the DDI potential of pomotrelvir is minimal, so excluding patients on concomitant medicines in clinical studies would not be required. |
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| MeSH term(s) | Humans ; Female ; Cytochrome P-450 CYP3A ; Antiviral Agents/pharmacology ; Hepatitis C, Chronic ; Cytochrome P-450 Enzyme System ; Drug Interactions ; Protein Isoforms ; Models, Biological ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Computer Simulation |
| Chemical Substances | Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Antiviral Agents ; Cytochrome P-450 Enzyme System (9035-51-2) ; Protein Isoforms ; Cytochrome P-450 CYP3A Inhibitors |
| Language | English |
| Publishing date | 2023-08-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2697010-7 |
| ISSN | 2163-8306 ; 2163-8306 |
| ISSN (online) | 2163-8306 |
| ISSN | 2163-8306 |
| DOI | 10.1002/psp4.13034 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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