Article ; Online: Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children.
2021 Volume 148, Issue 4
Abstract: Background and objectives: Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C.: Methods: This is ... ...
| Abstract | Background and objectives: Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C. Methods: This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from April 17 to June 20, 2020. Patients were followed ∼2 weeks, 8 weeks, and 6 months postadmission, with those with coronary aneurysms evaluated more frequently. Results: Acutely, 31 (62%) patients required intensive care with vasoactive support, 26 (52%) had left ventricular (LV) systolic dysfunction, 16 (32%) had LV diastolic dysfunction, 8 (16%) had coronary aneurysms Conclusions: Children with MIS-C treated with immunomodulators have favorable early outcomes with no mortality, normalization of LV systolic function, recovery of coronary abnormalities, and no inflammation or scarring on cardiac MRI. Persistence of diastolic dysfunction is of uncertain significance and indicates need for larger studies to improve understanding of MIS-C. These findings may help guide clinical management, outpatient monitoring, and considerations for sports clearance. |
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| MeSH term(s) | Adolescent ; COVID-19/complications ; COVID-19/drug therapy ; Child ; Child, Preschool ; Coronary Aneurysm/etiology ; Coronary Vessels/pathology ; Female ; Heart/diagnostic imaging ; Humans ; Immunomodulating Agents/therapeutic use ; Infant ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Myocarditis/drug therapy ; Myocarditis/etiology ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/drug therapy ; Ventricular Dysfunction, Left/etiology ; Ventricular Function, Left/drug effects | ||||||||||
| Chemical Substances | Immunomodulating Agents | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-07-29 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 207677-9 | ||||||||||
| ISSN | 1098-4275 ; 0031-4005 | ||||||||||
| ISSN (online) | 1098-4275 | ||||||||||
| ISSN | 0031-4005 | ||||||||||
| DOI | 10.1542/peds.2021-050973 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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