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Article ; Online: Acute longus colli calcific tendinitis.

Crone, Michael / Keating, Richard

2023 Volume 43, Issue 3, Page(s) 1261–1262

MeSH term(s)	Humans ; Tomography, X-Ray Computed ; Tendinopathy/diagnostic imaging ; Neck Muscles/diagnostic imaging ; Diagnosis, Differential ; Neck Pain
Language	English
Publishing date	2023-11-16
Publishing country	Germany
Document type	Editorial
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06815-1
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Book: Pere Marquette State Park, Jersey County, Illinois

Keating, Richard C

An unofficial guide to history, natural history, trails, and drives

2017

Abstract: Pere Marquette State Park in Jersey County, Illinois is Illinois' largest, natural landscape state park. This field guide to the park, the first comprehensive and illustrated guide to any Illinois state park, introduces readers to the fascinating history ...

Author's details	Richard C. Keating
Abstract	Pere Marquette State Park in Jersey County, Illinois is Illinois' largest, natural landscape state park. This field guide to the park, the first comprehensive and illustrated guide to any Illinois state park, introduces readers to the fascinating history and rich ecology of the park. On its west side, the eight-thousand-acre landscape is bounded by the Illinois River near its confluence with the Mississippi, and it is situated on one of the state's few unglaciated regions, while the rugged topography exposes ancient geology and supports a diversity of forests and prairies.
Keywords	Natural history ; Natural areas ; Parks ; Natural areas. ; Natural history. ; Parks. ; Illinois ; Pere Marquette State Park (Ill.) ; Illinois.
Language	English
Dates of publication	2017-2017
Size	xiv, 180 pages :, illustrations (mostly color), maps ;, 23 cm
Document type	Book
Note	Includes bibliographical references (pages 158-165) and index.
ISBN	9781935641131 ; 1935641131
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: "COVID Toes" After mRNA COVID-19 Vaccines.

Kelso, John M / Coda, Alvin B / Keating, Richard M / Vaccari, Dana M

The journal of allergy and clinical immunology. In practice

2021 Volume 9, Issue 8, Page(s) 3196–3197

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Toes
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger
Language	English
Publishing date	2021-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2021.05.030
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Book: Colorado's Spanish Peaks region

Keating, Richard C

an exploration guide to history, natural history, trails, and drives

2011

Author's details	Richard C. Keating
Keywords	Natural history ; Trails ; Scenic byways ; Spanish Peaks (Colo.)
Language	English
Size	xii, 350 p. :, ill., maps ;, 23 cm.
Publisher	Missouri Botanical Garden Press
Publishing place	St. Louis, Mo
Document type	Book
ISBN	9781930723856 ; 1930723857
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Association of Antibodies to Prevotella copri in Anti-Cyclic Citrullinated Peptide-Positive Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis.

Seifert, Jennifer A / Bemis, Elizabeth A / Ramsden, Kristina / Lowell, Cassidy / Polinski, Kristen / Feser, Marie / Fleischer, Chelsie / Demoruelle, M Kristen / Buckner, Jane / Gregersen, Peter K / Keating, Richard M / Mikuls, Ted R / O'Dell, James R / Weisman, Michael H / Deane, Kevin D / Norris, Jill M / Steere, Allen C / Holers, V Michael

Arthritis & rheumatology (Hoboken, N.J.)

2023 Volume 75, Issue 4, Page(s) 507–516

Abstract: Objective: Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti-P copri (anti-Pc) antibody responses in our participant cohorts ...

Abstract	Objective: Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti-P copri (anti-Pc) antibody responses in our participant cohorts and to determine when in the natural history of RA such responses develop. Methods: We analyzed serum levels of immunoglobulin A (IgA) and IgG antibodies from a 27-kd protein of P copri (anti-Pc-p27), an immunogenic P copri protein, in study participants at risk of developing RA, participants who transitioned to RA, participants with early RA (<1 year of disease), and participants with established RA, with comparisons made to their matched controls. We also evaluated anti-Pc-p27 antibody levels in individuals stratified by RA-related autoantibody status. Results: Overall, participants with RA had significantly higher IgA anti-Pc-p27 antibody levels and trended toward higher IgG anti-Pc-p27 antibody levels compared with matched controls. When stratified by early versus established RA, participants with early RA had median IgG anti-Pc-p27 antibody levels that were overall higher, whereas median IgA anti-Pc-p27 antibody levels were statistically significantly higher in participants with established RA compared with their matched controls. In the autoantibody-specific analyses, the at-risk population with anti-cyclic citrullinated peptide (anti-CCP) antibodies, but not rheumatoid factor (RF), trended toward increased levels of IgG anti-Pc-p27. Additionally, RA participants who were seropositive for both CCP and RF had significantly increased levels of IgA anti-Pc-p27 antibodies and trended toward higher levels of IgG anti-Pc-p27 antibodies compared with matched controls. Conclusion: Our findings support a potential etiologic role for P copri in both RA preclinical evolution and the subsequent pathogenesis of synovitis.
MeSH term(s)	Humans ; Arthritis, Rheumatoid ; Autoantibodies ; Rheumatoid Factor ; Peptides, Cyclic ; Anti-Citrullinated Protein Antibodies ; Immunoglobulin G ; Immunoglobulin A
Chemical Substances	Autoantibodies ; Rheumatoid Factor (9009-79-4) ; Peptides, Cyclic ; Anti-Citrullinated Protein Antibodies ; Immunoglobulin G ; Immunoglobulin A
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42370
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Article ; Online: Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA), a prospective cohort study.

Hughes-Austin, Jan M / Ix, Joachim H / Ward, Samuel R / Weisman, Michael H / ODell, James R / Mikuls, Ted R / Buckner, Jane H / Gregersen, Peter K / Keating, Richard M / Demoruelle, M Kristen / Deane, Kevin D / Holers, V Michael / Norris, Jill M

BMJ open

2021 Volume 11, Issue 9, Page(s) e050883

Abstract: Objective: Physical activity (PA) in preclinical rheumatoid arthritis (RA) is associated with lower RA risk and disease severity. As joint signs and symptoms of inflammatory arthritis serve as a barrier to PA in RA, it is important to consider whether ... ...

Abstract	Objective: Physical activity (PA) in preclinical rheumatoid arthritis (RA) is associated with lower RA risk and disease severity. As joint signs and symptoms of inflammatory arthritis serve as a barrier to PA in RA, it is important to consider whether they affect PA in the time prior to RA. Therefore, we investigated whether joint swelling, stiffness or pain were associated with PA in first-degree relatives (FDRs) of patients with RA, a population at higher risk for future RA. Design: Prospective study design. Setting: We recruited FDRs of patients with RA from academic centres, Veterans' hospitals and rheumatology clinics or through responses to advertising from six sites across the USA. Participants: We evaluated associations of joint stiffness, joint swelling and joint pain with PA time in 268 FDRs with ≥2 visits over an average 1.2 years. Clinicians confirmed joint swelling. Participants self-reported joint stiffness and/or pain. Primary outcome measures: PA during a typical 24-hour day was quantified via questionnaire, weighted to reflect metabolic expenditure, where 24 hours was the minimum PA time. Linear mixed models evaluated associations between symptoms and change in PA over time, adjusting for age, sex, race, body mass index, smoking and RA-related autoantibodies. Results: Average weighted PA time was 37±7 hours. In the cross-sectional analysis, PA time was 1.3±0.9 hours higher in FDRs reporting joint pain (p=0.15); and 0.8±1.6 and 0.4±1 hours lower in FDRs with joint swelling (p=0.60) and stiffness (p=0.69), respectively. Longitudinally, adjusting for baseline PA time, baseline symptoms were not significantly associated with changes in PA time. However, on average over time, joint stiffness and pain were associated with lower PA time (p Conclusion: Baseline symptoms did not predict future PA time, but on average over time, joint symptoms influenced PA time.
MeSH term(s)	Arthralgia/etiology ; Arthritis, Rheumatoid ; Cross-Sectional Studies ; Exercise ; Humans ; Prospective Studies
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-050883
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Article ; Online: Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti-Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti-Tumor Necrosis Factor on B Cells.

Meednu, Nida / Barnard, Jennifer / Callahan, Kelly / Coca, Andreea / Marston, Bethany / Thiele, Ralf / Tabechian, Darren / Bolster, Marcy / Curtis, Jeffrey / Mackay, Meggan / Graf, Jonathan / Keating, Richard / Smith, Edwin / Boyle, Karen / Keyes-Elstein, Lynette / Welch, Beverly / Goldmuntz, Ellen / Anolik, Jennifer H

Arthritis & rheumatology (Hoboken, N.J.)

2021 Volume 74, Issue 2, Page(s) 200–211

Abstract: Objective: B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This study was ... ...

Abstract	Objective: B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This study was undertaken to characterize the peripheral B cell compartment longitudinally during anti-TNF therapy in RA. Methods: Participants were randomized in a 2:1 ratio to receive standard dosing regimens of etanercept (n = 43) or adalimumab (n = 20) for 24 weeks. Eligible participants met the American College of Rheumatology 1987 criteria for RA, had clinically active disease (Disease Activity Score in 28 joints >4.4), and were receiving stable doses of methotrexate. The primary mechanistic end point was the change in switched memory B cell fraction from baseline to week 12 in each treatment group. Results: B cell subsets remained surprisingly stable over the course of the study regardless of treatment group, with no significant change in memory B cells. Blockade of TNF and LT with etanercept compared to blockade of TNF alone with adalimumab did not translate into significant differences in clinical response. The frequencies of multiple activated B cell populations, including CD21- double-negative memory and activated naive B cells, were higher in RA nonresponders at all time points, and CD95+ activated B cell frequencies were increased in patients receiving anti-TNF treatment in the nonresponder group. In contrast, frequencies of transitional B cells-a putative regulatory subset-were lower in the nonresponders. Conclusion: Overall, our results support the notion that peripheral blood B cell subsets are remarkably stable in RA and not differentially impacted by dual blockade of TNF and LT with etanercept or single blockade of TNF with adalimumab. Activated B cells do associate with a less robust response.
MeSH term(s)	Adalimumab/pharmacology ; Adalimumab/therapeutic use ; Adult ; Aged ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; B-Lymphocytes/drug effects ; B-Lymphocytes/physiology ; Etanercept/pharmacology ; Etanercept/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Single-Blind Method ; Tumor Necrosis Factor Inhibitors/pharmacology ; Tumor Necrosis Factor Inhibitors/therapeutic use
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor Inhibitors ; Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Clinical Trial, Phase IV ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41941
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Article ; Online: Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus.

Frontiers in immunology

2022 Volume 13, Page(s) 881332

Abstract: Objective: Higher 25-hydroxyvitamin D (25(OH)D) levels have been associated with reduced risk for autoimmune diseases and are influenced by vitamin D metabolism genes. We estimated genetically-determined vitamin D levels by calculating a genetic risk ... ...

Abstract	Objective: Higher 25-hydroxyvitamin D (25(OH)D) levels have been associated with reduced risk for autoimmune diseases and are influenced by vitamin D metabolism genes. We estimated genetically-determined vitamin D levels by calculating a genetic risk score (GRS) and investigated whether the vitamin D GRS was associated with the presence of autoantibodies related to rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in those at increased risk for developing RA and SLE, respectively. Methods: In this cross-sectional study, we selected autoantibody positive (aAb+) and autoantibody negative (aAb-) individuals from the Studies of the Etiologies of Rheumatoid Arthritis (SERA), a cohort study of first-degree relatives (FDRs) of individuals with RA (189 RA aAb+, 181 RA aAb-), and the Lupus Family Registry and Repository (LFRR), a cohort study of FDRs of individuals with SLE (157 SLE aAb+, 185 SLE aAb-). Five SNPs known to be associated with serum 25(OH)D levels were analyzed individually as well as in a GRS: rs4588 ( Results: Both cohorts had similar demographic characteristics, with significantly older and a higher proportion of males in the aAb+ FDRs. The vitamin D GRS was inversely associated with RA aAb+ (OR = 0.85, 95% CI = 0.74-0.99), suggesting a possible protective factor for RA aAb positivity in FDRs of RA probands. The vitamin D GRS was not associated with SLE aAb+ in the LFRR (OR = 1.09, 95% CI = 0.94-1.27). The Conclusion: Genes associated with vitamin D levels may play a protective role in the development of RA aAbs in FDRs of RA probands, perhaps through affecting lifelong vitamin D status. The GRS and the
MeSH term(s)	Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Autoantibodies ; Cohort Studies ; Cross-Sectional Studies ; Humans ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/genetics ; Male ; Risk Factors ; Vitamin D ; Vitamins
Chemical Substances	Autoantibodies ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.881332
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Article ; Online: Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting.

Bemis, Elizabeth A / Demoruelle, M Kristen / Seifert, Jennifer A / Polinski, Kristen J / Weisman, Michael H / Buckner, Jane H / Gregersen, Peter K / Mikuls, Ted R / ODell, James R / Keating, Richard M / Deane, Kevin D / Holers, V Michael / Norris, Jill M

Annals of the rheumatic diseases

2020 Volume 80, Issue 2, Page(s) 154–161

Abstract: Objectives: Little is known about the likelihood of developing inflammatory arthritis (IA) in individuals who screen autoantibody positive (aAb+) in a non-clinical research setting.: Methods: We screened for serum cyclic citrullinated peptide ... ...

Abstract	Objectives: Little is known about the likelihood of developing inflammatory arthritis (IA) in individuals who screen autoantibody positive (aAb+) in a non-clinical research setting. Methods: We screened for serum cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor isotype aAbs in subjects who were at increased risk for rheumatoid arthritis (RA) because they are a first-degree relative of an individual with classified RA (n=1780). We evaluated combinations of aAbs and high titre aAbs, as defined by 2-times (2 x) the standard cut-off and an optimal cut-off, as predictors of our two outcomes, aAb+ persistence and incident IA. Results: 304 subjects (17.1%) tested aAb+; of those, 131 were IA-free and had at least one follow-up visit. Sixty-four per cent of these tested aAb+ again on their next visit. Anti-CCP+ at levels ≥2 x the standard cut-off was associated with 13-fold higher likelihood of aAb +persistence. During a median of 4.4 years (IQR: 2.2-7.2), 20 subjects (15.3%) developed IA. Among subjects that screened anti-CCP+ at ≥ 2 x or ≥an optimal cut-off, 32% and 26% had developed IA within 5 years, respectively. Both anti-CCP cut-offs conferred an approximate fourfold increased risk of future IA (HR 4.09 and HR 3.95, p<0.01). Conclusions: These findings support that aAb screening in a non-clinical setting can identify RA-related aAb+ individuals, as well as levels and combinations of aAbs that are associated with higher risk for future IA. Monitoring for the development of IA in aAb+ individuals and similar aAb testing approaches in at-risk populations may identify candidates for prevention studies in RA.
MeSH term(s)	Adult ; Anti-Citrullinated Protein Antibodies/blood ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Disease Progression ; Female ; Genetic Predisposition to Disease/genetics ; Genetic Testing/statistics & numerical data ; Humans ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Pedigree ; Prospective Studies ; Rheumatoid Factor/blood ; Risk Factors
Chemical Substances	Anti-Citrullinated Protein Antibodies ; Autoantibodies ; Rheumatoid Factor (9009-79-4)
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2020-217066
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Article ; Online: Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort.

Polinski, Kristen J / Bemis, Elizabeth A / Feser, Marie / Seifert, Jennifer / Demoruelle, M Kristen / Striebich, Christopher C / Brake, Stacey / O'Dell, James R / Mikuls, Ted R / Weisman, Michael H / Gregersen, Peter K / Keating, Richard M / Buckner, Jane / Nicassio, Perry / Holers, V Michael / Deane, Kevin D / Norris, Jill M

Arthritis care & research

2020 Volume 72, Issue 12, Page(s) 1766–1771

Abstract: Objective: The aim of this study was to determine the association of perceived stress with incident inflammatory arthritis (IA) defined as having at least 1 joint consistent with rheumatoid arthritis (RA)-like synovitis based on examination.: Methods!# ...

Abstract	Objective: The aim of this study was to determine the association of perceived stress with incident inflammatory arthritis (IA) defined as having at least 1 joint consistent with rheumatoid arthritis (RA)-like synovitis based on examination. Methods: We conducted a prospective cohort study in the Studies of the Etiologies of Rheumatoid Arthritis cohort. Participants without IA were recruited if they were a first-degree relative of an RA proband or screened positive for anti-citrullinated protein antibody. Perceived stress was measured using the Perceived Stress Scale-14 (PSS-14), in which scores can range from 0 to 56, and a higher score indicates greater perceived stress. The total PSS-14 score, as well as 2 subscores indicative of perceived distress and self-efficacy, were averaged across all study visits until development of IA or the last follow-up. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) of IA associated with average PSS-14 scores were obtained using Cox proportional hazards models. Results: The mean total PSS-14 score was 20.4. We found that a 1-point increase in the perceived distress score was significantly associated with a 10-percent increase in the risk of IA (adjusted HR 1.10 [95% CI 1.02-1.19]). Total PSS-14 and self-efficacy were not associated with IA risk (adjusted HR 1.05 [95% CI 0.99-1.10] and 1.04 [95% CI 0.91-1.18], respectively). Conclusion: An association between perceived distress and incident IA was observed in this at-risk cohort. Replication of this finding in other preclinical and at-risk RA populations is needed.
MeSH term(s)	Adult ; Aged ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Colorado/epidemiology ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Risk Assessment ; Risk Factors ; Stress, Psychological/diagnosis ; Stress, Psychological/epidemiology
Language	English
Publishing date	2020-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24085
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