LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article: Antiretroviral therapy in sub-Saharan Africa: myth or reality?

Kebba, Anthony

The Journal of antimicrobial chemotherapy

2003 Volume 52, Issue 5, Page(s) 747–749

MeSH term(s)	Africa South of the Sahara ; Anti-HIV Agents/economics ; Anti-HIV Agents/therapeutic use ; Drug Therapy, Combination ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV-1 ; Health Resources ; Humans ; Uganda
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2003-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkg453
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: An anniversary without celebration?

Imami, Nesrina / Kebba, Anthony / Gotch, Frances

Nature immunology

2006 Volume 7, Issue 9, Page(s) 893

MeSH term(s)	Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/therapy ; Humans ; Poverty ; Poverty Areas ; Zambia
Language	English
Publishing date	2006-08-21
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/ni0906-893
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals.

Kebba, Anthony / Kaleebu, Pontiano / Rowland, Samantha / Ingram, Rebecca / Whitworth, Jimmy / Imami, Nesrina / Gotch, Frances

The Journal of infectious diseases

2004 Volume 189, Issue 9, Page(s) 1705–1713

Abstract: It is unclear how human immunodeficiency virus (HIV) type 1-specific immune responses in exposed seronegative (ESN) individuals differ from those in HIV-1-infected subjects. By use of overlapping peptides spanning Gag, Tat, Nef, Vif, Vpr, and Vpu, ... ...

Abstract	It is unclear how human immunodeficiency virus (HIV) type 1-specific immune responses in exposed seronegative (ESN) individuals differ from those in HIV-1-infected subjects. By use of overlapping peptides spanning Gag, Tat, Nef, Vif, Vpr, and Vpu, peripheral blood mononuclear cells from ESN individuals, their seropositive (SP) partners, and unexposed seronegative control subjects were screened for interferon- gamma production. Responses were more frequent (95.7% vs. 20%), of a higher magnitude (9-fold), and of wider breadth (median number of peptides recognized, 18 vs. 2.5) in SP than in ESN individuals. Peptides recognized by ESN individuals were less frequently recognized by their SP partners. SP subjects infrequently recognized peptides from Vif, and such responses were subdominant; among ESN individuals, this HIV-1 protein was most frequently recognized. Immunodominant peptides recognized by SP subjects tended to be from relatively conserved regions, whereas peptides recognized by ESN individuals were associated with slow disease progression.
MeSH term(s)	Adult ; Amino Acid Sequence ; Female ; Gene Products, vif/immunology ; HIV Antigens/chemistry ; HIV Antigens/immunology ; HIV Seronegativity/immunology ; HIV Seropositivity/immunology ; HIV-1/immunology ; Humans ; Interferon-gamma/metabolism ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation ; Male ; Peptides/chemistry ; Peptides/immunology ; Spouses ; Viral Proteins/chemistry ; Viral Proteins/immunology ; vif Gene Products, Human Immunodeficiency Virus
Chemical Substances	Gene Products, vif ; HIV Antigens ; Peptides ; Viral Proteins ; vif Gene Products, Human Immunodeficiency Virus ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2004-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1086/383227
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trials.

Kebba, Anthony / Imami, Nesrina / Bugembe-Lule, Daniel / Senkaali, David / Kaleebu, Pontiano / Grosskurth, Heiner / Gotch, Frances

Pharmacogenomics

2007 Volume 8, Issue 4, Page(s) 409–414

Abstract: Assessment of vaccine efficacy on end points used in Phase IIB test-of-concept trials will require taking into consideration the effect of variables correlated with the end points and distribution of the variables within subgroups of the trial population. ...

Abstract	Assessment of vaccine efficacy on end points used in Phase IIB test-of-concept trials will require taking into consideration the effect of variables correlated with the end points and distribution of the variables within subgroups of the trial population. Here we report that evaluation of sexual activity in vaccinees and longitudinal collection of plasma viral load data from putative transmitters prior to transmission will contribute to the plausible assessment of efficacy against acquisition of infection. Data also suggest that efficacy on post-infection end points may depend on whether transmission pairs are matched or mismatched for HLA class I alleles.
MeSH term(s)	AIDS Vaccines/therapeutic use ; Adult ; Cohort Studies ; Female ; Follow-Up Studies ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV-1 ; Humans ; Male ; Risk Factors ; Uganda/epidemiology ; Viral Load/methods
Chemical Substances	AIDS Vaccines
Language	English
Publishing date	2007-03-27
Publishing country	England
Document type	Clinical Trial, Phase II ; Comparative Study ; Journal Article
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/14622416.8.4.409
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Therapeutic responses to AZT + 3TC + EFV in advanced antiretroviral naive HIV type 1-infected Ugandan patients.

Kebba, Anthony / Atwine, Diana / Mwebaze, Raymond / Kityo, Cissy / Nakityo, Rose / Peter, Mulenyi

AIDS research and human retroviruses

2002 Volume 18, Issue 16, Page(s) 1181–1187

Abstract: Convenient, non-food-dependent dosing, low tablet volume, and relatively low cost have made nonnucleoside reverse transcriptase inhibitors a first choice for both clinicians and patients in Uganda. Concerns exist as to their efficacy in patients with ... ...

Abstract	Convenient, non-food-dependent dosing, low tablet volume, and relatively low cost have made nonnucleoside reverse transcriptase inhibitors a first choice for both clinicians and patients in Uganda. Concerns exist as to their efficacy in patients with viral loads (VL) above 100,000 copies/ml, a feature common to about 75% of HIV-1-infected patients presenting at the Joint Clinical Research Center (JCRC) in Uganda. Furthermore, there are few data on the response to such therapy of non-B subtypes, A and D, predominant in Uganda. Presented here is a retrospective analysis of therapeutic responses in 11 antiretroviral (ARV) naïve HIV-1-infected Ugandan patients who had been initiated on zidovudine (AZT), lamivudine (3TC), and efavirenz (EFV). Laboratory assessments subsequent to initiation of ARV therapy, done at 11.6 +/- 3.9 weeks and 30.6 +/- 5.9 weeks, showed 88.9 and 71.4% patients achieved undetectable viral load, respectively. Virological suppression to below detection occurred in 85.7% of patients at 11.6 weeks despite baseline VL >or= 100,000 copies/ml. At 31 weeks there was a median increment of +183 cells/mm(3) in CD4(+) T lymphocytes. These findings reflect significant efficacy in the use of AZT + 3TC + EFV in advanced ARV naive non-B subtype HIV-1-infected patients. The therapeutic responses were comparable to those previously described in the western world.
MeSH term(s)	Adult ; Benzoxazines ; CD4 Lymphocyte Count ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy ; HIV-1/isolation & purification ; Humans ; Lamivudine/administration & dosage ; Lamivudine/therapeutic use ; Male ; Middle Aged ; Oxazines/administration & dosage ; Oxazines/therapeutic use ; Patient Compliance ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/therapeutic use ; Uganda ; Viral Load ; Zidovudine/administration & dosage ; Zidovudine/therapeutic use
Chemical Substances	Benzoxazines ; Oxazines ; Reverse Transcriptase Inhibitors ; Lamivudine (2T8Q726O95) ; Zidovudine (4B9XT59T7S) ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2002-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/08892220260387922
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1928: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects.

Kebba, Anthony / Stebbing, Justin / Rowland, Samantha / Ingram, Rebecca / Agaba, John / Patterson, Steve / Kaleebu, Pontiano / Imami, Nesrina / Gotch, Frances

Journal of leukocyte biology

2005 Volume 78, Issue 1, Page(s) 37–42

Abstract: The significantly higher surface expression of the surface heat-shock protein receptor CD91 on monocytes of human immunodeficiency virus type-1 (HIV-1)-infected, long-term nonprogressors suggests that HIV-1 antigen uptake and cross-presentation mediated ... ...

Abstract	The significantly higher surface expression of the surface heat-shock protein receptor CD91 on monocytes of human immunodeficiency virus type-1 (HIV-1)-infected, long-term nonprogressors suggests that HIV-1 antigen uptake and cross-presentation mediated by CD91 may contribute to host anti-HIV-1 defenses and play a role in protection against HIV-1 infection. To investigate this further, we performed phenotypic analysis to compare CD91 surface expression on CD14(+) monocytes derived from a cohort of HIV-1-exposed seronegative (ESN) subjects, their seropositive (SP) partners, and healthy HIV-1-unexposed seronegative (USN) subjects. The median fluorescent intensity (MFI) of CD91 on CD14(+) monocytes was significantly higher in ESN compared with SP (P = 0.028) or USN (P = 0.007), as well as in SP compared with USN subjects (P = 0.018). CD91 MFI was not normalized in SP subjects on highly active antiretroviral therapy (HAART) despite sustainable, undetectable plasma viraemia. Data in three SP subjects experiencing viral rebounds following interruption of HAART showed low CD91 MFI comparable with levels in USN subjects. There was a significant positive correlation between CD91 MFI and CD8(+) T cell counts in HAART-naïve SP subjects (r = 0.7, P = 0.015). Increased surface expression of CD91 on CD14(+) monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects.
MeSH term(s)	Adult ; Antigens, CD/biosynthesis ; Antigens, CD/immunology ; Antiretroviral Therapy, Highly Active ; CD8-Positive T-Lymphocytes/immunology ; Cohort Studies ; Female ; HIV Antigens/immunology ; HIV Antigens/metabolism ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Seronegativity/immunology ; HIV Seropositivity/immunology ; HIV-1/immunology ; Humans ; Immunity, Innate/immunology ; Lipopolysaccharide Receptors/immunology ; Low Density Lipoprotein Receptor-Related Protein-1 ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Up-Regulation/immunology
Chemical Substances	Antigens, CD ; HIV Antigens ; LRP1 protein, human ; Lipopolysaccharide Receptors ; Low Density Lipoprotein Receptor-Related Protein-1
Language	English
Publishing date	2005-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.0105049
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: HIV type 1 antigen-responsive CD4+ T-lymphocytes in exposed yet HIV Type 1 seronegative Ugandans.

Kebba, Anthony / Kaleebu, Pontiano / Serwanga, Jennifer / Rowland, Samantha / Yirrell, David / Downing, Robert / Gilmour, Jill / Imami, Nesrina / Gotch, Frances / Whitworth, Jimmy

AIDS research and human retroviruses

2004 Volume 20, Issue 1, Page(s) 67–75

Abstract: CD4(+) T cell help is important for the functionality of CD8(+) cytotoxic T-lymphocytes (CTLs) in limiting viral replication and may contribute to mediation of apparent resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Using five ... ...

Abstract	CD4(+) T cell help is important for the functionality of CD8(+) cytotoxic T-lymphocytes (CTLs) in limiting viral replication and may contribute to mediation of apparent resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Using five HIV-1 antigens in an intracellular cytokine assay, the presence of specific antigen-responsive interferon- gamma-positive (IFN-gamma(+)) CD69(+) CD4(+) T-lymphocytes was evaluated in ESNs, their seropositive partners, and unexposed seronegative controls. Ten ESNs (five females, five uncircumcised males) were identified from 10 HIV-1 serodiscordant couples with a history of frequent unprotected sexual intercourse. All ESNs and controls were negative on two EIAs and for HIV-1 proviral DNA. The frequency of ESNs with antigen-responsive IFN-gamma(+) CD69(+) CD4(+) T-lymphocytes ranged from three to five of eight for the different HIV-1 antigens. Six of eight ESNs tested had a positive response to at least one of the five antigens. Responses were on average 3.5 times higher among seropositives compared to ESNs and absent in the five unexposed controls. A negative correlation was noted between responses in ESNs and the plasma viral load of their seropositive spouse. Clade-specific and cross-clade reactivity were noted in both ESNs and seropositive partners tested. The findings confirm that ESNs are in a state of HIV-1-specific immune activation and suggest that HIV-1-specific IFN-gamma(+) CD69(+) CD4(+) T-lymphocytes in addition to HIV-1-specific CD8(+) CTLs already described by others are potential immunological correlates of protection from persistent HIV-1 infection.
MeSH term(s)	Adult ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Female ; HIV Antigens/immunology ; HIV Seronegativity/immunology ; HIV Seropositivity/immunology ; HIV-1/immunology ; Humans ; Interferon-gamma/biosynthesis ; Lectins, C-Type ; Male ; Spouses ; Uganda ; Viral Load
Chemical Substances	Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; HIV Antigens ; Lectins, C-Type ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2004-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/088922204322749512
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1928: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults.

Takahashi, Hidehiko / Oishi, Kazunori / Yoshimine, Hiroyuki / Kumatori, Atsushi / Moji, Kazuhiko / Watanabe, Kiwao / Nalwoga, Hawa / Tugume, Sitefano Buguruka / Kebba, Anthony / Mugerwa, Roy / Mugyenyi, Peter / Nagatake, Tsuyoshi

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2003 Volume 37, Issue 11, Page(s) 1534–1540

Abstract: Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan ... ...

Abstract	Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1-infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1-infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7-11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4+ lymphocyte numbers also tended to correlate with serum opsonic activity in asymptomatic HIV-1-infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1-infected African adults, which may expose them to a serious risk of invasive pneumococcal infections.
MeSH term(s)	Adult ; HIV ; HIV Infections/immunology ; HIV Infections/microbiology ; Humans ; Immunoglobulin G/immunology ; Opsonin Proteins/blood ; Opsonin Proteins/metabolism ; Pneumococcal Infections/complications ; Pneumococcal Infections/immunology ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/physiology
Chemical Substances	Immunoglobulin G ; Opsonin Proteins
Language	English
Publishing date	2003-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1086/379511
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito