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  1. Article: Childhood autism, feeding problems and failure to thrive in early infancy. Seven case studies.

    Keen, Daphne V

    European child & adolescent psychiatry

    2008  Volume 17, Issue 4, Page(s) 209–216

    Abstract: Despite longstanding clinical experience of unusual feeding difficulties in children with autism, there is no published literature describing their association with early onset FTT. This paper examines literature that may link feeding problems and ... ...

    Abstract Despite longstanding clinical experience of unusual feeding difficulties in children with autism, there is no published literature describing their association with early onset FTT. This paper examines literature that may link feeding problems and abnormal growth with developmental and psychiatric conditions and describes seven cases of children with autism, who showed growth failure caused by severe feeding problems starting in the first year of life. Inadequacies in existing classifications systems are highlighted. The presence of severe or atypical feeding problems and FTT in infancy should alert professionals to possible underlying ASD. The aetiology of feeding disorders in autism appears to involve an unusually complex interactional model with biological vulnerabilities due to dysfunction in sensory, cognitive and emotional response interacting with dysfunctional attachment and learnt behaviours to produce a severe and intractable problem. Effective treatment therefore requires a novel multifaceted approach that can address each of these areas.
    MeSH term(s) Autistic Disorder/complications ; Autistic Disorder/psychology ; Body Mass Index ; Child ; Child, Preschool ; Failure to Thrive/etiology ; Failure to Thrive/psychology ; Feeding and Eating Disorders/etiology ; Feeding and Eating Disorders/psychology ; Female ; Humans ; Infant ; Male ; Severity of Illness Index ; United Kingdom
    Language English
    Publishing date 2008-06
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-007-0655-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Conduct disorders and us: from heart sink to heart warming?

    Keen, Daphne V

    Archives of disease in childhood

    2007  Volume 92, Issue 10, Page(s) 838–841

    MeSH term(s) Adolescent ; Child ; Child Behavior Disorders/diagnosis ; Child Behavior Disorders/etiology ; Child, Preschool ; Conduct Disorder/diagnosis ; Conduct Disorder/psychology ; Female ; Humans ; Male ; Parent-Child Relations
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.2006.106369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Innovations in Practice: 'Off-label' clonidine: UK Paediatric and Child and Adolescent Psychiatry prescribing practice for sleep problems.

    MacLeod, Rebecca L / Keen, Daphne V

    Child and adolescent mental health

    2013  Volume 19, Issue 2, Page(s) 147–150

    Abstract: Background: Psychopharmacological prescribing of clonidine has been described in Australia and in the United States but not in Europe. This study explores UK clinician experience of clonidine 'off label' in treating paediatric sleep problems in the ... ...

    Abstract Background: Psychopharmacological prescribing of clonidine has been described in Australia and in the United States but not in Europe. This study explores UK clinician experience of clonidine 'off label' in treating paediatric sleep problems in the context of a paucity of evidence for its use.
    Methods: Survey of UK Child and Adolescent Psychiatrists (CAPs) and specialist Paediatricians.
    Results: Of 389 respondents (30% Paediatricians, 70% CAPs), 172 prescribed clonidine and 85 having used it for treating sleep. Treatment targets were sleep onset, night waking and nonspecific sleep problems, and carer respite, in patients with significant coexisting neurological and neurodevelopmental disorders. Most used clonidine as a second line medication after trying nonpharmacological approaches. The majority reported initial effectiveness, and adverse effects were mild or transient. Issues of reducing long-term effectiveness, drug tolerance and considerable differences in dosing regimes were identified.
    Conclusions: Clonidine use appears less widespread in the United Kingdom than reported elsewhere. It is seen as a potentially effective and safe intervention but this study highlights the need for good quality RCT evidence for the most effective use of clonidine in paediatric sleep disorders.
    Language English
    Publishing date 2013-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073663-0
    ISSN 1475-3588 ; 1475-357X
    ISSN (online) 1475-3588
    ISSN 1475-357X
    DOI 10.1111/camh.12032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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