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  1. Article ; Online: Polysomnographic Subtypes and Incident Cancer: Another Adverse Outcome Related to Period Limb Movements.

    Lim, Diane C / Keenan, Brendan T

    Chest

    2023  Volume 164, Issue 2, Page(s) 287–289

    MeSH term(s) Humans ; Polysomnography ; Restless Legs Syndrome ; Neoplasms/epidemiology ; Movement
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.04.035
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  2. Article ; Online: Pro: Comparing adherent to non-adherent patients can provide useful estimates of the effect of CPAP on cardiovascular outcomes.

    Keenan, Brendan T / Magalang, Ulysses J / Maislin, Greg

    Sleep

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsae064
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    Zs.A 1475: Show issues Location:
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  3. Article ; Online: Rare Genetic Variants Provide Protection for Obstructive Sleep Apnea.

    Pack, Allan I / Keenan, Brendan T

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 10, Page(s) 1199–1200

    MeSH term(s) Humans ; Caveolin 1 ; Sleep Apnea, Obstructive/physiopathology ; Body Mass Index
    Chemical Substances Caveolin 1
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202207-1414ED
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  4. Article ; Online: Using Real-World Data to Understand Who Has Cardiovascular Benefits from Continuous Positive Airway Pressure: The Importance of Male Sex, Excessive Sleepiness, and Primary Prevention.

    Keenan, Brendan T / Heinzer, Raphael

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 11, Page(s) 1314–1316

    MeSH term(s) Humans ; Male ; Continuous Positive Airway Pressure ; Sleepiness ; Disorders of Excessive Somnolence ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/therapy ; Cardiovascular Diseases/prevention & control ; Primary Prevention
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202207-1359ED
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  5. Article ; Online: Night-to-night reliability and agreement of physiological endotypes: two steps forward, one step back.

    Keenan, Brendan T / Magalang, Ulysses J / Schwab, Richard J

    Sleep

    2023  Volume 46, Issue 8

    MeSH term(s) Humans ; Aged ; Polysomnography ; Reproducibility of Results ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad116
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    Zs.A 1475: Show issues Location:
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  6. Article ; Online: A Need for Understanding Clinically Meaningful Differences in Endotypes Derived From Polysomnography.

    Keenan, Brendan T / Magalang, Ulysses J / Schwab, Richard J

    Chest

    2023  Volume 164, Issue 5, Page(s) e160–e161

    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.05.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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  7. Article ; Online: Symptom Subtypes in OSA: Ready for the Clinic?

    Magalang, Ulysses J / Keenan, Brendan T

    Chest

    2021  Volume 160, Issue 6, Page(s) 2003–2004

    MeSH term(s) Ambulatory Care Facilities ; Humans ; Polysomnography ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.09.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Single-nucleus RNA-seq identifies one galanin neuronal subtype in mouse preoptic hypothalamus activated during recovery from sleep deprivation.

    Guo, Xiaofeng / Keenan, Brendan T / Reiner, Benjamin C / Lian, Jie / Pack, Allan I

    Cell reports

    2024  Volume 43, Issue 5, Page(s) 114192

    Abstract: The preoptic area of the hypothalamus (POA) is essential for sleep regulation. However, the cellular makeup of the POA is heterogeneous, and the molecular identities of the sleep-promoting cells remain elusive. To address this question, this study ... ...

    Abstract The preoptic area of the hypothalamus (POA) is essential for sleep regulation. However, the cellular makeup of the POA is heterogeneous, and the molecular identities of the sleep-promoting cells remain elusive. To address this question, this study compares mice during recovery sleep following sleep deprivation to mice allowed extended sleep. Single-nucleus RNA sequencing (single-nucleus RNA-seq) identifies one galanin inhibitory neuronal subtype that shows upregulation of rapid and delayed activity-regulated genes during recovery sleep. This cell type expresses higher levels of growth hormone receptor and lower levels of estrogen receptor compared to other galanin subtypes. single-nucleus RNA-seq also reveals cell-type-specific upregulation of purinergic receptor (P2ry14) and serotonin receptor (Htr2a) during recovery sleep in this neuronal subtype, suggesting possible mechanisms for sleep regulation. Studies with RNAscope validate the single-nucleus RNA-seq findings. Thus, the combined use of single-nucleus RNA-seq and activity-regulated genes identifies a neuronal subtype functionally involved in sleep regulation.
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114192
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  9. Article ; Online: The Effect of Surgical Therapy for Obstructive Sleep Apnea on Blood Pressure and Peripheral Arterial Tonometry.

    Tangutur, Akshay / Cai, Yi / Seay, Everett G / Thaler, Erica R / Keenan, Brendan T / Dedhia, Raj C

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  

    Abstract: Objective: To determine the effect of upper airway surgery on cardiovascular function in patients with obstructive sleep apnea (OSA).: Study design: A prospective, self-controlled study from 2018 to 2023.: Setting: Two academic medical centers.: ...

    Abstract Objective: To determine the effect of upper airway surgery on cardiovascular function in patients with obstructive sleep apnea (OSA).
    Study design: A prospective, self-controlled study from 2018 to 2023.
    Setting: Two academic medical centers.
    Methods: Seventy-four patients underwent surgery for OSA, including: tonsillectomy, adenoidectomy, epiglottidectomy, modified uvulopalatopharyngoplasty, maxillary expansion, and maxillomandibular advancement. Twenty-four-hour ambulatory blood pressure (BP), peripheral arterial tonometry (PAT)-based home sleep study, and sleep-related patient-reported outcomes (PROs) were captured preoperatively and at 6 months postoperatively. Paired T-tests evaluated changes in outcomes after surgery.
    Results: Forty-one patients successfully completed preoperative and postoperative assessments. Patients were generally middle-aged (43.8 ± 12.5 years), obese (BMI 33.0 ± 5.8 kg/m
    Conclusion: Surgical therapy for OSA did not demonstrate statistically significant improvements in 24-h BP. However, clinically meaningful reductions in nocturnal BP were observed, particularly in skeletal surgery patients, supporting the need for larger studies of cardiovascular outcomes following OSA surgery.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.718
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  10. Article ; Online: Using the Remote Monitoring Framework to Promote Adherence to Continuous Positive Airway Pressure.

    Keenan, Brendan T / Schwab, Richard J

    Sleep medicine clinics

    2020  Volume 16, Issue 1, Page(s) 85–99

    Abstract: The ability to remotely monitor positive airway pressure therapy adherence and efficacy provides a unique opportunity for the field of sleep medicine to quickly and efficiently improve patient adherence. Smaller randomized studies and larger-scale ... ...

    Abstract The ability to remotely monitor positive airway pressure therapy adherence and efficacy provides a unique opportunity for the field of sleep medicine to quickly and efficiently improve patient adherence. Smaller randomized studies and larger-scale retrospective evaluations show that telemedicine interventions leveraging these data can increase average usage and efficiency of care. However, more evidence on the impact of these programs on longer-term adherence and improving patient-reported outcomes is needed. Combining data from remote monitoring with clinical information in electronic health records may prove to be invaluable to the future of clinical sleep medicine practice and research.
    MeSH term(s) Continuous Positive Airway Pressure ; Humans ; Patient Compliance/statistics & numerical data ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Sleep Apnea, Obstructive/therapy ; Telemedicine
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2020.11.001
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