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  1. Article ; Online: Author Correction: Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities.

    Dissanayake, Indeewarie H / Bandaranayake, Upeka / Keerthirathna, Lakshika R / Manawadu, Chamalika / Silva, Rajitha M / Mohamed, Boudjelal / Ali, Rizwan / Peiris, Dinithi C

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3962

    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30967-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities.

    Dissanayake, Indeewarie H / Bandaranayake, Upeka / Keerthirathna, Lakshika R / Manawadu, Chamalika / Silva, Rajitha M / Mohamed, Boudjelal / Ali, Rizwan / Peiris, Dinithi C

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 20848

    Abstract: Marine algae are found to be excellent in their nutritional and potential therapeutic properties. This study explores the antidiabetic and anticancer potential of fractionated polyphenolic extract of Caulerpa racemosa, green macroalgae. Crude ... ...

    Abstract Marine algae are found to be excellent in their nutritional and potential therapeutic properties. This study explores the antidiabetic and anticancer potential of fractionated polyphenolic extract of Caulerpa racemosa, green macroalgae. Crude polyphenolic extract (CPE) of C. racemosa and its fractions (n-hexane, ethyl acetate, chloroform, and distilled water) were tested for its total phenol and flavonoid contents and antioxidant potential. The ethyl acetate fraction was subjected to gas chromatography/mass spectrometry (GC/MS). The in vitro antidiabetic activity was assessed by alpha-amylase, glucosidase inhibition and anti-glycation assays. Also, in-silico studies were conducted to test the binding affinities between caulerpin with alpha-glucosidase enzyme and estrogen receptor (ER) active sites. Each fraction was tested for its in vitroin vitroanticancer activity by CellTiter-Glo and MTT cell proliferation assays. The total phenolic and flavonoid contents and the antioxidant potential of the crude extract were observed to be dose dependent. The GC/MS analysis of the ethyl acetate fraction yielded 47 peaks, whereas n-hexadecanoic acid and hexadecanoic acid methyl ester showed the highest compatibility percentages of 99% and 96%, respectively. The CPE exhibited a higher potential in both alpha-amylase inhibitory and anti-glycation activities. The ethyl acetate fraction was more effective against alpha-glucosidase inhibition. Molecular docking revealed a high binding affinity between the alpha-glucosidase enzyme and caulerpin and showed high binding affinity toward caulerpin, with H-bond interactions. The in vitro anticancer analyses revealed that chloroform fraction and CPE exhibited moderate activity on the KAIMRC1 cell line. Also, the CPE exhibited high specificity compared to the standard drug in anticancer studies. Our findings evidence the pharmacological potential of the CPE of C. racemosa, and bioactive compounds of the species may be utilized as lead molecules to develop anti-diabetic and anti-cancer drugs.
    MeSH term(s) Caulerpa ; Hypoglycemic Agents/pharmacology ; Antioxidants/pharmacology ; alpha-Glucosidases ; Molecular Docking Simulation ; Chloroform ; Palmitic Acid ; alpha-Amylases ; Phenols/pharmacology ; Flavonoids ; Amylases
    Chemical Substances Hypoglycemic Agents ; Antioxidants ; ethyl acetate (76845O8NMZ) ; alpha-Glucosidases (EC 3.2.1.20) ; Chloroform (7V31YC746X) ; Palmitic Acid (2V16EO95H1) ; alpha-Amylases (EC 3.2.1.1) ; Phenols ; Flavonoids ; Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-24021-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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