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Buch ; Dissertation / Habilitation: 19F-MR-Bildgebung mit semifluorierten Alkanen zur Untersuchung des Oxygenierungsstatus in Tumoren

Kegel, Stefan

2015

Titelvarianten	Neunzehn-F-MR-Bildgebung mit semifluorierten Alkanen zur Untersuchung des Oxygenierungsstatus in Tumoren
Verfasserangabe	vorgelegt von Stefan Kegel
Sprache	Deutsch
Umfang	115 Blätter, Illustrationen, Diagramme
Erscheinungsort	Heidelberg
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2016
Anmerkung	Im Titel ist "19" hochgestellt
HBZ-ID	HT019055643
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2016 E 1234	bestellbar zur Ausleihe	Magazin

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Buch ; Dissertation / Habilitation: Zur Klinik der Thromboembolie der Lunge

Kegel, Silvia

1999

Verfasserangabe	von Silvia Kegel
Sprache	Deutsch
Umfang	75 Bl., graph. Darst., 30 cm
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Halle, Univ., Diss., 1999
HBZ-ID	HT013087568
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2001 E 2184	bestellbar zur Ausleihe	Magazin

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Buch ; Dissertation / Habilitation: Besonderheiten der Prüfung viskoelastischer Materialien auf ihre Bioverträglichkeit an Zellkulturen

Kegel, Stefan

Beispiel: Hydroxypropylmethylcellulose

1994

Verfasserangabe	vorgelegt von Stefan Kegel
Sprache	Deutsch
Umfang	98 S. : Ill., graph. Darst.
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Aachen, Techn. Hochsch., Diss., 1994
HBZ-ID	HT006347405
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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95 D 475	bestellbar zur Ausleihe	Magazin

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Buch ; Dissertation / Habilitation: Langzeitergebnisse der Ligatur des Stenonschen Ganges als therapeutische Maßnahme bei nichttumorbedingten Erkrankungen der Glandula parotis

Kegel, Silvia

1988

Verfasserangabe	vorgelegt von Silvia Kegel
Umfang	80, 12, 2 Bl. : Ill., graph. Darst.
Erscheinungsland	XA-DDDE
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Berlin, Humboldt-Univ., Diss. A, 1989
HBZ-ID	HT003739616
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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91 E 836	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: The impact of early diagnosis of fetal single-ventricle cardiac defects on reproductive choices.

Kegel, Samantha / Abi Habib, Paola / Seger, Lindsey / Turan, Ozhan M / Turan, Sifa

American journal of obstetrics & gynecology MFM

2023 Band 5, Heft 9, Seite(n) 101093

Abstract: Background: Congenital heart defects are the most common fetal anomaly. Congenital heart defects with single-ventricle cardiac defects have high mortality rates, and in pregnancies diagnosed with this condition, patients are often offered termination of ...

Abstract	Background: Congenital heart defects are the most common fetal anomaly. Congenital heart defects with single-ventricle cardiac defects have high mortality rates, and in pregnancies diagnosed with this condition, patients are often offered termination of pregnancy as an option. Objective: This study aimed to investigate the relationship between gestational age at diagnosis and reproductive choices in fetuses diagnosed with single-ventricle cardiac defects. Study design: This was a retrospective single-center cohort study in which 158 patients with a fetal diagnosis of single-ventricle cardiac defects were reviewed. Cases were categorized as isolated or complex. Complex cases included fetuses with single-ventricle cardiac defects in addition to other fetal extracardiac anomalies or chromosomal abnormalities. Results: A total of 158 patients were diagnosed with single-ventricle cardiac defects during the study period. Of those patients, 37 (23.4%) underwent termination of pregnancy, 113 (71.5%) delivered, and 8 (5.1%) had an intrauterine fetal demise. Gestational age at diagnosis and race were significant predictors of the termination decision. The median gestational age at diagnosis was earlier in the termination of pregnancy group (20.4 vs 23.6 weeks; P<.001). Pregnancies complicated by single-ventricle cardiac defects diagnosed in early gestation (11 0/7 to 14 5/7 weeks of gestation) were more likely to be terminated than pregnancies complicated by single-ventricle cardiac defects diagnosed in middle gestation (15 0/7 to 27 5/7 weeks of gestation) and late gestation (≥28 weeks of gestation) (54.2% vs 23.2% and 2.9%; P<.001). Earlier gestational age at diagnosis was correlated with earlier gestational age at termination (r=0.92; P<.001). Conclusion: Termination of pregnancy was more common when the single-ventricle cardiac defect was diagnosed earlier in pregnancy. This could be explained by the fact that early diagnoses allow parents to make deliberate and informed decisions.
Mesh-Begriff(e)	Female ; Pregnancy ; Humans ; Infant ; Cohort Studies ; Retrospective Studies ; Ultrasonography, Prenatal ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/epidemiology ; Fetus ; Early Diagnosis
Sprache	Englisch
Erscheinungsdatum	2023-07-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2023.101093
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A pilot study: Application of paired ultrasound simulator training in obstetrics.

Kegel, Samantha / Elsamadicy, Emad / Seger, Lindsey / Ahmed, Amiya A / Makar, Erica / Turan, Ozhan / Turan, Sifa

Journal of clinical ultrasound : JCU

2023 Band 51, Heft 7, Seite(n) 1155–1163

Abstract: Objective: Medical trainees in obstetrics must develop competency in fetal ultrasonography. To date, no studies have utilized ultrasound simulator training for basic fetal anatomy with paired didactic coursework. We hypothesize that ultrasound simulator ...

Abstract	Objective: Medical trainees in obstetrics must develop competency in fetal ultrasonography. To date, no studies have utilized ultrasound simulator training for basic fetal anatomy with paired didactic coursework. We hypothesize that ultrasound simulator training with paired didactics improves medical trainee competency in fetal ultrasonography. Methods: A prospective observational study was performed at a tertiary care center during the 2021-2022 academic year. Medical trainees in obstetrics without prior simulator experience could participate. Participants completed ultrasound simulator training with standardized paired didactics and subsequent real-time patient scanning. All images were reviewed by the same physician for competency. Trainees completed 11-point Likert scale surveys at three time points: pre-simulator, post-simulator, and post-real-time patient scanning. Two-tailed student's t-tests with 95% confidence intervals were performed, and p-values <0.05 were considered significant. Results: Of the 26 trainees that completed the training, 96% reported that simulation positively impacted their confidence and ability to perform real-time scanning of patients. Self-reported knowledge of fetal anatomy, ultrasound techniques, and application to clinical obstetrics all significantly increased after simulator training (p < 0.01). Conclusions: Paired ultrasound simulation with didactic instruction significantly improves medical trainees' knowledge of fetal anatomy and ability to perform fetal ultrasonography. Implementing an ultrasound simulation curriculum may become an essential tool for obstetric residency programs.
Mesh-Begriff(e)	Pregnancy ; Female ; Humans ; Obstetrics/education ; Pilot Projects ; Ultrasonography/methods ; Ultrasonography, Prenatal ; Curriculum ; Internship and Residency ; Clinical Competence ; Simulation Training/methods
Sprache	Englisch
Erscheinungsdatum	2023-05-22
Erscheinungsland	United States
Dokumenttyp	Observational Study ; Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23494
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Focused ultrasound robotic system for very small bore magnetic resonance imaging.

Damianou, Christakis / Giannakou, Marinos / Evripidou, Nikolas / Kegel, Stefan / Huber, Peter / Jenne, Juergen

The international journal of medical robotics + computer assisted surgery : MRCAS

2020 Band 16, Heft 6, Seite(n) 1–9

Abstract: Background: A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed for small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The robotic ... ...

Abstract	Background: A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed for small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The robotic system includes two computer-controlled linear stages. Materials and methods: The robotic system was evaluated in a mouse-shaped, real-size agar-based mimicking material, which has similar acoustical properties as soft tissues. The agar content was 6% weight per volume (w/v), 4% w/v silica while the rest was degassed water. The transducer used has a diameter of 4 cm, operates with 2.6 MHz and focuses energy at 5 cm. Results: The MRI compatibility of the robotic system was evaluated in a 9.4 T small animal scanner. The efficacy of the ultrasonic transducer was evaluated in the mimicking material using temperature measurements. Conclusions: The proposed robotic system can be utilized in a 9.4 T small animal MRI scanner. The proposed system is functional, compact and simple thus providing a useful tool for preclinical research in mice and rats.
Mesh-Begriff(e)	Animals ; Magnetic Resonance Imaging ; Mice ; Phantoms, Imaging ; Rats ; Robotic Surgical Procedures ; Transducers ; Ultrasonics
Sprache	Englisch
Erscheinungsdatum	2020-09-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2165
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Stem Cell Therapy in Single-Ventricle Physiology: Recent Progress and Future Directions.

Abdullah, Mohamed / Kegel, Samantha / Gunasekaran, Muthukumar / Saha, Progyaparamita / Fu, Xuebin / Mishra, Rachana / Sharma, Sudhish / Sunjay Kaushal

Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual

2021 Band 24, Seite(n) 67–76

Abstract: Current surgical and medical treatment options for single ventricle physiology conditions remain palliative. On the long term, despite treatment, the systemic ventricle has a significant risk of developing failure. There are unmet needs to develop novel ... ...

Abstract	Current surgical and medical treatment options for single ventricle physiology conditions remain palliative. On the long term, despite treatment, the systemic ventricle has a significant risk of developing failure. There are unmet needs to develop novel treatment modalities to help ameliorate the ventricular dysfunction. Advances in the field of stem cell therapy have been promising for the treatment of heart failure. Numerous stem cell populations have been identified. Preclinical studies in small and large animal models provide evidence for effectiveness of this treatment modality and reveal several mechanisms of action by which stem cells exert their effect. Many clinical trials have been designed to further investigate the therapeutic potential that stem cell therapy may hold for pediatric populations with single ventricle physiology. In this review, we discuss the stem cell types used in these populations, some preclinical studies, and the clinical trials of stem cell therapy in single ventricle patients.
Mesh-Begriff(e)	Child ; Clinical Trials as Topic ; Fontan Procedure ; Heart Defects, Congenital/therapy ; Heart Failure/therapy ; Heart Ventricles ; Humans ; Stem Cell Transplantation ; Univentricular Heart
Sprache	Englisch
Erscheinungsdatum	2021-05-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1425449-9
ISSN	1876-4665 ; 1092-9126
ISSN (online)	1876-4665
ISSN	1092-9126
DOI	10.1053/j.pcsu.2021.03.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Measurement of the α-Particle Monopole Transition Form Factor Challenges Theory: A Low-Energy Puzzle for Nuclear Forces?

Kegel, S / Achenbach, P / Bacca, S / Barnea, N / Beričič, J / Bosnar, D / Correa, L / Distler, M O / Esser, A / Fonvieille, H / Friščić, I / Heilig, M / Herrmann, P / Hoek, M / Klag, P / Kolar, T / Leidemann, W / Merkel, H / Mihovilovič, M /

Müller, J / Müller, U / Orlandini, G / Pochodzalla, J / Schlimme, B S / Schoth, M / Schulz, F / Sfienti, C / Širca, S / Spreckels, R / Stöttinger, Y / Thiel, M / Tyukin, A / Walcher, T / Weber, A

Physical review letters

2023 Band 130, Heft 15, Seite(n) 152502

Abstract: We perform a systematic study of the α-particle excitation from its ground state 0_{1}^{+} to the 0_{2}^{+} resonance. The so-called monopole transition form factor is investigated via an electron scattering experiment in a broad Q^{2} range (from 0.5 to ...

Abstract	We perform a systematic study of the α-particle excitation from its ground state 0_{1}^{+} to the 0_{2}^{+} resonance. The so-called monopole transition form factor is investigated via an electron scattering experiment in a broad Q^{2} range (from 0.5 to 5.0 fm^{-2}). The precision of the new data dramatically supersedes that of older sets of data, each covering only a portion of the Q^{2} range. The new data allow the determination of two coefficients in a low-momentum expansion, leading to a new puzzle. By confronting experiment to state-of-the-art theoretical calculations, we observe that modern nuclear forces, including those derived within chiral effective field theory that are well tested on a variety of observables, fail to reproduce the excitation of the α particle.
Sprache	Englisch
Erscheinungsdatum	2023-04-28
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.152502
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: 19

Kegel, Stefan / Chacon-Caldera, Jorge / Tsagogiorgas, Charalambos / Theisinger, Bastian / Glatting, Gerhard / Schad, Lothar R

Artificial cells, nanomedicine, and biotechnology

2016 Band 44, Heft 8, Seite(n) 1861–1866

Abstract: This work examines the variation of longitudinal relaxation rate R1(= 1/T1) of ... ...

Abstract	This work examines the variation of longitudinal relaxation rate R1(= 1/T1) of the
Mesh-Begriff(e)	Animals ; Fluorine-19 Magnetic Resonance Imaging/methods ; Fluorocarbons/chemistry ; Humans ; Oximetry/methods
Chemische Substanzen	Fluorocarbons
Sprache	Englisch
Erscheinungsdatum	2016-12
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.3109/21691401.2015.1111228
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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