Article ; Online: A Highly Potent SARS-CoV-2 Blocking Lectin Protein.
ACS infectious diseases
2022 Volume 8, Issue 7, Page(s) 1253–1264
Abstract: The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been ... ...
| Abstract | The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR |
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| MeSH term(s) | Animals ; COVID-19/drug therapy ; COVID-19/prevention & control ; Humans ; Lectins ; Mice ; Pandemics ; SARS-CoV-2 |
| Chemical Substances | Lectins |
| Language | English |
| Publishing date | 2022-04-15 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2373-8227 |
| ISSN (online) | 2373-8227 |
| DOI | 10.1021/acsinfecdis.2c00006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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