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  1. Book ; Thesis: Tryptophan deficiency signals in autoimmune neuroinflammation

    Keil, Melanie

    2015  

    Author's details presented by Melanie Keil
    Language English
    Size IX, 68, XI - XXVIII S. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2015
    Note Zsfassung in dt. Sprache
    HBZ-ID HT018803735
    Database Catalogue ZB MED Medicine, Health

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    2013 MB 1259 order for loan Magazin

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  2. Book ; Thesis: Rechtsfragen der individualisierten Medizin

    Keil, Miriam

    (Kölner Schriften zum Medizinrecht ; 18)

    2015  

    Author's details Miriam Keil
    Series title Kölner Schriften zum Medizinrecht ; 18
    Collection
    Keywords Deutschland ; Individualisierte Medizin ; Recht
    Subject Personalisierte Medizin ; Individualmedizin ; Patientenindividuelle Medizin ; Patientenindividuelle Therapie ; Maßgeschneiderte Pharmakotherapie ; Personalised medicine ; Präzisionsmedizin
    Language German
    Size XX, 287 S.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    HBZ-ID HT018665624
    ISBN 978-3-662-45580-7 ; 9783662455814 ; 3-662-45580-3 ; 3662455811
    Database Catalogue ZB MED Medicine, Health

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    2015 A 2214 available for loan (reading room) Lesesaal EG

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  3. Article: Deutschlandcup 15./16.09.2022. 8. "Bundesweites Fußballturnier der Bildungseinrichtungen für Hörgeschädigte" in Braunschweig

    Keil, Markus

    Hörgeschädigtenpädagogik

    2022  Volume 76, Issue 1, Page(s) 57

    Language German
    Document type Article
    ZDB-ID 123136-4
    ISSN 0342-4898
    Database Current Contents Medicine

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  4. Article ; Online: Greenhouse gas emissions of an outpatient care service: a cost-based approach.

    Keil, Mattis / Grün, Leona

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2022  Volume 175, Page(s) 90–95

    Abstract: Introduction: Climate change is already having an impact on global health and will continue to do so even more. Heat waves and extreme weather events are only part of the impact. Adapting health services to these threats is only partially possible, so ... ...

    Abstract Introduction: Climate change is already having an impact on global health and will continue to do so even more. Heat waves and extreme weather events are only part of the impact. Adapting health services to these threats is only partially possible, so another focus should be on mitigating climate change by minimising greenhouse gas emissions. In this context, health care can play an important role. However, evidence about greenhouse gas emission hotspots and alternative action to mitigate greenhouse gas emissions is needed for the shift to a climate-friendly health system.
    Methods: In this paper, the greenhouse gas emissions of an outpatient care service will be calculated. On the one hand, focal points of the emissions will be identified and the effects of climate-friendly measures calculated. In order to calculate a comprehensive footprint, a hybrid approach was chosen in which emissions from electricity, gas and fuels are determined on the basis of quantities, and emissions resulting from the production of consumer goods are calculated using cost-based emission factors. The expenditure and consumption data required come from a care service in Lower Saxony providing for 132 people in need of care.
    Results: The outpatient care service emitted a total of 37,258 kg CO
    Discussion: The study shows that the outpatient care service produces greenhouse gas emissions of about 282 kg CO
    Conclusion: The majority of the emissions of an ambulatory care service comes from the production and combustion of fuels. However, this source can be significantly reduced by switching to modern technologies. To validate the results of this study, further studies should be conducted, preferably with a bottom-up methodology.
    Language English
    Publishing date 2022-11-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2022.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations.

    Tatsi, Christina / Pitsava, Georgia / Faucz, Fabio R / Keil, Meg / Stratakis, Constantine A

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Carney complex (CNC) is a familial neoplasia syndrome associated with growth hormone (GH) excess (GHE).: Objective: To describe the frequency of GHE in a large cohort of patients with CNC, and to identify genotype-phenotype correlations.: ... ...

    Abstract Context: Carney complex (CNC) is a familial neoplasia syndrome associated with growth hormone (GH) excess (GHE).
    Objective: To describe the frequency of GHE in a large cohort of patients with CNC, and to identify genotype-phenotype correlations.
    Methods: Patients with CNC with at least one biochemical evaluation of GH secretion at our center from 1995-2021 (n=140) were included in the study. Diagnosis of GHE was based on levels of insulin-like growth factor-1 (IGF-1), GH suppression during oral glucose tolerance test (OGTT), GH stimulation after thyrotropin (TRH) administration and overnight GH secretion.
    Results: Fifty patients (35.7%) had GHE and 28 subjects (20%) had symptomatic acromegaly, with median age at diagnosis of 25.3 and 26.1 years respectively. Most of the patients (99.3%) had a PRKAR1A gene defect. There was a higher risk of GHE in patients harboring a variant that led to no expression of the affected allele [Hazard risk (HR): 3.06, 95% Confidence Intervals (CI): 1.2-7.8] and for patients harboring the hotspot variant c.491_492delTG (HR: 2.10, 95%CI: 1.1-4.1). Almost half of patients with CNC had an abnormal finding on pituitary imaging. CNC patients with an abnormal pituitary imaging had higher risk of GHE (HR: 2.94, 95%CI: 1.5-5.8), especially when single or multiple adenoma-like lesions were identified. Management of patients with symptomatic acromegaly involved surgical and medical approaches.
    Conclusion: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Mittel- bis langfristige Ergebnisse der operativen Versorgung frischer bzw. chronischer vorderer Kreuzbandinstabilitäten

    Keil, Michael

    Semitendinosus-augmentierte Kreuzbandnaht versus kombiniert autolog-alloplastische Rekonstruktionstechnik

    1996  

    Author's details vorgelegt von Michael Keil
    Language German
    Size 68 Bl. : Ill.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche
    HBZ-ID HT008594095
    Database Catalogue ZB MED Medicine, Health

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    1998 MB 1090 order for loan Magazin

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  7. Article: Understanding how physician perceptions of job demand and process benefits evolve during CPOE implementation.

    Rai, Arun / Keil, Mark / Choi, Hyoungyong / Mindel, Vitali

    Health systems (Basingstoke, England)

    2022  Volume 12, Issue 1, Page(s) 98–122

    Abstract: We examine how physicians' perceptions of two computerized provider order entry (CPOE) capabilities, standardisation of care protocols and documentation quality, are associated with their perceptions of turnaround time, medical error, and job demand at ... ...

    Abstract We examine how physicians' perceptions of two computerized provider order entry (CPOE) capabilities, standardisation of care protocols and documentation quality, are associated with their perceptions of turnaround time, medical error, and job demand at three phases of CPOE implementation: pre-go-live, initial use, and continued use. Through a longitudinal study at a large urban hospital, we find standardisation of care protocols is positively associated with turnaround time reduction in all phases but positively associated with job demand increase only in the initial use phase. Standardisation also has a positive association with medical error reduction in the initial use phase, but later this effect becomes fully mediated through turnaround time reduction in the continued use phase. Documentation quality has a positive association with medical error reduction in the initial use phase and this association strengthens in the continued use phase. Our findings provide insights to effectively manage physicians' response to CPOE implementation.
    Language English
    Publishing date 2022-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669693-9
    ISSN 2047-6973 ; 2047-6965
    ISSN (online) 2047-6973
    ISSN 2047-6965
    DOI 10.1080/20476965.2022.2113343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction: The Wnt target protein Peter Pan defines a novel p53-independent nucleolar stress-response pathway.

    Pfister, Astrid S / Keil, Marina / Kühl, Michael

    The Journal of biological chemistry

    2022  Volume 299, Issue 1, Page(s) 102808

    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The impact of switching from single-use to reusable healthcare products: a transparency checklist and systematic review of life-cycle assessments.

    Keil, Mattis / Viere, Tobias / Helms, Kevin / Rogowski, Wolf

    European journal of public health

    2022  Volume 33, Issue 1, Page(s) 56–63

    Abstract: Background: Replacing single-use products with reusable ones may reduce the environmental impact of healthcare. This study aimed to broadly assess the environmental effects of that substitution.: Methods: A systematic review of comparative cradle-to- ... ...

    Abstract Background: Replacing single-use products with reusable ones may reduce the environmental impact of healthcare. This study aimed to broadly assess the environmental effects of that substitution.
    Methods: A systematic review of comparative cradle-to-grave life-cycle assessments (LCAs) of single-use and reusable healthcare products was conducted. The main outcomes assessed were changes in the environmental impact that resulted after switching from single-use to reusable products. As no standardized transparency checklist was available, one was developed here using DIN ISO 14040/14044. The final checklist included 22 criteria used to appraise the included studies.
    Results: After screening, 27 studies were included in the analysis. The healthcare products were assigned to four categories: invasive medical devices, non-invasive medical devices, protection equipment and inhalers. The outcomes revealed a reduction in mean effect sizes for all environmental impacts except water use. Non-invasive medical devices have greater relative mitigation potential than invasive devices. On average, information on 64% of the transparency checklist items was reported. Gaps included the reporting of data quality requirements.
    Conclusions: Switching to reusable healthcare products is likely to reduce most impacts on the environment except water use, but the effect size differs among product categories. Possible study limitations include location bias, no systematic search of the grey literature and small samples for some impacts. This study's strengths are its approach to product categories and developed transparency catalogue. This catalogue could be useful to inform and guide a future process towards creating a standardized transparency checklist for the systematic reviews of LCAs.
    MeSH term(s) Humans ; Checklist ; Delivery of Health Care
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckac174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Über eiserne Bettstätten. Zur Geschichte des Krankenhausbettes (1700-1900).

    Keil, Maria

    Historia hospitalium

    2014  Volume 29, Page(s) 542–552

    Title translation Iron bedsteads. On the history of the hospital bed (1700 - 1900).
    MeSH term(s) Beds/history ; Europe ; Germany ; History, 17th Century ; History, 18th Century ; History, 19th Century ; Hospitals/history ; Iron/history
    Chemical Substances Iron (E1UOL152H7)
    Language German
    Publishing date 2014
    Publishing country Germany
    Document type Historical Article ; Journal Article
    ZDB-ID 800342-7
    ISSN 0440-9043
    ISSN 0440-9043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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