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  1. Book ; Online: Integrative Research on Organic Matter Cycling Across Aquatic Gradients

    G. Keil, Richard / Robinson, Carol / Seidel, Michael / M. Medeiros, Patricia / S. Bianchi, Thomas / Ward, Nicholas D.

    2017  

    Abstract: The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is ... ...

    Abstract The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is increasingly important that we recognize the interconnected nature of earth systems and embrace the complexities of ecosystem transitions. We are pleased to present this body of work, which embodies the spirit of research spanning across the terrestrial-aquatic continuum, from mountains to the sea. Sincerely, The Editors
    Keywords Science (General) ; Oceanography ; Physical geography
    Size 1 electronic resource (201 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095917
    ISBN 9782889452125 ; 2889452123
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The urban political ecology of antimicrobial resistance: A critical lens on integrative governance.

    Aguiar, Raphael / Keil, Roger / Wiktorowicz, Mary

    Social science & medicine (1982)

    2024  Volume 348, Page(s) 116689

    Abstract: The objective of this paper is to integrate Urban Political Ecology (UPE) as a theory for identifying under-exposed urban dimensions of Antimicrobial Resistance (AMR). A UPE lens allows us to conceptualize urbanization as a ubiquitous socio-ecological ... ...

    Abstract The objective of this paper is to integrate Urban Political Ecology (UPE) as a theory for identifying under-exposed urban dimensions of Antimicrobial Resistance (AMR). A UPE lens allows us to conceptualize urbanization as a ubiquitous socio-ecological process and an interpretive frame that could inform AMR governance strategies across related contexts by: a) situating AMR risks in relation to urbanization processes shaping social and political co-determinants of such systemic threats as climate change; b) aligning UPE scholarship with One Health (OH) approaches that address AMR to reveal the under-exposed link of AMR to environmental threats and broader structural dimensions that influence these threats; and c) identifying shared AMR and environmental governance pathways that inform the rationale for more equitable governance arrangements. We delineate a context in which the speed and scale of human activity in the larger context of urbanization, driven by global market integration strategies, impacts human-animal-environmental health threats such as AMR. We demonstrate how UPE scholarship can be leveraged to offer theoretical depth to approaches considering the interdependencies of AMR and climate change threats. We then propose a strategic approach focused on identifying shared governance pathways and intersectoral accountability frameworks to address upstream structural drivers of AM-Environmental threats. The co-benefits of a UPE-informed framework to human-animal-environmental health that leverages enabling policy environments to foster a more collaborative, equitable and sustainable approach to address systemic global health threats are clarified. Just as the concept of "health in all policies" emphasized taking health implications into account in all public policy development, the integration of UPE in AMR governance arrangements would emphasize the need to take other sectors into account through an intersectoral whole-of-government approach that fosters shared AMR - climate change governance pathways.
    MeSH term(s) Humans ; Politics ; Climate Change ; Urbanization ; Drug Resistance, Microbial
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2024.116689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Anthropogenic Forcing of Carbonate and Organic Carbon Preservation in Marine Sediments.

    Keil, Richard

    Annual review of marine science

    2017  Volume 9, Page(s) 151–172

    Abstract: Carbon preservation in marine sediments, supplemented by that in large lakes, is the primary mechanism that moves carbon from the active surficial carbon cycle to the slower geologic carbon cycle. Preservation rates are low relative to the rates at which ...

    Abstract Carbon preservation in marine sediments, supplemented by that in large lakes, is the primary mechanism that moves carbon from the active surficial carbon cycle to the slower geologic carbon cycle. Preservation rates are low relative to the rates at which carbon moves between surface pools, which has led to the preservation term largely being ignored when evaluating anthropogenic forcing of the global carbon cycle. However, a variety of anthropogenic drivers-including ocean warming, deoxygenation, and acidification, as well as human-induced changes in sediment delivery to the ocean and mixing and irrigation of continental margin sediments-all work to decrease the already small carbon preservation term. These drivers affect the cycling of both carbonate and organic carbon in the ocean. The overall effect of anthropogenic forcing in the modern ocean is to decrease delivery of carbon to sediments, increase sedimentary dissolution and remineralization, and subsequently decrease overall carbon preservation.
    MeSH term(s) Carbon ; Carbon Cycle ; Carbon Dioxide ; Carbonates ; Geologic Sediments ; Oceans and Seas
    Chemical Substances Carbonates ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2017--03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2458404-6
    ISSN 1941-0611 ; 1941-1405
    ISSN (online) 1941-0611
    ISSN 1941-1405
    DOI 10.1146/annurev-marine-010816-060724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling.

    Müller, Lisa / Keil, René / Hatzfeld, Mechthild

    Cell reports

    2023  Volume 42, Issue 1, Page(s) 112031

    Abstract: Plakophilin 3 (PKP3) is a component of desmosomes and is frequently overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we identify a signaling axis from ERK to the retinoblastoma (RB) protein and the E2F1 transcription ... ...

    Abstract Plakophilin 3 (PKP3) is a component of desmosomes and is frequently overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we identify a signaling axis from ERK to the retinoblastoma (RB) protein and the E2F1 transcription factor that is controlled by PKP3. RB and E2F1 are key components controlling G1/S transition in the cell cycle. We show that PKP3 stimulates the activity of ERK and its target RSK1. This inhibits expression of the transcription factor RUNX3, a positive regulator of the CDK inhibitor CDKN1A/p21, which is also downregulated by PKP3. Elevated CDKN1A prevents RB phosphorylation and E2F1 target gene expression, leading to delayed S phase entry and reduced proliferation in PKP3-depleted cells. Elevated PKP3 expression not only increases ERK activity but also captures phosphorylated RB (phospho-RB) in the cytoplasm to promote E2F1 activity and cell-cycle progression. These data identify a mechanism by which PKP3 promotes proliferation and acts as an oncogene.
    MeSH term(s) Animals ; Mice ; Cell Division ; Cytoplasm/metabolism ; E2F1 Transcription Factor/metabolism ; ErbB Receptors/metabolism ; Phosphorylation ; Plakophilins/genetics ; Plakophilins/metabolism ; Retinoblastoma Protein/metabolism ; S Phase ; Signal Transduction
    Chemical Substances E2F1 Transcription Factor ; ErbB Receptors (EC 2.7.10.1) ; Pkp3 protein, mouse ; Plakophilins ; Retinoblastoma Protein
    Language English
    Publishing date 2023-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Wege zur molekularen Kartierung des Azoospermiefaktors

    Keil, Ralf

    1995  

    Author's details vorgelegt von Ralf Keil
    Language German
    Size 123 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1995
    HBZ-ID HT006855141
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    96 E 160 order for loan Magazin

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  6. Article: Přínos urgentně provedené endoskopické retrográdní cholangiopankreatografie pro terapii akutní pankreatitidy.

    Keil, Radan

    Vnitrni lekarstvi

    Fall 2016  Volume 62, Issue 7-8, Page(s) 588–591

    Abstract: Unlabelled: Pancreatitis of biliary etiology accounts for 30-60 % of all cases of acute pancreatitis. A number of randomized studies have been completed to assess the role of acute endoscopic retrograde cholangiopancreatography (ERCP) and ... ...

    Title translation The benefit of urgent endoscopic retrograde cholangiopancreatography for the therapy of acute pancreatitis.
    Abstract Unlabelled: Pancreatitis of biliary etiology accounts for 30-60 % of all cases of acute pancreatitis. A number of randomized studies have been completed to assess the role of acute endoscopic retrograde cholangiopancreatography (ERCP) and papilosphincterotomy in the therapy of biliary pancreatitis. Analysis of the respective studies has shown that urgent endoscopy is clearly indicated for the patients with a severe form of acute biliary pancreatitis as well as for those with an ongoing acute cholangitis or obstructive icterus. The author believes that based on a detailed analysis of the results, urgent endoscopic retrograde cholangiopancreatography can also be recommended for patients with a mild form of the illness provided the procedure is performed within 12 hours of admission to a hospital by an experienced endoscopist.
    Key words: biliary pancreatitis - endoscopic retrograde cholangiopancreatography - papilosphincterotomy.
    MeSH term(s) Acute Disease ; Cholangiopancreatography, Endoscopic Retrograde ; Cholangitis/diagnosis ; Cholangitis/therapy ; Hospitalization ; Humans ; Pancreatitis/diagnosis ; Pancreatitis/therapy
    Language Czech
    Publishing date Fall 2016
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 327: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 526: Show issues

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  7. Book ; Thesis: Experimentelle Untersuchungen zu zentralnervösen Effekten der Acetylsalicylsäure bei Patienten mit Migräne

    Keil, Rainer

    1993  

    Author's details vorgelegt von Rainer Keil
    Keywords Aspirin / pharmacology ; Temporal Muscle ; Electromyography ; Pain Measurement ; Migraine
    Language German
    Size 83 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1993
    HBZ-ID HT006232267
    Database Catalogue ZB MED Medicine, Health

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    94 E 531 order for loan Magazin

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  8. Book ; Thesis: Beitrag zur Organtopographie und den wesentlichen Erkrankungen bei ungiftigen Schlangen der Familien Boidae, Colubridae und Xenopeltidae

    Keil, Renate

    1990  

    Author's details vorgelegt von Renate Keil
    Size 238 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Tierärztl. Hochsch., Diss., 1990
    Note Zsfassung in engl. Sprache
    HBZ-ID HT003741676
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    AY 15160 order for loan Geschlossenes Magazin (U2)

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  9. Article ; Online: Introduction

    Tzaninis, Yannis / Mandler, Tait / Kaika, Maria / Keil, Roger

    Turning up the Heat ; ISBN: 9781526170040

    Urban political ecology for a climate emergency

    2023  

    Abstract: This introduction frames the book in a debate on urban political ecology (UPE). UPE focuses on unsettling traditional understandings of ‘cities’ as ontological entities separate from ‘nature’ and on how the production of settlements is metabolically ... ...

    Abstract This introduction frames the book in a debate on urban political ecology (UPE). UPE focuses on unsettling traditional understandings of ‘cities’ as ontological entities separate from ‘nature’ and on how the production of settlements is metabolically linked with flows of capital and more-than-human ecological processes. The contribution of this paper is to recalibrate UPE to new urban forms and processes of extended urbanisation. This exploration goes against the reduction of what goes on outside of cities to processes that emanate unidirectionally from cities. Acknowledging UPE’s rich intellectual history and aiming to enrich rather than split the field, this paper identifies emerging discourses that go beyond UPE’s original formulation. The chapter introduces the individual chapters of the book in this context.
    Keywords Life Science
    Language English
    Publisher Manchester University Press
    Publishing country nl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Epilogue

    Mandler, Tait / Keil, Roger / Tzaninis, Yannis / Kaika, Maria

    Turning up the Heat ; ISBN: 9781526170040

    Is an integrated UPE research and policy agenda possible?

    2023  

    Keywords Life Science
    Language English
    Publisher Manchester University Press
    Publishing country nl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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