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  1. Article ; Online: Fitness Trade-Offs between Phage and Antibiotic Sensitivity in Phage-Resistant Variants

    Jumpei Fujiki / Keisuke Nakamura / Tomohiro Nakamura / Hidetomo Iwano

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    Molecular Action and Insights into Clinical Applications for Phage Therapy

    2023  Volume 15628

    Abstract: In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although ... ...

    Abstract In recent decades, phage therapy has been overshadowed by the widespread use of antibiotics in Western countries. However, it has been revitalized as a powerful approach due to the increasing prevalence of antimicrobial-resistant bacteria. Although bacterial resistance to phages has been reported in clinical cases, recent studies on the fitness trade-offs between phage and antibiotic resistance have revealed new avenues in the field of phage therapy. This strategy aims to restore the antibiotic susceptibility of antimicrobial-resistant bacteria, even if phage-resistant variants develop. Here, we summarize the basic virological properties of phages and their applications within the context of antimicrobial resistance. In addition, we review the occurrence of phage resistance in clinical cases, and examine fitness trade-offs between phage and antibiotic sensitivity, exploring the potential of an evolutionary fitness cost as a countermeasure against phage resistance in therapy. Finally, we discuss future strategies and directions for phage-based therapy from the aspect of fitness trade-offs. This approach is expected to provide robust options when combined with antibiotics in this era of phage ‘re’-discovery.
    Keywords bacteriophage ; antimicrobial resistance (AMR) ; fitness cost ; phage cocktail ; engineered phage ; infectious disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions

    Keisuke Nakamura / Ryou Kubota / Takuma Aoyama / Kenji Urayama / Itaru Hamachi

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Synthetic hydrogels composed of covalent polymers and supramolecular fibers have been investigated for controlled delivery of biopharmaceuticals, but characterisation of the structures and properties can be challenging. Here, the authors report an ... ...

    Abstract Synthetic hydrogels composed of covalent polymers and supramolecular fibers have been investigated for controlled delivery of biopharmaceuticals, but characterisation of the structures and properties can be challenging. Here, the authors report an imaging study for the composite network, categorizing into four distinct patterns controlled by network formation kinetics and interactions between
    Keywords Science ; Q
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Art, Design and Communication Theory in Creating the Communicative Social Robot ‘Haru’

    Eleanor Sandry / Randy Gomez / Keisuke Nakamura

    Frontiers in Robotics and AI, Vol

    2021  Volume 8

    Abstract: Haru is a social, affective robot designed to support a wide range of research into human–robot communication. This article analyses the design process for Haru beta, identifying how both visual and performing arts were an essential part of that process, ...

    Abstract Haru is a social, affective robot designed to support a wide range of research into human–robot communication. This article analyses the design process for Haru beta, identifying how both visual and performing arts were an essential part of that process, contributing to ideas of Haru’s communication as a science and as an art. Initially, the article examines how a modified form of Design Thinking shaped the work of the interdisciplinary development team—including animators, performers and sketch artists working alongside roboticists—to frame Haru’s interaction style in line with sociopsychological and cybernetic–semiotic communication theory. From these perspectives on communication, the focus is on creating a robot that is persuasive and able to transmit precise information clearly. The article moves on to highlight two alternative perspectives on communication, based on phenomenological and sociocultural theories, from which such a robot can be further developed as a more flexible and dynamic communicative agent. The various theoretical perspectives introduced are brought together by considering communication across three elements: encounter, story and dance. Finally, the article explores the potential of Haru as a research platform for human–robot communication across various scenarios designed to investigate how to support long-term interactions between humans and robots in different contexts. In particular, it gives an overview of plans for humanities-based, qualitative research with Haru.
    Keywords human–robot interaction ; human–robot communication ; art ; design ; design thinking ; communication theory ; Mechanical engineering and machinery ; TJ1-1570 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 629
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Putative Mechanisms Underlying the Beneficial Effects of Polyphenols in Murine Models of Metabolic Disorders in Relation to Gut Microbiota

    Yoshimi Niwano / Hidetsugu Kohzaki / Midori Shirato / Shunichi Shishido / Keisuke Nakamura

    Current Issues in Molecular Biology, Vol 44, Iss 91, Pp 1353-

    2022  Volume 1375

    Abstract: The beneficial effects of polyphenols on metabolic disorders have been extensively reported. The interaction of these compounds with the gut microbiota has been the focus of recent studies. In this review, we explored the fundamental mechanisms ... ...

    Abstract The beneficial effects of polyphenols on metabolic disorders have been extensively reported. The interaction of these compounds with the gut microbiota has been the focus of recent studies. In this review, we explored the fundamental mechanisms underlying the beneficial effects of polyphenols in relation to the gut microbiota in murine models of metabolic disorders. We analyzed the effects of polyphenols on three murine models of metabolic disorders, namely, models of a high-fat diet (HFD)-induced metabolic disorder, dextran sulfate sodium (DSS)-induced colitis, and a metabolic disorder not associated with HFD or DSS. Regardless of the model, polyphenols ameliorated the effects of metabolic disorders by alleviating intestinal oxidative stress, improving inflammatory status, and improving intestinal barrier function, as well as by modulating gut microbiota, for example, by increasing the abundance of short-chain fatty acid-producing bacteria. Consequently, polyphenols reduce circulating lipopolysaccharide levels, thereby improving inflammatory status and alleviating oxidative imbalance at the lesion sites. In conclusion, polyphenols likely act by regulating intestinal functions, including the gut microbiota, and may be a safe and suitable therapeutic agent for various metabolic disorders.
    Keywords polyphenol ; metabolic disorders ; murine models ; gut microbiota ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Comparison of original and alternative incremental sit-to-stand exercise protocol for anaerobic threshold assessment

    Keisuke Nakamura / Yuya Nagasawa / Shoji Sawaki / Yoshihiko Yokokawa

    Journal of Physical Fitness and Sports Medicine, Vol 9, Iss 2, Pp 83-

    2020  Volume 88

    Abstract: Anaerobic threshold (AT) is an established parameter of aerobic fitness. The incremental sit-to-stand exercise (ISTS), using one of the activities of daily living, is used to assess physical capacity in patients who are unable to safely pedal or walk. ... ...

    Abstract Anaerobic threshold (AT) is an established parameter of aerobic fitness. The incremental sit-to-stand exercise (ISTS), using one of the activities of daily living, is used to assess physical capacity in patients who are unable to safely pedal or walk. However, the effect of an alternative ISTS protocol on AT remains unclear. The aim of this study was to compare the effect of the original ISTS protocol with an alternative shortened ISTS protocol on AT values in healthy young adults, and to assess the difference in AT values obtained during the ISTS protocols and the cycle ergometer test. Twelve healthy young adults (mean [range] age: 26.8 [22–33] years, 6 men and 6 women) performed the shortened version of the ISTS (S-ISTS), the original version of ISTS (O-ISTS), and cycle ergometer (CE) tests in a randomized order. The AT values of participants were measured during each of the three tests. No significant difference in AT values was observed among the three tests. AT obtained by individuals in the S-ISTS was significantly correlated with that obtained during the O-ISTS and CE tests with r values of 0.96 and 0.81, respectively (p < 0.05). Similar to the O-ISTS and CE test, the S-ISTS test may be used as an exercise test for the assessment of AT in a clinical setting.
    Keywords shortened incremental sit-to-stand test ; anaerobic threshold ; fitness assessment ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
    Subject code 796
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Japanese Society of Physical Fitness and Sports Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Growth of Single-Walled Carbon Nanotubes from Solid Carbon Nanoparticle Seeds via Cap Formation Engineering with a Two-Step Growth Process and Water Vapor Supply

    Mengyue Wang / Keisuke Nakamura / Michiharu Arifuku / Noriko Kiyoyanagi / Taiki Inoue / Yoshihiro Kobayashi

    ACS Omega, Vol 7, Iss 4, Pp 3639-

    2022  Volume 3648

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correction

    Atsushi Maruyama / Keisuke Nakamura / Hiroki Yamanaka / Michio Kondoh / Toshifumi Minamoto

    PLoS ONE, Vol 14, Iss 2, p e

    The Release Rate of Environmental DNA from Juvenile and Adult Fish.

    2019  Volume 0212145

    Abstract: This corrects the article DOI:10.1371/journal.pone.0114639.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0114639.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of exercise on kidney and physical function in patients with non-dialysis chronic kidney disease

    Keisuke Nakamura / Tomohiro Sasaki / Shuhei Yamamoto / Hiroto Hayashi / Shinji Ako / Yuu Tanaka

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    a systematic review and meta-analysis

    2020  Volume 18

    Abstract: Abstract Patients with non-dialysis chronic kidney disease (CKD) are at greater risk of early mortality and decreased physical function with an advance in the stage of CKD. However, the effect of exercise in these patients is unclear. This meta-analysis ... ...

    Abstract Abstract Patients with non-dialysis chronic kidney disease (CKD) are at greater risk of early mortality and decreased physical function with an advance in the stage of CKD. However, the effect of exercise in these patients is unclear. This meta-analysis aimed to determine the effects of physical exercise training on the risk of mortality, kidney and physical functions, and adverse events in patients with non-dialysis CKD. The meta-analysis conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement and the Cochrane Handbook recommendations. On 16 August 2019, the PubMed, CINAHL, Cochrane Library databases, and Embase were electronically searched, with no restrictions for date/time, language, document type, or publication status, for eligible randomized controlled trials (RCTs) investigating the effects of exercise on mortality and kidney and physical function in patients with non-dialysis CKD. Eighteen trials (28 records), including 848 patients, were analyzed. The effects of exercise on all-cause mortality and estimated glomerular filtration rate were not significantly different from that of usual care. Exercise training improved peak/maximum oxygen consumption compared to usual care. Regular exercise improves physical and walking capacity for patients with non-dialysis CKD. Effect on leg muscle strength was unclear.
    Keywords Medicine ; R ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry

    Dr. Ryou Kubota / Keisuke Nakamura / Shogo Torigoe / Prof. Dr. Itaru Hamachi

    ChemistryOpen, Vol 9, Iss 1, Pp 67-

    In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels

    2020  Volume 79

    Abstract: Abstract Multicomponent supramolecular hydrogels are promising scaffolds for applications in biosensors and controlled drug release due to their designer stimulus responsiveness. To achieve rational construction of multicomponent supramolecular hydrogel ... ...

    Abstract Abstract Multicomponent supramolecular hydrogels are promising scaffolds for applications in biosensors and controlled drug release due to their designer stimulus responsiveness. To achieve rational construction of multicomponent supramolecular hydrogel systems, their in‐depth structural analysis is essential but still challenging. Confocal laser scanning microscopy (CLSM) has emerged as a powerful tool for structural analysis of multicomponent supramolecular hydrogels. CLSM imaging enables real‐time observation of the hydrogels without the need of drying and/or freezing to elucidate their static and dynamic properties. Through multiple, selective fluorescent staining of materials of interest, multiple domains formed in supramolecular hydrogels (e. g. inorganic materials and self‐sorting nanofibers) can also be visualized. CLSM and the related microscopic techniques will be indispensable to investigate complex life‐inspired supramolecular chemical systems.
    Keywords confocal microscopy ; gels ; self-assembly ; stimulus response ; supramolecular chemistry ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wiley-VCH
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Involvement of an autotoxic compound in asparagus decline

    Kato-Noguchi, Hisashi / Keisuke Nakamura / Nobuyuki Okuda

    Journal of plant physiology. 2018 May, June, v. 224-225

    2018  

    Abstract: Asparagus (Asparagus officinalis L.) is a widely cultivated perennial veritable and can be harvested more than ten years. However, the crop quality and yield decline after a few year’s cultivation, which is called “asparagus decline”. Even though those ... ...

    Abstract Asparagus (Asparagus officinalis L.) is a widely cultivated perennial veritable and can be harvested more than ten years. However, the crop quality and yield decline after a few year’s cultivation, which is called “asparagus decline”. Even though those asparagus plants were replaced with new young asparagus plants, the productivity and quality of the crop remain relatively low, which is known as a “asparagus replant problem”. One of the possible reasons for “asparagus decline” and “asparagus replant problem” is thought to be autotoxicity of asparagus. However, the compounds involved in the autotoxicity is not clear. The objective of this study was therefore to determine the potential role of autotoxicity in the “asparagus decline” and “asparagus replant problem”. An aqueous methanol extract of 10-year-asparagus-cultivated soils inhibited the growth of asparagus seedlings and other two test plants with concentration dependent manner. The result confirmed that the asparagus soils have autotoxic activity. The extract was then purified by several chromatographies with monitoring the inhibitory activity and a potent growth inhibitory substance causing the autotoxic effect was isolated. The chemical structures of the compound was determined by spectral data to be trans-cinnamic acid. trans-Cinnamic acid inhibited the growth of asparagus seedlings at concentrations greater than 10 μM. The concentrations required for 50% growth inhibition of asparagus (IC50) were 24.1–41.6 μM. trans-Cinnamic acid accumulated 174 μM in the 10-year-asparagus-cultivated soils, which may be enough levels to cause the growth inhibition on asparagus considering its IC50 value. Therefore, trans-cinnamic acid may contribute to the autotoxic effect of asparagus soils, and may be in part responsible for “asparagus decline” and “asparagus replant problem”.
    Keywords Asparagus officinalis ; chemical structure ; crop quality ; decline ; growth retardation ; inhibitory concentration 50 ; methanol ; monitoring ; seedlings ; soil ; spectral analysis
    Language English
    Dates of publication 2018-05
    Size p. 49-55.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2018.03.005
    Database NAL-Catalogue (AGRICOLA)

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