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  1. Article ; Online: Modifiable prognostic factors in uterine fibroid development: a systematic review of literature.

    Keizer, Alieke L / Semmler, Annika / Kok, Helen S / van Kesteren, Paul J M / Huirne, Judith A F / Hehenkamp, Wouter J K

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2023  Volume 44, Issue 1, Page(s) 2288225

    Abstract: Background: Many risk factors in uterine fibroid development have been identified, but women and their physicians are less aware of the influence of lifestyle on uterine fibroid development. The objective of this systematic review is to investigate and ... ...

    Abstract Background: Many risk factors in uterine fibroid development have been identified, but women and their physicians are less aware of the influence of lifestyle on uterine fibroid development. The objective of this systematic review is to investigate and summarize modifiable prognostic factors associated with uterine fibroid development.
    Methods: Pubmed and Embase were searched for relevant articles according to PRISMA guidelines. References from included articles were screened and when relevant also included. Human in vivo studies on modifiable factors in fibroid development were included. Studies on non-modifiable factors and treatment, in vitro studies and animal studies were excluded. 607 articles were screened and 33 articles were included. Two independent investigators collected data from the report.
    Results: The strongest risk factor for fibroid development was a high BMI, while the strongest protective factors were a high fruit and vegetable intake and high vitamin D intake.
    Conclusion: More high-quality studies are necessary to better understand the impact of the abovementioned factors as well as the role they play in the growth of already existing fibroids.
    MeSH term(s) Animals ; Female ; Humans ; Uterine Neoplasms/complications ; Prognosis ; Leiomyoma/complications ; Risk Factors
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2023.2288225
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  2. Article ; Online: Uterine Fibroid Symptom and Quality of Life questionnaire (UFS-QOL NL) in the Dutch population: a validation study.

    Keizer, Alieke L / van Kesteren, Paul J M / Terwee, Caroline / de Lange, Maria E / Hehenkamp, Wouter J K / Kok, Helen S

    BMJ open

    2021  Volume 11, Issue 11, Page(s) e052664

    Abstract: Objective: Uterine fibroids can cause a variety of symptoms in women, from heavy menstrual bleeding and dysmenorrhea to bulk symptoms. The Uterine Fibroid Symptom and health-related Quality Of Life questionnaire (UFS-QOL) is a patient-reported outcome ... ...

    Abstract Objective: Uterine fibroids can cause a variety of symptoms in women, from heavy menstrual bleeding and dysmenorrhea to bulk symptoms. The Uterine Fibroid Symptom and health-related Quality Of Life questionnaire (UFS-QOL) is a patient-reported outcome measure developed for assessing fibroid-related symptoms in a standardised way. Our aim was to translate and validate the UFS-QOL in Dutch.
    Design: Validation study.
    Setting: Patients were recruited by a gynaecologist at the outpatient clinic.
    Participants: Women with uterine fibroids.
    Methods: The UFS-QOL was translated into Dutch (UFS-QOL NL) and validated through testing construct validity (comprising of structural validity and hypotheses testing), reliability, responsiveness and interpretability, assessing floor and ceiling effects and minimal important change. An option to answer 'not applicable' was added to the translated questionnaire.
    Results: 191 women with uterine fibroids completed the UFS-QOL NL at baseline, after 2 weeks and after 3 months. The questionnaire retained the same factor structure after translation (Comparative Fit Index 0.94-0.95; Tucker-Lewis fit Index 0.93-0.95; Root Mean Square Error of Approximation 0.10-0.11) and correlations to other questionnaires (RAND 36, Hospital Anxiety and Depression Scale and Golombok Rust Inventory of Sexual Satisfaction) were generally moderate, as hypothesised (Pearson's r 0.3-0.7). We found a sufficient reliability with intraclass correlation coefficients of approximately 0.8-0.9 for all subscales. Responsiveness was sufficient when testing hypotheses comparing women who had surgery with those who did not. Cronbach's alpha was higher than 0.7 for all subscales, indicating sufficient internal consistency and there were no concerns about floor or ceiling effects. Minimal important change could not be calculated due to low correlation between the different subscales and the anchor question.
    Conclusions: The results support the measurement properties of the Dutch UFS-QOL for assessing fibroid-related symptoms and health-related quality of life in Dutch women with uterine fibroids.
    MeSH term(s) Female ; Humans ; Leiomyoma ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires ; Uterine Neoplasms
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-052664
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  3. Article ; Online: The effect of transcervical resection of submucous fibroids on menstrual blood loss: A prospective cohort study.

    Keizer, Alieke L / Jacobs, Bracha L / Thurkow, Andreas L / de Lange, Maria E / Radder, Celine M / van Kesteren, Paul J M / Hanstede, Miriam M F / Huirne, Judith A F / Hehenkamp, Wouter J K

    European journal of obstetrics, gynecology, and reproductive biology

    2022  Volume 274, Page(s) 128–135

    Abstract: Objectives: Transcervical resection of myoma (TCRM) is a widely implemented treatment for submucous fibroids. The aim of this study is to evaluate the effect of TCRM on menstrual bleeding, fibroid related symptoms and quality of life and hemoglobin (Hb) ...

    Abstract Objectives: Transcervical resection of myoma (TCRM) is a widely implemented treatment for submucous fibroids. The aim of this study is to evaluate the effect of TCRM on menstrual bleeding, fibroid related symptoms and quality of life and hemoglobin (Hb) levels.
    Study design: A prospective cohort study was conducted in three teaching hospitals and two academic hospitals in the Netherlands. Patients with HMB (PBAC score > 150) and submucous fibroids (type 0, 1, 2, 3, 4 and hybrid type 2-5) scheduled for TCRM were eligible. At baseline and 3 months after TCRM a Trans Vaginal Ultrasound (TVU) was performed and a Hb sample was taken. Patients filled out the Pictorial Blood Assessment Chart (PBAC) and the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire at baseline and up to 6 months after surgery. Primary outcome was improvement in PBAC score 6 months after surgery. Secondary outcomes were improvement in PBAC score and Hb level 3 months after surgery and UFS-QOL scores 3 and 6 months after surgery.
    Results: 126 patients were included and 104 were operated. PBAC were obtained from 98 patients. Six months after surgery, 56.6% of patients went from HMB to normal menstrual bleeding (PBAC < 150). A significant reduction in median PBAC scores of 427 (IQR 198 - 1392) (p <.0001) was found (86% improvement). UFS-QOL scores were obtained from 91 patients. Symptom severity improved from a median of 54 on a scale of 100 (IQR 44-66) at baseline to 22 (IQR 9-41) after 6 months (p <.0001) (59% improvement). Health related quality of life (HRQOL) improved from a median score of 44 on a scale of 100 (IQR 33-62) to 89 (IQR 67-97) 6 months after surgery (p <.0001) (102% improvement).
    Conclusion: TCRM significantly reduces the amount of menstrual bleeding, severity of fibroid related symptoms and improves HRQOL in patients with submucous fibroids.
    MeSH term(s) Female ; Hemorrhage ; Humans ; Leiomyoma/complications ; Leiomyoma/surgery ; Menorrhagia/etiology ; Menorrhagia/surgery ; Prospective Studies ; Quality of Life ; Uterine Neoplasms/complications ; Uterine Neoplasms/surgery
    Language English
    Publishing date 2022-05-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2022.05.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 837: Show issues Location:
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  4. Article ; Online: Role of 3-Dimensional Sonography in the Assessment of Submucous Fibroids: A Pilot Study.

    Keizer, Alieke L / Nieuwenhuis, Lotte L / Twisk, Jos W R / Huirne, Judith A F / Hehenkamp, Wouter J K / Brölmann, Hans A M

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2017  Volume 37, Issue 1, Page(s) 191–199

    Abstract: Objectives: To investigate the accuracy and reliability of 3-dimensional (3D) transvaginal sonography in classifying submucous fibroids using the International Federation of Gynecology and Obstetrics PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy ...

    Abstract Objectives: To investigate the accuracy and reliability of 3-dimensional (3D) transvaginal sonography in classifying submucous fibroids using the International Federation of Gynecology and Obstetrics PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, and not yet classified) classification and protrusion (percent) compared to 2-dimensional (2D) transvaginal sonography, 2D saline infusion sonography, and 3D saline infusion sonography, using hysteroscopy as a reference test.
    Methods: A prospective cohort pilot study was performed among 14 consecutive patients undergoing hysteroscopic surgery, preceded by routine sonography (2D transvaginal sonography, 2D saline infusion sonography, 3D transvaginal sonography, and 3D saline infusion sonography).
    Results: The intraclass correlation coefficient (ICC) for 2D transvaginal sonography versus hysteroscopy was 0.69 (95% confidence interval [CI], 0.06, 0.90) compared to 0.94 (95% CI, 0.83, 0.98) for 2D saline infusion sonography. The ICCs for 3D transvaginal sonography versus hysteroscopy were 0.69 (95% CI, 0.03, 0.90 [investigator A]) and 0.55 (95% CI, -0.48, 0.86 [investigator B]). The ICCs for 3D saline infusion sonography versus hysteroscopy were 0.94 (95% CI, 0.81, 0.98 [investigator A]) and 0.87 (95% CI, 0.60, 0.96 [investigator B]). Interobserver agreement of 3D transvaginal sonography was 0.81 (95% CI, 0.43, 0.94) compared to 0.86 (95% CI, 0.56, 0.96) for 3D saline infusion sonography.
    Conclusions: In these preliminary data, 3D transvaginal sonography was not as accurate as 2D or 3D saline infusion sonography and was not more accurate than 2D transvaginal sonography. There was moderate interobserver agreement for 3D transvaginal sonography. There might be room for improvement, as 3D transvaginal sonography is more accurate when endometrial thickness increases. Further study is warranted to evaluate in which patients saline infusion sonography eventually can be obviated.
    MeSH term(s) Adult ; Cohort Studies ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Leiomyoma/diagnostic imaging ; Middle Aged ; Pilot Projects ; Prospective Studies ; Reproducibility of Results ; Ultrasonography/methods ; Uterine Neoplasms/diagnostic imaging ; Uterus/diagnostic imaging
    Language English
    Publishing date 2017-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.14331
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    Zs.A 1793: Show issues Location:
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    Zs.MO 495: Show issues

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  5. Article ; Online: Spontaneous adrenal haemorrhage in early pregnancy.

    Keizer, Alieke L / Peters, Louisette W / de Vries, Cees / Smets, Yves F C / de Wit, Laurens Th / van Pampus, Mariëlle G

    BMJ case reports

    2013  Volume 2013

    Abstract: A 32-year-old primigravida presented at our emergency room at 6 weeks of gestation with acute severe right upper quadrant abdominal pain, radiating to the right flank. Vital signs were stable. Abdominal ultrasound showed a round inhomogeneous mass of 10 ... ...

    Abstract A 32-year-old primigravida presented at our emergency room at 6 weeks of gestation with acute severe right upper quadrant abdominal pain, radiating to the right flank. Vital signs were stable. Abdominal ultrasound showed a round inhomogeneous mass of 10 cm diameter behind the right kidney, suspected for adrenal haemorrhage. The patient was admitted for observation. An MRI showed some right-sided pleural effusion and a round mass in the adrenal region with no recognisable adrenal gland, therefore most likely originating from the right adrenal. After 10 days the patient was discharged with no change in size of the haematoma. MRI was carried out every 2 months which showed a decrease in size of the haematoma, with no other abnormalities. Based on stable MRI and the patient's preference, a vaginal delivery mode was chosen. At 37 weeks of gestation labour was induced, followed by an uncomplicated delivery.
    MeSH term(s) Adrenal Gland Diseases/diagnosis ; Adult ; Female ; Hemorrhage/diagnosis ; Humans ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Pregnancy Trimester, First
    Language English
    Publishing date 2013-08-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-008062
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  6. Article ; Online: Computerized prospective screening for high levels of emotional distress in head and neck cancer patients and referral rate to psychosocial care.

    Verdonck-de Leeuw, Irma M / de Bree, Remco / Keizer, Alieke L / Houffelaar, Ton / Cuijpers, Pim / van der Linden, Mecheline H / Leemans, C René

    Oral oncology

    2009  Volume 45, Issue 10, Page(s) e129–33

    Abstract: To investigate prospectively the prevalence of high levels of emotional distress and referral rate to psychosocial care in head and neck cancer (HNSCC) patients. Fifty-five consecutive newly diagnosed HNSCC patients were asked to complete the hospital ... ...

    Abstract To investigate prospectively the prevalence of high levels of emotional distress and referral rate to psychosocial care in head and neck cancer (HNSCC) patients. Fifty-five consecutive newly diagnosed HNSCC patients were asked to complete the hospital anxiety and depression scale (HADS) and the EORTC QLQ-C30 and H&N35 quality of life questionnaires on a touch screen computer-assisted data collection system on their first visit and during follow-up visit. Sociodemographic, clinical, and quality of life parameters were compared to a high level of distress (HADS score >15). Number of patients with a high level of distress were compared to referral rates to psychosocial care as retrieved from patient hospital files. At time of diagnosis, 18% (10/55) of the patients had a high level of distress (related to tumor stage and site, and global quality of life and social eating) versus 25% (14/55) at follow-up (related to a variety of quality of life parameters). Low levels of distress at baseline or follow-up was noted in 64%; 18% had normal scores at baseline and developed distress at follow-up; 11% had high levels at baseline and returned to normal scores at follow-up, and 7% had persistent distress from baseline to follow-up. No patients were referred to psychosocial care at time of diagnosis. At follow-up visit 21% (3/14) were referred, all patients who developed a high level of distress after initial diagnosis. High level of emotional distress is common and few patients are referred to psychosocial care. Development of a stepped care model (including careful monitoring by using a touch screen computer system) may meet the potentially unmet needs of HNC patients and contribute improving cancer care.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Data Collection/methods ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Female ; Head and Neck Neoplasms/psychology ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Quality of Life ; Referral and Consultation/statistics & numerical data ; Risk Factors ; Social Support ; Stress, Psychological/diagnosis ; Stress, Psychological/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2009.01.012
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    Zs.A 4869: Show issues Location:
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