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  1. Article ; Online: Radiation Therapy Castle Under Siege: Will It Hold or Fold?

    Kelekis, Alexis

    Radiology

    2023  Volume 307, Issue 2, Page(s) e222944

    MeSH term(s) Humans ; Thyroid Neoplasms
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.222944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Radiation Therapy Castle Under Siege: Will It Hold or Fold?

    Kelekis, Alexis

    Radiology

    2023  Volume 306, Issue 3, Page(s) e239002

    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.239002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Avoiding complications in percutaneous osteoplasty.

    Filippiadis, Dimitrios / Kelekis, Alexis

    Techniques in vascular and interventional radiology

    2022  Volume 25, Issue 1, Page(s) 100799

    Abstract: Percutaneous osteoplasty techniques include cement injection either solely performed or in combination to hardware such as cannulated screws, peek implants or other metallic hardware including micro-needles and Kirschner wires. Depending on bone and ... ...

    Abstract Percutaneous osteoplasty techniques include cement injection either solely performed or in combination to hardware such as cannulated screws, peek implants or other metallic hardware including micro-needles and Kirschner wires. Depending on bone and local forces applied, fracture and osseous defect characteristics as well as symptoms and operator's preference percutaneous osteoplasty techniques include cementoplasty, fixation by internal cemented screw and augmented osteoplasty. Literature data support efficacy and safety of these techniques, focusing mainly on the minimal invasive nature of these approaches along with minimum overall morbidity and mortality and an impressive pain reduction effect. Percutaneous osteoplasty techniques in the peripheral skeleton are indicated for pain palliation or for prevention of impeding pathologic fractures. Although safe, osteoplasty techniques are not without risk of complications and adverse events. Complications are classified based either upon clinical impact or timing of occurrence; complications' reviewing and grading should be performed on terms of a uniform and accurate reproducible and validated categorization system. Significant factors for avoiding complications in percutaneous osteoplasty techniques include proper training, patient- and lesion-tailored approach, high-quality imaging guidance, sterility as well as appropriate selection of technique and materials. The present article reports the possible complications of percutaneous osteoplasty techniques and reviews the prerequisites necessary for avoiding and managing these adverse events.
    MeSH term(s) Bone Cements/adverse effects ; Cementoplasty/adverse effects ; Cementoplasty/methods ; Fractures, Spontaneous/chemically induced ; Fractures, Spontaneous/drug therapy ; Humans ; Pain/prevention & control ; Pain Management ; Treatment Outcome
    Chemical Substances Bone Cements
    Language English
    Publishing date 2022-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2170922-1
    ISSN 1557-9808 ; 1089-2516
    ISSN (online) 1557-9808
    ISSN 1089-2516
    DOI 10.1016/j.tvir.2022.100799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6023: Show issues Location:
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  4. Article: Percutaneous bipolar radiofrequency ablation for spine metastatic lesions.

    Filippiadis, Dimitrios / Kelekis, Alexis

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2021  Volume 31, Issue 8, Page(s) 1603–1610

    Abstract: Purpose: The purpose of this review is to become familiar with the most common indications for imaging guided percutaneous bipolar radiofrequency ablation, to learn about different technical considerations during performance providing the current ... ...

    Abstract Purpose: The purpose of this review is to become familiar with the most common indications for imaging guided percutaneous bipolar radiofrequency ablation, to learn about different technical considerations during performance providing the current evidence. Controversies concerning products will be addressed.
    Methods: We performed a literature review excluding non-English studies and case reports. All references of the obtained articles were also evaluated for any additional information.
    Results: RFA achieves cytotoxicity by raising target area temperatures above 60 °C, and may be used to achieve total necrosis of lesions smaller than 3 cm in diameter, to debulk and reduce the pain associated with larger lesions, to prevent pathological fractures due to progressive osteolysis or for cavity creation aiming for targeted cement delivery in case of posterior vertebral wall breaching. Protective ancillary techniques should be used in order to increase safety and augment efficacy of RFA in the spine.
    Conclusion: Percutaneous radiofrequency ablation of vertebral lesions is a reproducible, successful and safe procedure. Ablation should be combined with vertebral augmentation in all cases. In order to optimize maximum efficacy a patient- and a lesion-tailored approach should both be offered focusing upon clinical and performance status along with life expectancy of the patient as well as upon lesion characteristics.
    MeSH term(s) Bone Cements ; Catheter Ablation ; Humans ; Radiofrequency Ablation ; Spinal Neoplasms/surgery ; Spine/surgery ; Treatment Outcome
    Chemical Substances Bone Cements
    Language English
    Publishing date 2021-03-30
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-021-02947-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3479: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Update on Interventional Radiology of the Spine.

    Filippiadis, Dimitrios K / Masala, Salvatore / Lucatelli, Pierleone / Kelekis, Alexis

    Seminars in musculoskeletal radiology

    2022  Volume 26, Issue 4, Page(s) 412–423

    Abstract: Interventional radiologists now perform spinal interventions routinely for diagnostic and therapeutic purposes. New technologies for the management of spine pathologies have emerged with promising results in terms of safety and efficacy. Interventional ... ...

    Abstract Interventional radiologists now perform spinal interventions routinely for diagnostic and therapeutic purposes. New technologies for the management of spine pathologies have emerged with promising results in terms of safety and efficacy. Interventional radiology techniques in the spine include percutaneous biopsy and therapies for intervertebral disk herniation or spinal stenosis, facet and sacroiliac joint pathologies, vertebral and sacral fractures, and metastases. These techniques can also be easily combined one with the other or to further therapeutic approaches including systemic therapies, surgical approaches, and radiotherapy. This review provides a comprehensive overview of current percutaneous imaging-guided interventional radiology techniques in the spine. It will help readers become familiar with the most common indications, learn about different technical considerations during performance, and review the available evidence. Controversies concerning new products and technical approaches are also addressed.
    MeSH term(s) Humans ; Radiology, Interventional ; Spine
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0042-1748913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4887: Show issues Location:
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  6. Article: Intradiscal Gelified Ethanol Nucleolysis versus Endoscopic Surgery for Lumbar Disc Herniation Radiculopathy.

    Gogos, Christos / Filippiadis, Dimitrios K / Velonakis, Georgios / Kelekis, Nikolaos / Papagelopoulos, Panayiotis / Kelekis, Alexis

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: The purpose of this study was to retrospectively compare efficacy and safety between intradiscal injection of a gelified ethanol product and tubular discectomy in the treatment of intervertebral disk herniation. A bi-central institutional database ... ...

    Abstract The purpose of this study was to retrospectively compare efficacy and safety between intradiscal injection of a gelified ethanol product and tubular discectomy in the treatment of intervertebral disk herniation. A bi-central institutional database research identified forty (40) patients suffering from symptomatic contained disc herniation. Nucleolysis Group included 20 patients [mean 50.05 ± 9.27 years-of-age (male/female 14/6-70/30%)] and Surgery Group included 20 patients [mean 48.45 ± 14.53 years-of-age, (male/female 12/8-60/40%)]. Primary outcome was overall 12-month improvement over baseline in leg pain (NVS units). Procedural technical outcomes were recorded, and adverse events were evaluated at all follow-up intervals. CIRSE classification system was used for complications' reporting. Mean pre-operative pain score in Nucleolysis Group was 7.95 ± 0.94 reduced to 1.25 ± 1.11 at month 1 and 0.45 ± 0.75 NVS units at year 1. Mean pre-operative pain score in Surgery Group was 7.65 ± 1.13 reduced to 1.55 ± 1.79 at month 1 and 0.70 ± 1.38 NVS units at year 1. Pain decrease was statistically significant after both procedures (
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132164
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  7. Article ; Online: Ablative Techniques for Sarcoma Metastatic Disease: Current Role and Clinical Applications.

    Efthymiou, Evgenia / Charalampopoulos, Georgios / Velonakis, Georgios / Grigoriadis, Stauros / Kelekis, Alexis / Kelekis, Nikolaos / Filippiadis, Dimitrios

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Sarcomas are heterogenous mesenchymal neoplasms with more than 80 different histologic subtypes. Lung followed by liver and bone are the most common sites of sarcoma metastatic disease. Ablative techniques have been recently added as an additional ... ...

    Abstract Sarcomas are heterogenous mesenchymal neoplasms with more than 80 different histologic subtypes. Lung followed by liver and bone are the most common sites of sarcoma metastatic disease. Ablative techniques have been recently added as an additional alternative curative or palliative therapeutic tool in sarcoma metastatic disease. When compared to surgery, ablative techniques are less invasive therapies which can be performed even in non-surgical candidates and are related to decreased recovery time as well as preservation of the treated organ's long-term function. Literature data upon ablative techniques for sarcoma metastatic disease are quite heterogeneous and variable regarding the size and the number of the treated lesions and the different histologic subtypes of the original soft tissue or bone sarcoma. The present study focuses upon the current role of minimal invasive thermal ablative techniques for the management of metastatic sarcoma disease. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of metastatic soft tissue and bone sarcoma, including local control and survival rates.
    MeSH term(s) Humans ; Sarcoma/surgery ; Soft Tissue Neoplasms/pathology ; Bone Neoplasms/surgery ; Neoplasms, Second Primary
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030485
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  8. Article: The Role of Percutaneous Ablation in the Management of Colorectal Cancer Liver Metastatic Disease.

    Filippiadis, Dimitrios K / Velonakis, Georgios / Kelekis, Alexis / Sofocleous, Constantinos T

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 2

    Abstract: Approximately 50% of colorectal cancer patients will develop metastases during the course of the disease. Local or locoregional therapies for the treatment of liver metastases are used in the management of oligometastatic colorectal liver disease, ... ...

    Abstract Approximately 50% of colorectal cancer patients will develop metastases during the course of the disease. Local or locoregional therapies for the treatment of liver metastases are used in the management of oligometastatic colorectal liver disease, especially in nonsurgical candidates. Thermal ablation (TA) is recommended in the treatment of limited liver metastases as free-standing therapy or in combination with surgery as long as all visible disease can be eradicated. Percutaneous TA has been proven as a safe and efficacious therapy offering sustained local tumor control and improved patient survival. Continuous technological advances in diagnostic imaging and guidance tools, the evolution of devices allowing for optimization of ablation parameters, as well as the ability to perform margin assessment have improved the efficacy of ablation. This allows resectable small volume diseases to be cured with percutaneous ablation. The ongoing detailed information and increasing understanding of tumor biology, genetics, and tissue biomarkers that impact oncologic outcomes as well as their implications on the results of ablation have further allowed for treatment customization and improved oncologic outcomes even in those with more aggressive tumor biology. The purpose of this review is to present the most common indications for image-guided percutaneous ablation in colorectal cancer liver metastases, to describe technical considerations, and to discuss relevant peer-reviewed evidence on this topic. The growing role of imaging and image-guidance as well as controversies regarding several devices are addressed.
    Language English
    Publishing date 2021-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11020308
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  9. Article ; Online: Percutaneous Microwave Ablation and Osteoplasty of an Aneurysmal Bone Cyst.

    Filippiadis, Dimitrios / Charalampopoulos, George / Zampakidis, Xristos / Brountzos, Elias / Kelekis, Alexis

    Journal of vascular and interventional radiology : JVIR

    2021  Volume 32, Issue 6, Page(s) 923–925

    MeSH term(s) Ablation Techniques ; Bone Cysts, Aneurysmal/diagnostic imaging ; Bone Cysts, Aneurysmal/therapy ; Cementoplasty ; Child, Preschool ; Combined Modality Therapy ; Humans ; Male ; Microwaves/therapeutic use ; Recurrence ; Treatment Outcome
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2021.02.015
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    Zs.A 3720: Show issues Location:
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  10. Article ; Online: Navigation Guidance for Percutaneous Splanchnic Nerve Radiofrequency Neurolysis: Preliminary Results.

    Grigoriadis, Stavros / Filippiadis, Dimitrios / Stamatopoulou, Vasiliki / Alexopoulou, Efthimia / Kelekis, Nikolaos / Kelekis, Alexis

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Splanchnic Nerves/surgery ; Prospective Studies ; Tomography, X-Ray Computed/methods ; Ethanol
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58101359
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