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  1. Article ; Online: Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer.

    Abate, Ebsitu / Mehdi, Mohammed / Addisu, Sisay / Degef, Maria / Tebeje, Solomon / Kelemu, Tsehayneh

    Biochemistry and biophysics reports

    2023  Volume 35, Page(s) 101528

    Abstract: Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of ... ...

    Abstract Although it was traditionally believed that gluconeogenesis enzymes were absent from cancers that did not originate in gluconeogenic organs, numerous investigations have shown that they are functionally expressed in a variety of tumors as mediators of shortened forms of Gluconeogenesis. One of the isomers of PEPCK, the first-rate limiting enzyme in gluconeogenesis, is PCK 1, which catalyzes the conversion of oxaloacetate (OAA) and GTP into PEP, CO2, and GDP. It is also known as PEPCK-C or PCK1, and it is cytosolic. Despite being paradoxical, it has been demonstrated that, in addition to its enzymatic role in normal metabolism, this enzyme also plays a role in tumors that arise in gluconeogenic and non-gluconeogenic organs. According to newly available research, it has metabolic and non-metabolic roles in tumor progression and development. Thus, this review will give insight into
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Estimating prognostic relevant cutoff values for a multiplex PCR detecting BCR::ABL1 in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy in resource-limited settings.

    Hailu, Saifu / Kinde, Samuel / Cross, Michael / Tsegaye, Aster / Kelemu, Tsehayneh / Seifu, Daniel / Alemayehu, Dawit / Tarekegn, Azeb / Jabessa, Gutema / Abeje, Desalegn / Abebe, Markos / Sherif, Abdulaziz / Tadesse, Fisihatsion / Platzbecker, Uwe / Howe, Rawleigh / Gebremedhin, Amha

    Annals of hematology

    2023  Volume 102, Issue 7, Page(s) 1723–1729

    Abstract: The prognosis of chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) treatment is based on the quantification of BCR::ABL1 fusion gene transcript copy number, harmonized by an international scale (IS) based on TaqMan-based real-time ... ...

    Abstract The prognosis of chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) treatment is based on the quantification of BCR::ABL1 fusion gene transcript copy number, harmonized by an international scale (IS) based on TaqMan-based real-time quantitative PCR (qRT-PCR). In Ethiopia, as in most low- and middle-income countries (LMICs), access to standard diagnostic, follow-up, and prognostic tools is very limited, and it has been challenging to strictly follow international guidelines. This seriously compromises clinical outcome, despite the availability of TKIs through the Glivec International Patient Assistance Program (GIPAP). Multiplex PCR (mpx-PCR), conventionally regarded as a "screening tool," offers a potential solution to this problem. A total of 219 samples from confirmed CML patients were assayed. In reference to qRT-PCR, the AUC of ROC curve for mpx-PCR was 0.983 (95% CI: 0.957 to 0.997). At the optimum cut-off value, equivalent to BCR::ABL1 (IS) transcript copy number of 0.6%, the specificity and sensitivity were 93% and 95%, respectively, with 94% accuracy. Albeit the sensitivity and accuracy of mpx-PCR decrease below the optimum cutoff of 0.6% (IS), the specificity at 0.1% (IS) was 100%, making it an attractive means to rule-out relapse and drug non-adherence at later stages of treatment, which is particularly an issue in a low income setting. We conclude that the relative simplicity and low cost of mpx-PCR and prognostic relevant cutoff values (0.1-0.6% IS) should allow its use in peripheral clinics and thus maximize the positive impact of TKIs made available through GIPAP in most LMICs.
    MeSH term(s) Humans ; Prognosis ; Tyrosine Kinase Inhibitors ; Fusion Proteins, bcr-abl/genetics ; Multiplex Polymerase Chain Reaction ; Resource-Limited Settings ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Imatinib Mesylate/therapeutic use ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Tyrosine Kinase Inhibitors ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; Imatinib Mesylate (8A1O1M485B) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-05-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05254-x
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  3. Article ; Online: Association of Maternal Regulatory Single Nucleotide Polymorphic CD99 Genotype with Preeclampsia in Pregnancies Carrying Male Fetuses in Ethiopian Women.

    Kelemu, Tsehayneh / Erlandsson, Lena / Seifu, Daniel / Abebe, Markos / Teklu, Sisay / Storry, Jill R / Hansson, Stefan R

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: Preeclampsia (PE) is a human specific syndrome with unknown etiology causing maternal and fetal morbidities and mortalities. In PE, maternal inflammatory responses are more exaggerated if the fetus is male than female. Other pregnancy complications such ... ...

    Abstract Preeclampsia (PE) is a human specific syndrome with unknown etiology causing maternal and fetal morbidities and mortalities. In PE, maternal inflammatory responses are more exaggerated if the fetus is male than female. Other pregnancy complications such as spontaneous abortions are also more common if the fetus is male. Recent transcriptome findings showed an increased expression of CD99 in erythroid cells from male cord blood in PE. The single nucleotide polymorphism (SNP) rs311103, located in a GATA-binding site in a regulatory region on the X/Y chromosomes, governs a coordinated expression of the Xg blood group members CD99 and Xg
    MeSH term(s) 12E7 Antigen/genetics ; Adult ; Ethiopia ; Female ; Fetus/pathology ; Gene Frequency/genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Polymorphism, Single Nucleotide/genetics ; Pre-Eclampsia/genetics ; Pregnancy ; Pregnancy Outcome
    Chemical Substances 12E7 Antigen ; CD99 protein, human
    Language English
    Publishing date 2020-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165837
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  4. Article ; Online: Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population.

    Kelemu, Tsehayneh / Erlandsson, Lena / Seifu, Daniel / Hansson, Eva / Abebe, Markos / Teklu, Sisay / Girma, Selfu / Traherne, James A / Moffett, Ashley / Hansson, Stefan R

    Journal of reproductive immunology

    2020  Volume 141, Page(s) 103169

    Abstract: Introduction: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2-8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal Human Leukocyte Antigen- ... ...

    Abstract Introduction: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2-8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal Human Leukocyte Antigen-C (HLA-C) may predispose pregnant mothers for PE due to defective trophoblast invasion into the maternal decidua. Our study aimed to investigate the association between maternal KIR and fetal HLA-C polymorphism and PE in Ethiopian pregnant women.
    Methods: We included a total of 288 (157 controls and 131 PE cases) in a case-controls study at Adama Regional Referral Hospital, Ethiopia. The KIR and HLA-C genotyping was done using traditional polymerase chain reaction on genomic DNA extracted form maternal venous and cord blood followed by 2% agarose gel electrophoresis.
    Results: The statistical associations between variables were evaluated using Pearson's Chi-square test. P < 0.05, with 95 % confidence interval was considered statistically significant. A significant association was observed between the KIR2DS1 and PE, with a higher frequency (60.5 %) of the gene in the control group. Similarly, a significant association was observed between KIR AA genotype and PE, with a higher frequency (38.2 %) of this genotype in the PE group. Ethiopians share the same risk genotype for PE as seen in previous African and European studies, namely homozygosity of a maternal KIR AA genotype. However, Ethiopians differ from other East African populations by sharing the same protective KIR2DS1 gene as Europeans.
    Language English
    Publishing date 2020-06-20
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2020.103169
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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