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  1. Book ; Thesis: Die aorto-koronare Bypassoperation am schlagenden Herzen

    Keller, Beat

    erste Resultate bei Patienten mit erhöhtem Risiko

    2001  

    Author's details vorgelegt von Beat Keller
    Language German
    Size 49 Bl. : Ill., graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 2001
    HBZ-ID HT013335995
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 1462 order for loan Magazin

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  2. Article ; Online: Oat genome - sequence of a superfood.

    Krattinger, Simon G / Keller, Beat

    Nature plants

    2022  Volume 8, Issue 6, Page(s) 602–603

    MeSH term(s) Avena/genetics ; Chromosome Mapping ; Genome, Plant
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2055-0278
    ISSN (online) 2055-0278
    DOI 10.1038/s41477-022-01169-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: NLR immune receptors and diverse types of non-NLR proteins control race-specific resistance in Triticeae.

    Sánchez-Martín, Javier / Keller, Beat

    Current opinion in plant biology

    2021  Volume 62, Page(s) 102053

    Abstract: Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild ... ...

    Abstract Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild relatives. Here, we describe the growing repertoire of identified R and Avr genes with special emphasis on novel R gene architectures, revealing that there is a large diversity of proteins encoded by race-specific resistance genes that extends beyond the canonical nucleotide-binding domain leucine-rich repeat proteins. Immune receptors with unique domain architectures controlling race-specific resistance possibly reveal novel aspects on the biology of host-pathogen interactions. We conclude that the polyploid cereal genomes have a large evolutionary potential to generate diverse types of resistance genes.
    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2021.102053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  4. Article ; Online: Breeding for durable resistance against biotrophic fungal pathogens using transgenes from wheat.

    Camenzind, Marcela / Koller, Teresa / Armbruster, Cygni / Jung, Esther / Brunner, Susanne / Herren, Gerhard / Keller, Beat

    Molecular breeding : new strategies in plant improvement

    2024  Volume 44, Issue 2, Page(s) 8

    Abstract: Breeding for resistant crops is a sustainable way to control disease and relies on the introduction of novel resistance genes. Here, we tested three strategies on how to use transgenes from wheat to achieve durable resistance against fungal pathogens in ... ...

    Abstract Breeding for resistant crops is a sustainable way to control disease and relies on the introduction of novel resistance genes. Here, we tested three strategies on how to use transgenes from wheat to achieve durable resistance against fungal pathogens in the field. First, we tested the highly effective, overexpressed single transgene
    Supplementary information: The online version contains supplementary material available at 10.1007/s11032-024-01451-2.
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230924-2
    ISSN 1572-9788 ; 1380-3743
    ISSN (online) 1572-9788
    ISSN 1380-3743
    DOI 10.1007/s11032-024-01451-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 6088: Show issues

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  5. Book: Bauzone und Siedlungsgebiet

    Keller, Beat

    Vorschläge zur Revision des Raumplanungsgesetzes

    (Boden ; 59)

    1990  

    Author's details Beat Keller
    Series title Boden ; 59
    Collection
    Keywords Schweiz ; Siedlung ; Neubaugebiet ; Bauland
    Subject Besiedelung ; Besiedlung ; Siedlungsstätte ; Siedlungsgebiet ; Siedlungen ; Baugelände ; Baugrund ; Bauplatz ; Neubausiedlung ; Baugebiet
    Language German
    Size 126 S.
    Publisher Nationales Forschungsprogramm "Nutzung des Bodens in der Schweiz"
    Publishing place Liebefeld-Bern
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016585851
    ISBN 3-907086-51-1 ; 978-3-907086-51-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    904/724 order for loan Geschlossenes Magazin (U2)

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  6. Article: Nagelpsoriasis mit PDE-4-Hemmer behandelt

    Keller, Beat

    Haut

    2017  Volume 28, Issue 5, Page(s) 264

    Language German
    Document type Article
    ZDB-ID 1129257-x
    ISSN 0938-2216
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3498: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; Thesis: Analyzing photosynthetic performance in natural fluctuating environment using light-induced fluorescence transient (LIFT) method in high-throughput

    Keller, Beat [Verfasser]

    2018  

    Author's details Beat Keller
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: NLR immune receptors and diverse types of non-NLR proteins control race-specific resistance in Triticeae

    Sánchez-Martín, Javier / Keller, Beat

    Current opinion in plant biology. 2021 Aug., v. 62

    2021  

    Abstract: Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild ... ...

    Abstract Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild relatives. Here, we describe the growing repertoire of identified R and Avr genes with special emphasis on novel R gene architectures, revealing that there is a large diversity of proteins encoded by race-specific resistance genes that extends beyond the canonical nucleotide-binding domain leucine-rich repeat proteins. Immune receptors with unique domain architectures controlling race-specific resistance possibly reveal novel aspects on the biology of host–pathogen interactions. We conclude that the polyploid cereal genomes have a large evolutionary potential to generate diverse types of resistance genes.
    Keywords barley ; genomics ; plant biology ; polyploidy ; rye ; wheat
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2021.102053
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  9. Article ; Online: The broad use of the Pm8 resistance gene in wheat resulted in hypermutation of the AvrPm8 gene in the powdery mildew pathogen.

    Kunz, Lukas / Sotiropoulos, Alexandros G / Graf, Johannes / Razavi, Mohammad / Keller, Beat / Müller, Marion C

    BMC biology

    2023  Volume 21, Issue 1, Page(s) 29

    Abstract: Background: Worldwide wheat production is under constant threat by fast-evolving fungal pathogens. In the last decades, wheat breeding for disease resistance heavily relied on the introgression of chromosomal segments from related species as genetic ... ...

    Abstract Background: Worldwide wheat production is under constant threat by fast-evolving fungal pathogens. In the last decades, wheat breeding for disease resistance heavily relied on the introgression of chromosomal segments from related species as genetic sources of new resistance. The Pm8 resistance gene against the powdery mildew disease has been introgressed from rye into wheat as part of a large 1BL.1RS chromosomal translocation encompassing multiple disease resistance genes and yield components. Due to its high agronomic value, this translocation has seen continuous global use since the 1960s on large growth areas, even after Pm8 resistance was overcome by the powdery mildew pathogen. The long-term use of Pm8 at a global scale provided the unique opportunity to study the consequences of such extensive resistance gene application on pathogen evolution.
    Results: Using genome-wide association studies in a population of wheat mildew isolates, we identified the avirulence effector AvrPm8 specifically recognized by Pm8. Haplovariant mining in a global mildew population covering all major wheat growing areas of the world revealed 17 virulent haplotypes of the AvrPm8 gene that grouped into two functional categories. The first one comprised amino acid polymorphisms at a single position along the AvrPm8 protein, which we confirmed to be crucial for the recognition by Pm8. The second category consisted of numerous destructive mutations to the AvrPm8 open reading frame such as disruptions of the start codon, gene truncations, gene deletions, and interference with mRNA splicing. With the exception of a single, likely ancient, gain-of-virulence mutation found in mildew isolates around the world, all AvrPm8 virulence haplotypes were found in geographically restricted regions, indicating that they occurred recently as a consequence of the frequent Pm8 use.
    Conclusions: In this study, we show that the broad and prolonged use of the Pm8 gene in wheat production worldwide resulted in a multitude of gain-of-virulence mechanisms affecting the AvrPm8 gene in the wheat powdery mildew pathogen. Based on our findings, we conclude that both standing genetic variation as well as locally occurring new mutations contributed to the global breakdown of the Pm8 resistance gene introgression.
    MeSH term(s) Triticum/genetics ; Triticum/microbiology ; Disease Resistance/genetics ; Genome-Wide Association Study ; Plant Breeding ; Ascomycota/genetics ; Plant Diseases/genetics ; Plant Diseases/microbiology
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-023-01513-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pyramiding of transgenic immune receptors from primary and tertiary wheat gene pools improves powdery mildew resistance in the field.

    Koller, Teresa / Camenzind, Marcela / Jung, Esther / Brunner, Susanne / Herren, Gerhard / Armbruster, Cygni / Keller, Beat

    Journal of experimental botany

    2023  Volume 75, Issue 7, Page(s) 1872–1886

    Abstract: Introgression of resistance genes from wild or related species is a common strategy to improve disease resistance of wheat cultivars. Pm17 is a gene that confers powdery mildew resistance in wheat. It encodes an NLR type of immune receptor and was ... ...

    Abstract Introgression of resistance genes from wild or related species is a common strategy to improve disease resistance of wheat cultivars. Pm17 is a gene that confers powdery mildew resistance in wheat. It encodes an NLR type of immune receptor and was introgressed from rye to wheat as part of the 1RS chromosome arm translocation several decades ago. So far it has not been possible to separate Pm17 from its co-introgressed rye genes due to suppressed recombination. Here we tested in the field transgenic Bobwhite wheat overexpressing Pm17 without any other rye genes. Four transgenic events showed high levels of PM17 protein accumulation, strong powdery mildew resistance, and no pleiotropic effects during three field seasons. We used a combined approach of transgene insertion and cross-breeding to generate lines co-expressing Pm17 and Pm3, or Pm17 and Pm8. Blumeria graminis f. sp. tritici infection tests confirmed additive, race-specific resistance of the two pyramided transgenes in lines Pm17+Pm3b and Pm17+Pm8. Furthermore, pyramided lines showed strong powdery mildew resistance during three field seasons. We conclude that the combination of overexpressed NLR genes from the extended gene pool broadens and diversifies wheat disease resistance.
    MeSH term(s) Triticum/genetics ; Disease Resistance/genetics ; Gene Pool ; Ascomycota/genetics ; Plant Breeding ; Plant Diseases
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erad493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 55/29: Show issues

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