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Article ; Online: Brett stöd för rekommendation om screening för bukaortaaneurysm.

Keller, Lina

2016 Volume 113

Title translation	Widespread support for the recommendation concerning screening for abdominal aortic aneurysm.
MeSH term(s)	Aortic Aneurysm, Abdominal/diagnosis ; Humans ; Mass Screening
Language	Swedish
Publishing date	2016-06-14
Publishing country	Sweden
Document type	Letter
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Ua VI Zs.411: Show issues

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Article ; Online: [No title information]

Keller, Lina / Adolfsson, Jan / Larsson, Lars-Torsten / Hall, Charlotte

Lakartidningen

2016 Volume 113

Title translation	Replik från Socialstyrelsen och SBU: - Kraven på opartiskhet och vetenskaplighet är höga.
Language	Swedish
Publishing date	2016-10-19
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults.

Kalpouzos, Grégoria / Rizzuto, Debora / Keller, Lina / Fastbom, Johan / Santoni, Giola / Angleman, Sara / Graff, Caroline / Bäckman, Lars / Fratiglioni, Laura

The journals of gerontology. Series A, Biological sciences and medical sciences

2016 Volume 71, Issue 2, Page(s) 188–195

Abstract: Telomere length has been associated with longevity. As telomere length is partly determined by the human telomerase reverse transcriptase (hTERT), we investigated the association between an hTERT polymorphism located in its promoter region ((-) (1327)T/C) ...

Abstract	Telomere length has been associated with longevity. As telomere length is partly determined by the human telomerase reverse transcriptase (hTERT), we investigated the association between an hTERT polymorphism located in its promoter region ((-) (1327)T/C) and longevity in two cohorts of older adults. Participants from the Kungsholmen project (KP; n = 1,205) and the Swedish National study of Aging and Care in Kungsholmen (SNAC-K; n = 2,764) were followed for an average period of 7.5 years. The main outcomes were hazard ratios (HR) of mortality and median age at death. In both cohorts, mortality was lower in female T/T carriers, aged 75+ years in KP (HR = 0.8, 95% CI: 0.5-0.9) and 78+ years in SNAC-K (HR = 0.6, 95% CI: 0.4-0.8) compared with female C/C carriers. T/T carriers died 1.8-3 years later than the C/C carriers. This effect was not present in men, neither in SNAC-K women aged 60-72 years. The association was not modified by presence of cancer, cardiovascular diseases, number of chronic diseases, or markers of inflammation, and did not interact with APOE genotype or estrogen replacement therapy. The gender-specific increased survival in T/T carriers can be due to a synergistic effect between genetic background and the life-long exposure to endogenous estrogen.
MeSH term(s)	Aged ; Aging/genetics ; Female ; Genotype ; Humans ; Longevity/genetics ; Longitudinal Studies ; Male ; Middle Aged ; Mortality/trends ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Survival Analysis ; Sweden ; Telomerase/genetics
Chemical Substances	TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glu222
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Article ; Online: Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75.

Rizzuto, Debora / Keller, Lina / Orsini, Nicola / Graff, Caroline / Bäckman, Lars / Bellocco, Rino / Wang, Hui-Xin / Fratiglioni, Laura

Journal of the American Geriatrics Society

2016 Volume 64, Issue 12, Page(s) 2440–2447

Abstract: Objectives: To explore the association between genes that may be related to human mortality, taking into account the possible contribution of morbidity, and investigate whether lifestyle behaviors may attenuate genetic risk.: Design: Twenty-five-year ...

Abstract	Objectives: To explore the association between genes that may be related to human mortality, taking into account the possible contribution of morbidity, and investigate whether lifestyle behaviors may attenuate genetic risk. Design: Twenty-five-year population-based cohort study. Setting: Kungsholmen cohort, Stockholm, Sweden. Participants: Individuals aged 75 and older (N = 1,229). Measurements: The associations between single-nucleotide variations in 14 genes (previously associated with mortality or to diseases linked to mortality), relevant lifestyle risk behaviors (smoking; mental, physical, or social inactivity; moderate or poor social network), and mortality were estimated using Cox regression. Results: People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO)C1 GG and AG carriers, APOE ɛ4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers. Individuals with multiple adverse alleles had 62% higher mortality rate than those with none. In contrast, people with no risk behaviors (low-risk profile) had 65% lower mortality rate than people with all examined risk behaviors (high-risk profile). Combining the genetic and environmental factors, it was found that, independent of genetic profile, individuals with a low-risk profile had up to 64% lower mortality rate than those with a moderate high- or high-risk profile and at least one genetic risk factor. Conclusion: This study supports and expands evidence that genetic variations in APOE, IDE, and PI3KCB are associated with lower mortality rate, although lifestyle behaviors can modulate their effects.
MeSH term(s)	Aged ; Alleles ; Apolipoprotein C-I/genetics ; Apolipoproteins E/genetics ; Class Ib Phosphatidylinositol 3-Kinase/genetics ; Female ; Humans ; Insulysin/genetics ; Life Style ; Longevity/genetics ; Male ; Risk Factors ; Risk-Taking ; Sweden
Chemical Substances	APOC1 protein, human ; ApoE protein, human ; Apolipoprotein C-I ; Apolipoproteins E ; Class Ib Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Insulysin (EC 3.4.24.56)
Language	English
Publishing date	2016-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.14391
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Article ; Online: Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia.

Laukka, Erika J / Lövdén, Martin / Kalpouzos, Grégoria / Papenberg, Goran / Keller, Lina / Graff, Caroline / Li, Tie-Qiang / Fratiglioni, Laura / Bäckman, Lars

PloS one

2015 Volume 10, Issue 8, Page(s) e0134766

Abstract: Background: Reduced white matter integrity, as indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), has been related to poorer perceptual speed (PS) performance. As the ε4 allele has been associated with lower white matter ... ...

Abstract	Background: Reduced white matter integrity, as indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), has been related to poorer perceptual speed (PS) performance. As the ε4 allele has been associated with lower white matter integrity in old age, this represents a potential mechanism through which APOE may affect PS. Objective: To examine whether the association between APOE and PS is mediated by white matter microstructure in very old persons without dementia. Method: Participants were selected from the population-based SNAC-K study. After excluding persons with dementia, preclinical dementia, and other neurological disorders, 652 persons (age range 78-90) were included in the study, of which 89 had data on diffusion tensor imaging (DTI). We used structural equation modeling to form seven latent white matter factors (FA and MD) and one latent PS factor. Separate analyses were performed for FA and MD and mediational analyses were carried out for tracts where significant associations were observed to both APOE and PS. Results: APOE was associated with white matter microstructure in 2 out of 14 tracts; ε4 carriers had significantly lower FA in forceps major and higher MD in the cortico-spinal tract. Allowing the white matter microstructure indicators in these tracts to mediate the association between APOE and PS resulted in a markedly attenuated association between these variables. Bootstrapping statistics in the subsample with DTI data (n = 89) indicated that FA in forceps major significantly mediated the association between APOE and PS (indirect effect: -0.070, 95% bias corrected CIs -0.197 to -0.004). Conclusion: Lower white matter integrity may represent one of several mechanisms through which APOE affects PS performance in elderly persons free of dementia and preclinical dementia.
MeSH term(s)	Aged ; Aged, 80 and over ; Apolipoprotein E4/genetics ; Dementia/genetics ; Dementia/pathology ; Diffusion Tensor Imaging ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Models, Biological ; Perception ; White Matter/pathology
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0134766
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Article ; Online: HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.

Xu, Wei-Li / Pedersen, Nancy L / Keller, Lina / Kalpouzos, Grégoria / Wang, Hui-Xin / Graff, Caroline / Winblad, Bengt / Bäckman, Lars / Fratiglioni, Laura

PLoS medicine

2015 Volume 12, Issue 7, Page(s) e1001853

Abstract: Background: Research has suggested that variations within the IDE/HHEX gene region may underlie the association of type 2 diabetes with Alzheimer disease (AD). We sought to explore whether IDE genes play a role in the association of diabetes with ... ...

Abstract	Background: Research has suggested that variations within the IDE/HHEX gene region may underlie the association of type 2 diabetes with Alzheimer disease (AD). We sought to explore whether IDE genes play a role in the association of diabetes with dementia, AD, and structural brain changes using data from two community-based cohorts of older adults and a subsample with structural MRI. Methods and findings: The first cohort, which included dementia-free adults aged ≥75 y (n = 970) at baseline, was followed for 9 y to detect incident dementia (n = 358) and AD (n = 271) cases. The second cohort (for replication), which included 2,060 dementia-free participants aged ≥60 y at baseline, was followed for 6 y to identify incident dementia (n = 166) and AD (n = 121) cases. A subsample (n = 338) of dementia-free participants from the second cohort underwent MRI. HHEX_23 and IDE_9 were genotyped, and diabetes (here including type 2 diabetes and prediabetes) was assessed. In the first cohort, diabetes led to an adjusted hazard ratio (HR) of 1.73 (95% CI 1.19-2.32) and 1.66 (95% CI 1.06-2.40) for dementia and AD, respectively, among all participants. Compared to people carrying the GG genotype without diabetes, AA genotype carriers with diabetes had an adjusted HR of 5.54 (95% CI 2.40-7.18) and 4.81 (95% CI 1.88-8.50) for dementia and AD, respectively. There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes. In the second cohort, the HRs were 1.68 (95% CI 1.04-2.99) and 1.64 (1.02-2.33) for the diabetes-AD and dementia-AD associations, respectively, and 4.06 (95% CI 1.06-7.58, p = 0.039) and 3.29 (95% CI 1.02-8.33, p = 0.044) for the interactions, respectively. MRI data showed that HHEX_23-AA carriers with diabetes had significant structural brain changes compared to HHEX_23-GG carriers without diabetes. No joint effects of IDE_9 and diabetes on dementia were shown. As a limitation, the sample sizes were small for certain subgroups. Conclusions: A variant in the HHEX_23 gene interacts with diabetes to be associated with a substantially increased risk of dementia and AD, and with structural brain changes among dementia-free elderly people.
MeSH term(s)	Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Comorbidity ; Dementia/epidemiology ; Dementia/genetics ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Genotype ; Homeodomain Proteins ; Humans ; Insulysin/genetics ; Longitudinal Studies ; Polymorphism, Genetic ; Prediabetic State/epidemiology ; Prediabetic State/genetics ; Transcription Factors
Chemical Substances	HHEX protein, human ; Homeodomain Proteins ; Transcription Factors ; Insulysin (EC 3.4.24.56)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185925-5
ISSN	1549-1676 ; 1549-1277
ISSN (online)	1549-1676
ISSN	1549-1277
DOI	10.1371/journal.pmed.1001853
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Article ; Online: The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study.

Keller, Lina / Xu, Weili / Wang, Hui-Xin / Winblad, Bengt / Fratiglioni, Laura / Graff, Caroline

Journal of Alzheimer's disease : JAD

2011 Volume 23, Issue 3, Page(s) 461–469

Abstract: The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer's disease (AD) and ... ...

Abstract	The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer's disease (AD) and dementia. Thus, our aim was to explore the impact of FTO on AD and dementia risk. Nine years of follow-up data was gathered from the Kungsholmen project, a prospective population-based study on 1,003 persons without dementia. Cox-regression models were used to assess the relative risks of developing AD and dementia (DSM-III-R criteria) according to FTO genotypes (rs9939609), taking into account APOE, physical inactivity, BMI, diabetes, and cardiovascular disease (CVD). Compared to carriers of the FTO TT-genotype, AA-carriers had a higher risk for AD (RR 1.58, 95% CI: 1.11-2.24) and for dementia (RR 1.48, 95% CI: 1.09-2.02) after adjustment for age, gender, education, and APOE genotype. This effect remained after additional adjustment for physical inactivity, BMI, diabetes, and CVD. An interaction between FTO and APOE was found, with increased risk for dementia for those carrying both FTO AA and APOE ϵ4. Importantly, the effect of the AA-genotype on dementia/AD risk seems to act mostly through the interaction with APOE ϵ4. Our findings suggest that the FTO AA-genotype increases the risk for dementia, and in particular AD, independently of physical inactivity, BMI, diabetes, and CVD measured at baseline. Our results are in line with the recently reported association between FTO and reduced brain volume in cognitively healthy subjects.
MeSH term(s)	Aged ; Aged, 80 and over ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Motor Activity/genetics ; Obesity/genetics ; Obesity/metabolism ; Prospective Studies ; Proteins/genetics ; Proteins/metabolism ; Risk Factors
Chemical Substances	Apolipoprotein E4 ; Proteins ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
Language	English
Publishing date	2011
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-2010-101068
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Zs.A 6084: Show issues

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Article ; Online: Interactive effects of KIBRA and CLSTN2 polymorphisms on episodic memory in old-age unipolar depression.

Pantzar, Alexandra / Laukka, Erika J / Atti, Anna Rita / Papenberg, Goran / Keller, Lina / Graff, Caroline / Fratiglioni, Laura / Bäckman, Lars

Neuropsychologia

2014 Volume 62, Page(s) 137–142

Abstract: The KIBRA (rs17070145) C-allele and the CLSTN2 (rs6439886) T-allele have both been associated with poorer episodic memory performance. Given that episodic memory is affected in depression, we hypothesized that the combination of these risk alleles would ... ...

Abstract	The KIBRA (rs17070145) C-allele and the CLSTN2 (rs6439886) T-allele have both been associated with poorer episodic memory performance. Given that episodic memory is affected in depression, we hypothesized that the combination of these risk alleles would be particularly detrimental to episodic memory performance in depressed persons. In the population-based SNAC-K study, 2170 participants (≥ 60 years) without dementia (DSM-IV criteria) and antidepressant pharmacotherapy were clinically examined and diagnosed following ICD-10 criteria for unipolar depression, and genotyped for KIBRA and CLSTN2. Participants were categorized according to unipolar depression status (yes, no) and genotype combinations (KIBRA: CC, any T; CLSTN2: TT, any C). Critically, a three-way interaction effect showed that the CC/TT genotype combination was associated with poorer episodic recall and recognition performance only in depressed elderly persons, with depressed CC/TT carriers consistently performing at the lowest level. This finding supports the view that effects of genetic polymorphisms on cognitive functioning may be most easily disclosed at suboptimal levels of cognitive ability, such as in old-age depression.
MeSH term(s)	Aged ; Aged, 80 and over ; Calcium-Binding Proteins/genetics ; Chi-Square Distribution ; Depressive Disorder/complications ; Depressive Disorder/genetics ; Female ; Genotype ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Membrane Proteins/genetics ; Memory Disorders/etiology ; Memory Disorders/genetics ; Memory, Episodic ; Middle Aged ; Neuropsychological Tests ; Phosphoproteins/genetics ; Polymorphism, Genetic/genetics
Chemical Substances	CLSTN2 protein, human ; Calcium-Binding Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Phosphoproteins ; WWC1 protein, human
Language	English
Publishing date	2014-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2014.07.020
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Article ; Online: The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.

Ferencz, Beata / Laukka, Erika J / Welmer, Anna-Karin / Kalpouzos, Grégoria / Angleman, Sara / Keller, Lina / Graff, Caroline / Lövdén, Martin / Bäckman, Lars

Psychology and aging

2014 Volume 29, Issue 2, Page(s) 440–449

Abstract: PICALM, BIN1, CLU, and APOE are top candidate genes for Alzheimer's disease, and they influence episodic memory performance in old age. Physical activity, however, has been shown to protect against age-related decline and counteract genetic influences on ...

Abstract	PICALM, BIN1, CLU, and APOE are top candidate genes for Alzheimer's disease, and they influence episodic memory performance in old age. Physical activity, however, has been shown to protect against age-related decline and counteract genetic influences on cognition. The aims of this study were to assess whether (a) a genetic risk constellation of PICALM, BIN1, and CLU polymorphisms influences cognitive performance in old age; and (b) if physical activity moderates this effect. Data from the SNAC-K population-based study were used, including 2,480 individuals (age range = 60 to 100 years) free of dementia at baseline and at 3- to 6-year follow-ups. Tasks assessing episodic memory, perceptual speed, knowledge, and verbal fluency were administered. Physical activity was measured using self-reports. Individuals who had engaged in frequent health- or fitness-enhancing activities within the past year were compared with those who were inactive. Genetic risk scores were computed based on an integration of risk alleles for PICALM (rs3851179 G allele, rs541458 T allele), BIN1 (rs744373 G allele), and CLU (rs11136000 T allele). High genetic risk was associated with reduced episodic memory performance, controlling for age, education, vascular risk factors, chronic diseases, activities of daily living, and APOE gene status. Critically, physical activity attenuated the effects of genetic risk on episodic memory. Our findings suggest that participants with high genetic risk who maintain a physically active lifestyle show selective benefits in episodic memory performance.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Aged ; Aged, 80 and over ; Aging/genetics ; Aging/physiology ; Aging/psychology ; Alleles ; Alzheimer Disease/genetics ; Clusterin/genetics ; Cognition/physiology ; Exercise/physiology ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Memory, Episodic ; Middle Aged ; Monomeric Clathrin Assembly Proteins/genetics ; Nuclear Proteins/genetics ; Risk Factors ; Sweden ; Tumor Suppressor Proteins/genetics
Chemical Substances	Adaptor Proteins, Signal Transducing ; BIN1 protein, human ; CLU protein, human ; Clusterin ; Monomeric Clathrin Assembly Proteins ; Nuclear Proteins ; PICALM protein, human ; Tumor Suppressor Proteins
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	635596-1
ISSN	1939-1498 ; 0882-7974
ISSN (online)	1939-1498
ISSN	0882-7974
DOI	10.1037/a0035465
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Article: The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age.

Ferencz, Beata / Laukka, Erika J / Lövdén, Martin / Kalpouzos, Grégoria / Keller, Lina / Graff, Caroline / Wahlund, Lars-Olof / Fratiglioni, Laura / Bäckman, Lars

Frontiers in human neuroscience

2013 Volume 7, Page(s) 198

Abstract: Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is ... ...

Abstract	Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sought to discern the influence of TOMM40 single nucleotide polymorphisms (SNPs), which have previously been associated with medial temporal lobe integrity (rs11556505 and rs2075650), on HC volume and EM. The study sample consisted of individuals from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) who were free of dementia and known neurological disorders, and 60-87 years of age (n = 424). EM was measured by using a 16-item word list with a 2-min free recall period and delineation of the HC was performed manually. The influence of Apolipoprotein E (APOE) and TOMM40 was assessed by 2 × 2 ANOVAs and partial correlations. There was no effect of APOE and TOMM40 on EM performance and HC volume. However, partial correlations revealed that HC volume was positively associated with free recall performance (r = 0.21, p < 0.01, r (2) = 0.04). When further stratified for TOMM40, the observed association between HC volume and free recall in APOE ε4 carriers was present in combination with TOMM40 rs11556505 any T (r = 0.28, p < 0.01, R (2) = 0.08) and rs2075650 any G (r = 0.28, p < 0.01, R (2) = 0.08) "risk" alleles. This pattern might reflect higher reliance on HC volume for adequate EM performance among APOE ε4 carriers with additional TOMM40 "risk" alleles suggesting that the TOMM40 gene cannot merely be considered a marker of APOE genotype. Nevertheless, neither APOE nor TOMM40 influenced HC volume or EM in this population-based sample of cognitively intact individuals over the age of 60.
Language	English
Publishing date	2013-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2013.00198
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