LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 107

Search options

  1. Article ; Online: Sorting through the extensive and confusing roles of sortilin in metabolic disease.

    Mitok, Kelly A / Keller, Mark P / Attie, Alan D

    Journal of lipid research

    2022  Volume 63, Issue 8, Page(s) 100243

    Abstract: Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of ... ...

    Abstract Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding more than 50 proteins, covering a wide range of biological functions including lipid and lipoprotein metabolism, neuronal growth and death, inflammation, and lysosomal degradation. Sortilin has a complex cellular trafficking itinerary, where it functions as a receptor in the trans-Golgi network, endosomes, secretory vesicles, multivesicular bodies, and at the cell surface. In addition, sortilin is associated with hypercholesterolemia, Alzheimer's disease, prion diseases, Parkinson's disease, and inflammation syndromes. The 1p13.3 locus containing SORT1, the gene encoding sortilin, carries the strongest association with LDL-C of all loci in human genome-wide association studies. However, the mechanism by which sortilin influences LDL-C is unclear. Here, we review the role sortilin plays in cardiovascular and metabolic diseases and describe in detail the large and often contradictory literature on the role of sortilin in the regulation of LDL-C levels.
    MeSH term(s) Adaptor Proteins, Vesicular Transport ; Cholesterol, LDL ; Genome-Wide Association Study ; Humans ; Hypercholesterolemia ; Inflammation ; Protein Transport
    Chemical Substances Adaptor Proteins, Vesicular Transport ; Cholesterol, LDL ; sortilin (Z020Y8WIJ4)
    Language English
    Publishing date 2022-06-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2022.100243
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice.

    Zhang, Qijun / Hutchison, Evan R / Pan, Calvin / Warren, Matthew F / Keller, Mark P / Attie, Alan D / Lusis, Aldons J / Rey, Federico E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The molecular basis for how host genetic variation impacts gut microbial community and bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic mouse strains from the Hybrid Mouse Diversity Panel (HMDP), previously studied ...

    Abstract The molecular basis for how host genetic variation impacts gut microbial community and bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic mouse strains from the Hybrid Mouse Diversity Panel (HMDP), previously studied for a variety of cardio-metabolic traits. Metagenomic analysis of cecal DNA followed by genome-wide association analysis identified genomic loci that were associated with microbial enterotypes in the gut. Among these we detected a genetic locus surrounding multiple amylase genes that was associated with abundances of Firmicutes (
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.28.582610
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: QTLViewer: an interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations.

    Vincent, Matthew / Gerdes Gyuricza, Isabela / Keele, Gregory R / Gatti, Daniel M / Keller, Mark P / Broman, Karl W / Churchill, Gary A

    G3 (Bethesda, Md.)

    2022  Volume 12, Issue 8

    Abstract: The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci ... ...

    Abstract The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross and Diversity Outbred studies, increasing the accessibility of these genetic resources to the broader scientific community.
    MeSH term(s) Animals ; Chromosome Mapping ; Collaborative Cross Mice/genetics ; Mice ; Phenotype ; Quantitative Trait Loci ; Software
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkac146
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice.

    Keller, Mark P / O'Connor, Chris / Bitzer, Markus / Schueler, Kathryn L / Stapleton, Donald S / Emfinger, Christopher H / Broman, Aimee Teo / Hodgin, Jeffrey B / Attie, Alan D

    Diabetes

    2023  Volume 73, Issue 2, Page(s) 312–317

    MeSH term(s) Humans ; Mice ; Animals ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/pathology ; Leptin ; Diabetes Mellitus, Type 2/genetics ; Mice, Inbred C57BL ; Disease Models, Animal ; Mice, Inbred Strains ; Obesity/complications ; Obesity/genetics ; Mice, Obese
    Chemical Substances Leptin
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db23-0444
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.

    Keller, Mark P / Hawes, Emily M / Schueler, Kathryn L / Stapleton, Donnie S / Mitok, Kelly A / Simonett, Shane P / Oeser, James K / Sampson, Leesa L / Attie, Alan D / Magnuson, Mark A / O'Brien, Richard M

    Diabetes

    2023  Volume 72, Issue 11, Page(s) 1621–1628

    MeSH term(s) Animals ; Humans ; Mice ; Blood Glucose/metabolism ; Glucose/metabolism ; Glucose-6-Phosphatase/genetics ; Insulin/metabolism ; Islets of Langerhans/metabolism ; Mice, Inbred C57BL
    Chemical Substances Blood Glucose ; G6pc2 protein, mouse (EC 3.1.3.9.) ; Glucose (IY9XDZ35W2) ; Glucose-6-Phosphatase (EC 3.1.3.9) ; Insulin ; Abcb11 protein, mouse
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db23-0215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Novel regulators of islet function identified from genetic variation in mouse islet Ca

    Emfinger, Christopher H / Clark, Lauren E / Yandell, Brian / Schueler, Kathryn L / Simonett, Shane P / Stapleton, Donnie S / Mitok, Kelly A / Merrins, Matthew J / Keller, Mark P / Attie, Alan D

    eLife

    2023  Volume 12

    Abstract: Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of ... ...

    Abstract Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca
    MeSH term(s) Mice ; Humans ; Animals ; Islets of Langerhans/metabolism ; Genome-Wide Association Study ; Insulin/metabolism ; Glucose/metabolism ; Genetic Variation ; Amino Acids/metabolism
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2) ; Amino Acids
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88189
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: D2H2: diabetes data and hypothesis hub.

    Marino, Giacomo B / Ahmed, Nasheath / Xie, Zhuorui / Jagodnik, Kathleen M / Han, Jason / Clarke, Daniel J B / Lachmann, Alexander / Keller, Mark P / Attie, Alan D / Ma'ayan, Avi

    Bioinformatics advances

    2023  Volume 3, Issue 1, Page(s) vbad178

    Abstract: Motivation: There is a rapid growth in the production of omics datasets collected by the diabetes research community. However, such published data are underutilized for knowledge discovery. To make bioinformatics tools and published omics datasets from ... ...

    Abstract Motivation: There is a rapid growth in the production of omics datasets collected by the diabetes research community. However, such published data are underutilized for knowledge discovery. To make bioinformatics tools and published omics datasets from the diabetes field more accessible to biomedical researchers, we developed the Diabetes Data and Hypothesis Hub (D2H2).
    Results: D2H2 contains hundreds of high-quality curated transcriptomics datasets relevant to diabetes, accessible via a user-friendly web-based portal. The collected and processed datasets are curated from the Gene Expression Omnibus (GEO). Each curated study has a dedicated page that provides data visualization, differential gene expression analysis, and single-gene queries. To enable the investigation of these curated datasets and to provide easy access to bioinformatics tools that serve gene and gene set-related knowledge, we developed the D2H2 chatbot. Utilizing GPT, we prompt users to enter free text about their data analysis needs. Parsing the user prompt, together with specifying information about all D2H2 available tools and workflows, we answer user queries by invoking the most relevant tools via the tools' API. D2H2 also has a hypotheses generation module where gene sets are randomly selected from the bulk RNA-seq precomputed signatures. We then find highly overlapping gene sets extracted from publications listed in PubMed Central with abstract dissimilarity. With the help of GPT, we speculate about a possible explanation of the high overlap between the gene sets. Overall, D2H2 is a platform that provides a suite of bioinformatics tools and curated transcriptomics datasets for hypothesis generation.
    Availability and implementation: D2H2 is available at: https://d2h2.maayanlab.cloud/ and the source code is available from GitHub at https://github.com/MaayanLab/D2H2-site under the CC BY-NC 4.0 license.
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ISSN 2635-0041
    ISSN (online) 2635-0041
    DOI 10.1093/bioadv/vbad178
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.

    Niemi, Natalie M / Serrano, Lia R / Muehlbauer, Laura K / Balnis, Catie / Kozul, Keri-Lyn / Rashan, Edrees H / Shishkova, Evgenia / Schueler, Kathryn L / Keller, Mark P / Attie, Alan D / Pagan, Julia / Coon, Joshua J / Pagliarini, David J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pptc7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice ... ...

    Abstract Pptc7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.28.530351
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (

    Price, Tara R / Stapleton, Donnie S / Schueler, Kathryn L / Norris, Marie K / Parks, Brian W / Yandell, Brian S / Churchill, Gary A / Holland, William L / Keller, Mark P / Attie, Alan D

    bioRxiv : the preprint server for biology

    2023  

    Abstract: We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where ... ...

    Abstract We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where several phospholipids in liver showed strong genetic association to distinct gene loci. In this study, we integrated gene expression data with genetic association data to identify a single gene at the chromosome 7 locus as the driver of the phospholipid phenotypes. The gene encodes α/β-hydrolase domain 2 (
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.23.533902
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin.

    Price, Tara R / Stapleton, Donnie S / Schueler, Kathryn L / Norris, Marie K / Parks, Brian W / Yandell, Brian S / Churchill, Gary A / Holland, William L / Keller, Mark P / Attie, Alan D

    PLoS genetics

    2023  Volume 19, Issue 7, Page(s) e1010713

    Abstract: We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where ... ...

    Abstract We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where several phospholipids in liver showed strong genetic association to distinct gene loci. In this study, we integrated gene expression data with genetic association data to identify a single gene at the chromosome 7 locus as the driver of the phospholipid phenotypes. The gene encodes α/β-hydrolase domain 2 (Abhd2), one of 23 members of the ABHD gene family. We validated this observation by measuring lipids in a mouse with a whole-body deletion of Abhd2. The Abhd2KO mice had a significant increase in liver levels of phosphatidylcholine and phosphatidylethanolamine. Unexpectedly, we also found a decrease in two key mitochondrial lipids, cardiolipin and phosphatidylglycerol, in male Abhd2KO mice. These data suggest that Abhd2 plays a role in the synthesis, turnover, or remodeling of liver phospholipids.
    MeSH term(s) Animals ; Male ; Mice ; Cardiolipins/genetics ; Cardiolipins/metabolism ; Collaborative Cross Mice/metabolism ; Hydrolases/genetics ; Hydrolases/metabolism ; Lipidomics ; Phosphatidylcholines/genetics ; Phospholipids/genetics ; Phospholipids/metabolism
    Chemical Substances Cardiolipins ; Hydrolases (EC 3.-) ; Phosphatidylcholines ; Phospholipids ; Abhd2 protein, mouse (EC 3.1.1.-)
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010713
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top