Article ; Online: Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α.
Proceedings of the National Academy of Sciences of the United States of America
2024 Volume 121, Issue 10, Page(s) e2317735121
Abstract: Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We have shown previously that Δ133p53α, an endogenous isoform of the human TP53 ...
| Abstract | Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We have shown previously that Δ133p53α, an endogenous isoform of the human TP53 gene, decreases in expression with age in human T cells, and that reconstitution of Δ133p53α in poorly functional T cells can rescue proliferation [A. M. Mondal |
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| MeSH term(s) | Humans ; Immunotherapy, Adoptive/methods ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Antigens, CD19 ; Cell- and Tissue-Based Therapy ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism | |||||
| Chemical Substances | Receptors, Chimeric Antigen ; Tumor Suppressor Protein p53 ; Antigens, CD19 ; Receptors, Antigen, T-Cell | |||||
| Language | English | |||||
| Publishing date | 2024-02-26 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 209104-5 | |||||
| ISSN | 1091-6490 ; 0027-8424 | |||||
| ISSN (online) | 1091-6490 | |||||
| ISSN | 0027-8424 | |||||
| DOI | 10.1073/pnas.2317735121 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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