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Article ; Online: 'The likes of me running and walking? No chance': Exploring the perceptions of adult patients with bronchiectasis towards exercise.

Royle, Holly / Kelly, Carol

2022 Volume 19, Issue 1, Page(s) 157–171

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Adult ; Qualitative Research ; Exercise ; Walking ; Running ; Bronchiectasis
Language	English
Publishing date	2022-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2191311-0
ISSN	1745-9206 ; 1742-3953
ISSN (online)	1745-9206
ISSN	1742-3953
DOI	10.1177/17423953221108223
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Article ; Online: Evaluation of outcome reporting in clinical trials of physiotherapy in bronchiectasis: The first stage of core outcome set development.

Hamzeh, Hayat / Spencer, Sally / Kelly, Carol / Pilsworth, Samantha

PloS one

2023 Volume 18, Issue 3, Page(s) e0282393

Abstract: Introduction: The aim of this study is to explore outcomes currently reported in physiotherapy trials for bronchiectasis and investigate the level of consistency in outcome reporting. This mapping of outcomes will be used to inform the development of a ... ...

Abstract	Introduction: The aim of this study is to explore outcomes currently reported in physiotherapy trials for bronchiectasis and investigate the level of consistency in outcome reporting. This mapping of outcomes will be used to inform the development of a core outcome set (COS) for physiotherapy research in bronchiectasis. Outcomes reported in randomised clinical trials (RCTs) and RCT protocols were reviewed and evaluated. We included trials with physiotherapy as the main intervention, including pulmonary rehabilitation, exercise prescription, airway clearance, positive expiratory pressure devices, breathing training, self-management plans, and home exercise program. Medline, CINAHL, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and the physiotherapy evidence database (PEDro) were searched from inception using a prespecified search strategy. Records including adult patients with bronchiectasis were included. Outcomes were listed verbatim and categorised into domains based on a pre-specified system, frequency of reporting and sources of variation were inspected. Results: Of 2158 abstracts screened, 37 trials (1202 participants) and 17 trial protocols were identified. Eighteen different physiotherapy techniques were investigated. A total of 331 outcomes were reported. No single outcome was reported by all trials. The most reported outcomes were lung function (27 trials, 50%), health related quality of life (26 trials, 48.1%), and dyspnoea (18 trials, 33.3%). A list of 104 unique outcomes covering 23 domains was created. Trials focus on physiological outcomes, mainly those related to respiratory system functions. Outcomes related to functioning and life impact are often neglected. Conclusion: Outcome reporting in physiotherapy research for bronchiectasis was found to be inconsistent in terms of choosing and defining outcomes. Developing a core outcome set in this area of research is needed to facilitate aggregation of future trial results in systematic reviews that will in turn inform the strength of evidence for the effectiveness of physiotherapy. Outcome choice should include all stakeholders, including patients. Trial registration: This study is registered in the PROSPERO registry under the number CRD42021266247.
MeSH term(s)	Adult ; Humans ; Systematic Reviews as Topic ; Bronchiectasis/therapy ; Physical Therapy Modalities ; Exercise Therapy ; Quality of Life ; Outcome Assessment, Health Care
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282393
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Outcomes of physiotherapy for people living with bronchiectasis: qualitative study to inform development of a core outcome set.

Hamzeh, Hayat / Kelly, Carol / Spencer, Sally

Physiotherapy

2023 Volume 121, Page(s) 37–45

Abstract: Introduction: Evidence of the effectiveness of physiotherapy for bronchiectasis is inconsistent, partly due to variation in the selection and reporting of outcomes in clinical trials. This qualitative study is a component of the development of a core ... ...

Abstract	Introduction: Evidence of the effectiveness of physiotherapy for bronchiectasis is inconsistent, partly due to variation in the selection and reporting of outcomes in clinical trials. This qualitative study is a component of the development of a core outcome set (COS). The COS will identify a minimum group of outcomes for use in clinical trials of physiotherapy considering the views of researchers, patients, and clinicians. Objectives: To identify outcomes for use in physiotherapy research that are important to patients and physiotherapists and to explain their significance. Methods: Semi-structured interviews were conducted with adult patients with bronchiectasis who received physiotherapy, in addition to physiotherapists clinically involved in bronchiectasis care. Interviews were audio recorded and transcribed verbatim. Thematic analysis was used to identify, classify, and explain the significance of outcomes. Outcomes were mapped into the list created from literature review and classified into domains. Results: We interviewed 18 participants from four countries covering a range of experiences in different settings. Seventy outcomes were identified and grouped into 15 domains. Thirty-three outcomes were not previously reported in the literature. Thematic analysis revealed exacerbations, quality of life, use of healthcare resources, patient-reported symptoms, physical functioning, and sputum as the prominent themes reported by both patients and physiotherapists. Conclusions: This qualitative study highlighted the importance of considering stakeholder perspectives when planning research trials. Outcomes identified will be used to inform the next phase of COS development. Registration: This study is part of the COS development project registered with the Core Outcome Measures in Effectiveness Trials initiative (COMET) https://www.comet-initiative.org/Studies/Details/1931 CONTRIBUTION OF THE PAPER.
Language	English
Publishing date	2023-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	391109-3
ISSN	1873-1465 ; 0031-9406
ISSN (online)	1873-1465
ISSN	0031-9406
DOI	10.1016/j.physio.2023.07.001
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Article ; Online: REPRODUCTIVE PHENOLOGIES IN LOBELIA INFLATA (LOBELIACEAE) AND THEIR ENVIRONMENTAL CONTROL.

Kelly, Carol A

American journal of botany

2018 Volume 79, Issue 10, Page(s) 1126–1133

Abstract: Flowering and fruiting phenologies of individual plants and flowers of Lobelia inflata, a North American summer annual, were studied in the field and greenhouse to determine whether onset of flowering and fruit maturation were correlated, and the degree ... ...

Abstract	Flowering and fruiting phenologies of individual plants and flowers of Lobelia inflata, a North American summer annual, were studied in the field and greenhouse to determine whether onset of flowering and fruit maturation were correlated, and the degree to which these reproductive phenologies were influenced by the environment. Within each of two field populations, larger plants flowered earlier and produced more flowers than smaller plants. Onset of flowering was positively correlated with onset of fruit maturation but not perfectly so. Two factors decreased the intensity of this correlation. First, at the flower level, the earlier a flower bloomed, the longer the resulting fruit took to develop. Second, fruit development times varied significantly among individual plants. In the greenhouse, individuals watered more frequently attained greater size and flowered earlier than individuals watered less frequently. Nutrient additions did not affect plant size or onset of flowering. These results indicate that for the summer annual Lobelia inflata, reproductive phenologies are phenotypically correlated, and that timing of reproduction is resource and size dependent, as it is for other monocarpic plant species.
Language	English
Publishing date	2018-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2935-x
ISSN	1537-2197 ; 0002-9122
ISSN (online)	1537-2197
ISSN	0002-9122
DOI	10.1002/j.1537-2197.1992.tb13708.x
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Article: Registration of CA 4008 cotton germplasm line

Dever, Jane / Kelly, Carol / Morgan, Valerie

Journal of plant registrations. 2022 Jan., v. 16, no. 1

2022

Abstract: Enhancing genetic diversity to breed cotton (Gossypium hirsutum L.) for water‐limited production in the Texas High Plains is one objective of the Texas A&M AgriLife Research breeding program in Lubbock. CA 4008 (Reg. no. GP‐1099, PI 698821) was derived ... ...

Abstract	Enhancing genetic diversity to breed cotton (Gossypium hirsutum L.) for water‐limited production in the Texas High Plains is one objective of the Texas A&M AgriLife Research breeding program in Lubbock. CA 4008 (Reg. no. GP‐1099, PI 698821) was derived from TX 307 (PI 165390) and 07‐A‐05, an unreleased breeding line. TX 307, wild material of species Gossypium hirsutum, was used as a parent based on performance in hydroponic salinity characterization of 290 accessions conducted at Texas A&M AgriLife Research in Lubbock from 2006 to 2009. Performance testing for yield, fiber quality, and other agronomic properties was conducted at six site‐years from 2014 to 2017 with check cultivars ‘FM 958’ (PI 619096), a high‐yield and fiber quality regional standard, and ‘DP 491’ (PI 618609), which historically produced good yield and quality under water stress in the Texas High Plains. CA 4008 produced similar yield and fiber quality, lower lint percentage, and taller plants across site‐years compared with checks. CA 4008 was tested at 11 locations across the United States in the 2017 Regional Breeder Testing Network and showed low leaf defoliation under Verticillium wilt pressure. In previous studies, CA 4008 had less germination reduction under salinity than 27 of 31 Texas A&M AgriLife Research in Lubbock lines but equal to cultivar ‘FM 989’ (PI 603956). CA 4008 had less root dry weight reduction under salinity in hydroponic studies but equal to FM 989 in shoot and leaves dry weight reduction. CA 4008 is adapted to Texas High Plains stress conditions developed from a wild accession.
Keywords	Gossypium hirsutum ; Verticillium wilt ; cultivars ; defoliation ; fiber quality ; genetic variation ; germination ; germplasm ; hydroponics ; leaves ; lint cotton ; salinity ; water stress ; weight loss ; Texas
Language	English
Dates of publication	2022-01
Size	p. 87-93.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2381569-3
ISSN	1940-3496 ; 1936-5209
ISSN (online)	1940-3496
ISSN	1936-5209
DOI	10.1002/plr2.20175
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Development of a core outcome set and outcome measurement set for physiotherapy trials in adults with Bronchiectasis (COS-PHyBE study): A protocol.

Hamzeh, Hayat / Spencer, Sally / Kelly, Carol

PloS one

2022 Volume 17, Issue 2, Page(s) e0263695

Abstract: Background: Bronchiectasis is a chronic respiratory disease characterised by airways widening and recurrent infections, resulting in episodes of chronic cough, sputum expectoration, and dyspnoea. This leads to deterioration in daily function, repeated ... ...

Abstract	Background: Bronchiectasis is a chronic respiratory disease characterised by airways widening and recurrent infections, resulting in episodes of chronic cough, sputum expectoration, and dyspnoea. This leads to deterioration in daily function, repeated hospital admissions and poor quality of life. The prevalence and mortality related to bronchiectasis is increasing worldwide with growing economic burden on healthcare systems. Physiotherapy for bronchiectasis aims to decrease accumulation of sputum, dyspnoea, and improve exercise capacity and daily function. A robust evidence base to support physiotherapy in bronchiectasis is currently lacking. This is partly because of inconsistency and poor reporting of outcomes in available studies. A core outcome set is the minimum acceptable group of outcomes that should be used in clinical trials for a specific condition. This decreases research waste by improving consistency and reporting of key outcomes and facilitates the synthesis of study outcomes in systematic reviews and guidelines. The aim of the study is therefore to develop a core outcome set and outcome measurement set for physiotherapy research in adults with bronchiectasis. This will ensure outcomes important to key stakeholders are consistently used and reported in future research. Methods and analysis: This project will use the COMET Initiative and COSMIN guidelines of core outcome set development and will include three phases. In the first phase, a comprehensive list of outcomes will be developed using systematic review of reported outcomes and qualitative interviews with patients and physiotherapists. Then consensus on key outcomes will be established in phase two using a Delphi survey and a consensus meeting. Finally, in phase three, we will identify appropriate instruments to measure the core outcomes by evaluating the psychometric properties of available instruments and a stakeholders' meeting to establish consensus. Ethics: The study was reviewed and has received ethical approval from the health-related Research Ethics Committee- Edge Hill University (ETH2021-0217). Registration: This study is registered with the COMET database. https://www.comet-initiative.org/Studies/Details/1931. The full systematic review protocol is registered in PROSPERO under the number CRD42021266247.
MeSH term(s)	Bronchiectasis/therapy ; Clinical Trials as Topic ; Consensus ; Data Collection ; Delphi Technique ; Endpoint Determination ; Humans ; Outcome Assessment, Health Care/methods ; Physical Therapy Modalities/standards ; Research Design/standards ; Systematic Reviews as Topic ; Treatment Outcome
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0263695
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Respiratory nursing at a glance

Preston, Wendy / Kelly, Carol

(At a glance series)

2017

Author's details	edited by Wendy Preston, Carol Kelly
Series title	At a glance series
MeSH term(s)	Respiratory Tract Diseases/nursing
Language	English
Size	ix, 142 pages :, illustrations
Document type	Book
ISBN	9781119048305 ; 9781119048299 ; 9781119048275 ; 1119048303 ; 111904829X ; 1119048273
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Oxygen therapy: time to move on?

Kelly, Carol

Therapeutic advances in respiratory disease

2014 Volume 8, Issue 6, Page(s) 191–199

Abstract: This analysis examines the roots of clinical practice regarding oxygen therapy and finds that some aspects have changed very little over the past 200 years. Oxygen is commonly prescribed and administered as a therapy across all healthcare settings, ... ...

Abstract	This analysis examines the roots of clinical practice regarding oxygen therapy and finds that some aspects have changed very little over the past 200 years. Oxygen is commonly prescribed and administered as a therapy across all healthcare settings, particularly for the treatment and management of respiratory conditions, both acute and chronic. Yet despite its widespread use and recent advances in understanding and guidance, poor practice and controversies regarding its use persist. This historical analysis highlights origins in practice that may suggest where the roots of these fallacies lie, highlighting potential ambiguities and myths that have permeated clinical and social contexts. It can be considered that based on clinical presumptions and speculation the prolific and injudicious use of oxygen was encouraged and the legacy for today's practice seeded. The conjectures proposed here may enable modern day erroneous beliefs to be confronted and clinical practice to move on.
MeSH term(s)	Humans ; Oxygen/therapeutic use ; Oxygen Inhalation Therapy/trends ; Pulmonary Medicine/methods
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2014-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/1753465814549011
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Article ; Online: Staff perceptions of patient safety in the NHS ambulance services: an exploratory qualitative study.

Shepard, Keegan / Spencer, Sally / Kelly, Carol / Wankhade, Paresh

British paramedic journal

2021 Volume 6, Issue 4, Page(s) 18–25

Abstract: Objectives: Most research investigating staff perceptions of patient safety has been based in primary care or hospitals, with little research on emergency services. Therefore, this study aimed to explore staff perceptions of patient safety in the NHS ... ...

Abstract	Objectives: Most research investigating staff perceptions of patient safety has been based in primary care or hospitals, with little research on emergency services. Therefore, this study aimed to explore staff perceptions of patient safety in the NHS ambulance services. Design: A stratified qualitative study using semi-structured interviews. Setting: Three urban or rural ambulance service NHS trusts in England. Participants: A total of 44 participants from three organisational levels, including executives, managers and operational staff. Methods: The semi-structured interviews explored the interpretation and definition of patient safety, perceived risks, incident reporting, communication and organisational culture. The framework method of qualitative data analysis was used to analyse the interviews and NVivo software was used to manage and organise the data. Results: We identified five dominant themes: varied interpretation of patient safety; significant patient safety risks; reporting culture shift; communication; and organisational culture. The findings demonstrated that staff perceptions of patient safety ranged widely across the three organisational levels, while they remained consistent within those levels across the participating ambulance service NHS trusts in England. Conclusions: The findings suggest that participants from all organisational levels perceive that the NHS ambulance services have become much safer for patients over recent years, which signifies an awareness of the historical issues and how they have been addressed. The inclusion of three distinct ambulance service NHS trusts and organisational levels provides deepened insight into the perceptions of patient safety by staff. As the responses of participants were consistent across the three NHS trusts, the identified issues may be generic and have application in other ambulance and emergency service settings, with implications for health policy on a national basis.
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article
ISSN	1478-4726
ISSN (online)	1478-4726
DOI	10.29045/14784726.2022.03.6.4.18
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Article: Self-management in chronic lung disease: what is missing?

Kelly, Carol / Heslop-Marshall, Karen / Jones, Steve / Roberts, Nicola J

Breathe (Sheffield, England)

2022 Volume 18, Issue 1, Page(s) 210179

Abstract: Self-management, as a strategy to support those living with chronic respiratory conditions such as asthma and COPD, has been widely advocated in guidelines and adopted in practice. However, there can be a disconnect between the goals of patients and ... ...

Abstract	Self-management, as a strategy to support those living with chronic respiratory conditions such as asthma and COPD, has been widely advocated in guidelines and adopted in practice. However, there can be a disconnect between the goals of patients and healthcare professionals. Goals and barriers to self-management are often compounded by the complex social, emotional and medical needs of patients. People living with chronic respiratory conditions also often have symptoms of anxiety and depression, which can impact on self-management. Self-management therefore requires patients and healthcare professionals to work together and it is essential to involve patients when designing, implementing and evaluating self-management interventions. Patient preferences are clearly important and goal setting needs an individual, flexible and responsive approach from healthcare professionals, which aligns to a more personalised approach to management of treatable traits and the burden of disease. To achieve these goals, healthcare professionals need education to support patients in self-management and behaviour change. This approach should lead to shared decision-making and partnership working that puts the patient right at the centre of their care.
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2562899-9
ISSN	2073-4735 ; 1810-6838
ISSN (online)	2073-4735
ISSN	1810-6838
DOI	10.1183/20734735.0179-2021
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