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  1. Article ; Online: The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

    Denis Miyashiro / Bruno de Castro e Souza / Marina Passos Torrealba / Kelly Cristina Gomes Manfrere / Maria Notomi Sato / José Antonio Sanches

    International Journal of Molecular Sciences, Vol 23, Iss 936, p

    2022  Volume 936

    Abstract: Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. ... ...

    Abstract Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.
    Keywords Sézary syndrome ; cutaneous T-cell lymphoma ; tumor microenvironment ; cytokines ; chemokines ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome

    Kelly Cristina Gomes Manfrere / Marina Passos Torrealba / Frederico Moraes Ferreira / Emanuella Sarmento Alho de Sousa / Denis Miyashiro / Franciane Mouradian Emidio Teixeira / Ricardo Wesley Alberca Custódio / Helder I. Nakaya / Yasmin Alefe Leuzzi Ramos / Mirian Nacagami Sotto / Anders Woetmann / Niels Ødum / Alberto José da Silva Duarte / José Antonio Sanches / Maria Notomi Sato

    International Journal of Molecular Sciences, Vol 24, Iss 4674, p

    2023  Volume 4674

    Abstract: Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and ...

    Abstract Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to the active form by inflammasomes. In this study, we assessed the skin, serum, peripheral mononuclear blood cell (PBMC) and lymph-node samples of SS patients and control groups (healthy donors (HDs) and idiopathic erythroderma (IE) nodes) to investigate the inflammatory markers IL-1B and IL-18 at the protein and transcript expression levels, as potential markers of inflammasome activation. Our findings showed increased IL-1B and decreased IL-18 protein expression in the epidermis of SS patients; however, in the dermis layer, we detected increased IL-18 protein expression. In the lymph nodes of SS patients at advanced stages of the disease (N2/N3), we also detected an enhancement of IL-18 and a downregulation of IL-1B at the protein level. Moreover, the transcriptomic analysis of the SS and IE nodes confirmed the decreased expression of IL1B and NLRP3 , whereas the pathway analysis indicated a further downregulation of IL1B -associated genes. Overall, the present findings showed compartmentalized expressions of IL-1B and IL-18 and provided the first evidence of their imbalance in patients with Sézary syndrome.
    Keywords Sézary syndrome ; lymph nodes ; inflammasome ; IL-1B ; IL-18 ; erythroderma skin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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