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  1. Book ; Online ; E-Book: Recombinant protein expression

    O'Dell, William B. / Kelman, Zvi

    eukaryotic hosts

    (Issn)

    2022  

    Author's details edited by Zvi Kelman and William B. O'Dell
    Series title Issn
    Keywords Recombinant proteins ; Enzymes ; Gene expression
    Subject code 660.634
    Language English
    Size 1 online resource (384 pages)
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands ; London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-90738-5 ; 0-323-90737-7 ; 978-0-323-90738-5 ; 978-0-323-90737-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Isotope labeling of biomolecules - applications

    Kelman, Zvi

    (Methods in enzymology ; volume 566)

    2016  

    Author's details edited by Zvi Kelman
    Series title Methods in enzymology ; volume 566
    Collection
    Keywords Isotopenmarkierung ; Massenspektrometrie ; NMR-Spektroskopie
    Subject Kerninduktion ; Kernmagnetische Resonanzspektroskopie ; Kernresonanzspektroskopie ; Kernspinresonanz-Spektroskopie ; KMR-Spektroskopie ; Magnetische Kernresonanzspektroskopie ; FT-NMR-Spektroskopie ; Magnetresonanzspektroskopie ; MRS ; Massenspektrographie ; Massenspektroskopie ; Radioaktive Markierung
    Language English
    Size xvi, 465 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Literaturangaben
    HBZ-ID HT018883127
    ISBN 978-0-12-803049-3 ; 0-12-803049-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -566- verfügbar in Königswinter Königswinter

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  3. Book: Isotope labeling of biomolecules: labeling methods

    Kelman, Zvi

    (Methods in enzymology ; 565)

    2015  

    Title variant Isotope labeling of biomolecules
    Author's details ed. by Zvi Kelman
    Series title Methods in enzymology ; 565
    Collection
    Language English
    Size XX, 614 S., [13] Bl., Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier, Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018817675
    ISBN 978-0-12-803048-6 ; 0-12-803048-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -565- verfügbar in Königswinter Königswinter

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  4. Book ; Online: The DNA Replication Machinery as Therapeutic Targets

    Gardner, Andrew F. / Kelman, Zvi

    2019  

    Keywords Science: general issues ; Antibacterial drug ; CMG ; DNA polymerase ; DNA Replication ; therapeutic targets
    Size 1 electronic resource (144 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230814
    ISBN 9782889459278 ; 2889459276
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online: DNA Polymerases in Biotechnology

    Gardner, Andrew F. / Kelman, Zvi

    2015  

    Abstract: DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of ... ...

    Abstract DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase engineering for biotechnology. For example, DNA polymerases have been engineered for increased speed and fidelity in PCR while lowering amplification sequence bias. Inhibitor resistant DNA polymerase variants enable PCR directly from tissue (i.e. blood). Design of DNA polymerases that efficiently incorporate modified nucleotide have been critical for development of next generation DNA sequencing, synthetic biology and other labeling and detection technologies. The Frontiers in Microbiology Research Topic on DNA polymerases in Biotechnology aims to capture current research on DNA polymerases and their use in emerging technologies
    Keywords Microbiology ; Science (General)
    Size 1 electronic resource (146 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090921
    ISBN 9782889194551 ; 2889194558
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

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  6. Article ; Online: Preface.

    Kelman, Zvi

    Methods in enzymology

    2016  Volume 566, Page(s) xv–xvi

    MeSH term(s) Fluorine-19 Magnetic Resonance Imaging/methods ; Isotope Labeling/methods ; Magnetic Resonance Spectroscopy/methods
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Introductory Journal Article
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/S0076-6879(15)00692-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Isotope labeling of biomolecules

    Kelman, Zvi

    applications

    (Methods in enzymology ; volume 566)

    2016  

    Author's details edited by Zvi Kelman
    Series title Methods in enzymology ; volume 566
    Keywords Isotopenmarkierung ; Biomolekül
    Language English
    Size xvi, 465 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier, Academic Press
    Publishing place Amsterdam ; Heidelberg
    Document type Book
    Note LIteraturangaben
    ISBN 0128030496 ; 9780128030493
    Database Leibniz Institute of Plant Genetics and Crop Plant Research

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    Inter-library loan at ZB MED

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  8. Book: Isotope labeling of biomolecules

    Kelman, Zvi

    (Methods in enzymology, ; volume 566)

    2016  

    Author's details edited by Zvi Kelman
    Series title Methods in enzymology, ; volume 566
    MeSH term(s) Isotope Labeling/methods ; Molecular Biology/methods
    Language English
    Dates of publication 2016-2016
    Size xvi, 465 pages, 30 unnumbered pages of plates :, illustrations (some color) ;, 24 cm.
    Edition First edition.
    Document type Book
    ISBN 9780128030493 ; 0128030496
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Effects of glycans and hinge on dynamics in the IgG1 Fc.

    Bergonzo, Christina / Hoopes, J Todd / Kelman, Zvi / Gallagher, D Travis

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–9

    Abstract: The crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two important structural variables in Fc constructs are the hinge region connecting the Fc to the antigen ... ...

    Abstract The crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two important structural variables in Fc constructs are the hinge region connecting the Fc to the antigen binding fragments (Fab) and the glycans present in various glycoforms. These components affect receptor binding interactions that mediate immune activation. To design new antibody drugs, a robust in silico method for linking stability to structural changes is necessary. In this work, all-atom simulations were used to compare the dynamic behavior of the four structural variants arising from presence or absence of the hinge and glycans. We expressed the simplest of these constructs, the 'minimal Fc' with no hinge and no glycans, in
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2270749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Preface.

    Kelman, Zvi

    Methods in enzymology

    2015  Volume 565, Page(s) xix–xx

    MeSH term(s) Isotope Labeling ; Nucleic Acids/chemistry ; Proteins/chemistry
    Chemical Substances Nucleic Acids ; Proteins
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/S0076-6879(15)00622-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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