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  1. Article ; Online: The value of difficult-topic critical analysis in textbooks for young surgeons.

    Jehle, Charles / Kelsey Snapp, W

    The Journal of hand surgery, European volume

    2021  Volume 46, Issue 10, Page(s) 1118–1119

    MeSH term(s) Humans ; Surgeons
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/17531934211042510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1940: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Altered ventricular torsion and transmural patterns of myocyte relaxation precede heart failure in aging F344 rats.

    Campbell, Stuart G / Haynes, Premi / Kelsey Snapp, W / Nava, Kristofer E / Campbell, Kenneth S

    American journal of physiology. Heart and circulatory physiology

    2013  Volume 305, Issue 5, Page(s) H676–86

    Abstract: The purpose of this study was to identify and explain changes in ventricular and cellular function that contribute to aging-associated cardiovascular disease in aging F344 rats. Three groups of female F344 rats, aged 6, 18, and 22 mo, were studied. ... ...

    Abstract The purpose of this study was to identify and explain changes in ventricular and cellular function that contribute to aging-associated cardiovascular disease in aging F344 rats. Three groups of female F344 rats, aged 6, 18, and 22 mo, were studied. Echocardiographic measurements in isoflurane-anesthetized animals showed an increase in peak left ventricular torsion between the 6- and the 18-mo-old groups that was partially reversed in the 22-mo-old animals (P < 0.05). Epicardial, midmyocardial, and endocardial myocytes were subsequently isolated from the left ventricles of each group of rats. Unloaded sarcomere shortening and Ca(2+) transients were then measured in these cells (n = >75 cells for each of the nine age-region groups). The decay time of the Ca(2+) transient and the time required for 50% length relaxation both increased with age but not uniformly across the three regions (P < 0.02). Further analysis revealed a significant shift in the transmural distribution of these properties between 18 and 22 mo of age, with the largest changes occurring in epicardial myocytes. Computational modeling suggested that these changes were due in part to slower Ca(2+) dissociation from troponin in aging epicardial myocytes. Subsequent biochemical assays revealed a >50% reduction in troponin I phosphoprotein content in 22-mo-old epicardium relative to the other regions. These data suggest that between 18 and 22 mo of age (before the onset of heart failure), F344 rats display epicardial-specific myofilament-level modifications that 1) break from the progression observed between 6 and 18 mo and 2) coincide with aberrant patterns of cardiac torsion.
    MeSH term(s) Adaptation, Physiological/physiology ; Aging/pathology ; Aging/physiology ; Animals ; Calcium/metabolism ; Disease Models, Animal ; Echocardiography ; Female ; Heart Failure/pathology ; Heart Failure/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Muscle Relaxation/physiology ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Rats ; Rats, Inbred F344 ; Sarcomeres/pathology ; Time Factors ; Torsion Abnormality/pathology ; Torsion Abnormality/physiopathology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-06-21
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00797.2012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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