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  1. Article ; Online: The effects of demographic, psychosocial, and socioeconomic characteristics on access to heart transplantation and left ventricular assist device.

    Kelty, C E / Dickinson, M G / Fogarty, K J

    American heart journal plus : cardiology research and practice

    2022  Volume 17, Page(s) 100172

    Abstract: Background: This study aims to better understand how demographic, psychosocial, and socioeconomic factors influence the selection of patients for advanced therapies for heart failure (heart transplant and left ventricular assist device (LVAD)).: ... ...

    Abstract Background: This study aims to better understand how demographic, psychosocial, and socioeconomic factors influence the selection of patients for advanced therapies for heart failure (heart transplant and left ventricular assist device (LVAD)).
    Methods: Patients evaluated for heart transplant or LVAD at a large, Midwestern hospital system were assessed retrospectively. Three outcomes were analyzed: 1) Patients who were evaluated and approved to receive a transplant or LVAD were compared to patients who were not approved for transplant or LVAD; 2) Patients who were listed for transplant were compared to patients not listed; and 3) Patients who received a transplant or LVAD were compared to patients who did not receive a transplant or LVAD. ANOVA was used for continuous variables and Chi-squared test for categorical variables. Significant variables were further analyzed by logistic regression.
    Results: Four hundred fifty-nine patients were included. Marital status (p = 0.004), race (p = 0.008), social support (p < 0.001), mental health (p = 0.006), and substance use (p < 0.001) were associated with whether patients were approved for transplant or LVAD. Patients with public insurance were half as likely (OR 0.495) to be listed for transplant once approved.
    Conclusions: Financial, psychosocial, and demographic characteristics all play a role in selection for advanced therapies for heart failure. These insights can help guide future work on interventions to address the social disparities in access to heart transplant and LVAD.
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2022.100172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Columnar-lined esophagus without intestinal metaplasia should not be dismissed as having no cancer risk.

    Kelty, Clive

    The American journal of gastroenterology

    2008  Volume 103, Issue 12, Page(s) 3205; author reply 3205–6

    MeSH term(s) Adenocarcinoma/epidemiology ; Adenocarcinoma/etiology ; Barrett Esophagus/complications ; Barrett Esophagus/pathology ; Esophagus/pathology ; Humans ; Metaplasia ; Neoplasms/epidemiology ; Neoplasms/etiology ; Risk
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1111/j.1572-0241.2008.02161_1.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Disentangling public participation in science and biomedicine.

    Kelty, Christopher / Panofsky, Aaron

    Genome medicine

    2014  Volume 6, Issue 1, Page(s) 8

    Abstract: Background: This article provides a framework for disentangling the concept of participation, with emphasis on participation in genomic medicine. We have derived seven 'dimensions' of participation that are most frequently invoked in the extensive, ... ...

    Abstract Background: This article provides a framework for disentangling the concept of participation, with emphasis on participation in genomic medicine. We have derived seven 'dimensions' of participation that are most frequently invoked in the extensive, heterogeneous literature on participation. To exemplify these dimensions, we use material from a database of 102 contemporary cases of participation, and focus here on cases specific to science and medicine. We describe the stakes of public participation in biomedical research, with a focus on genomic medicine and lay out the seven dimensions.
    Discussion: We single out five cases of participation that have particular relevance to the field of genomic medicine, we apply the seven dimensions to show how we can differentiate among forms of participation within this domain.
    Summary: We conclude with some provocations to researchers and some recommendations for taking variation in participation more seriously.
    Language English
    Publishing date 2014-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2484394-5
    ISSN 1756-994X
    ISSN 1756-994X
    DOI 10.1186/gm525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Beyond Implications and Applications: the Story of 'Safety by Design'

    M Kelty, Christopher

    Nanoethics

    2009  Volume 3, Issue 2, Page(s) 79–96

    Abstract: Using long-term anthropological observations at the Center for Biological and Environmental Nanotechnology in Houston, Texas, the article demonstrates in detail the creation of new objects, new venues and new modes of veridiction which have reoriented ... ...

    Abstract Using long-term anthropological observations at the Center for Biological and Environmental Nanotechnology in Houston, Texas, the article demonstrates in detail the creation of new objects, new venues and new modes of veridiction which have reoriented the disciplines of materials chemistry and nanotoxicology. Beginning with the confusion surrounding the meaning of 'implications' and 'applications' the article explores the creation of new venues (CBEN and its offshoot the International Council on Nanotechnology); it then demonstrates how the demands for a responsible, safe or ethical science were translated into new research and experiment in and through these venues. Finally it shows how 'safety by design' emerged as a way to go beyond implications and applications, even as it introduced a whole new array of controversies concerning its viability, validity and legitimacy.
    Language English
    Publishing date 2009-09-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2424594-X
    ISSN 1871-4765 ; 1871-4757
    ISSN (online) 1871-4765
    ISSN 1871-4757
    DOI 10.1007/s11569-009-0066-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editor's quiz: Oesophagogastric fistula: a post-operative complication.

    Alzaraa, A / Kelty, C / Jacob, G / White, D

    Gut

    2007  Volume 56, Issue 9, Page(s) 1225, 1231

    MeSH term(s) Adult ; Endoscopy, Gastrointestinal ; Esophageal Fistula/etiology ; Gastric Fistula/etiology ; Gastroesophageal Reflux/surgery ; Humans ; Male ; Postoperative Complications/etiology
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.2006.105551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Re-epithelialisation of Barrett's oesophagus.

    Kelty, C / Ackroyd, R

    Gut

    2001  Volume 48, Issue 4, Page(s) 580

    MeSH term(s) Adenocarcinoma/pathology ; Barrett Esophagus/pathology ; Barrett Esophagus/surgery ; Esophageal Neoplasms/pathology ; Humans ; Precancerous Conditions/pathology ; Precancerous Conditions/surgery ; Risk Factors
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.48.4.580a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Re-epithelialisation of Barrett's oesophagus.

    Kelty, C / Ackroyd, R

    Gut

    2001  Volume 47, Issue 5, Page(s) 741

    MeSH term(s) Adenocarcinoma/etiology ; Barrett Esophagus/surgery ; Esophageal Neoplasms/etiology ; Humans ; Postoperative Complications ; Risk Factors
    Language English
    Publishing date 2001-02-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.47.5.741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Quantitative CrAssphage PCR Assays for Human Fecal Pollution Measurement.

    Stachler, Elyse / Kelty, Catherine / Sivaganesan, Mano / Li, Xiang / Bibby, Kyle / Shanks, Orin C

    Environmental science & technology

    2017  Volume 51, Issue 16, Page(s) 9146–9154

    Abstract: Environmental waters are monitored for fecal pollution to protect public health and water resources. Traditionally, general fecal-indicator bacteria are used; however, they cannot distinguish human fecal waste from other animal pollution sources. ... ...

    Abstract Environmental waters are monitored for fecal pollution to protect public health and water resources. Traditionally, general fecal-indicator bacteria are used; however, they cannot distinguish human fecal waste from other animal pollution sources. Recently, a novel bacteriophage, crAssphage, was discovered by metagenomic data mining and reported to be abundant in and closely associated with human fecal waste. To confirm bioinformatic predictions, 384 primer sets were designed along the length of the crAssphage genome. Based on initial screening, two novel crAssphage qPCR assays (CPQ_056 and CPQ_064) were designed and evaluated in reference fecal samples and water matrices. The assays exhibited high specificities (98.6%) when tested against an animal fecal reference library, and crAssphage genetic markers were highly abundant in raw sewage and sewage-impacted water samples. In addition, CPQ_056 and CPQ_064 performance was compared to HF183/BacR287 and HumM2 assays in paired experiments. Findings confirm that viral crAssphage qPCR assays perform at a similar level to well-established bacterial human-associated fecal-source-identification approaches. These new viral-based assays could become important water quality management and research tools.
    MeSH term(s) Animals ; Bacteria ; Feces ; Humans ; Polymerase Chain Reaction ; Real-Time Polymerase Chain Reaction ; Sewage ; Water Pollution ; Water Quality
    Chemical Substances Sewage
    Language English
    Publishing date 2017-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.7b02703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oesophagogastric fistula: a post-operative complication.

    Alzaraa, A / Kelty, C / Jacob, G / White, D

    BMJ case reports

    2009  Volume 2009, Page(s) bcr2006105551

    Language English
    Publishing date 2009-02-16
    Publishing country England
    Document type Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.2006.105551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Risk of Developing Acute Kidney Injury on the VA ECLS Circuit in Patients with Acute Decompensated Heart Failure

    Reaz, Shams / Loyaga-Rendon, Renzo / Dickinson, Michael G. / Lee, Sangjin / Fitch, Stephen J. / Marco, Greg / Boeve, Theodore / Langholz, David E. / Kelty, Catherine / Shrestha, Nabin Manandhar / Leacche, Marzia / Jovinge, Stefan

    Journal of Cardiac Critical Care TSS

    2022  Volume 06, Issue 01, Page(s) 7–11

    Abstract: Aims: Venoarterial extracorporeal life support (VA ECLS) is a life-saving treatment with a high risk of mortality. Appropriate patient selection is critical for optimal patient outcomes. Acute kidney injury (AKI) is a common risk among VA ECLS patients, ...

    Abstract Aims: Venoarterial extracorporeal life support (VA ECLS) is a life-saving treatment with a high risk of mortality. Appropriate patient selection is critical for optimal patient outcomes. Acute kidney injury (AKI) is a common risk among VA ECLS patients, and more information is needed to understand how AKI affects the mortality risk of these patients. To do this, we examined acute decompensated heart failure (ADHF) patients supported by VA ECLS and compared their risk of developing AKI to a background population. VA ECLS has become an increasingly important tool to bridge or recover patients with severe ADHF as the primary indication of VA ECLS.
    Methods and Results: All VA ECLS patients from a single center were included. ADHF patients supported by VA ECLS were compared with the remaining VA ECLS cohort. CATEGORICAL comparisons were made between groups using chi-squared and Fisher's exact tests. A survival analysis was conducted to determine freedom from AKI between the two groups. Predictor variables were tested by multiple logistic regression. Of the 255 patients included in this study, 110 had ADHF as their primary indication for VA ECLS and 145 patients had other VA ECLS indications. The survival analysis showed that patients with ADHF had a decreased risk of developing AKI on the VA ECLS circuit. Multiple logistic regression revealed no predictors in AKI development between groups and no difference in 30-day mortality was observed.
    Conclusion: Patients supported by VA ECLS are at high risk of mortality and complications. This research demonstrated that medically complex ADHF patients had less chance of developing AKI when compared with other patients supported by VA ECLS. Future research is needed to investigate potential protective mechanisms of VA ECLS support.
    Keywords extracorporeal membrane oxygenation ; acute kidney injury ; acute decompensated heart failure
    Language English
    Publishing date 2022-01-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2456-9224
    ISSN (online) 2456-9224
    DOI 10.1055/s-0042-1750191
    Database Thieme publisher's database

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