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  1. Book ; Online ; Thesis: CRISPR-Cas9-mediated gene editing in primary human B cells identifies critical cellular factors for Epstein-Barr virus infection

    Akidil, Ezgi [Verfasser] / Kempkes, Bettina [Akademischer Betreuer]

    2023  

    Author's details Ezgi Akidil ; Betreuer: Bettina Kempkes
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Book ; Online ; Thesis: A systematic analysis of Epstein-Barr virus genes and their individual contribution to virus production and composition reveals critical downstream functions

    Chen, Yen-Fu Adam [Verfasser] / Kempkes, Bettina [Akademischer Betreuer]

    2021  

    Author's details Yen-Fu Adam Chen ; Betreuer: Bettina Kempkes
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online ; Thesis: Inhibition of PLK1-dependent phosphorylation of EBNA2 promotes EBV-induced carcinogenesis in humanized mice

    Zhang, Xiang [Verfasser] / Kempkes, Bettina [Akademischer Betreuer]

    2021  

    Author's details Xiang Zhang ; Betreuer: Bettina Kempkes
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Book ; Online ; Thesis: The glycoprotein gp350 of EBV - an in vivo antigen and a promising druggable target molecule

    Fiestas Cárcaba, Elena [Verfasser] / Kempkes, Bettina [Akademischer Betreuer]

    2021  

    Author's details Elena Fiestas Cárcaba ; Betreuer: Bettina Kempkes
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: The role of the EBNA2-EBF1 complex in EBV driven B cell transformation

    Beer, Sophie [Verfasser] / Kempkes, Bettina [Akademischer Betreuer]

    2021  

    Author's details Sophie Beer ; Betreuer: Bettina Kempkes
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: EBNA2 and Its Coactivator EBNA-LP.

    Kempkes, Bettina / Ling, Paul D

    Current topics in microbiology and immunology

    2015  Volume 391, Page(s) 35–59

    Abstract: While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription ... ...

    Abstract While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
    MeSH term(s) Animals ; B-Lymphocytes/virology ; Cell Transformation, Viral ; Epstein-Barr Virus Infections/virology ; Epstein-Barr Virus Nuclear Antigens/genetics ; Epstein-Barr Virus Nuclear Antigens/metabolism ; Gene Expression Regulation, Viral ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/metabolism ; Humans ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances EBNA-2 protein, Human herpesvirus 4 ; EBNA-LP protein, Human herpesvirus 4 ; Epstein-Barr Virus Nuclear Antigens ; Viral Proteins
    Language English
    Publishing date 2015
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-319-22834-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.

    Beer, Sophie / Wange, Lucas E / Zhang, Xiang / Kuklik-Roos, Cornelia / Enard, Wolfgang / Hammerschmidt, Wolfgang / Scialdone, Antonio / Kempkes, Bettina

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 30, Page(s) e2200512119

    Abstract: Epstein-Barr virus (EBV) is a human tumor virus which preferentially infects resting human B cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent protein EBV nuclear antigen 2 (EBNA2) is essential for B cell ... ...

    Abstract Epstein-Barr virus (EBV) is a human tumor virus which preferentially infects resting human B cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent protein EBV nuclear antigen 2 (EBNA2) is essential for B cell activation and immortalization; it targets and binds the cellular and ubiquitously expressed DNA-binding protein CBF1, thereby transactivating a plethora of viral and cellular genes. In addition, EBNA2 uses its N-terminal dimerization (END) domain to bind early B cell factor 1 (EBF1), a pioneer transcription factor specifying the B cell lineage. We found that EBNA2 exploits EBF1 to support key metabolic processes and to foster cell cycle progression of infected B cells in their first cell cycles upon activation. The α1-helix within the END domain was found to promote EBF1 binding. EBV mutants lacking the α1-helix in EBNA2 can infect and activate B cells efficiently, but activated cells fail to complete the early S phase of their initial cell cycle. Expression of
    MeSH term(s) B-Lymphocytes/immunology ; B-Lymphocytes/virology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Nuclear Antigens/genetics ; Epstein-Barr Virus Nuclear Antigens/metabolism ; Gene Expression Regulation ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/metabolism ; Humans ; Proto-Oncogene Proteins c-myc/genetics ; S Phase ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances EBF1 protein, human ; EBNA-2 protein, Human herpesvirus 4 ; Epstein-Barr Virus Nuclear Antigens ; MYC protein, human ; Proto-Oncogene Proteins c-myc ; Trans-Activators ; Viral Proteins
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2200512119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Epstein-Barr virus latency: current and future perspectives.

    Kempkes, Bettina / Robertson, Erle S

    Current opinion in virology

    2015  Volume 14, Page(s) 138–144

    Abstract: EBV drives resting B cells to continuous proliferating latently infected cells. A restricted program of viral transcription contributes to latency and cell proliferation important for growth transformation. Recent interest in latency and transformation ... ...

    Abstract EBV drives resting B cells to continuous proliferating latently infected cells. A restricted program of viral transcription contributes to latency and cell proliferation important for growth transformation. Recent interest in latency and transformation has provided new data about the roles of the EBV encoded latent proteins and non-coding RNAs. We broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin chain assembly complex and TRAF1 which are important for transformation. This review explores recent discoveries with new insights into therapeutic avenues for EBV related malignancies.
    MeSH term(s) Carcinogenesis ; Gene Expression Regulation ; Herpesvirus 4, Human/physiology ; Host-Pathogen Interactions ; Humans ; Virus Latency
    Language English
    Publishing date 2015-11-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2015.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Dissecting the role of selenothiol- versus thiol-based catalysis using the model enzyme glutathione peroxidase 4 (GPx4)

    Mannes, Alexander Markward / Kempkes, Bettina

    2014  

    Author's details Alexander Markward Mannes. Betreuer: Bettina Kempkes
    Language English
    Size Online-Ressource
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis München, Ludwig-Maximilians-Universität, Diss., 2014
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book ; Online ; Thesis: Dissecting the role of selenothiol- versus thiol-based catalysis using the model enzyme glutathione peroxidase 4 (GPx4)

    Mannes, Alexander Markward / Kempkes, Bettina

    2014  

    Author's details Alexander Markward Mannes. Betreuer: Bettina Kempkes
    Language English
    Size Online-Ressource
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis München, Ludwig-Maximilians-Universität, Diss., 2014
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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