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Article: Impaired Testicular Function without Altering Testosterone Concentration Using an Anti-Follicular-Stimulating Hormone Receptor (Anti-FSHr) Single-Chain Variable Fragment (scFv) in Long-Tailed Macaques (

Navanukraw, Pakpoom / Chotimanukul, Sroisuda / Kemthong, Taratorn / Choowongkomon, Kiattawee / Chatdarong, Kaywalee

Animals : an open access journal from MDPI

2023 Volume 13, Issue 14

Abstract: FSHr antibodies have been shown to inhibit the differentiation of spermatogonia to primary spermatocytes, resulting in infertility without a pathological effect on reproductive organs. The aim of this study was to develop single-chain variable fragments ( ...

Abstract	FSHr antibodies have been shown to inhibit the differentiation of spermatogonia to primary spermatocytes, resulting in infertility without a pathological effect on reproductive organs. The aim of this study was to develop single-chain variable fragments (scFvs) against the follicular-stimulating hormone receptor (anti-FSHr) using phage-display technology and to evaluate the effects of intratesticular administration of the anti-FSHr scFv on testicular function and testosterone production. A phage clone against the extracellular domain of FSHr selected from a scFv phagemid library was analyzed for binding kinetics by surface plasmon resonance. Using ultrasound guidance, three adult macaques (
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13142282
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Article ; Online: Impaired Testicular Function without Altering Testosterone Concentration Using an Anti-Follicular-Stimulating Hormone Receptor (Anti-FSHr) Single-Chain Variable Fragment (scFv) in Long-Tailed Macaques (Macaca fascicularis)

Navanukraw, Pakpoom / Chotimanukul, Sroisuda / Kemthong, Taratorn / Choowongkomon, Kiattawee / Chatdarong, Kaywalee

Animals. 2023 July 12, v. 13, no. 14

2023

Abstract	FSHr antibodies have been shown to inhibit the differentiation of spermatogonia to primary spermatocytes, resulting in infertility without a pathological effect on reproductive organs. The aim of this study was to develop single-chain variable fragments (scFvs) against the follicular-stimulating hormone receptor (anti-FSHr) using phage-display technology and to evaluate the effects of intratesticular administration of the anti-FSHr scFv on testicular function and testosterone production. A phage clone against the extracellular domain of FSHr selected from a scFv phagemid library was analyzed for binding kinetics by surface plasmon resonance. Using ultrasound guidance, three adult macaques (M. fascicularis) were administered with 1 mL of 0.4 mg/mL anti-FSHr scFv (treatment) and 1 mL sterile phosphate buffer solution (control) into the left and right rete testis, respectively. Testicular appearance and volume, ejaculate quality, and serum testosterone levels were recorded on day 0 (before injection) and on days 7, 28, and 56 (after injection). Testicular tissue biopsies were performed on day 7 and day 56 to quantify the mRNA expressions of androgen binding protein (ABP), inhibin subunit beta B (IHBB), and vascular endothelial growth factor A (VEGFA). The results demonstrated that the anti-FSHr scFv molecule was calculated as 27 kDa with a dissociation constant (KD) of 1.03 µM. The volume of the anti-FSHr scFv-injected testicle was reduced on days 28 and 56 compared with day 0 (p < 0.05). Total sperm number was reduced from day 0 (36.4 × 10⁶ cells) to day 56 (1.6 × 10⁶ cells) (p < 0.05). The percentage of sperm motility decreased from day 0 (81.7 ± 1.0%) to day 7 (23.3 ± 1.9%), day 28 (41.7 ± 53.4%), and day 56 (8.3 ± 1.9%) (p < 0.05). Sperm viability on day 0 was 86.8 ± 0.5%, which reduced to 64.2 ± 1.5%, 67.1 ± 2.2%, and 9.3 ± 1.1% on days 7, 28, and 56, respectively (p < 0.05). The expression of ABP and VEGFA on days 7 (14.2- and 3.2-fold) and 56 (5.6- and 5.5-fold) was less in the scFv-treated testicle compared with the controls (p < 0.05). On day 56, the expression of IHBB was less (p < 0.05) in the treated testis (1.3-fold) compared with the controls. Serum testosterone levels were unchanged throughout the study period (p > 0.05). This study characterized the anti-FSHr scFv and demonstrated that treatment with anti-FSHr ameliorates testicular function without altering testosterone levels, offering a potential alternative contraceptive for the long-tailed macaques.
Keywords	Macaca fascicularis ; adults ; bacteriophages ; blood serum ; contraceptives ; dissociation ; hormone receptors ; inhibin ; phosphates ; rete testis ; sperm motility ; spermatocytes ; spermatogonia ; spermatozoa ; surface plasmon resonance ; testosterone ; ultrasonics ; vascular endothelial growth factor A ; viability
Language	English
Dates of publication	2023-0712
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13142282
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Article ; Online: Alteration of gut microbiota in wild-borne long-tailed macaques after 1-year being housed in hygienic captivity.

Sawaswong, Vorthon / Chanchaem, Prangwalai / Kemthong, Taratorn / Warit, Saradee / Chaiprasert, Angkana / Malaivijitnond, Suchinda / Payungporn, Sunchai

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5842

Abstract: The wild-born long-tailed macaques (Macaca fascicularis) were recently recruited and used as breeders for the National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU), and changes in their in-depth gut microbiota profiles were ... ...

Abstract	The wild-born long-tailed macaques (Macaca fascicularis) were recently recruited and used as breeders for the National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU), and changes in their in-depth gut microbiota profiles were investigated. The Oxford Nanopore Technology (ONT) was used to explore full-length 16S rDNA sequences of gut microbiota in animals once captured in their natural habitat and 1-year following translocation and housing in a hygienic environment at NPRCT-CU. Our findings show that the gut microbiota of macaques after 1 year of hygienic housing and programmed diets feeding was altered and reshaped. The prevalent gut bacteria such as Prevotella copri and Faecalibacterium prausnitzii were enriched after translocation, causing the lower alpha diversity. The correlation analysis revealed that Prevotella copri, Phascolarctobacterium succinatutens, and Prevotella stercorea, showed a positive correlation with each other. Significantly enriched pathways in the macaques after translocation included biosynthesis of essential amino acids, fatty acids, polyamine and butanoate. The effects of microbiota change could help macaques to harvest the energy from programmed diets and adapt their gut metabolism. The novel probiotics and microbiota engineering approach could be further developed based on the current findings and should be helpful for captive animal health care management.
MeSH term(s)	Animals ; Gastrointestinal Microbiome ; Housing ; Macaca fascicularis
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33163-6
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Article ; Online: Development of Quantitative Real-Time PCR and Loop-Mediated Isothermal Amplification Assays for the Surveillance and Diagnosis of Herpes B Virus Infection.

Amano, Murasaki / Sapkanarak, Krittiga / Thbthimthong, Wipaporn / Meesawat, Suthirote / Kemthong, Taratorn / Suttisan, Nutchanat / Abe, Haruka / Malaivijitnond, Suchinda / Yasuda, Jiro

Viruses

2023 Volume 15, Issue 10

Abstract: Herpes B virus (BV) is a zoonotic virus which can be transmitted from macaques to humans, which is often associated with high mortality rates. Because macaques often exhibit asymptomatic infections, individuals who come into contact with these animals ... ...

Abstract	Herpes B virus (BV) is a zoonotic virus which can be transmitted from macaques to humans, which is often associated with high mortality rates. Because macaques often exhibit asymptomatic infections, individuals who come into contact with these animals face unexpected risks of BV infections. A serological test is widely performed to investigate BV infections. However, the assay's sensitivity and specificity appeared to be inadequate, and it does not necessarily indicate ongoing viral shedding. Here, we developed LAMP and qPCR assays aiming to detect BVs with a high sensitivity and specificity in various macaque species and validated them using oral swab samples collected from 97 wild cynomolgus macaques living in Thailand. Our LAMP and qPCR assays detected more than 50 and 10 copies of the target sequences per reaction, respectively. The LAMP assay could detect BV within 25 min, indicating its advantages for the rapid detection of BV. Collectively, our findings indicated that both assays developed in this study exhibit advantages and usefulness for BV surveillance and the diagnosis of BV infections in macaques. Furthermore, for the first time, we determined the partial genome sequences of BVs detected in cynomolgus macaques in Thailand. Phylogenetic analysis revealed the species-specific evolution of BV within macaques.
MeSH term(s)	Humans ; Animals ; Herpesvirus 1, Cercopithecine/genetics ; Real-Time Polymerase Chain Reaction ; Phylogeny ; Herpesviridae Infections/diagnosis ; Herpesviridae Infections/veterinary ; Nucleic Acid Amplification Techniques ; Molecular Diagnostic Techniques ; Sensitivity and Specificity ; Macaca fascicularis
Language	English
Publishing date	2023-10-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15102086
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Article ; Online: Advancing tuberculosis diagnosis and management in cynomolgus macaques using Xpert MTB/RIF ultra assay.

Srilohasin, Prapaporn / Warit, Saradee / Prammananan, Therdsak / Smithtikarn, Saijai / Kanitpun, Reka / Kaewparuehaschai, Mutchamon / Noradechanon, Kirana / Meesawat, Suthirote / Thakaew, Nattakan / Sakulwittayasuk, Nonthakorn / Kemthong, Taratorn / Palaga, Tanapat / Malaivijitnond, Suchinda / Chaiprasert, Angkana

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1518

Abstract: The detection and management of Mycobacterium tuberculosis complex (MTBC) infection, the causative agent of tuberculosis (TB), in macaques, including cynomolgus macaques (Macaca fascicularis), are of significant concern in research and regions where ... ...

Abstract	The detection and management of Mycobacterium tuberculosis complex (MTBC) infection, the causative agent of tuberculosis (TB), in macaques, including cynomolgus macaques (Macaca fascicularis), are of significant concern in research and regions where macaques coexist with humans or other animals. This study explored the utility of the Xpert MTB/RIF Ultra assay, a widely adopted molecular diagnostic tool to diagnose tuberculosis (TB) in humans, to detect DNA from the Mycobacterium tuberculosis complex in clinical samples obtained from cynomolgus macaques. This investigation involved a comprehensive comparative analysis, integrating established conventional diagnostic methodologies, assessing oropharyngeal-tracheal wash (PW) and buccal swab (BS) specimen types, and follow-up assessments at 3-month, 6-month, and 12-month intervals. Our results demonstrated that the Xpert MTB/RIF Ultra assay was able to detect MTBC in 12 of 316 clinical samples obtained from cynomolgus macaques, presenting a potential advantage over bacterial culture and chest radiographs. The Xpert MTB/RIF Ultra assay exhibited exceptional sensitivity (100%) at the animal level, successfully detecting all macaques positive for M. tuberculosis as confirmed by traditional culture methods. The use of PW samples revealed that 5 positive samples from 99 (5.1%) were recommended for testing, compared to 0 samples from 99 buccal swab (BS) samples (0.0%). In particular, the definitive diagnosis of TB was confirmed in three deceased macaques by MTB culture, which detected the presence of the bacterium in tissue autopsy. Our findings demonstrate that the implementation of the Xpert MTB/RIF Ultra assay, along with prompt isolation measures, effectively reduced active TB cases among cynomolgus macaques over a 12-month period. These findings highlight the advance of the Xpert MTB/RIF Ultra assay in TB diagnosis and its crucial role in preventing potential outbreaks in cynomolgus macaques. With its rapidity, high sensitivity, and specificity, the Xpert MTB/RIF Ultra assay can be highly suitable for use in reference laboratories to confirm TB disease and effectively interrupt TB transmission.
MeSH term(s)	Animals ; Humans ; Tuberculosis, Pulmonary/microbiology ; Rifampin/pharmacology ; Macaca fascicularis ; Sensitivity and Specificity ; Tuberculosis/diagnosis ; Tuberculosis/veterinary ; Tuberculosis/drug therapy ; Mycobacterium tuberculosis ; Sputum/microbiology ; Antibiotics, Antitubercular/therapeutic use ; Drug Resistance, Bacterial/genetics
Chemical Substances	Rifampin (VJT6J7R4TR) ; Antibiotics, Antitubercular
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51824-y
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Article ; Online: Full-length 16S rDNA sequencing based on Oxford Nanopore Technologies revealed the association between gut-pharyngeal microbiota and tuberculosis in cynomolgus macaques.

Sawaswong, Vorthon / Chanchaem, Prangwalai / Klomkliew, Pavit / Rotcheewaphan, Suwatchareeporn / Meesawat, Suthirote / Kemthong, Taratorn / Kaewparuehaschai, Mutchamon / Noradechanon, Kirana / Ekatat, Monya / Kanitpun, Reka / Srilohasin, Prapaporn / Warit, Saradee / Chaiprasert, Angkana / Malaivijitnond, Suchinda / Payungporn, Sunchai

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3404

Abstract: Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis complex (Mtbc), which develops from asymptomatic latent TB to active stages. The microbiome was purposed as a potential factor affecting TB pathogenesis, but the study ... ...

Abstract	Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis complex (Mtbc), which develops from asymptomatic latent TB to active stages. The microbiome was purposed as a potential factor affecting TB pathogenesis, but the study was limited. The present study explored the association between gut-pharyngeal microbiome and TB stages in cynomolgus macaques using the full-length 16S rDNA amplicon sequencing based on Oxford Nanopore Technologies. The total of 71 macaques was divided into TB (-) control, TB (+) latent and TB (+) active groups. The differential abundance analysis showed that Haemophilus hemolyticus was decreased, while Prevotella species were increased in the pharyngeal microbiome of TB (+) macaques. In addition, Eubacterium coprostanoligenes in the gut was enriched in TB (+) macaques. Alteration of these bacteria might affect immune regulation and TB severity, but details of mechanisms should be further explored and validated. In summary, microbiota may be associated with host immune regulation and affect TB progression. The findings suggested the potential mechanisms of host-microbes interaction, which may improve the understanding of the role of microbiota and help develop therapeutics for TB in the future.
MeSH term(s)	Animals ; Nanopores ; Tuberculosis/microbiology ; Gastrointestinal Microbiome/genetics ; Microbiota/genetics ; Macaca fascicularis/genetics ; RNA, Ribosomal, 16S/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53880-w
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Article ; Online: Ultrasensitive malaria detection system for Anopheles mosquito field surveillance using droplet digital PCR.

Araki, Tamasa / Koyama, Akihide / Yoshimura, Hiro / Arai, Ayako / Kawai, Satoru / Sekizawa, Shuto / Umeki, Yuko / Saito-Nakano, Yumiko / Imai, Takashi / Okamoto, Munehiro / Sato, Megumi / Thabthimthong, Wipaporn / Kemthong, Taratorn / Hisaeda, Hajime / Malaivijitnond, Suchinda / Annoura, Takeshi

Parasitology international

2024 Volume 101, Page(s) 102891

Abstract: Malaria remains a significant global public health concern, with a recent increase in the number of zoonotic malaria cases in Southeast Asian countries. However, limited reports on the vector for zoonotic malaria exist owing to difficulties in detecting ... ...

Abstract	Malaria remains a significant global public health concern, with a recent increase in the number of zoonotic malaria cases in Southeast Asian countries. However, limited reports on the vector for zoonotic malaria exist owing to difficulties in detecting parasite DNA in Anopheles mosquito vectors. Herein, we demonstrate for the first time that several Anopheles mosquitoes contain simian malaria parasite DNA using droplet digital PCR (ddPCR), a highly sensitive PCR method. An entomological survey was conducted to identify simian malaria vector species at Phra Phothisat Temple (PPT), central Thailand, recognized for a high prevalence of simian malaria in wild cynomolgus macaques. A total of 152 mosquitoes from six anopheline species were collected and first analyzed by a standard 18S rRNA nested-PCR analysis for malaria parasite which yielded negative results in all collected mosquitoes. Later, ddPCR was used and could detect simian malaria parasite DNA, i.e. Plasmodium cynomolgi, in 25 collected mosquitoes. And this is the first report of simian malaria parasite DNA detection in Anopheles sawadwongporni. This finding proves that ddPCR is a powerful tool for detecting simian malarial parasite DNA in Anopheles mosquitoes and can expand our understanding of the zoonotic potential of malaria transmission between monkeys and humans.
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2024.102891
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Article: Oral-fecal mycobiome in wild and captive cynomolgus macaques (Macaca fascicularis)

Sawaswong, Vorthon / Chanchaem, Prangwalai / Khamwut, Ariya / Praianantathavorn, Kesmanee / Kemthong, Taratorn / Malaivijitnond, Suchinda / Payungporn, Sunchai

Fungal genetics and biology. 2020 Nov., v. 144

2020

Abstract: Cynomolgus macaque (Macaca fascicularis) is currently a common animal model for biomedical research. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) translocated wild-borne macaques to reared colony for research ... ...

Abstract	Cynomolgus macaque (Macaca fascicularis) is currently a common animal model for biomedical research. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) translocated wild-borne macaques to reared colony for research purposes. At present, no studies focus on fungal microbiome (Mycobiome) of this macaque. The functional roles of mycobiome and fungal pathogens have not been elucidated. Thus, this study aimed to investigate and compare oral and fecal mycobiome between wild and captive macaques by using high-throughput sequencing on internal transcribed spacer 2 (ITS2) rDNA. The results showed that the mycobiome of wild macaque has greater alpha diversity. The fecal mycobiome has more limited alpha diversity than those in oral cavity. The community is mainly dominated by saprophytic yeast in Kasachstania genus which is related to aiding metabolic function in gut. The oral microbiome of most captive macaques presented the Cutaneotrichosporon suggesting the fungal transmission through skin-oral contact within the colony. The potential pathogens that would cause harmful transmission in reared colonies were not found in either group of macaques but the pathogen prevention and animal care is still important to be concerned. In conclusion, the results of gut mycobiome analysis in Thai cynomolgus macaques provide us with the basic information of oral and fecal fungi and for monitoring macaque's health status for animal care of research use.
Keywords	Cutaneotrichosporon ; Macaca fascicularis ; animal care ; animal models ; biochemical pathways ; biomedical research ; health status ; internal transcribed spacers ; microbial genetics ; microbiome ; mouth ; pathogens ; saprophytes ; species diversity ; yeasts ; Thailand
Language	English
Dates of publication	2020-11
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1319820-8
ISSN	1096-0937 ; 1087-1845 ; 0147-5975
ISSN (online)	1096-0937
ISSN	1087-1845 ; 0147-5975
DOI	10.1016/j.fgb.2020.103468
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Article ; Online: Oral-fecal mycobiome in wild and captive cynomolgus macaques (Macaca fascicularis).

Sawaswong, Vorthon / Chanchaem, Prangwalai / Khamwut, Ariya / Praianantathavorn, Kesmanee / Kemthong, Taratorn / Malaivijitnond, Suchinda / Payungporn, Sunchai

Fungal genetics and biology : FG & B

2020 Volume 144, Page(s) 103468

Abstract	Cynomolgus macaque (Macaca fascicularis) is currently a common animal model for biomedical research. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) translocated wild-borne macaques to reared colony for research purposes. At present, no studies focus on fungal microbiome (Mycobiome) of this macaque. The functional roles of mycobiome and fungal pathogens have not been elucidated. Thus, this study aimed to investigate and compare oral and fecal mycobiome between wild and captive macaques by using high-throughput sequencing on internal transcribed spacer 2 (ITS2) rDNA. The results showed that the mycobiome of wild macaque has greater alpha diversity. The fecal mycobiome has more limited alpha diversity than those in oral cavity. The community is mainly dominated by saprophytic yeast in Kasachstania genus which is related to aiding metabolic function in gut. The oral microbiome of most captive macaques presented the Cutaneotrichosporon suggesting the fungal transmission through skin-oral contact within the colony. The potential pathogens that would cause harmful transmission in reared colonies were not found in either group of macaques but the pathogen prevention and animal care is still important to be concerned. In conclusion, the results of gut mycobiome analysis in Thai cynomolgus macaques provide us with the basic information of oral and fecal fungi and for monitoring macaque's health status for animal care of research use.
MeSH term(s)	Animals ; DNA, Ribosomal Spacer/genetics ; Feces/microbiology ; Fungi/classification ; Fungi/genetics ; Fungi/isolation & purification ; Genetic Variation/genetics ; High-Throughput Nucleotide Sequencing ; Macaca fascicularis/genetics ; Macaca fascicularis/microbiology ; Mouth/microbiology ; Mycobiome/genetics
Chemical Substances	DNA, Ribosomal Spacer
Language	English
Publishing date	2020-09-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1319820-8
ISSN	1096-0937 ; 1087-1845 ; 0147-5975
ISSN (online)	1096-0937
ISSN	1087-1845 ; 0147-5975
DOI	10.1016/j.fgb.2020.103468
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Article ; Online: Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys.

Namken, Sureerat / Songvut, Phanit / Nuengchamnong, Nitra / Kemthong, Taratorn / Khemawoot, Phisit / Malaivijitnond, Suchinda

Planta medica

2020 Volume 87, Issue 5, Page(s) 395–403

Abstract: ... Pueraria ... ...

Abstract	Pueraria mirifica
MeSH term(s)	Animals ; Female ; Isoflavones ; Macaca fascicularis ; Phytoestrogens ; Plant Extracts ; Pueraria ; Thailand
Chemical Substances	Isoflavones ; Phytoestrogens ; Plant Extracts ; puerarin (Z9W8997416)
Language	English
Publishing date	2020-10-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1271-7092
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