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Article ; Online: Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests

Hiroshige Mori / Hanaka Machimura / Amika Iwaya / Masaru Baba / Ken Furuya

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 ... ...

Abstract	Abstract The liver-spleen contrast (LSC) using hepatobiliary-phase images could replace the receptor index (LHL15) in liver scintigraphy; however, few comparative studies exist. This study aimed to verify the convertibility from LSC into LHL15. In 136 patients, the LSC, not at 20 min, but at 60 min after injecting gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid was compared with the LHL15, albumin–bilirubin (ALBI) score, and the related laboratory parameters. The LHL15 was also compared with their biochemical tests. The correlation coefficients of LSC with LHL15, ALBI score, total bilirubin, and albumin were 0.740, –0.624, –0.606, and 0.523 (P < 0.00001), respectively. The correlation coefficients of LHL15 with ALBI score, total bilirubin, and albumin were –0.647, –0.553, and 0.569 (P < 0.00001), respectively. The linear regression equation on the estimated LHL15 (eLHL15) from LSC was eLHL15 = 0.460 · LSC + 0.727 (P < 0.00001) and the coefficient of determination was 0.548. Regarding a contingency table using imaging-based clinical stage classification, the degree of agreement between eLHL15 and LHL15 was 65.4%, and Cramer's V was 0.568 (P < 0.00001). Therefore, although the LSC may be influenced by high total bilirubin, the eLHL15 can replace the LSC as an index to evaluate liver function.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Takako Masuda / Keisuke Inomura / Naoto Takahata / Takuhei Shiozaki / Yuji Sano / Curtis Deutsch / Ondřej Prášil / Ken Furuya

Communications Biology, Vol 6, Iss 1, Pp 1-

Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations

2023 Volume 1

Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication

Masato Nakai / Yoshiya Yamamoto / Masaru Baba / Goki Suda / Akinori Kubo / Yoshimasa Tokuchi / Takashi Kitagataya / Ren Yamada / Taku Shigesawa / Kazuharu Suzuki / Akihisa Nakamura / Takuya Sho / Kenichi Morikawa / Koji Ogawa / Ken Furuya / Naoya Sakamoto

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 10

Abstract: Abstract Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors ... ...

Abstract	Abstract Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age ≥ 71 years (hazard ratio [HR]: 3.402) and LSM ≥ 9.2 kPa (HR: 6.328); SVR24 factors were age ≥ 71 years (HR: 2.689) and LSM ≥ 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (≥ 9.2 kPa) and SVR24 LSM (≥ 8.4 kPa) and age (≥ 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exploring the effect of psychometric variables on willingness to pay for marine ecosystem services: A survey in Japan

Wakita, Kazumi / Hisashi Kurokura / Taro Oishi / Zhonghua Shen / Ken Furuya

Ecosystem services. 2019 Feb., v. 35

2019

Abstract: This study examined psychometric variables that would make differences in people’s willingness to pay (WTP) for conserving marine ecosystem services (MES) based on a large-scale survey in Japan. Among various MES, we selected “the ocean’s CO2 absorption ... ...

Abstract	This study examined psychometric variables that would make differences in people’s willingness to pay (WTP) for conserving marine ecosystem services (MES) based on a large-scale survey in Japan. Among various MES, we selected “the ocean’s CO2 absorption capacity” as an invisible object having little connection to people’s daily lives. At the opposite end of the invisible services, “fishery resources (FR)” were taken as visible objects for comparison to make understanding the valuation of invisible services more explicit. For both the 10-year and the 100-year scenarios, the marginal WTP to prevent a 1% CO2 increase by maintaining the ocean’s CO2 absorption capacity was larger than that to prevent a 1% FR decrease. The analysis revealed that the respondents with a higher WTP to conserve MES had a higher public spirit and connection with people. On the other hand, free riders had a lower public spirit and connection with both humans and non-humans. These findings are consistent with the Theory of Planned Behavior and the Value-Belief-Norm Theory. That is, strong altruistic values, subjective norms, and biospheric values positively influence the WTP for the environment. The results could serve as a reference for stakeholders considering the introduction of payment for MES.
Keywords	absorption ; biosphere ; carbon dioxide ; ecosystem services ; fishery resources ; humans ; marine ecosystems ; stakeholders ; surveys ; willingness to pay ; Japan
Language	English
Dates of publication	2019-02
Size	p. 130-138.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2681542-4
ISSN	2212-0416
ISSN	2212-0416
DOI	10.1016/j.ecoser.2018.12.003
Database	NAL-Catalogue (AGRICOLA)

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Article: Stable isotopic evidence for the differential contribution of diazotrophs to the epipelagic grazing food chain in the mid‐Pacific Ocean

Horii, Sachiko / Kazutaka Takahashi / Takuhei Shiozaki / Fuminori Hashihama / Ken Furuya

Global ecology and biogeography. 2018 Dec., v. 27, no. 12

2018

Abstract: AIM: Biological nitrogen fixation supports primary production in oligotrophic water, but its link to higher trophic levels has not been described fully on a biogeographical basis. Here, we determine the regional patterns of the contribution of the ... ...

Abstract	AIM: Biological nitrogen fixation supports primary production in oligotrophic water, but its link to higher trophic levels has not been described fully on a biogeographical basis. Here, we determine the regional patterns of the contribution of the combined nitrogen to biological production within the epipelagic layer of the mid‐Pacific Ocean using the isotopic signatures of nitrogen (δ¹⁵N) and carbon (δ¹³C) in the biological components. LOCATION: The mid‐Pacific Ocean along 170° W between the southern subtropical front and the Chukchi Sea. TIME PERIOD: Northern and austral summer in 2013 and 2014. MAJOR TAXA STUDIED: Planktonic and micronektonic biota in the euphotic layer. METHODS: We measured the geographical variations in δ¹⁵N and δ¹³C of the suspended particulate organic matter (POM), mesozooplankton assemblage and micronektonic fish. We analysed the relationships among these values and the environmental variables of temperature, nitrate concentration and biological nitrogen fixation activity along a 12,000‐km meridional transect. RESULTS: The POM δ¹⁵N at 0 m was negatively correlated with in situ N₂ fixation activity in the subtropical region, whereas that in the equatorial and high‐latitude regions was correlated with the nitrate concentration at 0 m. We found that the ratios of the increase in δ¹⁵N to δ¹³C along the grazing food chain were consistent throughout the equatorial and subtropical regions. Cluster analyses based on the stable isotopic signatures in the biotic components revealed that the food chains in the stations within the subtropical mid‐Pacific Ocean were separated into three groups based on the differential contributions of biological nitrogen fixation. MAIN CONCLUSIONS: Distinct food chains from primary to tertiary production sustained by different nitrogen sources, nitrate below the euphotic zone, and diazotrophic nitrogen occur within the same biogeographical provinces in the subtropical mid‐Pacific Ocean. The diazotroph‐dominant community contributes substantially to the apex predators in the central areas of the subtropical gyres.
Keywords	biogeography ; biological production ; carbon ; cluster analysis ; environmental factors ; euphotic zone ; fish ; food chain ; grazing ; latitude ; nitrates ; nitrogen ; nitrogen fixation ; nitrogen-fixing bacteria ; particulate organic matter ; predators ; primary productivity ; stable isotopes ; subtropics ; summer ; temperature ; trophic levels ; zooplankton ; Chukchi Sea
Language	English
Dates of publication	2018-12
Size	p. 1467-1480.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2021283-5
ISSN	1466-8238 ; 1466-822X ; 0960-7447
ISSN (online)	1466-8238
ISSN	1466-822X ; 0960-7447
DOI	10.1111/geb.12823
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nanomolar phosphate supply and its recycling drive net community production in the subtropical North Pacific

Fuminori Hashihama / Ichiro Yasuda / Aki Kumabe / Mitsuhide Sato / Hiroshi Sasaoka / Yosuke Iida / Takuhei Shiozaki / Hiroaki Saito / Jota Kanda / Ken Furuya / Philip W. Boyd / Masao Ishii

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 8

Abstract: Primary productivity in the oligotrophic ocean sustains Earth’s ecosystems, but nutrient concentrations are vanishingly low. Here the authors measure nanomolar macronutrient concentrations in the North Pacific and find that net community production is ... ...

Abstract	Primary productivity in the oligotrophic ocean sustains Earth’s ecosystems, but nutrient concentrations are vanishingly low. Here the authors measure nanomolar macronutrient concentrations in the North Pacific and find that net community production is sustained through high rates of phosphorus recycling.
Keywords	Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Utilization of ammonium by the hydrocarbon-producing microalga, Botryococcus braunii Showa

Nakamura, Hiromasa / Ken Furuya / Natsuki Gonda / Shigeki Matsunaga / Shigeru Okada / Takuhei Shiozaki

Algal research. 2017 July, v. 25

2017

Abstract: As a prospective feedstock for sustainable biofuels, the green microalga Botryococcus braunii race B has attracted significant attention since this colony-forming alga has the ability to accumulate considerable amounts of triterpene hydrocarbons, ... ...

Abstract	As a prospective feedstock for sustainable biofuels, the green microalga Botryococcus braunii race B has attracted significant attention since this colony-forming alga has the ability to accumulate considerable amounts of triterpene hydrocarbons, botryococcenes, in its extracellular matrix. However, its primary metabolism, nutrient uptake and utilization relevant to growth, are still poorly understood in this alga. From this perspective, we investigated the utilization of ammonium by B. braunii as a more reduced form of nitrogen source compared to nitrate, which is generally used for cultures of the alga. Isotope-ratio mass spectrometry analyses indicated that the uptake rate of ammonium was higher than that of nitrate at a certain concentration. When ammonium was added to culture medium, however, it inhibited algal growth even in the presence of nitrate. Buffered culture media ameliorated the toxicity of ammonium, and the alga accumulated the same levels of hydrocarbons and secondary carotenoids, irrespective of nitrogen source. To characterize utilization of ammonium by B. braunii at the molecular level, putative ammonium transporter (AMT) genes were screened from a cDNA library and four isogenes (BbAMT1;1, 1;2, 1;3 and 1;4) were cloned. Two of them, BbAMT1;1 and 1;2, were upregulated under nitrogen deficient conditions. BbAMT1;1 complemented the growth of an ammonium uptake-defective yeast strain, showing it to be a functional gene coding for AMT. These results could pave the way for culturing B. braunii more efficiently using ammonium as a sole nitrogen source by improving ammonium uptake through our understanding of AMT.
Keywords	ammonium ; biofuels ; Botryococcus braunii ; carotenoids ; cDNA libraries ; complementary DNA ; culture media ; extracellular matrix ; feedstocks ; genes ; mass spectrometry ; metabolism ; microalgae ; nitrates ; nitrogen ; nutrient uptake ; toxicity ; triterpenoids ; yeasts
Language	English
Dates of publication	2017-07
Size	p. 445-451.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2211-9264
DOI	10.1016/j.algal.2017.06.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma.

Taku Shigesawa / Goki Suda / Megumi Kimura / Osamu Maehara / Yoshimasa Tokuchi / Akinori Kubo / Ren Yamada / Ken Furuya / Masaru Baba / Takashi Kitagataya / Kazuharu Suzuki / Masatsugu Ohara / Naoki Kawagishi / Masato Nakai / Takuya Sho / Mitsuteru Natsuizaka / Kenichi Morikawa / Koji Ogawa / Naoya Sakamoto

PLoS ONE, Vol 16, Iss 3, p e

2021 Volume 0247728

Abstract: A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after ... ...

Abstract	A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after lenvatinib initiation. Patients with adequate clinical data and baseline preserved serum samples available were included. Baseline fibroblast growth factor (FGF)19 and 21, angiopoietin (ANG)2, and vascular endothelial growth factor (VEGF) levels were evaluated. Thirty-seven patients were included, and 6, 15, 14, and 2 experienced complete response, partial response, stable disease, and progressive disease, respectively. Twenty-four (65%) and 13 (35%) patients showed a maintained/improved and deteriorated Child-Pugh-score, respectively. While baseline clinical data, treatment response, and laboratory data were similar between these two patient groups, baseline ANG2 and VEGF levels were significantly higher (P = 0.0017) and lower (P = 0.0231), respectively, in patients with deteriorated Child-Pugh score than in those without. Based on receiver operating characteristic curve analysis, cut-off values for ANG2 and VEGF were found to be 3,108 pg/mL and 514.9 pg/mL, respectively. Among patients with low VEGF and high ANG2, 89% (8/9) exhibited a deteriorated Child-Pugh score, whereas none of the patients (0/9) with high VEGF and low ANG2 did. The deterioration of the Child-Pugh score in patients with unresectable HCC who are treated with lenvatinib may be predictable based on combined baseline serum ANG2 and VEGF levels.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Liquid waveguide spectrophotometric measurement of nanomolar ammonium in seawater based on the indophenol reaction with o-phenylphenol (OPP)

Hashihama, Fuminori / Jota Kanda / Ami Tauchi / Taketoshi Kodama / Hiroaki Saito / Ken Furuya

Talanta. 2015 Oct. 01, v. 143

2015

Abstract: We describe a highly sensitive colorimetric method for the determination of nanomolar concentrations of ammonium in seawater based on the indophenol reaction with o-phenylphenol [(1,1â²-biphenyl)-2-ol, abbreviated as OPP]. OPP is available as non-toxic, ...

Abstract	We describe a highly sensitive colorimetric method for the determination of nanomolar concentrations of ammonium in seawater based on the indophenol reaction with o-phenylphenol [(1,1â²-biphenyl)-2-ol, abbreviated as OPP]. OPP is available as non-toxic, stable flaky crystals with no caustic odor and has some advantages over phenol in practical use. The method was established by using a gas-segmented continuous flow analyzer equipped with two types of long path liquid waveguide capillary cell, LWCCs (100cm and 200cm) and an UltraPath (200cm), which have inner diameters of 0.55mm and 2mm, respectively. The reagent concentrations, flow rates of the pumping tubes, and reaction path and temperature were determined on the basis of a manual indophenol blue method with OPP (Kanda, Water Res. 29 (1995) 2746â2750). The sample mixed with reagents that form indophenol blue dye was measured at 670nm. Aged subtropical surface water was used as a blank, a matrix of standards, and the carrier. The detection limits of the analytical systems with a 100cm LWCC, a 200cm LWCC, and a 200cm UltraPath were 6, 4, and 4nM, respectively. These systems had high precision (<4% at 100nM) and a linear dynamic range up to 200nM. Non-linear baseline drift did not occur when using the UltraPath system. This is due to the elimination of cell clogging because of the larger inner diameter of the UltraPath compared to the LWCCs. The UltraPath system is thus more suitable for long-term measurements compared with the LWCC systems. The results of the proposed sensitive colorimetry and a conventional colorimetry for the determination of seawater samples showed no significant difference. The proposed analytical systems were applied to underway surface monitoring and vertical observation in the oligotrophic South Pacific.
Keywords	ammonium ; colorimetry ; crystals ; monitoring ; o-phenylphenol ; odors ; phenol ; seawater ; surface water ; temperature
Language	English
Dates of publication	2015-1001
Size	p. 374-380.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2015.05.007
Database	NAL-Catalogue (AGRICOLA)

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Article: Willingness to pay for ecosystem services of open oceans by choice-based conjoint analysis: A case study of Japanese residents

Shen, Zhonghua / Hisashi Kurokura / Kazumi Wakita / Ken Furuya / Nobuyuki Yagi / Robert Blasiak / Taro Oishi

Ocean & coastal management. 2015 Jan., v. 103

2015

Abstract: Today, greater attention has never been dedicated to the challenges of a changing climate and efforts to explore and utilize the open ocean. A range of different valuation data are needed in order to accurately assess the tradeoffs of different ... ...

Abstract	Today, greater attention has never been dedicated to the challenges of a changing climate and efforts to explore and utilize the open ocean. A range of different valuation data are needed in order to accurately assess the tradeoffs of different management regimes. Nevertheless, many aspects of the open ocean remain unstudied, and few case studies have been conducted on the valuation of the open ocean.This study explores the monetary value of open ocean ecosystem service (OPES) using conjoint analysis. A choice experiment with 814 Japanese respondents was conducted to elicit the marginal willingness to pay (WTP) of respondents for three main OPES: fish production, carbon dioxide absorption, and water purification. The case study in Japan found a 1% marginal WTP for fish production, carbon dioxide absorption, and water purification of open oceans with respective average per capita values of USD .06, .19 and .16 per year. We also found variation across different prefecture in WTP trends for the three OPES, implying the influence of traditional food culture, mass media and natural hazards. Differences in WTP trends were also found to depend on income level and gender. The case study included respondents across five income levels. Positive correlations can be observed between marginal WTP and income levels for each of the three OPES. In addition, female respondents were found to have a higher WTP than male respondents for improving each of the three OPES. Therefore, when formulating ecosystem-based management policies related to the open oceans, it is necessary to consider differences in WTP based on region, income, gender and other relative specific factors. This will aide in consensus-building and maximizing cost-benefit outcomes.
Keywords	absorption ; carbon dioxide ; case studies ; climate change ; ecosystem management ; ecosystem services ; females ; fish production ; foodways ; income ; issues and policy ; males ; mass media ; oceans ; traditional foods ; water purification ; willingness to pay ; Japan
Language	English
Dates of publication	2015-01
Size	p. 1-8.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0964-5691
DOI	10.1016/j.ocecoaman.2014.10.016
Database	NAL-Catalogue (AGRICOLA)

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