Article ; Online: Wnt target genes and where to find them [version 1; referees
F1000Research, Vol
3 approved]
2017 Volume 6
Abstract: Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most ...
Abstract | Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most notably cancer. Wnt stimulation results in stabilization and nuclear import of β-catenin, which then acts as a transcriptional co-activator. Transcription factors of the T-cell family (TCF) are the best-characterized nuclear binding partners of β-catenin and mediators of Wnt gene regulation. This review provides an update on what is known about the transcriptional activation of Wnt target genes, highlighting recent work that modifies the conventional model. Wnt/β-catenin signaling regulates genes in a highly context-dependent manner, and the role of other signaling pathways and TCF co-factors in this process will be discussed. Understanding Wnt gene regulation has served to elucidate many biological roles of the pathway, and we will use examples from stem cell biology, metabolism, and evolution to illustrate some of the rich Wnt biology that has been uncovered. |
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Keywords | Cell Growth & Division ; Cell Signaling ; Control of Gene Expression ; Developmental Molecular Mechanisms ; Morphogenesis & Cell Biology ; Nuclear Structure & Function ; Stem Cells & Regeneration ; Medicine ; R ; Science ; Q |
Subject code | 570 |
Language | English |
Publishing date | 2017-05-01T00:00:00Z |
Publisher | F1000 Research Ltd |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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