Article ; Online: Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients.
Nature biomedical engineering
2023 Volume 7, Issue 12, Page(s) 1649–1666
Abstract: The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumour from normal tissue via conventional ... ...
| Abstract | The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumour from normal tissue via conventional fluorescence intensity-based imaging. Here we show that, after systemic injection of the near-infrared dye indocyanine green in patients with various types of solid tumour, the fluorescence lifetime (FLT) of tumour tissue is longer than the FLT of non-cancerous tissue. This tumour-specific shift in FLT can be used to distinguish tumours from normal tissue with an accuracy of over 97% across tumour types, and can be visualized at the cellular level using microscopy and in larger specimens through wide-field imaging. Unlike fluorescence intensity, which depends on imaging-system parameters, tissue depth and the amount of dye taken up by tumours, FLT is a photophysical property that is largely independent of these factors. FLT imaging with indocyanine green may improve the accuracy of cancer surgeries. |
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| MeSH term(s) | Humans ; Indocyanine Green ; Fluorescence ; Neoplasms/diagnostic imaging ; Fluorescent Dyes |
| Chemical Substances | Indocyanine Green (IX6J1063HV) ; Fluorescent Dyes |
| Language | English |
| Publishing date | 2023-10-16 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2157-846X |
| ISSN (online) | 2157-846X |
| DOI | 10.1038/s41551-023-01105-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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