Article ; Online: Fatty acid challenge shifts cellular energy metabolism in a substrate-specific manner in primary bovine neonatal hepatocytes.
2023 Volume 13, Issue 1, Page(s) 15020
Abstract: Adipose tissue mobilization increases circulating fatty acid (FA) concentrations, leads to increased hepatic FA uptake, and influences hepatic metabolism. Our objective was to trace carbon flux through metabolic pathways in primary bovine neonatal ... ...
Abstract | Adipose tissue mobilization increases circulating fatty acid (FA) concentrations, leads to increased hepatic FA uptake, and influences hepatic metabolism. Our objective was to trace carbon flux through metabolic pathways in primary bovine neonatal hepatocytes challenged with FA, and to examine the effect of FA challenge on oxidative stress. Primary bovine neonatal hepatocytes were isolated from 4 Holstein bull calves and maintained for 24 h before treatment with either 0 or 1 mM FA cocktail. After 21 h, either [1- |
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MeSH term(s) | Cattle ; Animals ; Male ; Reactive Oxygen Species ; Hepatocytes ; Energy Metabolism ; Fatty Acids ; Glucose ; Glutathione ; Glycogen |
Chemical Substances | Reactive Oxygen Species ; Fatty Acids ; Glucose (IY9XDZ35W2) ; Glutathione (GAN16C9B8O) ; Glycogen (9005-79-2) |
Language | English |
Publishing date | 2023-09-12 |
Publishing country | England |
Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-023-41919-3 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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