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  1. Article ; Online: Sydney Brenner (1927-2019).

    Kenyon, Cynthia

    Science (New York, N.Y.)

    2019  Volume 364, Issue 6441, Page(s) 638

    Language English
    Publishing date 2019-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aax8563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Notes from the Field: Expanded Laboratory Testing for Varicella - Minnesota, 2016-2023.

    Ruprecht, Alison / Marin, Mona / Strain, Anna K / Harry, Katie / Kenyon, Cynthia

    MMWR. Morbidity and mortality weekly report

    2024  Volume 73, Issue 11, Page(s) 245–246

    MeSH term(s) Humans ; Chickenpox/diagnosis ; Chickenpox/epidemiology ; Minnesota/epidemiology
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7311a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The

    Kerr, Rex A / Roux, Antoine E / Goudeau, Jérôme / Kenyon, Cynthia

    Frontiers in aging

    2022  Volume 3, Page(s) 932656

    Abstract: Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical ... ...

    Abstract Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical challenges have prevented a comprehensive evaluation of how these components impact the trajectory of aging, and many components likely remain undiscovered. To facilitate the deeper exploration of aging trajectories at a sufficient scale to enable primary screening, we have created the
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2022.932656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Could a hormone point the way to life extension?

    Kenyon, Cynthia

    eLife

    2012  Volume 1, Page(s) e00286

    Abstract: Mice that have been genetically modified to produce high levels of fibroblast growth factor-21 live longer than mice with normal levels of this hormone. ...

    Abstract Mice that have been genetically modified to produce high levels of fibroblast growth factor-21 live longer than mice with normal levels of this hormone.
    MeSH term(s) Animals ; Female ; Fibroblast Growth Factors/genetics ; Growth Hormone/genetics ; Insulin-Like Growth Factor I/genetics ; Liver/metabolism ; Longevity/genetics ; Male ; Transgenes
    Chemical Substances fibroblast growth factor 21 ; insulin-like growth factor-1, mouse ; Fibroblast Growth Factors (62031-54-3) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2012-10-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.00286
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  5. Article ; Online: Silencing the ASI gustatory neuron pair extends lifespan.

    Chisnell, Peter / Kenyon, Cynthia

    microPublication biology

    2018  Volume 2018

    Language English
    Publishing date 2018-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/ft9e-7e37
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  6. Article ; Online: Silencing the ASI gustatory neuron pair increases expression of the stress-resistance gene

    Chisnell, Peter / Kenyon, Cynthia

    microPublication biology

    2018  Volume 2018

    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/W2W37V
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Application of Transcriptional Gene Modules to Analysis of

    Cary, Michael / Podshivalova, Katie / Kenyon, Cynthia

    G3 (Bethesda, Md.)

    2020  Volume 10, Issue 10, Page(s) 3623–3638

    Abstract: Identification of co-expressed sets of genes (gene modules) is used widely for grouping functionally related genes during transcriptomic data analysis. An organism-wide atlas of high-quality gene modules would provide a powerful tool for unbiased ... ...

    Abstract Identification of co-expressed sets of genes (gene modules) is used widely for grouping functionally related genes during transcriptomic data analysis. An organism-wide atlas of high-quality gene modules would provide a powerful tool for unbiased detection of biological signals from gene expression data. Here, using a method based on independent component analysis we call DEXICA, we have defined and optimized 209 modules that broadly represent transcriptional wiring of the key experimental organism
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Gene Expression ; Gene Expression Profiling ; Gene Regulatory Networks ; Transcription Factors/genetics
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.120.401270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: QnAs with Cynthia Kenyon.

    Kenyon, Cynthia

    Proceedings of the National Academy of Sciences of the United States of America

    2011  Volume 108, Issue 41, Page(s) 16875

    MeSH term(s) Aging/genetics ; Animals ; Caenorhabditis elegans/genetics ; Caloric Restriction ; Genes, Helminth ; Humans ; Longevity/genetics
    Language English
    Publishing date 2011-10-03
    Publishing country United States
    Document type Interview ; Portrait
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1114658108
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  9. Article ; Online: A pathway that links reproductive status to lifespan in Caenorhabditis elegans.

    Kenyon, Cynthia

    Annals of the New York Academy of Sciences

    2010  Volume 1204, Page(s) 156–162

    Abstract: In the nematode Caenorhabditis elegans and the fruit fly Drosophila, loss of the germline stem cells activates lifespan-extending FOXO-family transcription factors in somatic tissues and extends lifespan, suggesting the existence of an evolutionarily ... ...

    Abstract In the nematode Caenorhabditis elegans and the fruit fly Drosophila, loss of the germline stem cells activates lifespan-extending FOXO-family transcription factors in somatic tissues and extends lifespan, suggesting the existence of an evolutionarily conserved pathway that links reproductive state and aging. Consistent with this idea, reproductive tissues have been shown to influence the lifespans of mice and humans as well. In C. elegans, loss of the germ cells activates a pathway that triggers nuclear localization of the FOXO transcription factor DAF-16 in endodermal tissue. DAF-16 then acts in the endoderm to activate downstream lifespan-extending genes. DAF-16 is also required for inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling to extend lifespan. However, the mechanisms by which inhibition of insulin/IGF-1 signaling and germline loss activate DAF-16/FOXO are distinct. As loss of the germ cells further doubles the already-long lifespan of insulin/IGF-1 pathway mutants, a better understanding of this reproductive longevity pathway could potentially suggest powerful ways to increase healthy lifespan in humans.
    MeSH term(s) Aging/metabolism ; Aging/physiology ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Longevity/physiology ; Models, Biological ; Reproduction/physiology
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2010.05640.x
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  10. Article ; Online: The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.

    Kenyon, Cynthia

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2010  Volume 366, Issue 1561, Page(s) 9–16

    Abstract: Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm ... ...

    Abstract Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
    MeSH term(s) Aging/genetics ; Aging/physiology ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Insulin/genetics ; Insulin/physiology ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/physiology ; Mutation ; Signal Transduction
    Chemical Substances Insulin ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2010-11-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2010.0276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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