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  1. Book ; Online: The European Blood and Marrow Transplantation Textbook for Nurses

    Kenyon, Michelle / Babic, Aleksandra

    Under the Auspices of EBMT

    2023  

    Author's details edited by Michelle Kenyon, Aleksandra Babic
    Keywords Nursing ; Transplantation of organs, tissues, etc ; Surgery ; Children—Surgery
    Language English
    Size 1 Online-Ressource (X, 331 p. 38 illus., 29 illus. in color)
    Edition 2nd ed. 2023
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT030005270
    ISBN 978-3-031-23394-4 ; 9783031233937 ; 9783031233951 ; 3-031-23394-8 ; 303123393X ; 3031233956
    DOI 10.1007/978-3-031-23394-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The European Blood and Marrow Transplantation Textbook for Nurses

    Kenyon, Michelle / Babic, Aleksandra

    Under the Auspices of EBMT

    2023  

    Keywords Nursing ; Transplant surgery ; Surgery ; General surgery ; Haematopoietic Stem Cell Transplant ; Nursing care ; Cell Therapy ; Paediatric transplant nursing ; Apheresis
    Language English
    Size 1 electronic resource (331 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030378032
    ISBN 9783031233937 ; 303123393X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The European Blood and Marrow Transplantation Textbook for Nurses

    Kenyon, Michelle / Babic, Aleksandra

    Under the Auspices of EBMT

    2018  

    Author's details edited by Michelle Kenyon, Aleksandra Babic
    Keywords Medicine ; Blood transfusion ; Hematology ; Nursing ; Pediatric surgery ; Surgical transplantation ; Surgical oncology
    Subject code 610.73
    Language English
    Size 1 Online-Ressource (XVII, 311 p. 48 illus., 36 illus. in color)
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019641384
    ISBN 978-3-319-50026-3 ; 9783319500256 ; 3-319-50026-0 ; 3319500252
    DOI 10.1007/978-3-319-50026-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: The European Blood and Marrow Transplantation Textbook for Nurses: Under the Auspices of EBMT

    Babic, Aleksandra / Kenyon, Michelle

    2018  

    Keywords Nursing care ; Paediatric transplant nursing ; Apheresis ; Haemato-oncology nursing ; Haematopoietic Stem Cell Transplant
    Size 1 electronic resource (311 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021043493
    ISBN 9783319500256 ; 3319500252
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Strategies for Assessing Acceptable Intakes for Novel

    Ponting, David J / Dobo, Krista L / Kenyon, Michelle O / Kalgutkar, Amit S

    Journal of medicinal chemistry

    2022  Volume 65, Issue 23, Page(s) 15584–15607

    Abstract: The detection ... ...

    Abstract The detection of
    MeSH term(s) Nitrosamines/toxicity ; Amines ; Pharmaceutical Preparations
    Chemical Substances Nitrosamines ; Amines ; Pharmaceutical Preparations
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c01498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

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  6. Article ; Online: Global collaboration led by the EBMT Nurses Group.

    Trigoso, Eugenia / Ruiz, Julia / Kenyon, Michelle / Murray, John

    The Lancet. Haematology

    2021  Volume 8, Issue 6, Page(s) e396–e397

    MeSH term(s) Asia ; Bone Marrow Transplantation/nursing ; Bone Marrow Transplantation/standards ; Education, Nursing, Continuing/organization & administration ; Europe ; Evidence-Based Nursing/organization & administration ; Global Health ; Hematopoietic Stem Cell Transplantation/nursing ; Hematopoietic Stem Cell Transplantation/standards ; Humans ; International Cooperation ; Latin America ; Nurse's Role ; Quality Control ; Societies, Nursing/organization & administration
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(21)00133-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Haploidentical Transplant with Post-Transplant Cyclophosphamide for Acute Myeloid Leukaemia and Myelodysplastic Syndromes Patients: The Role of Previous Lines of Therapy.

    Avenoso, Daniele / Serpenti, Fabio / Slonim, Liron Barnea / Bouziana, Styliani / Dazzi, Francesco / Hannah, Guy / Kenyon, Michelle / Mehra, Varun / Kulasekararaj, Austin / Krishamurthy, Pramila / Shah, Mili Naresh / Lionel, Sharon / Pagliuca, Antonio / Potter, Victoria

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024002

    Abstract: Background: Allogeneic haematopoietic stem-cell transplant is an option, potentially curative, for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for the ... ...

    Abstract Background: Allogeneic haematopoietic stem-cell transplant is an option, potentially curative, for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for the selection of haploidentical donors in patients who are eligible for the procedure but do not have a fully matched donor since it can overcome the HLA barrier. There is still an active debate on whether intensifying the conditioning regimen is necessary with haploidentical donors when peripheral blood stem cells are used as the graft source. Herein, we report our decennial experience of haploidentical stem-cell transplant using peripheral blood stem cells (haplo-PBSC) at King's College Hospital.
    Objectives: The primary objective was to evaluate overall survival (OS) following haplo-PBSC. Secondary objectives were total OS for patients with less than two previous lines of therapy, OS according to cytomegalovirus (CMV) reactivation, incidence of transplant-related mortality (TRM), graft-versus-host disease (GVHD) and GVHD-relapse-free survival (GRFS).
    Results: One-year and three-year total OS were 62% and 43%, respectively, with a median OS of 22 months. One-year and three-year OS for patients with ≤2 and those with >2 previous lines of therapy were 72% and 55%, and 60% and 22%, respectively (p-value=0.04). The median OS in patients with >2 previous and ≤2 lines of therapy was 16 and 49 months, respectively. Cumulative incidence (CI) of relapse was 25% with a median time to relapse of 5 months (range 1 - 38 months).
    Conclusions: Haploidentical haematopoietic stem-cell transplant is potentially curative in chemosensitive AML and MDS and offers a high rate of prolonged remission. Our cohort further confirms the role of consolidative haploidentical transplant in patients in complete remission and highlights that patients with heavily pre-treated disease may not benefit from this strategy.
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Fludarabine-Melphalan-Campath, Followed by Unmanipulated Peripheral-Blood Haematopoietic Stem Cells, Can Still Cure Lymphoma.

    Avenoso, Daniele / Alabdulwahab, Amal / Kenyon, Michelle / Mehra, Varun / Krishnamurthy, Pramila / Dazzi, Francesco / Leung, Ye Ting / Anteh, Sandra / Shah, Mili Naresh / Kuhnl, Andrea / Sanderson, Robin / Patten, Piers / Yallop, Deborah / Pagliuca, Antonio / Potter, Victoria

    Mediterranean journal of hematology and infectious diseases

    2023  Volume 15, Issue 1, Page(s) e2023041

    Abstract: Background: The second decade of this millennium was characterized by a widespread availability of chimeric antigen receptor T-cell (CAR-T) therapies to treat relapsed and refractory lymphomas. As expected, the role and indication of allogeneic ... ...

    Abstract Background: The second decade of this millennium was characterized by a widespread availability of chimeric antigen receptor T-cell (CAR-T) therapies to treat relapsed and refractory lymphomas. As expected, the role and indication of allogeneic haematopoietic stem cell transplant (allo-HSCT) in the management of lymphoma changed. Currently, a non-neglectable proportion of patients will be considered candidate for an allo-HSCT, and the debate of which transplant platform should be offered is still active.
    Objectives: to report the outcome of patients affected with relapsed/refractory lymphoma and transplanted following reduced intensity conditioning at King's College Hospital, London, between January 2009 and April 2021.
    Methods: Conditioning was with 150mg/m2 of fludarabine and melphalan of 140mg/m2. The graft was unmanipulated G-CSF mobilized peripheral blood haematopoietic stem cells (PBSC). Graft-
    Results: One-year and five years OS were 87% and 79.9%, respectively, and median OS was not reached. The cumulative incidence of relapse was 16%. The incidence of acute GVHD was 48% (only grade I/II); no cases of grade III/IV were diagnosed. Chronic GVHD occurred in 39% of patients. TRM was 12%, with no cases developed within day 100 and 18 months after the procedure.
    Conclusions: The outcomes of heavily pretreated lymphoma patients are favorable, with median OS and survival not reached after a median of 49 months. In conclusion, even if some lymphoma subgroups cannot be treated (yet) with advanced cellular therapies, this study confirms the role of allo-HSCT as a safe and curative strategy.
    Language English
    Publishing date 2023-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2023.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Assessing the utility of common arguments used in expert review of in silico predictions as part of ICH M7 assessments.

    Cayley, Alex N / Foster, Robert S / Brigo, Alessandro / Muster, Wolfgang / Musso, Alyssa / Kenyon, Michelle O / Parris, Patricia / White, Angela T / Cohen-Ohana, Mirit / Nudelman, Raphael / Glowienke, Susanne

    Regulatory toxicology and pharmacology : RTP

    2023  Volume 144, Page(s) 105490

    Abstract: Expert review of two predictions, made by complementary (quantitative) structure-activity relationship models, to an overall conclusion is a key component of using in silico tools to assess the mutagenic potential of impurities as part of the ICH M7 ... ...

    Abstract Expert review of two predictions, made by complementary (quantitative) structure-activity relationship models, to an overall conclusion is a key component of using in silico tools to assess the mutagenic potential of impurities as part of the ICH M7 guideline. In lieu of a specified protocol, numerous publications have presented best practise guides, often indicating the occurrence of common prediction scenarios and the evidence required to resolve them. A semi-automated expert review tool has been implemented in Lhasa Limited's Nexus platform following collation of these common arguments and assignment to the associated prediction scenarios made by Derek Nexus and Sarah Nexus. Using datasets primarily donated by pharmaceutical companies, an automated analysis of the frequency these prediction scenarios occur, and the likelihood of the associated arguments assigning the correct resolution, could then be conducted. This article highlights that a relatively small number of common arguments may be used to accurately resolve many prediction scenarios to a single conclusion. The use of a standardised method of argumentation and assessment of evidence for a given impurity is proposed to improve the efficiency and consistency of expert review as part of an ICH M7 submission.
    Language English
    Publishing date 2023-08-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2023.105490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1711: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The European Society for Blood and Marrow Transplantation (EBMT) roadmap and perspectives to improve nutritional care in patients undergoing hematopoietic stem cell transplantation on behalf of the Cellular Therapy and Immunobiology Working Party (CTIWP) and the Nurses Group (NG) of the EBMT.

    Casirati, Amanda / Salcedo, Isabel / Cereda, Emanuele / Chabannon, Christian / Ruggeri, Annalisa / Kuball, Jurgen / Clout, Ruth / Mooyaart, Jarl E / Kenyon, Michelle / Caccialanza, Riccardo / Pedrazzoli, Paolo / Kisch, Annika M

    Bone marrow transplantation

    2023  Volume 58, Issue 9, Page(s) 965–972

    Abstract: Malnutrition is the most common comorbidity during the continuum of hematopoietic stem cell transplant (HSCT) and negatively impacts clinical outcomes, response to therapy, quality of life, and costs. The intensive conditioning regimen administered ... ...

    Abstract Malnutrition is the most common comorbidity during the continuum of hematopoietic stem cell transplant (HSCT) and negatively impacts clinical outcomes, response to therapy, quality of life, and costs. The intensive conditioning regimen administered before transplant causes inflammatory damages to the gastrointestinal system, which themselves contribute to trigger graft versus host disease (GvHD) in the allogeneic setting. GvHD and other post-transplant complications such as infections adversely affect food intake and gut absorption of nutrients. Consequently, patients exhibit signs of malnutrition such as weight loss and muscle wasting, thus triggering a "vicious circle" that favours additional complications. Among HSCT centres, there is marked variability in nutritional care, from screening for malnutrition to nutritional intervention. The present paper, elaborated by the Cellular Therapy and Immunobiology Working Party and the Nurses Group of the European Society for Blood and Marrow Transplantation, aims at defining a roadmap that identifies the main nutritional critical issues in the field of HSCT. This document will be propaedeutic to the development of clinical algorithms to counteract risk factors of malnutrition, based on scientific evidence and shared among HSCT centres, and thus maximize transplant outcomes.
    MeSH term(s) Humans ; Bone Marrow ; Quality of Life ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation Conditioning/adverse effects ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Malnutrition/therapy ; Malnutrition/complications ; Nurses
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-02018-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2168: Show issues Location:
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