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Article: Rhynchophorus ferrugineus

Niode, Nurdjannah Jane / Kepel, Billy Johnson / Hessel, Sofia Safitri / Kairupan, Tara Sefanya / Tallei, Trina Ekawati

2024 Volume 17, Issue 1, Page(s) 156–170

Abstract: Antimicrobial resistance is a growing concern due to the growth of antibiotic-resistant microorganisms, which makes it difficult to treat infection. Due to its broad-spectrum antimicrobial properties against a diverse array of bacteria, both Gram- ... ...

Abstract	Antimicrobial resistance is a growing concern due to the growth of antibiotic-resistant microorganisms, which makes it difficult to treat infection. Due to its broad-spectrum antimicrobial properties against a diverse array of bacteria, both Gram-positive and Gram-negative bacteria, and fungi,
Language	English
Publishing date	2024-01-20
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2456277-4
ISSN	2231-0916 ; 0972-8988
ISSN (online)	2231-0916
ISSN	0972-8988
DOI	10.14202/vetworld.2024.156-170
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Article: Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers Based on Wagner Grading: A Systematic Review and Meta-analysis.

Oley, Mendy Hatibie / Oley, Maximillian Christian / Kepel, Billy Johnson / Faruk, Muhammad / Wagiu, Angelica Maurene Joicetine / Sukarno, Irawan / Tulong, Marcella Tirsa / Sukarno, Vania

Plastic and reconstructive surgery. Global open

2024 Volume 12, Issue 3, Page(s) e5692

Abstract: Background: Diabetic foot ulcers (DFUs) are common complications of uncontrolled diabetes mellitus that can result in infection and amputation of the lower extremities. This study compared the benefits and risks of hyperbaric oxygen therapy with those ... ...

Abstract	Background: Diabetic foot ulcers (DFUs) are common complications of uncontrolled diabetes mellitus that can result in infection and amputation of the lower extremities. This study compared the benefits and risks of hyperbaric oxygen therapy with those of other DFU treatments, based on the Wagner grading system. Methods: Systematic searches for randomly controlled trials using hyperbaric oxygen therapy for DFUs were performed using PubMed, the Cochrane Library, and Embase. Data regarding demographics, wound healing, minor and major amputations, operative debridement, nonhealing wounds, and adverse effects were analyzed based on Wagner grades, using RevMan 5.4.1 and Microsoft Excel. Results: Hyperbaric oxygen therapy was significantly superior to other treatments for wound healing rates 8 or more weeks after the final treatment (RR = 2.39; 1.87-3.05; Conclusions: Moderate-quality evidence revealed that adjunctive hyperbaric oxygen therapy improved DFU wound healing for Wagner grades II, III, and IV; prevented minor and major amputations for grades III and IV, respectively; and prevented operative debridement in grade II wounds.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000005692
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Article ; Online: Antimicrobial Potential of

Niode, Nurdjannah Jane / Kepel, Billy Johnson / Phoanda, Tilesky Caprizio / Lukita, Stephanie / Tallei, Trina Ekawati

Pakistan journal of biological sciences : PJBS

2023 Volume 26, Issue 10, Page(s) 543–548

Abstract: ... Background and Objective: ... The emergence of methicillin-resistant community-acquired ... Staphylococcus aureus ... and antibiotic-resistant ... Neisseria gonorrhoeae ... has raised significant concerns. Efforts to combat resistance involve the ... ...

Abstract	Background and Objective: The emergence of methicillin-resistant community-acquired Staphylococcus aureus and antibiotic-resistant Neisseria gonorrhoeae has raised significant concerns. Efforts to combat resistance involve the exploration of novel alternative therapies, particularly those derived from insect components. Rhynchophorus sp., a coconut pest commonly found in Southeast Asia, has haemolymph that exhibits bactericidal properties. The objective of this study was to assess the potential of the haemolymph of Rhynchophorus sp., larvae as an antimicrobial agent against Methicillin-resistant Staphylococcus aureus (MRSA) and Neisseria gonorrhoeae. Materials and Methods: In this study, Rhynchophorus sp., larvae were gathered for the purpose of haemolymph extraction. These larvae were then divided into distinct groups, with one group subjected to immunization using Escherichia coli, while another group was left unimmunized. The study utilized the well diffusion method to evaluate antibacterial effectiveness. Results: Haemolymph fluid extracts from Escherichia coli-immunized Rhynchophorus sp., larvae, exhibited strong antibacterial activity, with an average value of 19.3±0.47 mm, against MRSA, more enhanced compared to unimmunized larvae. In contrast, haemolymph fluid extracts from Escherichia coli-immunized Rhynchophorus sp., larvae demonstrated a more moderate antibacterial activity, with a mean of 14.17±0.27 mm, against Neisseria gonorrhoeae, a level similar to unimmunized larvae. Conclusion: The haemolymph extracted from Rhynchophorus sp., beetles larvae exhibited antimicrobial effects against MRSA and Neisseria gonorrhoeae, particularly when it is enhanced through Escherichia coli immunization.
MeSH term(s)	Animals ; Methicillin-Resistant Staphylococcus aureus ; Neisseria gonorrhoeae ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents ; Larva ; Weevils ; Escherichia coli
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-12-18
Publishing country	Pakistan
Document type	Journal Article
ISSN	1812-5735
ISSN (online)	1812-5735
DOI	10.3923/pjbs.2023.543.548
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Article ; Online: Molecular Insight into the Pharmacological Potential of

Fatimawali / Tallei, Trina Ekawati / Kepel, Billy Johnson / Bodhi, Widdhi / Manampiring, Aaltje Ellen / Nainu, Firzan

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 11

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Humans ; Clerodendrum/metabolism ; Network Pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Insulin/metabolism ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Insulin ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59111899
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Article: Comparison of Bacterial Community Structure and Diversity in Traditional Gold Mining Waste Disposal Site and Rice Field by Using a Metabarcoding Approach.

Fatimawali / Kepel, Billy Johnson / Gani, Maria Apriliani / Tallei, Trina Ekawati

International journal of microbiology

2020 Volume 2020, Page(s) 1858732

Abstract: Traditional small-scale gold mining mostly use mercury to extract the gold from ores. However, mercury contamination in the environment can affect the composition and structure of the bacterial community. The purpose of this study was to determine the ... ...

Abstract	Traditional small-scale gold mining mostly use mercury to extract the gold from ores. However, mercury contamination in the environment can affect the composition and structure of the bacterial community. The purpose of this study was to determine the effect of mercury contamination on the bacterial community in the traditional gold mining waste disposal site and in the rice field. Mercury analysis was carried out using the CVAFS method. Analysis of bacterial communities and structure was carried out based on the results of metabarcoding of the V3-V4 16S rRNA regions obtained from paired-end Illumina MiSeq reads. The results showed that the sample from the mining waste disposal site had a mercury level of 230 mg/kg, while the sample from the rice field had 3.98 mg/kg. The results showed that there were differences in microbial composition and community structure in both locations. With the total reads of 57,031, the most dominant phylum was Firmicutes in the mining disposal site sample. Meanwhile, with the total reads of 33,080, the sample from rice field was dominated by Planctomycetes. The abundant classes of bacteria in the mining waste disposal site, from the highest were Bacilli, Gammaproteobacteria and Planctomycetia, while the sample from the rice field was dominated by the Planctomycetia and Acidobacteria subdivision 6. The families that dominated the sample in disposal site were Bacillaceae and Aeromonadaceae, while the sample from the rice field was dominated by Gemmataceae. The abundant genera in both locations were
Language	English
Publishing date	2020-01-07
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2467270-1
ISSN	1687-9198 ; 1687-918X
ISSN (online)	1687-9198
ISSN	1687-918X
DOI	10.1155/2020/1858732
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Article ; Online: Factors related to serum levels of intercellular adhesion molecule-1 in probable COVID-19 patients in surgical treatment: an observational study.

Oley, Mendy Hatibie / Oley, Maximillian Christian / Langi, Fima Lanra Fredrik Gerald / Kepel, Billy Johnson / Pajan, Jacob / Kepel, Regina Elizabeth Meriam / Wagiu, Angelica Maurene Joicetine / Kalitouw, Ferry / Kalesaran, Laurens / Faruk, Muhammad

The Pan African medical journal

2023 Volume 46, Page(s) 117

Abstract: Introduction: COVID-19 causes a systemic inflammatory response, involving dysregulation and misexpression of many inflammatory cytokines. The recruitment and activation of inflammatory cells depend on the expression of many classes of inflammatory ... ...

Abstract	Introduction: COVID-19 causes a systemic inflammatory response, involving dysregulation and misexpression of many inflammatory cytokines. The recruitment and activation of inflammatory cells depend on the expression of many classes of inflammatory mediators, with increased expression of endothelial cell adhesion molecules being related to COVID-19 disease severity. With the World Health Organization having recently updated case definitions to suspect, probable, and confirmed, this study aimed to measure the mean value of intercellular adhesion molecule 1 (ICAM-1) and its relation to suspected COVID-19. Methods: all suspected patients (n=20) were hospitalized and treated following the Indonesian National Guidelines for COVID-19 management. ICAM-1 levels were measured on days 1 and 7, demographic data were recorded, and routine blood count values were measured and additionally considered. Results: the results showed that the levels of ICAM-1 in the 1 Conclusion: the mean value of ICAM-1 levels for patients with confirmed positive COVID-19 cases was higher than those with suspected COVID-19 cases.
MeSH term(s)	Humans ; Intercellular Adhesion Molecule-1 ; COVID-19/diagnosis
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2023-12-27
Publishing country	Uganda
Document type	Observational Study ; Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2023.46.117.41690
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Article: Data on the docking of phytoconstituents of betel plant and matcha green tea on SARS-CoV-2

Fatimawali / Maulana, Rizky Ramadhan / Windah, Axl Laurens Lukas / Wahongan, Irma Febrianti / Tumilaar, Sefren Geiner / Adam, Ahmad Akroman / Kepel, Billy Johnson / Bodhi, Widdhi / Tallei, Trina Ekawati

Data in Brief. 2021 June, v. 36

2021

Abstract: Betel (Piper betle L.) and green tea (Camellia sinensis (L) O. Kuntze) have been used for a long time as traditional medicine. The docking of phytoconstituents contained in the betel plant was evaluated against Mᵖʳᵒ, and matcha green tea was evaluated ... ...

Abstract	Betel (Piper betle L.) and green tea (Camellia sinensis (L) O. Kuntze) have been used for a long time as traditional medicine. The docking of phytoconstituents contained in the betel plant was evaluated against Mᵖʳᵒ, and matcha green tea was evaluated against five target receptors of SARS-CoV-2 as follows: spike ectodomain structure (open state), receptor-binding domain (RDB), main protease (Mᵖʳᵒ), RNA-dependent RNA polymerase (RdRp), dan papain-like protease (PLᵖʳᵒ). The evaluation was carried out based on the value of binding-free energy and the types of interactions of the amino acids at the receptors that interact with the ligands.
Keywords	Camellia sinensis ; Piper betle ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; betel ; chemical constituents of plants ; energy ; green tea ; ligands ; proteinases ; traditional medicine
Language	English
Dates of publication	2021-06
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107049
Database	NAL-Catalogue (AGRICOLA)

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Article: Bactericidal effect of hyperbaric oxygen therapy in burn injuries.

Oley, Mendy Hatibie / Oley, Maximillian Christian / Wewengkang, Louise A J Waworuntu / Kepel, Billy Johnson / Langi, Fima Lanra Fredrik G / Setiadi, Taat / Aling, Deanette Michelle R / Gunawan, Deborah Florencia / Tulong, Marcella Tirsa / Faruk, Muhammad

Annals of medicine and surgery (2012)

2022 Volume 74, Page(s) 103314

Abstract: Introduction: Burn injuries are frequently encountered in emergency cases and often become the port of entry for pathogens. More than 450,000 burn injuries occur annually causing nearly 3,400 deaths in the United States. The prevalence of burn injury in ...

Abstract	Introduction: Burn injuries are frequently encountered in emergency cases and often become the port of entry for pathogens. More than 450,000 burn injuries occur annually causing nearly 3,400 deaths in the United States. The prevalence of burn injury in Indonesia is 0.7% in 2013. More than half of these According to several studies on the use of patients were treated for bacterial infections, some of which were resistant to certain antibiotics. Using hyperbaric oxygen therapy (HBOT) to treat burns has several positive effects including managing bacterial infections, as well as accelerating the wound healing process. Therefore, this study aims to prove the effectiveness of HBOT in inhibiting bacterial growth. Methods: This is an experimental research study in rabbits using a post-test control group design. 38 rabbits were given second-degree burns on the shoulder region with a metal iron plate that has been previously heated for 3 min. Bacterial cultures were taken on days 5 and 10 after exposure to the burns. The samples were divided into two groups, HBOT and control. Statistical analyses were performed using the Mann-Whitney U method. Results: Gram-negative bacteria were the most frequently found pathogen in both groups Conclusion: HBOT administration can significantly reduce bacterial growth in burn injuries.
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2022.103314
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Article: Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M

Tallei, Trina Ekawati / Tumilaar, Sefren Geiner / Niode, Nurdjannah Jane / Fatimawali / Kepel, Billy Johnson / Idroes, Rinaldi / Effendi, Yunus / Sakib, Shahenur Alam / Emran, Talha Bin

Scientifica

2020 Volume 2020, Page(s) 6307457

Abstract: Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory ... ...

Abstract	Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants using a molecular docking approach to inhibit the main protease (M
Language	English
Publishing date	2020-12-23
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2672321-9
ISSN	2090-908X
ISSN	2090-908X
DOI	10.1155/2020/6307457
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Article: ICAM-1 levels in patients with covid-19 with diabetic foot ulcers: A prospective study in southeast asia.

Oley, Mendy Hatibie / Oley, Maximillian Christian / Kepel, Billy Johnson / Tjandra, Djony E / Langi, Fima Lanra Fredrik G / Herwen / Aling, Deanette Michelle R / Joicetine Wagiu, Angelica Maurene / Faruk, Muhammad

Annals of medicine and surgery (2012)

2021 Volume 63, Page(s) 102171

Abstract: Background: Viral infection can compound the severity of pre-existing inflammation caused by underlying diseases. For those with a chronic, immune-related condition such as diabetic foot ulcers (DFUs), the coronavirus disease (COVID-19) serves to ... ...

Abstract	Background: Viral infection can compound the severity of pre-existing inflammation caused by underlying diseases. For those with a chronic, immune-related condition such as diabetic foot ulcers (DFUs), the coronavirus disease (COVID-19) serves to exacerbate the inflammatory burden. Serum levels of intracellular adhesion molecule-1 (ICAM-1), a primary mediator of cell adhesion express in the inflammatory process, are often used to indicate the gravity of all inflammatory conditions. Therefore, the purpose of this study was to investigate serum ICAM-1 levels before and after debridement in patients with DFUs who were also diagnosed as COVID-19 positive compared with those who were COVID-19 negative. Methods: 20 patients with DFUs were screened for COVID-19 and then divided into COVID-19 positive and negative groups according to the results. Before debridement, chest x-rays and blood analysis, including ICAM-1 serum levels, were performed in both groups. Only ICAM-1 serum levels were measured after debridement. Results: Of the 20 patients included in this study, 55% were male (n = 11) and 45% were female (n = 9). The mean age was 52.9 ± 1.9 years. ICAM-1 levels in patients with DFU in the COVID-19-positive group were significantly higher than those in the COVID-19-negative group (median 317.2 vs 149.2, respectively; p < 0.001). Serum levels of ICAM-1 reduced significantly in patients with DFU in the COVID-19-positive group were significantly higher than those in the COVID-19-negative group after debridement (median 312.5 vs 130.3; p < 0.001). Conclusion: ICAM-1 serum levels represent an additional, initial screening marker for COVID-19.
Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.02.017
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