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Article ; Online: Evaluation of infants with HIV-infected mothers and perinatal transmission in Turkey: A single-center experience.

Yakut, Nurhayat / Kepenekli, Eda

2021 Volume 8, Issue 3, Page(s) 243–248

Abstract: Objective: The most common route of HIV infection in children is through perinatal transmission. In this study, we aimed to evaluate the characteristics of infants with HIV-infected mothers and perinatal HIV transmission.: Methods: We conducted a ... ...

Abstract	Objective: The most common route of HIV infection in children is through perinatal transmission. In this study, we aimed to evaluate the characteristics of infants with HIV-infected mothers and perinatal HIV transmission. Methods: We conducted a retrospective, single-center study of HIV-exposed infants in between December 2017 and October 2019 in a Marmara University Pendik Training and Research Hospital. Results: A total of 18 infants were examined. All babies were born by cesarean section, and none of them were breastfed. Seventeen mothers were diagnosed with HIV before pregnancy. These mothers had received antiretroviral therapy (ART) during pregnancy, and their viral loads before delivery were negative. An antiretroviral prophylaxis with oral zidovudine was started in all infants within their 1 Conclusion: Our findings highlight the importance of initiating ART for all HIV-infected pregnant women and the importance of protection modalities during pregnancy, delivery, and the postnatal period for the prevention of perinatal transmission of HIV.
Language	English
Publishing date	2021-05-24
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2021.59013
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Article ; Online: Crimean-Congo hemorrhagic fever with hemophagocytic lymphohistiocytosis.

Yakut, Nurhayat / Kepenekli, Eda / Dogru, Omer

Revista da Sociedade Brasileira de Medicina Tropical

2021 Volume 54

MeSH term(s)	Hemorrhagic Fever, Crimean/complications ; Hemorrhagic Fever, Crimean/diagnosis ; Humans ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis
Language	English
Publishing date	2021-03-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0438-2020
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Article: A 4-Year-Old Child with a Giant Cerebral Hydatid Cyst: A Case Report.

Işık, Aylin Dizi / Sönmez, Özcan / Erdemli, Pınar Canizci / Kepenekli, Eda / Ergenç, Zeynep / Yılmaz, Seyhan / Tuncay, Sevgi Aslan / Parlak, Burcu / Dağçınar, Adnan

Iranian journal of parasitology

2024 Volume 19, Issue 1, Page(s) 113–116

Abstract: Echinococcosis is the most common cestode infection globally caused by ... ...

Abstract	Echinococcosis is the most common cestode infection globally caused by the
Language	English
Publishing date	2024-04-22
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v19i1.15218
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Article: Delayed diagnosed Gradenigo's syndrome associated with acute otitis media.

Demir, Berat / Abuzaid, Ghazi / Ergenc, Zeynep / Kepenekli, Eda

SAGE open medical case reports

2020 Volume 8, Page(s) 2050313X20966119

Abstract: Gradenigo's syndrome presents as a triad of retroorbital pain, ipsilateral abducens palsy, and purulent otorrhea. If the otologic pathologies in Gradenigo's syndrome go unnoticed, the condition could be misdiagnosed with neurological diseases because of ... ...

Abstract	Gradenigo's syndrome presents as a triad of retroorbital pain, ipsilateral abducens palsy, and purulent otorrhea. If the otologic pathologies in Gradenigo's syndrome go unnoticed, the condition could be misdiagnosed with neurological diseases because of retroorbital pain and abducens palsy. Treatment of Gradenigo's syndrome remains controversial. Although some reports state that long-term antibiotic treatment is sufficient, we recommended that management ought to be guided on a case-by-case basis depending on patient and disease factors. Herein, we report a delayed diagnosed pediatric case of Gradenigo's syndrome associated with acute otitis media that was treated with ventilation tube insertion.
Language	English
Publishing date	2020-10-20
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X20966119
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Article: Successful Treatment of

Ergenc, Zeynep / Kepenekli, Eda / Yakut, Nurhayat / Yapici, Ozge / Batu, Utku / Tutar, Engin

Iranian journal of parasitology

2022 Volume 17, Issue 4, Page(s) 596–598

Abstract: ... Fasciola ... ...

Abstract	Fasciola hepatica
Language	English
Publishing date	2022-10-07
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v17i4.11288
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Article: Cost and length of hospital stay for healthcare facilityonset Clostridioides Difficile infection in pediatric wards: a prospective cohort analysis.

Demir, Sevliya Öcal / Kepenekli, Eda / Akkoç, Gülşen / Yakut, Nurhayat / Soysal, Ahmet

The Turkish journal of pediatrics

2022 Volume 63, Issue 6, Page(s) 1004–1011

Abstract: Background: Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection, it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the incidence, and ... ...

Abstract	Background: Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection, it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the incidence, and economic burden of healthcare facility-onset C. difficile infection (HO-CDI) in children. Methods: Data was acquired with a prospective cohort study conducted in pediatric wards of a tertiary university hospital between August 2015 to August 2016. The HO-CDI was defined as diarrhea that began after 48 hours of admission with a positive cytotoxic stool assay for the presence of toxin A and/or B of C. difficile. Results: In the 3172 admissions in one year, 212 (7%) healthcare associated diarrhea (HAD) episodes were observed, in 25 (12%) of them C. difficile was identified in which 6 (25%) cases < 2-year-old. The incidence of HOCDI was estimated as 8.8/10,000 patient-days. Cases with HO-CDI (n=19) were compared with cases with non- CDI-HAD (n=102); the presence of one of the risk factors for CDI increased the risk for HO-CDI (5,05; 95% Cl: 1.10-23.05; P 0,037), the median length of stay (LOS) attributable HO-CDI was 7 days (IQR,5-10) per admission, whereas for non-CDI-HAD was 2 days (IQR,0-4) (p=0.036). General hospitalization costs in the two groups were similar, specifically estimated costs attributable to HO-CDI and non-CID-HAD were $294.0 and $137.0 per hospitalization respectively (p= < 0.0001). Conclusion: Although in children the incidence of HO-CDI is increasing, its clinical manifestation is still milder and effective infection control measures with antibiotic stewardship can limit related morbidly, mortality, LOS, and cost.
MeSH term(s)	Child ; Child, Preschool ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; Cohort Studies ; Cross Infection/epidemiology ; Delivery of Health Care ; Hospitals ; Humans ; Length of Stay ; Prospective Studies ; Retrospective Studies
Language	English
Publishing date	2022-01-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2021.06.008
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Article ; Online: How safe are children with COVID-19 from cardiac risks? Pediatric risk assesment; insights from echocardiography and electrocardiography

Çevik, Berna Şaylan / Arıcı, Şule / Ergenç, Zeynep / Kepenekli, Eda / Günal, Özge / Yakut, Nurhayat

Turkish journal of medical sciences

2021 Volume 51, Issue 3, Page(s) 981–990

Abstract: Background/aim: Approximately 40 million individuals worldwide have been infected with SARS-CoV-2, the virus responsible for the novel coronavirus disease-2019 (COVID-19). Despite the current literature about the cardiac effects of COVID-19 in children, ...

Abstract	Background/aim: Approximately 40 million individuals worldwide have been infected with SARS-CoV-2, the virus responsible for the novel coronavirus disease-2019 (COVID-19). Despite the current literature about the cardiac effects of COVID-19 in children, more information is required. We aimed to determine both cardiovascular and arrhythmia assessment via electrocardiographic and echocardiographic parameters. Materials and methods: We evaluated seventy children who were hospitalized with COVID-19 infections and seventy children as normal control group through laboratory findings, electrocardiography (ECG), and transthoracic echocardiography (TTE). Results: We observed significantly increased levels of Tp-Te, Tp-Te/QT, and Tp-Te/QTc compared with the control group. Twenty-five of 70 (35.7%) patients had fragmented QRS (fQRS) without increased troponin levels. On the other hand, none of the patients had pathologic corrected QT(QTc) prolongation during the illness or its treatment. On TTE, 20 patients had mild mitral insufficiency, among whom only five had systolic dysfunction (ejection fraction < 55%). There was no significant difference between the patient and control groups, except for isovolumic relaxation time (IVRT) in terms of mean systolic and diastolic function parameters. IVRT of COVID patients was significantly lower than that of control group. Conclusion: Despite all the adult studies, the effects of COVID‐19 on myocardial function are not well established in children. The thought that children are less affected by the illness may be a misconception.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Comorbidity ; Cross-Sectional Studies ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Humans ; Male ; Pandemics ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; SARS-CoV-2 ; Turkey/epidemiology
Language	English
Publishing date	2021-06-28
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2010-240
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Zs.A 3242: Show issues

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Article: Evaluation of Family Clusters of Children with SARS-CoV-2: Children Do Not Play the Leading Role

Ergenc, Zeynep / Kepenekli, Eda / Şenyürek, Betül / Yakut, Nurhayat / Boran, Perran

Journal of Pediatric Infectious Diseases

2021 Volume 17, Issue 01, Page(s) 18–23

Abstract: Objective: The exact role of children in the household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not clear. In this study, we investigated the role of children with coronavirus disease 2019 (COVID-19) in household ... ...

Abstract	Objective: The exact role of children in the household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not clear. In this study, we investigated the role of children with coronavirus disease 2019 (COVID-19) in household transmission by identifying the index patient and contact tracing the household members. Methods: A total of 103 children with COVID-19 who attended Marmara University Pendik Training and Research Hospital, Istanbul, between 25 th March and 27 th May 2020 were included in the study. A family cluster was defined as a group of ≥two confirmed cases of SARS-CoV-2 in the same family, and a household contact (HHC) was defined as any person who had stayed in the same residence. Results: In total, 78 family clusters and 307 HHCs belonging to these clusters were screened. In only four clusters was the index case determined to be in the pediatric age group (5.1%). Fathers, mothers, grandparents, and adult siblings were identified as the index cases in 37 (47.4%), 18 (23.0%), 8 (10.2%), and 6 (7.7%) clusters, respectively. Of the 307 HHCs, 88 were in the pediatric age group, and 39 were SARS-CoV-2 RT-PCR positive. Conclusion: Our data showed that SARS-CoV-2 is uncommon in children without any history of contact to a RT-PCR test positive patient. The role of children as the index patient in family clusters is 5.1%, and the actual index case is usually an adult individual who has had an outside contact.
Keywords	children ; contact tracing ; COVID-19 ; family cluster ; severe acute respiratory syndrome coronavirus 2
Language	English
Publishing date	2021-12-02
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2236947-8
ISSN	1305-7693 ; 1305-7707 ; 1871-0336
ISSN (online)	1305-7693
ISSN	1305-7707 ; 1871-0336
DOI	10.1055/s-0041-1739389
Database	Thieme publisher's database

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Article ; Online: Effect of video camera monitoring feedback on hand hygiene compliance in neonatal intensive care unit, an interventional study.

Bilgin, Huseyin / Sili, Uluhan / Pazar, Nazli / Kucuker, Isil / Kepenekli, Eda / Yanar, Meral Agirman / Memisoglu, Asli / Ozek, Eren / Adhikari, Neill Kj / Pinto, Ruxandra / Korten, Volkan

American journal of infection control

2023 Volume 51, Issue 9, Page(s) 1028–1033

Abstract: Background: The purpose of this study was to determine whether use of a video camera surveillance system for hand hygiene (HH) monitoring, video-based education, and feedback could improve the HH compliance in a neonatal intensive care unit (NICU).: ... ...

Abstract	Background: The purpose of this study was to determine whether use of a video camera surveillance system for hand hygiene (HH) monitoring, video-based education, and feedback could improve the HH compliance in a neonatal intensive care unit (NICU). Methods and materials: This was an interventional before-after trial conducted in a level-III NICU between July 2019 and June 2020. HH compliance was measured using randomly selected video-camera footage in the baseline, intervention, and maintenance periods. After the baseline, an intervention consisting of feedback and education with video scenarios was implemented. The primary outcome was change in HH compliance. The compliance rates were analyzed as an interrupted time series (ITS) with a segmented regression model adjusted for autocorrelation for each study period. Results: We identified a total of 8335 HH indications. There were non significant increases in the total compliance rate (9.0%, 95% CI -2% to 20%) at the time of intervention and in the compliance rate after intervention (0.26%, 95% CI -0.31% to 0.84%) per day. The hand hygiene compliance before patient contact significantly increased (19.8%, 95% CI, 4.8%-34.8%). Incorrect glove use improved non-significantly with the intervention (-3.4%, 95% CI -13.4% to 6.7%). Conclusion: In this study of HH monitoring using video-camera footage combined with an intervention including feedback and education, there were inconsistent improvements in HH compliance. However, these improvements were not sustained in the long term. Frequent feedback and education may be required to sustain high compliance.
MeSH term(s)	Humans ; Infant, Newborn ; Cross Infection/prevention & control ; Feedback ; Guideline Adherence ; Hand Hygiene/methods ; Health Personnel/education ; Infection Control/methods ; Intensive Care Units, Neonatal
Language	English
Publishing date	2023-01-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2022.12.011
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Article: Single-Center Experience in Vaccination of Children in Special Risk Groups: A Multidisciplinary Institutional Consensus Protocol.

Barış, Hatice Ezgi / Kepenekli, Eda / Akbolat Sakar, Fikriye İrem / Ütük, Burak / Şahin, Pınar / Ergenç, Zeynep / Tokuç, Ayşe Gülnur / Koç, Ahmet / Karakoç-Aydıner, Elif / Boran, Perran

Turkish archives of pediatrics

2023 Volume 58, Issue 5, Page(s) 531–538

Abstract: Objective: Despite marked improvements in the accessibility of childhood vaccines, knowledge gaps remain about the vaccination of children in special risk groups (SRG). This study aimed to analyze the clinical data of children vaccinated in SRG in a ... ...

Abstract	Objective: Despite marked improvements in the accessibility of childhood vaccines, knowledge gaps remain about the vaccination of children in special risk groups (SRG). This study aimed to analyze the clinical data of children vaccinated in SRG in a single-center unit to contribute to the clinical evidence for the specific planning of immunization of children in SRG. The second- ary aim is to present institutional consensus on the vaccination of children in SRG. Materials and methods: This retrospective study was conducted at a single-center pediatric vaccination clinic. Patient charts between 2018 and 2021 were retrospectively reviewed, and clinical and laboratory data were extracted. Serial joint meetings with multiple healthcare pro- fessionals were performed to develop an institutional protocol for vaccination. Results: There were 479 children vaccinated between 2018 and 2021 for reasons such as post- chemotherapy, after hematopoietic stem cell transplantation, before/after solid organ trans- plantation, allergies, and chronic diseases. Of these, 298 (62.2%) children vaccinated in the unit due to a history of food or vaccine allergies were excluded. One hundred eighty-one children were vaccinated at a median age of 11 [7-15] years. Most children were vaccinated after treat- ment for malignancies. Solid tumors were the most frequent malignancy (67%), followed by acute lymphoblastic leukemia (29.0%) and acute myeloid leukemia (4.0%). Institutional vacci- nation protocols for cancer survivors, hematopoietic stem cells, and solid organ recipient chil- dren were developed and presented. Conclusion: There is a need to prepare national guidelines for vaccinating children with altered immunocompetence. Sharing vaccination practices by multidisciplinary vaccination units might increase and provide knowledge to develop national policies.
Language	English
Publishing date	2023-09-06
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2023.23097
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