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  1. Book: Biology of the endoplasmic reticulum

    Kepp, Oliver

    (International review of cell and molecular biology ; volume 350)

    2020  

    Author's details edited by Oliver Kepp (Gustave Roussy Comprehensive Cancer Campus, Paris, France), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States)
    Series title International review of cell and molecular biology ; volume 350
    Collection
    Language English
    Size xvii, 325 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT020437049
    ISBN 978-0-12-819744-8 ; 0-12-819744-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 317 -350- verfügbar in Königswinter Königswinter

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  2. Book ; Online ; E-Book: Cellular Senescence and Aging

    Petroni, Giulia / Kepp, Oliver / Galluzzi, Lorenzo

    2024  

    Subject code 571.6
    Language English
    Size 1 online resource (252 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-18896-3 ; 0-443-18897-1 ; 978-0-443-18896-1 ; 978-0-443-18897-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Monitoring vesicular trafficking in cellular responses to stress - Part A / Volume 164 /

    Kepp, Oliver / Galluzzi, Lorenzo

    (Issn)

    2021  

    Author's details edited by Oliver Kepp and Lorenzo Galluzzi
    Series title Issn
    Keywords Cell organelles ; Biological transport
    Subject code 571.6
    Language English
    Size 1 online resource (224 pages)
    Publisher Academic press
    Publishing place Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-823545-4 ; 0-12-823544-6 ; 978-0-12-823545-4 ; 978-0-12-823544-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: Monitoring vesicular trafficking in cellular responses to stress / Part B /

    Kepp, Oliver / Galluzzi, Lorenzo

    (Methods in cell biology ; Volume 165)

    2021  

    Abstract: Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, Volume 165 in the Methods in Cell Biology series, highlights new advances in the field, with this new release presenting coverage of different topics, including A novel tool for ... ...

    Author's details edited by Oliver Kepp, Lorenzo Galluzzi
    Series title Methods in cell biology ; Volume 165
    Abstract "Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, Volume 165 in the Methods in Cell Biology series, highlights new advances in the field, with this new release presenting coverage of different topics, including A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy, Exploring selective autophagy in Drosophila, Assessment of EGFP-Q74 degradation for the measurement of autophagic flux, Multimodal assessment of autophagy in mammalian cells with a novel, LC3-based tandem reporter, Multiplex quantification of autophagic flux by imaging flow cytometry, Monitoring autophagic flux in Caenorhabditis elegans using p62/SQST-1 reporters, High throughput screening for autophagy, and much more."--Publisher's web page, viewed July 27, 2021
    Keywords Stress (Physiology)
    Subject code 616.98
    Language English
    Size 1 online resource (234 pages)
    Publisher Academic Press
    Publishing place Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-824488-7 ; 0-12-824487-9 ; 978-0-12-824488-3 ; 978-0-12-824487-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Immunogenic Cell Stress and Death Sensitize Tumors to Immunotherapy.

    Kepp, Oliver / Kroemer, Guido

    Cells

    2023  Volume 12, Issue 24

    Abstract: The efficacy of chemotherapy with cytotoxicants and that of targeted therapies with more sophisticated agents is limited due to the plasticity of malignant cells, which leads to the inevitable development of resistance [ ... ]. ...

    Abstract The efficacy of chemotherapy with cytotoxicants and that of targeted therapies with more sophisticated agents is limited due to the plasticity of malignant cells, which leads to the inevitable development of resistance [...].
    MeSH term(s) Humans ; Neoplasms/pathology ; Immunotherapy
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12242843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cellular senescence and aging at the crossroad between immunity and cancer.

    Kepp, Oliver / Galluzzi, Lorenzo / Petroni, Giulia

    Methods in cell biology

    2024  Volume 181, Page(s) xvii–xxiv

    MeSH term(s) Humans ; Aging/genetics ; Cellular Senescence ; Neoplasms/genetics
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Editorial
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/S0091-679X(24)00009-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy.

    Liu, Peng / Zhao, Liwei / Kroemer, Guido / Kepp, Oliver

    Genes and immunity

    2024  

    Abstract: Recently we developed a dendritic cell (DC) genotype-phenotype screening platform that is based on CRISPR/Cas9-mediated gene editing of immortalized DC precursors. Whole genome screening for gain-of-function phenotypes led to the identification of BCL2 ... ...

    Abstract Recently we developed a dendritic cell (DC) genotype-phenotype screening platform that is based on CRISPR/Cas9-mediated gene editing of immortalized DC precursors. Whole genome screening for gain-of-function phenotypes led to the identification of BCL2 as a DC-specific immune checkpoint. Genetic or pharmacological inhibition of BCL2 similarly enhanced the antigen presentation capacity of conventional type-1 dendritic cells (cDC1) and mediated T cell-dependent anticancer immunity. The therapeutic anticancer efficacy of the BCL2 inhibitor venetoclax in mice was further increased when combined with a PD-1-targeted immune checkpoint inhibitor. In sum, we delineated a novel strategy of dual checkpoint blockade for cancer immunotherapy in which improvement of DC antigen presentation and avoidance of T cell exhaustion can be advantageously combined.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-024-00256-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: PD-L1

    Liu, Peng / Zhao, Liwei / Kroemer, Guido / Kepp, Oliver

    Oncoimmunology

    2024  Volume 13, Issue 1, Page(s) 2338951

    Abstract: Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD- ... ...

    Abstract Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1
    MeSH term(s) Animals ; Mice ; B7-H1 Antigen ; T-Lymphocytes, Cytotoxic ; CD8-Positive T-Lymphocytes ; Macrophages ; Vaccines
    Chemical Substances B7-H1 Antigen ; Vaccines
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-402X
    ISSN (online) 2162-402X
    ISSN 2162-402X
    DOI 10.1080/2162402X.2024.2338951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A nanoparticle-based tour de force for enhancing immunogenic cell death elicited by photodynamic therapy.

    Kepp, Oliver / Kroemer, Guido

    Oncoimmunology

    2022  Volume 11, Issue 1, Page(s) 2098658

    Abstract: Immunogenic cell death (ICD) involves the release of ATP, which can be destroyed by ectonucleotidases, converting it into immunosuppressive adenosine. Hence, inhibition of such ectonucleotidases is a strategy for enhancing ICD-elicited anticancer ... ...

    Abstract Immunogenic cell death (ICD) involves the release of ATP, which can be destroyed by ectonucleotidases, converting it into immunosuppressive adenosine. Hence, inhibition of such ectonucleotidases is a strategy for enhancing ICD-elicited anticancer immunity. In a recent paper in Science Translational Medicine, Mao et al. report the construction of reactive oxygen-labile nanoparticles that bear two functionalities, namely (i) the capacity to sensitize cancer cells to near-infrared light (NIL) irradiation, hence inducing ICD in the context of photodynamic therapy, and (ii) the peculiarity to respond to NIL by releasing a pharmacological inhibitor of ectonucleotidases, hence enhancing intratumoral concentrations of ATP. In preclinical models, these nanoparticles are highly efficient in inducing anticancer immune responses.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Cell Line, Tumor ; Immunogenic Cell Death ; Nanoparticles/therapeutic use ; Photochemotherapy
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2022.2098658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic.

    Kepp, Oliver / Kroemer, Guido

    Trends in cancer

    2022  Volume 8, Issue 10, Page(s) 785–787

    Abstract: Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain ... ...

    Abstract Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.
    MeSH term(s) Arachidonic Acid/metabolism ; Coenzyme A/metabolism ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Ferroptosis ; Humans ; Lipid Metabolism ; Neoplasms
    Chemical Substances Arachidonic Acid (27YG812J1I) ; Coenzyme A Ligases (EC 6.2.1.-) ; Coenzyme A (SAA04E81UX)
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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