Article ; Online: Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population.
2022 Volume 76, Issue 9, Page(s) 606–611
Abstract: Aims: Non-alcoholic steatohepatitis (NASH), fatty liver disease and fibrosis are associated with diabetes mellitus and obesity. Previous autopsy series have reported prevalence of fatty liver disease to be 11%-24%. Recent studies, using imaging and ... ...
| Abstract | Aims: Non-alcoholic steatohepatitis (NASH), fatty liver disease and fibrosis are associated with diabetes mellitus and obesity. Previous autopsy series have reported prevalence of fatty liver disease to be 11%-24%. Recent studies, using imaging and serology, suggest a prevalence of 20%-35%, NASH of 5% and advanced fibrosis of 2%-3%. We examined the prevalence of NASH and liver fibrosis in a general autopsy population. Methods: A cross-sectional study of consecutive, adult, medicolegal autopsies over a 1-year period was conducted. Liver sections were scored for fibrosis, inflammation and steatosis using a modified NASH scoring system. Stepwise logistic regression was used to identify associations between NASH or moderate/severe fibrosis and several clinicopathological parameters, including postmortem haemoglobin A1c (HbA1c). Results: Of 376 cases, 86 (22.9%) were classified as NASH. Prevalence of diabetes mellitus, body mass index (BMI) and postmortem HbA1c were significantly higher in NASH cases (39.5%, 32.3 kg/m Conclusions: NASH and advanced fibrosis were higher in our general adult autopsy population compared with previously published estimates. This is a large series with histological evaluation showing that HbA1c >7.0% is independently associated with NASH and advanced fibrosis. |
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| MeSH term(s) | Adult ; Humans ; Glycated Hemoglobin ; Autopsy ; Cross-Sectional Studies ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology ; Liver Cirrhosis/pathology ; Liver/pathology ; Diabetes Mellitus/epidemiology | |||||
| Chemical Substances | Glycated Hemoglobin | |||||
| Language | English | |||||
| Publishing date | 2022-05-09 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 80261-x | |||||
| ISSN | 1472-4146 ; 0021-9746 | |||||
| ISSN (online) | 1472-4146 | |||||
| ISSN | 0021-9746 | |||||
| DOI | 10.1136/jclinpath-2021-207998 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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