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  1. Article: Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis.

    Dal Cero, Mariagiulia / Bencivenga, Maria / Liu, Drolaiz H W / Sacco, Michele / Alloggio, Mariella / Kerckhoffs, Kelly G P / Filippini, Federica / Saragoni, Luca / Iglesias, Mar / Tomezzoli, Anna / Carneiro, Fátima / Grabsch, Heike I / Verlato, Giuseppe / Torroni, Lorena / Piessen, Guillaume / Pera, Manuel / de Manzoni, Giovanni

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer ... ...

    Abstract Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies.
    Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed.
    Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma.
    Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications.
    Language English
    Publishing date 2023-10-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Internal Carotid Artery Stenosis and Collateral Recruitment in Stroke Patients.

    Dankbaar, Jan W / Kerckhoffs, Kelly G P / Horsch, Alexander D / van der Schaaf, Irene C / Kappelle, L Jaap / Velthuis, Birgitta K

    Clinical neuroradiology

    2017  Volume 28, Issue 3, Page(s) 339–344

    Abstract: Purpose: Leptomeningeal collaterals improve outcome in stroke patients. There is great individual variability in their extent. Internal carotid artery (ICA) stenosis may lead to more extensive recruitment of leptomeningeal collaterals. The purpose of ... ...

    Abstract Purpose: Leptomeningeal collaterals improve outcome in stroke patients. There is great individual variability in their extent. Internal carotid artery (ICA) stenosis may lead to more extensive recruitment of leptomeningeal collaterals. The purpose of this study was to evaluate the association of pre-existing ICA stenosis with leptomeningeal collateral filling visualized with computed tomography perfusion (CTP).
    Methods: From a prospective acute ischemic stroke cohort, patients were included with an M1 middle cerebral artery (MCA) occlusion and absent ipsilateral, extracranial ICA occlusion. ICA stenosis was determined on admission CT angiography (CTA). Leptomeningeal collaterals were graded as good (>50%) or poor (≤50%) collateral filling in the affected MCA territory on CTP-derived vessel images of the admission scan. The association between ipsilateral ICA stenosis ≥70% and extent of collateral filling was analyzed using logistic regression. In a multivariable analysis the odds ratio (OR) of ICA stenosis ≥70% was adjusted for complete circle of Willis, gender and age.
    Results: We included 188 patients in our analyses, 50 (26.6%) patients were classified as having poor collateral filling and 138 (73.4%) as good. Of the patients 4 with poor collateral filling had an ICA stenosis ≥70% and 14 with good collateral filling. Unadjusted and adjusted ORs of ICA stenosis ≥70% for good collateral filling were 1.30 (0.41-4.15) and 2.67 (0.81-8.77), respectively. Patients with poor collateral filling had a significantly worse outcome (90-day modified Rankin scale 3-6; 80% versus 52%, p = 0.001).
    Conclusion: No association was found between pre-existing ICA stenosis and extent of CTP derived collateral filling in patients with an M1 occlusion.
    MeSH term(s) Aged ; Carotid Artery, Internal ; Carotid Stenosis/physiopathology ; Cerebral Angiography ; Cerebrovascular Circulation ; Collateral Circulation ; Female ; Humans ; Male ; Middle Aged ; Middle Cerebral Artery/physiopathology ; Prospective Studies ; Retrospective Studies ; Stroke/physiopathology
    Language English
    Publishing date 2017-04-24
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-017-0568-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3413: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The disease recurrence rate after the canal wall up or canal wall down technique in adults.

    Kerckhoffs, Kelly G P / Kommer, Maarten B J / van Strien, Thom H L / Visscher, Simeon J A / Bruijnzeel, Hanneke / Smit, Adriana L / Grolman, Wilko

    The Laryngoscope

    2016  Volume 126, Issue 4, Page(s) 980–987

    Abstract: Objectives/hypothesis: To review which type of cholesteatoma surgery, canal wall up (CWU) or canal wall down (CWD), provides the lowest risk for residual and/or recurrent disease in adults with primary acquired cholesteatoma.: Data sources: PubMed, ... ...

    Abstract Objectives/hypothesis: To review which type of cholesteatoma surgery, canal wall up (CWU) or canal wall down (CWD), provides the lowest risk for residual and/or recurrent disease in adults with primary acquired cholesteatoma.
    Data sources: PubMed, Embase, CINAHL, the Cochrane Library, Scopus and Web of Science.
    Study design: We selected articles comparing CWU with CWD, reporting on disease recidivism (combined residual and recurrent disease) or independent residual or disease recurrence rates. We included studies with a moderate to high relevance.
    Results: Our search yielded 2,060 articles. We selected seven studies that carried a moderate risk of bias. Six studies described higher disease recidivism after the CWU procedure [16.7-61.0%] compared to the CWD technique [0-13.2%]. Four studies showed statistical significant difference (P < .05). One study showed opposite results: recidivism was found in 7.8% CWU and in 22.1% CWD cases (P < .001). Studies showed CWU recidivism more likely to be residual disease, whereas CWD recidivism tended to be recurrent disease.
    Conclusion: The majority of included studies showed CWU to result in more disease recidivism compared to the CWD technique in adult patients with a primary acquired cholesteatoma. If recidivism risk is the most important factor to consider a certain surgical technique, we recommend application of the CWD procedure. However, many additional factors in patient care will define the best treatment decision, such as residual hearing and access to health care. Our recommendations are based on Level II evidence, which underlines the need for future high-level evidence studies.
    MeSH term(s) Cholesteatoma, Middle Ear/surgery ; Humans ; Neoplasm Recurrence, Local/surgery ; Neoplasm, Residual/surgery ; Otologic Surgical Procedures/methods
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.25591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.82: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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