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Article: Medicine and Art at IMA and IMAJ.

Shoenfeld, Yehuda / Shemer, Joshua / Keren, Gad

The Israel Medical Association journal : IMAJ

2024 Volume 26, Issue 1, Page(s) 3

MeSH term(s)	Humans ; Medicine ; Societies, Medical
Language	English
Publishing date	2024-02-28
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5470: Show issues

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Article: Changes in Electrocardiogram During Romidepsin Therapy: A Case Report.

Rofe-Shmuel, May-Tal / Shapira, Michael / Keren, Gad

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 5, Page(s) 381–382

MeSH term(s)	Humans ; Depsipeptides/adverse effects ; Electrocardiography
Chemical Substances	romidepsin (CX3T89XQBK) ; Depsipeptides
Language	English
Publishing date	2023-05-27
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5470: Show issues

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Article ; Online: Potential roles in cardiac physiology and pathology of the cation channel TRPV2 expressed in cardiac cells and cardiac macrophages: a mini-review.

Entin-Meer, Michal / Keren, Gad

American journal of physiology. Heart and circulatory physiology

2019 Volume 318, Issue 1, Page(s) H181–H188

Abstract: TRPV2 is a well-conserved channel protein expressed in almost all tissues. Cardiomyocyte TRPV2 is expressed in the intercalated disks of the cardiac sarcomeres, where it is involved in maintaining the proper mechanoelectric coupling and structure. It is ... ...

Abstract	TRPV2 is a well-conserved channel protein expressed in almost all tissues. Cardiomyocyte TRPV2 is expressed in the intercalated disks of the cardiac sarcomeres, where it is involved in maintaining the proper mechanoelectric coupling and structure. It is also abundantly expressed in the intracellular pools, mainly the endoplasmic reticulum. Under pathological conditions, TRPV2 is translocated to the sarcolemma, where it mediates an abnormal [Ca]
MeSH term(s)	Animals ; Calcium Signaling ; Disease Progression ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Sarcomeres/metabolism ; Sarcomeres/pathology ; TRPV Cation Channels/metabolism
Chemical Substances	TRPV Cation Channels ; TRPV2 protein, human
Language	English
Publishing date	2019-12-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00491.2019
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Uc I Zs.89: Show issues

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Article: Diagnostic and Clinical Significance of T Wave Inversion in Athletes.

Milman, Anat / Keren, Gad

The Israel Medical Association journal : IMAJ

2018 Volume 20, Issue 2, Page(s) 114–118

Abstract: Background: Electrocardiography abnormalities are a common finding in athletes. To facilitate the differentiation of physiological adaptation versus pathological remodeling, a series of guidelines has emerged in the past decade that attempt to improve ... ...

Abstract	Background: Electrocardiography abnormalities are a common finding in athletes. To facilitate the differentiation of physiological adaptation versus pathological remodeling, a series of guidelines has emerged in the past decade that attempt to improve specificity while maintaining a high sensitivity. Recently, T wave inversion in the athletic population gained more attention, resulting in accelerated research leading to novel findings not yet integrated into clinical practice. We aim to simplify the knowledge to date and integrate it into one easy to use practical flowchart.
MeSH term(s)	Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/physiopathology ; Athletes ; Electrocardiography/methods ; Humans ; Mass Screening/methods ; Practice Guidelines as Topic ; Sensitivity and Specificity
Language	English
Publishing date	2018-02-12
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5470: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Cardiovascular medicine and the Israel Heart Society.

Keren, Gad

European heart journal

2011 Volume 32, Issue 12, Page(s) 1434–1435

Abstract: A review of cardiology in Israel by Prof. Gad Keren. ...

Abstract	A review of cardiology in Israel by Prof. Gad Keren.
MeSH term(s)	Cardiology/education ; Cardiology/organization & administration ; Cardiology/trends ; Coronary Care Units/supply & distribution ; Critical Care/organization & administration ; Heart Diseases/therapy ; Humans ; Israel ; Societies, Medical ; Thoracic Surgery/organization & administration
Language	English
Publishing date	2011-06
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article: The 20th anniversary of IMAJ.

Shoenfeld, Yehuda / Shemer, Joshua / Keren, Gad

The Israel Medical Association journal : IMAJ

2019 Volume 21, Issue 3, Page(s) 141

MeSH term(s)	Anniversaries and Special Events ; History, 20th Century ; History, 21st Century ; Humans ; Israel ; Periodicals as Topic/history ; Societies, Medical/history
Language	English
Publishing date	2019-03-21
Publishing country	Israel
Document type	Historical Article ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5470: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Elevated neutrophil gelatinase-associated lipocalin levels before contrast media administration among ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention.

Rozenfeld, Keren-Lee / Zahler, David / Shtark, Moshe / Goldiner, Ilana / Keren, Gad / Shacham, Yacov

Coronary artery disease

2021 Volume 31, Issue 2, Page(s) 118–123

Abstract: Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein released by renal tubular cells upon nephrotoxic or ischemic events and is considered an early marker of tubular damage. We aimed to demonstrate the presence of early renal ... ...

Abstract	Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein released by renal tubular cells upon nephrotoxic or ischemic events and is considered an early marker of tubular damage. We aimed to demonstrate the presence of early renal injury detected by elevated NGAL levels taken before contrast administration in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). Patients and methods: We prospectively included 88 patients with STEMI treated with PCI. Blood samples for plasma NGAL were drawn immediately before PCI (baseline NGAL; NGAL1) and 24 h after PCI (NGAL2). Abnormal elevations in NGAL levels were defined using the cardiac surgery associated NGAL score (NGAL score) with NGAL levels at least 100 ng/ml, suggesting renal tubular damage. Patients were also assessed for the dynamics between NGAL2 and NGAL1 levels. Results: The mean age of the patients was 62 ± 13 years and 78% were men. A total of 50/88 (56%) patients had baseline NGAL level of at least 100, suggesting possible tubular damage before PCI. Only 10 patients progressed to clinical acute kidney injury during hospitalization, all of whom had baseline NGAL level of at least 100 (P < 0.001). Among patients with baseline NGAL at least 100, 28/50 (56%) showed a decrease in the NGAL level within 24 h, whereas only 9/50 (18%) showed an elevation in the NGAL level. In contrast, only 7/38 (19%) patients with baseline NGAL level less than 100 showed an elevation in NGAL levels within 24 h. Conclusion: Elevated NGAL levels before primary PCI suggesting renal tubular damage are common among STEMI patients. Further trials are needed to assess the complex cardio-renal interactions.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Aged ; Biomarkers ; Contrast Media/adverse effects ; Coronary Artery Disease/surgery ; Female ; Humans ; Kidney Tubules/metabolism ; Lipocalin-2/metabolism ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Prospective Studies ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/metabolism ; ST Elevation Myocardial Infarction/surgery
Chemical Substances	Biomarkers ; Contrast Media ; LCN2 protein, human ; Lipocalin-2
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000000762
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3039: Show issues

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Article ; Online: Heart Failure Due to High-Degree Atrioventricular Block: How Frequent Is It and What Is the Cause?

Viskin, Dana / Halkin, Amir / Sherez, Jack / Megidish, Ricki / Fourey, Dana / Keren, Gad / Topilsky, Yan

The Canadian journal of cardiology

2021 Volume 37, Issue 10, Page(s) 1562–1568

Abstract: Background: The causes of heart failure (HF) during high-grade atrioventricular block (AVB) are poorly understood. This study assessed the mechanisms of HF in patients with AVB.: Methods: We studied patients presenting (between 2012 and 2016) with ... ...

Abstract	Background: The causes of heart failure (HF) during high-grade atrioventricular block (AVB) are poorly understood. This study assessed the mechanisms of HF in patients with AVB. Methods: We studied patients presenting (between 2012 and 2016) with high-grade AVB not related to acute myocardial infarction. Patients with preexisting significant valvular heart disease were excluded. All patients underwent comprehensive echocardiographic evaluation during AVB, before pacemaker implantation. The diagnosis of HF was based on the Framingham criteria. Results: A total of 122 patients were included in the study, 50% male, average age 76 ± 13 years. Twenty-eight patients (23%) with AVB presented with HF. Univariate correlates associated with HF were decrease in cardiac output (CO) (odds ratio [OR] 0.68 [95% confidence interval 0.49-0.9] per L/min; P = 0.007), measures of impaired left ventricular (LV) compliance, and increase in diastolic mitral regurgitation (MR) volume (OR 1.04 [1.01-1.07] per cc; P = 0.0016). Ventricular rate during AVB and LV ejection fraction were not significantly associated with the presence of HF. By multivariate nominal logistic analysis, the best model associated with HF included diastolic MR volume (OR 1.04 [1.001-1.09]; P = 0.02), A-wave deceleration time (OR 0.96 [0.94-0.9]; P = 0.001), and CO (OR 0.92 [0.4-1.00]; P = 0.005) (χ Conclusions: In the setting of high-degree AVB, clinical HF occurrence correlates with impaired LV compliance and diastolic MR volume, but not with heart rate or LV ejection fraction. The cardiac performance of patients with poor LV compliance and high-volume diastolic MR may show maladjustment to slow heart rates, manifesting as low CO and HF.
MeSH term(s)	Aged ; Atrioventricular Block/complications ; Atrioventricular Block/diagnosis ; Atrioventricular Block/epidemiology ; Echocardiography ; Electrocardiography ; Female ; Follow-Up Studies ; Heart Failure/epidemiology ; Heart Failure/etiology ; Heart Failure/physiopathology ; Humans ; Incidence ; Israel/epidemiology ; Male ; Prognosis ; ROC Curve ; Retrospective Studies ; Survival Rate/trends ; Ventricular Function, Left/physiology
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2021.05.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2150: Show issues

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Article: Sex differences in heart failure patients assessed by combined echocardiographic and cardiopulmonary exercise testing.

Rozenbaum, Zach / Granot, Yoav / Sadeh, Ben / Havakuk, Ofer / Arnold, Joshua H / Shimiaie, Jason / Ghermezi, Michael / Barak, Orly / Ben Gal, Yanai / Shacham, Yacov / Keren, Gad / Topilsky, Yan / Laufer-Perl, Michal

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1098395

Abstract: Background: We aimed to test the differences in peak VO: Methods: Patients who underwent CPET and SE for evaluation of dyspnea or exertional intolerance at our institution, between January 2013 and December 2017, were included and retrospectively ... ...

Abstract	Background: We aimed to test the differences in peak VO Methods: Patients who underwent CPET and SE for evaluation of dyspnea or exertional intolerance at our institution, between January 2013 and December 2017, were included and retrospectively assessed. Patients were divided into three groups: HF with preserved ejection fraction (HF Results: One hundred seventy-eight patients underwent CPET-SE testing, of which 40% were females. Females diagnosed with HF Conclusions: Combined CPET-SE testing allows for individualized non-invasive evaluation of exercise physiology stratified by sex. Female patients with HF have lower exercise capacity compared to men with HF. For females diagnosed with HF
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1098395
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage.

Bigelman, Einat / Pasmanik-Chor, Metsada / Dassa, Bareket / Itkin, Maxim / Malitsky, Sergey / Dorot, Orly / Pichinuk, Edward / Kleinberg, Yuval / Keren, Gad / Entin-Meer, Michal

PloS one

2023 Volume 18, Issue 8, Page(s) e0275550

Abstract: Background: Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze ... ...

Abstract	Background: Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze whether this agent could offer cardiac protection once an ischemic event has occurred. Methods and results: Metabolomics profiling of cardiac lysates and plasma samples derived from rats that underwent AKI 1 or 7 days earlier by 5/6 nephrectomy versus sham-operated controls was performed. We detected 26 differential metabolites in both heart and plasma samples at the two selected time points, relative to sham. Out of which, kynurenic acid (kynurenate, KYNA) seemed most relevant. Interestingly, KYNA given at 10 mM concentration significantly rescued the viability of H9C2 cardiac myoblast cells grown under anoxic conditions and largely increased their mitochondrial content and activity as determined by flow cytometry and cell staining with MitoTracker dyes. Moreover, KYNA diluted in the drinking water of animals induced with an acute myocardial infarction, highly enhanced their cardiac recovery according to echocardiography and histopathology. Conclusion: KYNA may represent a key metabolite absorbed by the heart following AKI as part of a compensatory mechanism aiming at preserving the cardiac function. KYNA preserves the in vitro myocyte viability following exposure to anoxia in a mechanism that is mediated, at least in part, by protection of the cardiac mitochondria. A short-term administration of KYNA may be highly beneficial in the treatment of the acute phase of kidney disease in order to attenuate progression to reno-cardiac syndrom and to reduce the ischemic myocardial damage following an ischemic event.
MeSH term(s)	Animals ; Rats ; Kynurenic Acid/pharmacology ; Tryptophan ; Heart ; Acute Kidney Injury ; Hypoxia ; Mitochondria, Heart
Chemical Substances	Kynurenic Acid (H030S2S85J) ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0275550
Database	MEDical Literature Analysis and Retrieval System OnLINE

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