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Article ; Online: Optimising remanufacturing decision-making using the bees algorithm in product digital twins.

Kerin, Mairi / Hartono, Natalia / Pham, D T

2023 Volume 13, Issue 1, Page(s) 701

Abstract: Remanufacturing is widely recognised as a key contributor to the circular economy (CE) as it extends the in-use life of products, but its synergy with Industry 4.0 (I4.0) has received little attention when compared to manufacturing. An agglomeration of ... ...

Abstract	Remanufacturing is widely recognised as a key contributor to the circular economy (CE) as it extends the in-use life of products, but its synergy with Industry 4.0 (I4.0) has received little attention when compared to manufacturing. An agglomeration of I4.0 technologies and methodologies is reflected in the emerging digital twin (DT) concept, which has been identified as a life-extending enabler. This article captures the design and demonstration of a DT model that optimises remanufacturing planning using data from different instances in a product's life cycle. The model uses a neural network for remaining useful life predictions and the Bees Algorithm for decision making within a DT. The model is validated using a real case study. The findings support the idea that intelligent tools within a DT can enhance decision-making if they have visibility and access to the product's current status and reliable remanufacturing process information.
MeSH term(s)	Industry ; Commerce ; Algorithms ; Neural Networks, Computer
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-27631-2
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Article ; Online: From sabers to spikes: A newfangled reconstruction of the ancient, giant, sexually dimorphic Pacific salmon, †Oncorhynchus rastrosus (SALMONINAE: SALMONINI).

Claeson, Kerin M / Sidlauskas, Brian L / Troll, Ray / Prescott, Zabrina M / Davis, Edward B

PloS one

2024 Volume 19, Issue 4, Page(s) e0300252

Abstract: The impressive †Oncorhynchus rastrosus of the Pacific Northwest's Miocene and Pliocene eras was the largest salmonid ever to live. It sported a hypertrophied premaxilla with a pair of enlarged teeth which the original describers reconstructed as ... ...

Abstract	The impressive †Oncorhynchus rastrosus of the Pacific Northwest's Miocene and Pliocene eras was the largest salmonid ever to live. It sported a hypertrophied premaxilla with a pair of enlarged teeth which the original describers reconstructed as projecting ventrally into the mouth, leading them to assign the species to "Smilodonichthys," a genus now in synonymy. Through CT reconstruction of the holotype and newly collected specimens, we demonstrate that the famed teeth projected laterally like tusks, not ventrally like sabers or fangs. We also expand the original description to characterize sexual dimorphism in mature, breeding individuals. Male and female †Oncorhynchus rastrosus differ in the form of the vomer, rostro-dermethmoid-supraethmoid, and dentary, much as do other extant species of Oncorhynchus. Male specimens possess a more elongate vomer than do females, and female vomers have concave ventral surfaces and prominent median dorsal keels. The dentary of females has no evidence of a kype, though some specimens of †O. rastrosus have a non-uniform density mesial to the tooth bed, which we interpret as a male kype. Unlike extant Oncorhynchus, male and female †O. rastrosus do not differ in premaxilla shape. Because male and females possess hypertrophied premaxillae and lateral premaxillary spikes, the former common name "Sabertoothed Salmon" no longer reflects our understanding of the species' morphology. Accordingly, we redub †O. rastrosus the Spike-Toothed Salmon and postulate that its spikes were multifunctional, serving as defense against predators, in agonism against conspecifics, and as a practical aid to nest construction.
MeSH term(s)	Animals ; Male ; Female ; Sex Characteristics ; Oncorhynchus/physiology ; Fossils ; Tooth/anatomy & histology ; Salmon/physiology
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300252
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Article ; Online: A lecture series - neurosurgery in an Irish Medical School without an associated neurosurgical Centre.

Curran, Sean / O'Brien, David / Kerin, Michael

British journal of neurosurgery

2022 Volume 36, Issue 3, Page(s) 372–376

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	COVID-19 ; Curriculum ; Education, Medical, Undergraduate ; Humans ; Neurosurgery/education ; Schools, Medical ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2021.2024505
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Article ; Online: A non-linear regression method for estimation of gene-environment heritability.

Kerin, Matthew / Marchini, Jonathan

Bioinformatics (Oxford, England)

2020 Volume 36, Issue 24, Page(s) 5632–5639

Abstract: Motivation: Gene-environment (GxE) interactions are one of the least studied aspects of the genetic architecture of human traits and diseases. The environment of an individual is inherently high dimensional, evolves through time and can be expensive and ...

Abstract	Motivation: Gene-environment (GxE) interactions are one of the least studied aspects of the genetic architecture of human traits and diseases. The environment of an individual is inherently high dimensional, evolves through time and can be expensive and time consuming to measure. The UK Biobank study, with all 500 000 participants having undergone an extensive baseline questionnaire, represents a unique opportunity to assess GxE heritability for many traits and diseases in a well powered setting. Results: We have developed a randomized Haseman-Elston non-linear regression method applicable when many environmental variables have been measured on each individual. The method (GPLEMMA) simultaneously estimates a linear environmental score (ES) and its GxE heritability. We compare the method via simulation to a whole-genome regression approach (LEMMA) for estimating GxE heritability. We show that GPLEMMA is more computationally efficient than LEMMA on large datasets, and produces results highly correlated with those from LEMMA when applied to simulated data and real data from the UK Biobank. Availability and implementation: Software implementing the GPLEMMA method is available from https://jmarchini.org/gplemma/. Supplementary information: Supplementary data are available at Bioinformatics online.
Language	English
Publishing date	2020-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btaa1079
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Article ; Online: Inferring Gene-by-Environment Interactions with a Bayesian Whole-Genome Regression Model.

Kerin, Matthew / Marchini, Jonathan

American journal of human genetics

2020 Volume 107, Issue 4, Page(s) 698–713

Abstract: The contribution of gene-by-environment (GxE) interactions for many human traits and diseases is poorly characterized. We propose a Bayesian whole-genome regression model for joint modeling of main genetic effects and GxE interactions in large-scale ... ...

Abstract	The contribution of gene-by-environment (GxE) interactions for many human traits and diseases is poorly characterized. We propose a Bayesian whole-genome regression model for joint modeling of main genetic effects and GxE interactions in large-scale datasets, such as the UK Biobank, where many environmental variables have been measured. The method is called LEMMA (Linear Environment Mixed Model Analysis) and estimates a linear combination of environmental variables, called an environmental score (ES), that interacts with genetic markers throughout the genome. The ES provides a readily interpretable way to examine the combined effect of many environmental variables. The ES can be used both to estimate the proportion of phenotypic variance attributable to GxE effects and to test for GxE effects at genetic variants across the genome. GxE effects can induce heteroskedasticity in quantitative traits, and LEMMA accounts for this by using robust standard error estimates when testing for GxE effects. When applied to body mass index, systolic blood pressure, diastolic blood pressure, and pulse pressure in the UK Biobank, we estimate that 9.3%, 3.9%, 1.6%, and 12.5%, respectively, of phenotypic variance is explained by GxE interactions and that low-frequency variants explain most of this variance. We also identify three loci that interact with the estimated environmental scores (-log
MeSH term(s)	Bayes Theorem ; Blood Pressure/physiology ; Body Mass Index ; Datasets as Topic ; Gene-Environment Interaction ; Genetic Markers ; Genome, Human ; Humans ; Models, Statistical ; Quantitative Trait Loci ; Quantitative Trait, Heritable ; United Kingdom
Chemical Substances	Genetic Markers
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2020.08.009
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Article ; Online: Effect of the World Health Organization Checklist on Patient Outcomes: A Stepped Wedge Cluster Randomized Controlled Trial.

Lynch, N / Kerin, M

Annals of surgery

2016 Volume 263, Issue 2, Page(s) e24

MeSH term(s)	Checklist ; Hospital Mortality ; Humans ; Length of Stay ; Patient Outcome Assessment ; Postoperative Complications/prevention & control ; World Health Organization
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000001012
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Article ; Online: "I know I didn't ask for it, but I've got it and I've let my kids down": A secondary data analysis of qualitative maternal perspectives of their and adolescent children's unmet needs through a cancer diagnosis.

Rodriguez, Leonor / Dolan, Pat / Kerin, Michael / Groarke, AnnMarie

European journal of oncology nursing : the official journal of European Oncology Nursing Society

2022 Volume 63, Page(s) 102191

Abstract: Purpose: This article is a secondary data analysis which explores maternal unmet needs and their perception of the 'unmet needs' of adolescent children when they experienced maternal cancer. The analysis is underpinned by the theoretical framework of ... ...

Abstract	Purpose: This article is a secondary data analysis which explores maternal unmet needs and their perception of the 'unmet needs' of adolescent children when they experienced maternal cancer. The analysis is underpinned by the theoretical framework of the Offspring Cancer Needs Instrument OCNI, (Patterson et al., 2013). Method: A secondary data analysis was carried out with ten maternal interviews analyzed using a deductive Thematic Analysis. This was to identify maternal unmet needs as well as their perceptions of their adolescent children's unmet needs and determine whether the OCNI framework was suitable to identify unmet needs of mothers and adolescent children in an Irish context. Results: The study found cancer is a challenging emotional burden for both mothers and their adolescent children. Emotions related to cancer recurrence were particularly difficult to deal with. Mothers struggle to identify the unmet needs of adolescent children and recognize that they lack the skills to approach the children, which adds to the burden of their illness burden and feelings of guilt. Conclusions: The study highlights the need to provide safe spaces for patients and adolescent children to deal with their emotions, strengthen relationships and improve communication associated with maternal cancer as these have a significant impact in their lives and may lead to tension and conflict within families.
MeSH term(s)	Female ; Humans ; Child ; Adolescent ; Secondary Data Analysis ; Mothers/psychology ; Emotions ; Neoplasms ; Cost of Illness
Language	English
Publishing date	2022-12-25
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2017117-1
ISSN	1532-2122 ; 1462-3889
ISSN (online)	1532-2122
ISSN	1462-3889
DOI	10.1016/j.ejon.2022.102191
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Article ; Online: Imprecise risk estimation of chemotherapy-related cardiotoxicity in HER2-positive breast cancer using the recently reported societal risk tools.

Soliman, Osama / Lowery, Aoife / Kerin, Michael

Breast cancer research and treatment

2021 Volume 190, Issue 3, Page(s) 355–356

MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Cardiotoxicity/etiology ; Female ; Humans ; Receptor, ErbB-2/genetics ; Trastuzumab/adverse effects
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2021-09-29
Publishing country	Netherlands
Document type	Letter
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06403-4
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Article: A review of emerging industry 4.0 technologies in remanufacturing

Kerin, Mairi / Pham, Duc Truong

Journal of cleaner production. 2019 Nov. 10, v. 237

2019

Abstract: This paper reviews the literature on the emerging digital technologies of Industry 4.0 (I4.0) focussed on the applicability of the Internet of Things (IoT), Virtual Reality (VR) and Augmented Reality (AR) in remanufacturing. Inspired by the frameworks ... ...

Abstract	This paper reviews the literature on the emerging digital technologies of Industry 4.0 (I4.0) focussed on the applicability of the Internet of Things (IoT), Virtual Reality (VR) and Augmented Reality (AR) in remanufacturing. Inspired by the frameworks developed to support exploration and realisation of I4.0 technologies for disassembly, the paper discusses the same emerging technologies in the wider context of remanufacturing. Trends and gaps have been identified from a value-creation perspective that encompasses the product to be remanufactured, the remanufacturing equipment and processes adopted and related organisation issues. Findings suggest there is a need to explore the connection of cyber-physical systems to the IoT to support smart remanufacturing, whilst aligning with evolving information and communication infrastructures and circular economy business models. The review highlights twenty-nine research topics that require attention to support this field.
Keywords	circular economy ; computer simulation ; equipment ; industry ; infrastructure ; Internet
Language	English
Dates of publication	2019-1110
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2019.117805
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The impacts of comparative anatomy of electric rays (Batoidea: Torpediniformes) on their systematic hypotheses.

Claeson, Kerin M

Journal of morphology

2014 Volume 275, Issue 6, Page(s) 597–612

Abstract: The Comparative anatomy of the 11 recognized genera within Torpediniformes is described, systematically categorized, and illustrated in a comprehensive photo-atlas. Data are compiled into a character matrix and cladistically analyzed using parsimony to ... ...

Abstract	The Comparative anatomy of the 11 recognized genera within Torpediniformes is described, systematically categorized, and illustrated in a comprehensive photo-atlas. Data are compiled into a character matrix and cladistically analyzed using parsimony to test hypotheses about the previously recognized subfamilies, while reconstructing the possible evolutionary history of Torpediniformes. Results are consistent with the previous rank-based classifications, regardless of the parsimony criteria used to generate the phylogenetic hypothesis, with one notable exception: a monophyletic Narcininae was never recovered. Torpedinoidea (=Hypnos + Torpedo) is supported by the presence of long, slender, flexible jaw cartilages, absence of a large rostral fontanelle, presence of suprascapular antimeres that are each shorter than the scapular process of the scapulocoracoid, antorbital cartilages that articulate on the anterior aspect of the nasal capsules and absence of a frontoparietal fontanelle. Subfamilial names Hypninae and Torpedininae are redundant with the genus names Hypnos and Torpedo and are not adopted here. Narcinoidea (=nontorpedinoid torpediniforms) is supported by unambiguous character transformations to the presence of a divided lower lip, labial cartilages, laterolingually compressed palatoquadrates, bifurcated antorbital cartilages, a rostral fontanelle, ventrally projecting nasal capsules, a dorsal rim of the synarcual mouth posterior to occipital condyle, posteriorly positioned lateral stays, and obtuse anterior margins of lateral stays. Narkidae is supported by unambiguous character transformations to the presence of an uncovered eye that protrudes above dorsal surface, a shared rim between the spiracle and the eye, an anterior nasal turret that projects ventrally, a nasal curtain that covers the upper lip and dentition when the mouth is closed, tab-like prepelvic processes, a mesopterygium that is shorter than propterygium but longer than metapterygium, a slender median rostral cartilage, and a basibranchial cartilage with an anterior margin that is depressed medially and a posterior margin that tapers.
MeSH term(s)	Animals ; Biological Evolution ; Cartilage/anatomy & histology ; Elasmobranchii/anatomy & histology ; Elasmobranchii/classification ; Female ; Jaw/anatomy & histology ; Phylogeny ; Skull/anatomy & histology ; Torpedo/anatomy & histology ; Torpedo/classification
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3084-3
ISSN	1097-4687 ; 0022-2887 ; 0362-2525
ISSN (online)	1097-4687
ISSN	0022-2887 ; 0362-2525
DOI	10.1002/jmor.20239
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