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  1. Book ; Thesis: Pharyngeale Ausbreitung von periimplantären Infektionen unter antiresorptiver/antiangiogener Behandlung

    Kern, Karsten

    2021  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Karsten Klaus Kern
    Language German ; English
    Size 39 Seiten, Illustrationen, 30 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2022
    Note Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 28-30. - Enthält 1 Sonderabdruck
    HBZ-ID HT021565844
    Database Catalogue ZB MED Medicine, Health

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    2022 E 983 order for loan Magazin

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  2. Article ; Online: Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy.

    Kern, Karsten / Lukmann, Fania / Obreja, Karina / Al-Maawi, Sara / Carla, Bellinghausen / Ghanaati, Shahram / Rohde, Gernot / Sader, Robert / Schwarz, Frank

    International journal of implant dentistry

    2021  Volume 7, Issue 1, Page(s) 43

    Abstract: Objectives: To assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region.: Material and methods: This analysis was based on tissue biopsies obtained from a total of twenty-five ... ...

    Abstract Objectives: To assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region.
    Material and methods: This analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bisphosphonate (Zoledronate) (Zo) (n=4), (2) RANKL inhibitor (Denosumab) (De) (n=4), (3) antiangiogenic medication (Bevacizumab) (Be) (n=4), (4) Zo+Be (n=3), (5) De+Be (n=5), or (6) no medication (Co) (n=5). Drug administration was repeated at 12 weeks. Chronic-type peri-implant infections were induced at titanium implants located in the upper jaws. The surface area (%) of infiltrated connective tissue (ICT) and CD68-positive cells was assessed within the lateral pharyngeal/retropharyngeal connective tissue zone.
    Results: Mean (±SD) and median ICT% values and CD68 counts were markedly highest in the De+Be (11.10±6.04; 11.81; 95% CI - 3.89; 26.11) and De (5.70±5.06; 6.19; 95% CI - 2.34; 13.75) groups, reaching statistical significance for De CD68 counts over the Co (0.18±0.25; 0.18; 95% CI -2.14; 2.51) group. In both De+Be and De groups, the ICTs were occasionally associated with an ulceration of the epithelial compartment.
    Conclusions: Induced peri-implant infections were not associated with any inflammatory lesions in pharyngeal tissues. While these findings were similar under Zo and Be medication, De and De+Be had a marked effect on ICT and CD68 values. The clinical relevance of these adverse findings needs further investigation.
    MeSH term(s) Animals ; Bone Density Conservation Agents ; Connective Tissue ; Diphosphonates ; Rats ; Titanium
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2021-06-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2198-4034
    ISSN (online) 2198-4034
    DOI 10.1186/s40729-021-00332-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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