Article ; Online: A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients.
2021 Volume 11, Issue 1, Page(s) 23491
Abstract: Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a ... ...
| Abstract | Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a close connection to the dysregulation of the patient's immune functions. We previously developed a simple, nanoparticle-enabled blood test that can determine the humoral immune status in animals. In this study, we applied this new test to analyze the immune function in relation to disease severity in COVID-19 patients. From the testing of 153 COVID-19 patient samples and 142 negative controls, we detected a drastic decrease of humoral immunity in COVID-19 patients who developed moderate to severe symptoms, but not in patients with no or mild symptoms. The new test may be potentially used to monitor the immunity change and predict the clinical risk of patients with COVID-19. |
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| MeSH term(s) | COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Case-Control Studies ; Gold/chemistry ; Humans ; Immunity, Humoral ; Immunoassay/methods ; Immunoglobulin G ; Metal Nanoparticles/chemistry ; Risk Factors ; SARS-CoV-2/isolation & purification ; Severity of Illness Index |
| Chemical Substances | Immunoglobulin G ; Gold (7440-57-5) |
| Language | English |
| Publishing date | 2021-12-06 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-02863-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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