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  1. Article ; Online: Management of oral potentially malignant disorders.

    Kerr, Alexander Ross / Lodi, Giovanni

    Oral diseases

    2021  Volume 27, Issue 8, Page(s) 2008–2025

    Abstract: Patients with oral potentially malignant disorders (OPMDs), including oral leukoplakia and erythroplakia, proliferative verrucous leukoplakia, oral submucous fibrosis, and oral lichen planus/lichenoid lesions, can be challenging to manage. A small ... ...

    Abstract Patients with oral potentially malignant disorders (OPMDs), including oral leukoplakia and erythroplakia, proliferative verrucous leukoplakia, oral submucous fibrosis, and oral lichen planus/lichenoid lesions, can be challenging to manage. A small proportion will undergo cancer development and determining a patient's cancer risk is key to making management decisions. Yet, our understanding of the natural history of OPMDs has not been fully elucidated, and a precision approach based on the integration of numerous predictive markers has not been validated by prospective studies. Evidence-based health promotion by clinicians and healthcare systems is not embraced universally. Medical and surgical interventions evaluated by rigorous research measuring important endpoints, such as cancer development, mortality, or survival, are difficult and expensive to run. Most of these studies employ non-ideal surrogate endpoints and have deep methodologic flaws. Diagnostic criteria for enrolling research subjects are not uniform, and patients with the highest risk for cancer development comprise small proportions of those enrolled. Few studies explore quality of life and patient preferences. It is time to rethink how we approach the management of these patients, across each OPMD, and considering the healthcare infrastructure and cost-effectiveness. Global networks with well-characterized patient populations with OPMDs and well-designed interventional trials using validated outcome measures are needed.
    MeSH term(s) Cell Transformation, Neoplastic ; Humans ; Leukoplakia, Oral/therapy ; Lichen Planus, Oral/therapy ; Mouth Mucosa ; Mouth Neoplasms/therapy ; Precancerous Conditions/therapy ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2021-10-09
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: World Workshop on Oral Medicine VIII-barriers to research in oral medicine: lessons learned from a bibliometric analysis of the oral potentially malignant disorders literature.

    Gueiros, Luiz Alcino / Ottaviani, Giulia / Jessri, Maryam / Shiboski, Caroline / Farag, Arwa / Sollecito, Thomas P / Warnakulasuriya, Saman / Kerr, Alexander Ross

    Oral surgery, oral medicine, oral pathology and oral radiology

    2024  

    Abstract: Objective: This study aimed to assess the impact of oral medicine (OM) practitioners on the literature regarding oral potentially malignant disorders (OPMDs), focusing on oral leukoplakia.: Study design: Using a bibliometric approach on the Scopus ... ...

    Abstract Objective: This study aimed to assess the impact of oral medicine (OM) practitioners on the literature regarding oral potentially malignant disorders (OPMDs), focusing on oral leukoplakia.
    Study design: Using a bibliometric approach on the Scopus database until September 1, 2022, the top 100 cited articles were analyzed for article type, subtopic, specialty contributions, author metrics, and keywords. The Bibliometrix package for R and VOSviewer were used to evaluate interactions and generate science maps.
    Results: OM practitioners, comprising 39% of contributors, played a significant role in studies related to nomenclature and screening of OPMDs. Notably, 4 OM specialists ranked among the most prolific authors, demonstrating denser collaboration with OM co-authors compared to other cancer specialists. However, there was a scarcity of OPMD management studies authored by OM practitioners.
    Conclusions: Despite the paucity of OM practitioners, the findings underscored the substantial contribution of OM practitioners in developing OPMD nomenclature and classification, emphasizing the need for increased collaboration with cancer specialists to conduct comprehensive clinical trials for OPMD management. The study highlights the importance of standardized criteria in OPMDs research for better data comparison and encourages further efforts from the OM scientific community.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2024.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation and Management of Oral Potentially Malignant Disorders.

    Nadeau, Christine / Kerr, Alexander Ross

    Dental clinics of North America

    2017  Volume 62, Issue 1, Page(s) 1–27

    Abstract: Oral potentially malignant disorders (OPMDs) refer to epithelial lesions and conditions with an increased risk for malignant transformation; oral leukoplakia is the most commonly encountered. Overall, OPMDs have a low risk for malignant transformation, ... ...

    Abstract Oral potentially malignant disorders (OPMDs) refer to epithelial lesions and conditions with an increased risk for malignant transformation; oral leukoplakia is the most commonly encountered. Overall, OPMDs have a low risk for malignant transformation, yet the challenge is the difficulty to reliably identify and predict which patients with OPMDs are at the highest risk for malignant transformation. Future research is needed to elucidate the molecular aspects of OPMDs, to improve current diagnostic strategies, leading to personalized management.
    MeSH term(s) Cell Transformation, Neoplastic ; Diagnosis, Differential ; Humans ; Mass Screening ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/therapy ; Precancerous Conditions/diagnosis ; Precancerous Conditions/therapy ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2017-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392075-6
    ISSN 1558-0512 ; 0011-8532
    ISSN (online) 1558-0512
    ISSN 0011-8532
    DOI 10.1016/j.cden.2017.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reported physical examination methods for screening of oral cancer and oral potentially malignant disorders: a systematic review.

    Louredo, Brendo Vinícius Rodrigues / de Lima-Souza, Reydson Alcides / Pérez-de-Oliveira, Maria Eduarda / Warnakulasuriya, Saman / Kerr, Alexander Ross / Kowalski, Luiz Paulo / Hunter, Keith David / Prado-Ribeiro, Ana Carolina / Vargas, Pablo Agustin / Santos-Silva, Alan Roger Dos

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 137, Issue 2, Page(s) 136–152

    Abstract: Objective: This systematic review aimed to describe the method followed during physical examination and the anatomical structures of the head and neck assessed in screening for oral cancer and oral potentially malignant disorders (OPMDs).: Study ... ...

    Abstract Objective: This systematic review aimed to describe the method followed during physical examination and the anatomical structures of the head and neck assessed in screening for oral cancer and oral potentially malignant disorders (OPMDs).
    Study design: An extensive literature search was carried out using MEDLINE/PubMed, EMBASE, Scopus, LILACS, Web of Science, Cochrane databases, and gray literature. The risk of bias was available in all papers included.
    Results: Of 9,688 records identified, 27 were included in this review, reporting data from 356,250 individuals screened and distributed across 11 countries. Most of these (n = 19) were based on 1 round of screening conducted by a dental professional or other health care workers. Most screening programs included visual inspection and palpation of the lips, oral cavity, and the most visible oropharyngeal sites, but the descriptions reported were imprecise. Additional inspection and palpation of the neck (submental, submandibular, cervical, and supraclavicular regions) to assess for the presence of swellings and any palpable neck nodes were also performed in 15 programs.
    Conclusion: In conclusion, there was considerable heterogeneity in the method of physical examination in screening programs for oral cancer and OPMDs among the included studies.
    MeSH term(s) Humans ; Early Detection of Cancer/methods ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/prevention & control ; Mouth Diseases ; Lip Neoplasms ; Physical Examination/methods ; Lip ; Precancerous Conditions
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for xerostomia.

    Wiriyakijja, Paswach / Niklander, Sven Eric / Santos-Silva, Alan Roger / Shorrer, Michal Kuten / Simms, Melanie Louise / Villa, Alessandro / Sankar, Vidya / Kerr, Alexander Ross / Riordain, Richeal Ni / Jensen, Siri Beier / Delli, Konstantina

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 135, Issue 6, Page(s) 827–875

    Abstract: Objective: The purpose of this study was to identify all outcome domains used in clinical studies of xerostomia, that is, subjective sensation of dry mouth. This study is part of the extended project "World Workshop on Oral Medicine Outcomes Initiative ... ...

    Abstract Objective: The purpose of this study was to identify all outcome domains used in clinical studies of xerostomia, that is, subjective sensation of dry mouth. This study is part of the extended project "World Workshop on Oral Medicine Outcomes Initiative for the Direction of Research" to develop a core outcome set for dry mouth.
    Study design: A systematic review was performed on MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials databases. All clinical and observational studies that assessed xerostomia in human participants from 2001 to 2021 were included. Information on outcome domains was extracted and mapped to the Core Outcome Measures in Effectiveness Trials taxonomy. Corresponding outcome measures were summarized.
    Results: From a total of 34,922 records retrieved, 688 articles involving 122,151 persons with xerostomia were included. There were 16 unique outcome domains and 166 outcome measures extracted. None of these domains or measures were consistently used across all the studies. The severity of xerostomia and physical functioning were the 2 most frequently assessed domains.
    Conclusion: There is considerable heterogeneity in outcome domains and measures reported in clinical studies of xerostomia. This highlights the need for harmonization of dry mouth assessment to enhance comparability across studies and facilitate the synthesis of robust evidence for managing patients with xerostomia.
    MeSH term(s) Humans ; Xerostomia/drug therapy
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunction.

    Simms, Melanie Louise / Kuten-Shorrer, Michal / Wiriyakijja, Paswach / Niklander, Sven Eric / Santos-Silva, Alan Roger / Sankar, Vidya / Kerr, Alexander Ross / Jensen, Siri Beier / Riordain, Richeal Ni / Delli, Konstantina / Villa, Alessandro

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 135, Issue 6, Page(s) 804–826

    Abstract: Objective: To identify all outcome measures used to assess salivary gland hypofunction (i.e., objective measures used to determine actual changes in saliva quantity or to assess response to treatment of salivary gland hypofunction) and to group these ... ...

    Abstract Objective: To identify all outcome measures used to assess salivary gland hypofunction (i.e., objective measures used to determine actual changes in saliva quantity or to assess response to treatment of salivary gland hypofunction) and to group these into domains.
    Study design: A systematic review including clinical trials and prospective or retrospective observational studies involving human participants with dry mouth, with any type of intervention where the objective assessment of salivary gland hypofunction was described.
    Results: Five hundred fifty-three studies involving 31,507 participants were identified. Most assessed salivary gland hypofunction and xerostomia (68.7%), whereas 31.3% assessed salivary gland hypofunction alone. Most studies investigated the "amount of saliva," and the highest number of outcome measures were within the domain of "clinical/objective signs of salivary gland hypofunction."
    Conclusions: Seven domains encompassing 30 outcome measures were identified, confirming the diversity in outcomes and outcome measures used in research regarding salivary gland hypofunction. Identified items will be used in conjunction with those identified regarding xerostomia to create a core outcome set for dry mouth quantification for use in future clinical trials, with the overall goal of improving the standardization of reporting, leading to the establishment of more robust evidence for the management of dry mouth and improving patient care.
    MeSH term(s) Humans ; Prospective Studies ; Retrospective Studies ; Xerostomia/drug therapy ; Salivary Glands ; Saliva
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2022.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: the patient perspective.

    Santos-Silva, Alan Roger / Villa, Alessandro / Kerr, Alexander Ross / Delli, Konstantina / Simms, Melanie Louise / Shorrer, Michal Kuten / Wiriyakija, Paswach / Jensen, Siri Beier / Niklander, Sven Eric / Sankar, Vidya / Ni Riordain, Rícheal

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 135, Issue 6, Page(s) 876–884

    Abstract: Objective: We conducted a qualitative study of patients' perspectives on dry mouth outcomes to explore their personal experiences and investigate which outcomes are most important to them. This work was part of the WONDER initiative (World Workshop on ... ...

    Abstract Objective: We conducted a qualitative study of patients' perspectives on dry mouth outcomes to explore their personal experiences and investigate which outcomes are most important to them. This work was part of the WONDER initiative (World Workshop on Oral Medicine Outcomes Initiative for the Direction of Research) exploring Core Outcome Measures in Effectiveness Trials.
    Study design: Using a study-specific topic guide, we conducted digitally recorded, semi-structured interviews of focus groups of patients with dry mouth secondary to Sjögren syndrome and head and neck radiotherapy. We conducted interviews until data saturation had been achieved and evaluated all transcripts for accuracy before we anonymized the data.
    Results: Two focus groups consisting of 4 participants per group identified 4 distinct themes: (1) impact on oral health and function, (2) social isolation and withdrawal, (3) frustration with dry mouth management, and (4) limited knowledge of the medical community and lack of understanding of family and friends.
    Conclusions: The diversity of self-reported outcomes and the complexity of patient perceptions identified in our work may represent additional barriers to successful dry mouth management that should be considered in the design of future clinical trials.
    MeSH term(s) Humans ; Xerostomia/therapy ; Sjogren's Syndrome ; Qualitative Research ; Patients ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a consensus study.

    Niklander, Sven Eric / Simms, Melanie Louise / Wiriyakijja, Paswach / Santos-Silva, Alan Roger / Kuten-Shorrer, Michal / Sankar, Vidya / Kerr, Alexander Ross / Jensen, Siri Beier / Riordain, Richeal Ni / Villa, Alessandro / Delli, Konstantina

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 135, Issue 6, Page(s) 885–892

    Abstract: Objective: This study aimed to develop a consensus-based core outcome set (COS) to be used in clinical trials assessing dry mouth interventions.: Study design: Through 2 systematic literature reviews and interviews with dry mouth patients, we ... ...

    Abstract Objective: This study aimed to develop a consensus-based core outcome set (COS) to be used in clinical trials assessing dry mouth interventions.
    Study design: Through 2 systematic literature reviews and interviews with dry mouth patients, we identified relevant outcome domains for dry mouth assessment. A Delphi survey was presented to health care providers attending the American Academy of Oral Medicine annual meeting in Memphis, Tennessee, USA, on May 2022 (n = 104) and 10 dry mouth patients at Cork University Dental School and Hospital, Republic of Ireland. The outcome domains for which no consensus was reached were subsequently discussed in a second consensus process led by a virtual Special Interest Group of 11 oral medicine experts from the World Workshop on Oral Medicine VIII dry mouth working group.
    Results: After the 2-step consensus process, a consensus was reached for 12 dry mouth outcome domains (i.e., salivary gland flow, signs of hyposalivation, mucosal moisture/wetness, the severity of xerostomia, duration of xerostomia, the overall impact of xerostomia, impact on physical functioning, impact of hyposalivation on general health, impact on social activities, quality of life, the economic impact of dry mouth, patient satisfaction) to be included in the final COS.
    Conclusions: We propose a consensus-based COS to assess dry mouth interventions in clinical trials. This COS includes the minimum but mandatory set of domains that all clinical trials evaluating dry mouth treatments should assess.
    MeSH term(s) Humans ; Quality of Life ; Xerostomia/therapy ; Salivary Glands ; Patient Satisfaction ; Outcome Assessment, Health Care ; Delphi Technique ; Treatment Outcome ; Research Design
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2022.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management.

    Rao, Naman R / Villa, Alessandro / More, Chandramani B / Jayasinghe, Ruwan D / Kerr, Alexander Ross / Johnson, Newell W

    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

    2020  Volume 49, Issue 1, Page(s) 3

    Abstract: Oral Submucous fibrosis (OSMF) has traditionally been described as "a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus". Millions of individuals are affected, especially in South and ... ...

    Abstract Oral Submucous fibrosis (OSMF) has traditionally been described as "a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus". Millions of individuals are affected, especially in South and South East Asian countries. The main risk factor is areca nut chewing. Due to its high morbidity and high malignant transformation rate, constant efforts have been made to develop effective management. Despite this, there have been no significant improvements in prognosis for decades. This expert opinion paper updates the literature and provides a critique of diagnostic and therapeutic pitfalls common in developing countries and of deficiencies in management. An inter-professional model is proposed to avoid these pitfalls and to reduce these deficiencies.
    MeSH term(s) Areca ; Cell Transformation, Neoplastic ; Early Diagnosis ; Humans ; Oral Submucous Fibrosis/diagnosis ; Oral Submucous Fibrosis/epidemiology ; Oral Submucous Fibrosis/etiology ; Oral Submucous Fibrosis/therapy ; Precancerous Conditions ; Prognosis ; Risk Factors
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2434004-2
    ISSN 1916-0216 ; 1916-0208 ; 0381-6605
    ISSN (online) 1916-0216
    ISSN 1916-0208 ; 0381-6605
    DOI 10.1186/s40463-020-0399-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: World Workshop on Oral Medicine VII: Editorial.

    Kerr, Alexander Ross / Greenberg, Martin S / Hodgson, Tim / Jensen, Siri Beier / Lockhart, Peter B / Lodi, Giovanni / Peterson, Douglas E

    Oral diseases

    2019  Volume 25 Suppl 1, Page(s) 1–7

    MeSH term(s) Bibliometrics ; Congresses as Topic ; Humans ; Oral Medicine ; Surveys and Questionnaires
    Language English
    Publishing date 2019-08-04
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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