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  1. Article ; Online: Public Interest in Myocarditis during the SARS-CoV-2 Pandemic.

    Perkins, Del / Wilkins, Rachel / Kerr, Randi / Greiner, Benjamin / Hartwell, Micah

    Disaster medicine and public health preparedness

    2023  Volume 17, Page(s) e349

    Abstract: Objective: Public interest in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been rising with regard to associated myocarditis. Thus, the objective of our study was to assess trends in public interest in myocarditis during ...

    Abstract Objective: Public interest in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been rising with regard to associated myocarditis. Thus, the objective of our study was to assess trends in public interest in myocarditis during the course of the pandemic and the SARS-CoV-2 vaccine rollout in the United States.
    Methods: We conducted a longitudinal assessment of public interest in myocarditis, and its association with actual coronavirus disease 2019 (COVID-19) -related myocarditis during the first wave of the pandemic and SARS-CoV-2 vaccine-related myocarditis following vaccine rollout. To complete this objective, we used data from 3 sources: a report from the Morbidity and Mortality Weekly Report, the Vaccine Adverse Event Reporting database, and from Google Trends.
    Results: Results show that Relative Search Interest (RSI) was low before and during the initial phase of the pandemic and peaked in April 2021, during the initial vaccine push. The ratio of myocarditis related to the SARS-CoV-2 vaccines was considerably lower than the ratio of myocarditis from natural infection.
    Conclusions: Search interest in myocarditis was low until SARS-CoV-2 vaccines were rolled out, in which media coverage intensely focused on a relatively small number of cases. This study highlights both the benefits of COVID-19 vaccine uptake and the impact of the media on public interest.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 Vaccines/adverse effects ; COVID-19/epidemiology ; COVID-19/prevention & control ; Myocarditis/epidemiology ; Myocarditis/etiology ; Pandemics
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2022.307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Examination of reporting status of pediatric oncology trials within the national library of medicine's trial database.

    Stewart, Carly / McPherson, Kristen / Whitaker, Liza-Ann / Sajjadi, Nicholas B / Kerr, Randi / Baxter, Michael A / Hartwell, Micah

    Pediatric hematology and oncology

    2023  Volume 40, Issue 8, Page(s) 766–777

    Abstract: Finding safer and more effective treatment options are critical in progressing the field of pediatric oncology. These treatment options are discovered through completion and publication of clinical trials. The primary objective of this study was to ... ...

    Abstract Finding safer and more effective treatment options are critical in progressing the field of pediatric oncology. These treatment options are discovered through completion and publication of clinical trials. The primary objective of this study was to assess the overall study characteristics of pediatric oncology clinical trials initiated between 2008 and 2021. The secondary objective of our study was to assess rates of discontinuation and reporting of results as required by the Food and Drug Administration (FDA). After acquiring pediatric oncology clinical trials from ClinicalTrials.gov, a cross-sectional study was performed. Included trials have an intervention exclusive to pediatrics and were conducted between 2008 and 2021. The results measured were characteristics of the clinical trials and their rate of discontinuation. Of the 7,930 trials originally returned from the search, 349 trials met inclusion criteria. The majority of the trials were phase 1 and 2 pharmaceutical interventions studying brain and blood cancer. Our study found that 14.9% (52) of the pediatric oncology trials were discontinued. Given the breadth of study within pediatric oncology, our overarching assessment shows that drug trials geared toward treating cancers of the brain and blood were dominant in the field. It is crucial for the advancement of science that results of trials are known. This avoids duplication of studies and waste of funds. Of the trials that were completed, 40.3% (58) did not report results to ClinicalTrials.gov. The nonreporting of this data limits the information available delaying the advancement of treatment options.
    MeSH term(s) Child ; Humans ; Clinical Trials as Topic ; Cross-Sectional Studies ; Medical Oncology ; National Library of Medicine (U.S.) ; Neoplasms/therapy ; Treatment Outcome ; United States ; Databases as Topic
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 632914-7
    ISSN 1521-0669 ; 0888-0018
    ISSN (online) 1521-0669
    ISSN 0888-0018
    DOI 10.1080/08880018.2023.2197935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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