LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: Phagocytes: fussy about carbs.

    Kerrigan, Ann M / Brown, Gordon D

    Current biology : CB

    2011  Volume 21, Issue 13, Page(s) R500–2

    Abstract: A new mechanistic model based on the formation of a phagocytic synapse explains how immune cells detect and respond to direct contact with fungal pathogens. ...

    Abstract A new mechanistic model based on the formation of a phagocytic synapse explains how immune cells detect and respond to direct contact with fungal pathogens.
    MeSH term(s) Animals ; Cell Wall/chemistry ; Cell Wall/immunology ; Cells, Cultured ; Humans ; Immunity, Innate/immunology ; Immunological Synapses/immunology ; Lectins, C-Type ; Membrane Proteins/chemistry ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Mice ; Models, Immunological ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/immunology ; Nerve Tissue Proteins/metabolism ; Phagocytosis/immunology ; Reactive Oxygen Species/metabolism ; Saccharomyces cerevisiae/immunology ; Signal Transduction ; beta-Glucans/chemistry ; beta-Glucans/immunology ; beta-Glucans/metabolism
    Chemical Substances Lectins, C-Type ; Membrane Proteins ; Nerve Tissue Proteins ; Reactive Oxygen Species ; beta-Glucans ; dectin 1
    Language English
    Publishing date 2011-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2011.05.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Syk-coupled C-type lectins in immunity.

    Kerrigan, Ann M / Brown, Gordon D

    Trends in immunology

    2011  Volume 32, Issue 4, Page(s) 151–156

    Abstract: The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens ... ...

    Abstract The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses. It subsequently emerged that Dectin-1 is one of a number of spleen tyrosine kinase-coupled C-type lectin receptors that have been implicated not just in fungal immunity, but also in viral, mycobacterial and helminth infections. Here, we consider the ability of these receptors to trigger different aspects of immunity and highlight their emerging roles in a number of infection scenarios.
    MeSH term(s) Animals ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Ligands ; Membrane Proteins/immunology ; Nerve Tissue Proteins/immunology ; Protein Binding ; Protein-Tyrosine Kinases/metabolism ; Receptors, Calcitonin/immunology ; Syk Kinase
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Lectins, C-Type ; Ligands ; Membrane Proteins ; Nerve Tissue Proteins ; Receptors, Calcitonin ; dectin 1 ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; SYK protein, human (EC 2.7.10.2) ; Syk Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2011-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2011.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs.

    Kerrigan, Ann M / Brown, Gordon D

    Immunological reviews

    2010  Volume 234, Issue 1, Page(s) 335–352

    Abstract: Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C-type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid ... ...

    Abstract Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C-type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid cells that can recognize endogenous ligands as well as a wide range of exogenous structures present on pathogens. Dual roles in homeostasis and immunity have been demonstrated for some members of this receptor family. Largely due to their endocytic ability and subset specific expression, DC-expressed CLRs have been the focus of significant antigen-targeting studies. A number of CLRs function on the basis of signaling via association with immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter proteins. Others contain ITAM-related motifs or immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic tails. Here we review CLRs that induce intracellular signaling via a single tyrosine-based ITAM-like motif and highlight their relevance in terms of DC function.
    MeSH term(s) Amino Acid Motifs ; Animals ; Dendritic Cells/enzymology ; Dendritic Cells/immunology ; Humans ; Intracellular Signaling Peptides and Proteins/immunology ; Lectins, C-Type/chemistry ; Lectins, C-Type/immunology ; Ligands ; Membrane Proteins/immunology ; Nerve Tissue Proteins/immunology ; Protein-Tyrosine Kinases/immunology ; Receptors, Mitogen/immunology ; Signal Transduction/immunology ; Syk Kinase ; Tyrosine
    Chemical Substances CLEC9a protein, human ; Intracellular Signaling Peptides and Proteins ; Lectins, C-Type ; Ligands ; Membrane Proteins ; Nerve Tissue Proteins ; Receptors, Mitogen ; dectin 1 ; Tyrosine (42HK56048U) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; SYK protein, human (EC 2.7.10.2) ; Syk Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2010-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/j.0105-2896.2009.00882.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: C-type lectins and phagocytosis.

    Kerrigan, Ann M / Brown, Gordon D

    Immunobiology

    2009  Volume 214, Issue 7, Page(s) 562–575

    Abstract: To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs) bind to conserved microbial structures and activate host defence systems, including microbial uptake by phagocytosis. Phagocytosis is a complex process that is ... ...

    Abstract To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs) bind to conserved microbial structures and activate host defence systems, including microbial uptake by phagocytosis. Phagocytosis is a complex process that is instrumental in the control of extracellular pathogens, and this activity is mediated by several PRRs, including a number of C-type lectins. While some of these receptors have clearly been shown to mediate or regulate the uptake of pathogens, others are more contentious and are less well understood in terms of their phagocytic potential. Furthermore, very little is known about the underlying phagocytic mechanisms. Here, we review the phagocytic roles of the mannose receptor, Dectin-1, dendritic cell-specific ICAM grabbing non-integrin (DC-SIGN), DCL-1, mannose binding lectin and surfactant proteins A and D.
    MeSH term(s) Animals ; Complement Activation ; Host-Pathogen Interactions ; Humans ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Phagocytosis/immunology ; Receptors, Pattern Recognition/immunology ; Signal Transduction/immunology
    Chemical Substances Lectins, C-Type ; Receptors, Pattern Recognition
    Language English
    Publishing date 2009-03-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2008.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.32: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Phagocytes: Fussy about Carbs

    Kerrigan, Ann M / Brown, Gordon D

    Current biology. 2011 July 12, v. 21, no. 13

    2011  

    Abstract: A new mechanistic model based on the formation of a phagocytic synapse explains how immune cells detect and respond to direct contact with fungal pathogens. ...

    Abstract A new mechanistic model based on the formation of a phagocytic synapse explains how immune cells detect and respond to direct contact with fungal pathogens.
    Keywords direct contact ; fungi ; models ; pathogens ; phagocytes ; synapse
    Language English
    Dates of publication 2011-0712
    Size p. R500-R502.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2011.05.041
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2005/718: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Syk-coupled C-type lectins in immunity

    Kerrigan, Ann M / Brown, Gordon D

    Trends in immunology. 2011 Apr., v. 32, no. 4

    2011  

    Abstract: The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens ... ...

    Abstract The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses. It subsequently emerged that Dectin-1 is one of a number of spleen tyrosine kinase-coupled C-type lectin receptors that have been implicated not just in fungal immunity, but also in viral, mycobacterial and helminth infections. Here, we consider the ability of these receptors to trigger different aspects of immunity and highlight their emerging roles in a number of infection scenarios.
    Keywords fungi ; helminthiasis ; immune response ; lectins ; pathogens ; receptors ; spleen ; tyrosine
    Language English
    Dates of publication 2011-04
    Size p. 151-156.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2011.01.002
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2005/708: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.

    Marakalala, Mohlopheni J / Kerrigan, Ann M / Brown, Gordon D

    Mammalian genome : official journal of the International Mammalian Genome Society

    2010  Volume 22, Issue 1-2, Page(s) 55–65

    Abstract: The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed ... ...

    Abstract The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
    MeSH term(s) Animals ; Fungi/immunology ; Fungi/physiology ; Humans ; Lectins, C-Type ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Mycoses/genetics ; Mycoses/immunology ; Mycoses/microbiology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/immunology ; Polymorphism, Genetic
    Chemical Substances Lectins, C-Type ; Membrane Proteins ; Nerve Tissue Proteins ; dectin 1
    Language English
    Publishing date 2010-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-010-9277-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs

    Kerrigan, Ann M / Brown, Gordon D

    Immunological reviews. 2010 Mar., v. 234, no. 1

    2010  

    Abstract: Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C-type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid ... ...

    Abstract Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C-type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid cells that can recognize endogenous ligands as well as a wide range of exogenous structures present on pathogens. Dual roles in homeostasis and immunity have been demonstrated for some members of this receptor family. Largely due to their endocytic ability and subset specific expression, DC-expressed CLRs have been the focus of significant antigen-targeting studies. A number of CLRs function on the basis of signaling via association with immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter proteins. Others contain ITAM-related motifs or immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic tails. Here we review CLRs that induce intracellular signaling via a single tyrosine-based ITAM-like motif and highlight their relevance in terms of DC function.
    Language English
    Dates of publication 2010-03
    Size p. 335-352.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/j.0105-2896.2009.00882.x
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Simple assays for measuring innate interactions with fungi.

    Kerrigan, Ann M / de Sousa, Maria da Glória Teixeira / Brown, Gordon D

    Methods in molecular biology (Clifton, N.J.)

    2012  Volume 845, Page(s) 303–317

    Abstract: In recent decades, there has been a steady rise in immunocompromised populations and consequently a dramatic increase in the clinical relevance of normally non-pathogenic and commensal fungi such as Aspergillus fumigatus and Candida albicans. ... ...

    Abstract In recent decades, there has been a steady rise in immunocompromised populations and consequently a dramatic increase in the clinical relevance of normally non-pathogenic and commensal fungi such as Aspergillus fumigatus and Candida albicans. Understanding how these fungi interact with the host immune system is important for the development of immunotherapeutic approaches. Here, we describe a number of methods which have been developed to investigate the interactions of fungi with host leukocytes in vitro, including measuring fungal binding and induction of cytokines, phagocytosis, the respiratory burst, and fungal killing.
    MeSH term(s) Animals ; Aspergillus fumigatus/immunology ; Candida albicans/immunology ; Host-Pathogen Interactions ; Immunity, Innate ; Leukocytes/cytology ; Leukocytes/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microbial Viability ; Phagocytosis ; Respiratory Burst
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-539-8_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

    Marakalala, Mohlopheni J / Kerrigan, Ann M / Brown, Gordon D

    Mammalian genome: official journal of the International Mammalian Genome Society. 2011 Feb., v. 22, no. 1-2

    2011  

    Abstract: The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed ... ...

    Abstract The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
    Keywords fungi ; genetic polymorphism ; genome ; human diseases ; humans ; immunity
    Language English
    Dates of publication 2011-02
    Size p. 55-65.
    Publisher Springer-Verlag
    Publishing place New York
    Document type Article
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-010-9277-3
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top