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  1. Book: Blind spot

    Keshavjee, Salmaan

    how neoliberalism infiltrated global health

    (California series in public anthropology ; 30)

    2014  

    Author's details Salmaan Keshavjee
    Series title California series in public anthropology ; 30
    Collection
    Keywords Health Services / economics ; Health Services Administration / economics ; Health Policy ; Organizations ; Socioeconomic Factors ; World Health ; Tajikistan
    Language English
    Size XXXVIII, 240 S. : Ill., Kt.
    Publisher Univ. of California Press
    Publishing place Oakland, Calif
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018430993
    ISBN 978-0-520-28284-1 ; 978-0-520-28283-4 ; 9780520958739 ; 0-520-28284-1 ; 0-520-28283-3 ; 052095873X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4296 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Statement regarding events in Ukraine from Shaf Keshavjee, MD, 102nd President, The American Association for Thoracic Surgery.

    Keshavjee, Shaf

    The Journal of thoracic and cardiovascular surgery

    2022  Volume 164, Issue 1, Page(s) 1

    MeSH term(s) Humans ; Societies, Medical ; Thoracic Surgery ; Thoracic Surgical Procedures ; Ukraine ; United States
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2022.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.104: Show issues Location:
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  3. Article ; Online: 102nd American Association for Thoracic Surgery Presidential Address: What's next?

    Keshavjee, Shaf

    The Journal of thoracic and cardiovascular surgery

    2022  Volume 165, Issue 3, Page(s) 925–941

    MeSH term(s) Humans ; Societies, Medical ; Thoracic Surgery ; Thoracic Surgical Procedures ; United States
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Address ; Editorial
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2022.10.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Advent of Semi-Elective Lung Transplantation-Prolonged Static Cold Storage at 10°C.

    Hoetzenecker, K / Benazzo, A / Schwarz, S / Keshavjee, S / Cypel, M

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12310

    Abstract: Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static ...

    Abstract Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static cold storage (SCS) in a cooler filled with ice. Depending on the length of SCS, organs usually arrive at the recipient hospital at a temperature of 0°C-4°C. The question of the optimal storage temperature for donor lung preservation has been revisited as data from large animal experiments demonstrated that organs stored at 10°C experience less mitochondrial damage. Thus, prolonged cold ischemic times can be better tolerated at 10°C-even in pre-damaged organs. The clinical applicability of these findings was demonstrated in an international multi-center observational study including three high-volume lung transplant centers. Total clinical preservation times of up to 24 hrs have been successfully achieved in organs stored at 10°C without hampering primary organ function and short-term outcomes. Currently, a randomized-controlled trial (RCT) is recruiting patients with the aim to compare standard SCS on ice with prolonged SCS protocol at 10°C. If, as anticipated, this RCT confirms data from previous studies, lung transplantation could indeed become a semi-elective procedure.
    MeSH term(s) Animals ; Humans ; Cold Temperature ; Ice ; Lung ; Lung Transplantation/methods ; Observational Studies as Topic ; Organ Preservation/methods ; Perfusion/methods ; Randomized Controlled Trials as Topic ; Temperature ; Multicenter Studies as Topic
    Chemical Substances Ice
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human organ repair centers: Fact or fiction?

    Keshavjee, Shaf

    JTCVS open

    2020  Volume 3, Page(s) 164–168

    Language English
    Publishing date 2020-05-13
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2020.05.001
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  6. Article ; Online: Creating superior lungs for transplantation with next-generation gene therapy during ex vivo lung perfusion.

    Nykänen, Antti I / Keshavjee, Shaf / Liu, Mingyao

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2024  Volume 43, Issue 5, Page(s) 838–848

    Abstract: Engineering donor organs to better tolerate the harmful non-immunological and immunological responses inherently related to solid organ transplantation would improve transplant outcomes. Our enhanced knowledge of ischemia-reperfusion injury, alloimmune ... ...

    Abstract Engineering donor organs to better tolerate the harmful non-immunological and immunological responses inherently related to solid organ transplantation would improve transplant outcomes. Our enhanced knowledge of ischemia-reperfusion injury, alloimmune responses and pathological fibroproliferation after organ transplantation, and the advanced toolkit available for gene therapies, have brought this goal closer to clinical reality. Ex vivo organ perfusion has evolved rapidly especially in the field of lung transplantation, where clinicians routinely use ex vivo lung perfusion (EVLP) to confirm the quality of marginal donor lungs before transplantation, enabling safe transplantation of organs originally considered unusable. EVLP would also be an attractive platform to deliver gene therapies, as treatments could be administered to an isolated organ before transplantation, thereby providing a window for sophisticated organ engineering while minimizing off-target effects to the recipient. Here, we review the status of lung transplant first-generation gene therapies that focus on inducing transgene expression in the target cells. We also highlight recent advances in next-generation gene therapies, that enable gene editing and epigenetic engineering, that could be used to permanently change the donor organ genome and to induce widespread transcriptional gene expression modulation in the donor lung. In a future vision, dedicated organ repair and engineering centers will use gene editing and epigenetic engineering, to not only increase the donor organ pool, but to create superior organs that will function better and longer in the recipient.
    MeSH term(s) Lung Transplantation/methods ; Humans ; Genetic Therapy/methods ; Perfusion/methods ; Lung ; Organ Preservation/methods ; Animals
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2024.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A practical and immediately available size-match strategy improves short and long term outcomes in lung transplantation.

    Keshavjee, Shaf / Riddell, Peter

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2022  Volume 41, Issue 9, Page(s) 1303

    MeSH term(s) Humans ; Lung Transplantation ; Tissue Donors ; Treatment Outcome
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2022.03.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Applications of transcriptomics in ischemia reperfusion research in lung transplantation.

    Jeon, Jamie E / Rajapaksa, Yasal / Keshavjee, Shaf / Liu, Mingyao

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2024  

    Abstract: Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques to profile the RNA transcripts within a sample and provides a unique ... ...

    Abstract Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques to profile the RNA transcripts within a sample and provides a unique view of the mechanisms underlying various biological processes. This review aims to highlight the applications of transcriptomics in lung IR injury studies, which have thus far revealed inflammatory responses to be the major event activated by IR, identified potential biomarkers and therapeutic targets, and investigated the mechanisms of therapeutic interventions. Ex vivo lung perfusion, together with advanced bioinformatic and transcriptomic techniques, including single-cell RNA-sequencing, microRNA profiling, and multi-omics, continue to expand the capabilities of transcriptomics. In the future, the construction of biospecimen banks and the promotion of international collaborations among clinicians and researchers have the potential to advance our understanding of IR injury and improve the management of lung transplant recipients.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation.

    Suzuki, Yamato / Juvet, Stephen / Liu, Mingyao / Keshavjee, Shaf

    Journal of visualized experiments : JoVE

    2023  , Issue 201

    Abstract: Murine intrapulmonary tracheal transplantation (IPTT) is used as a model of obliterative airway disease (OAD) following lung transplantation. Initially reported by our team, this model has gained use in the study of OAD due to its high technical ... ...

    Abstract Murine intrapulmonary tracheal transplantation (IPTT) is used as a model of obliterative airway disease (OAD) following lung transplantation. Initially reported by our team, this model has gained use in the study of OAD due to its high technical reproducibility and suitability for investigating immunological behaviors and therapeutic interventions. In the IPTT model, a rodent tracheal graft is directly inserted into the recipient's lung through the pleura. This model is distinct from the heterotopic tracheal transplantation (HTT) model, wherein grafts are transplanted into subcutaneous or omental sites, and from the orthotopic tracheal transplantation (OTT) model in which the donor trachea replaces the recipient's trachea. Successful implementation of the IPTT model requires advanced anesthetic and surgical skills. Anesthetic skills include endotracheal intubation of the recipient, setting appropriate ventilatory parameters, and appropriately timed extubation after recovery from anesthesia. Surgical skills are essential for precise graft placement within the lung and for ensuring effective sealing of the visceral pleura to prevent air leakage and bleeding. In general, the learning process takes approximately 2 months. In contrast to the HTT and OTT models, in the IPTT model, the allograft airway develops airway obliteration in the relevant lung microenvironment. This allows investigators to study lung-specific immunological and angiogenic processes involved in airway obliteration after lung transplantation. Furthermore, this model is also unique in that it exhibits tertiary lymphoid organs (TLOs), which are also seen in human lung allografts. TLOs are comprised of T and B cell populations and characterized by the presence of high endothelial venules that direct immune cell recruitment; therefore, they are likely to play a crucial role in graft acceptance and rejection. We conclude that the IPTT model is a useful tool for studying intrapulmonary immune and profibrotic pathways involved in the development of airway obliteration in the lung transplant allograft.
    MeSH term(s) Humans ; Mice ; Animals ; Bronchiolitis Obliterans/etiology ; Bronchiolitis Obliterans/surgery ; Trachea/transplantation ; Reproducibility of Results ; Lung Transplantation/adverse effects ; Anesthetics ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; Disease Models, Animal
    Chemical Substances Anesthetics
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mesenchymal Stromal Cell Therapy in Lung Transplantation.

    Nykänen, Antti I / Liu, Mingyao / Keshavjee, Shaf

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Lung transplantation is often the only viable treatment option for a patient with end-stage lung disease. Lung transplant results have improved substantially over time, but ischemia-reperfusion injury, primary graft dysfunction, acute rejection, and ... ...

    Abstract Lung transplantation is often the only viable treatment option for a patient with end-stage lung disease. Lung transplant results have improved substantially over time, but ischemia-reperfusion injury, primary graft dysfunction, acute rejection, and chronic lung allograft dysfunction (CLAD) continue to be significant problems. Mesenchymal stromal cells (MSC) are pluripotent cells that have anti-inflammatory and protective paracrine effects and may be beneficial in solid organ transplantation. Here, we review the experimental studies where MSCs have been used to protect the donor lung against ischemia-reperfusion injury and alloimmune responses, as well as the experimental and clinical studies using MSCs to prevent or treat CLAD. In addition, we outline ex vivo lung perfusion (EVLP) as an optimal platform for donor lung MSC delivery, as well as how the therapeutic potential of MSCs could be further leveraged with genetic engineering.
    Language English
    Publishing date 2023-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10060728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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